메뉴 건너뛰기




Volumn 313, Issue 1, 2007, Pages 146-155

Inhibition of p38 MAPK signaling in chondrocyte cultures results in enhanced osteogenic differentiation of perichondral cells

Author keywords

Chondrocyte; Ihh; Osteocalcin; Osterix; p38; Perichondral cell; Ptch; Runx2 Cbfa 1

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 NITROPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOCALCIN; OSTERIX; RECOMBINANT PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR RUNX2;

EID: 33845640215     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.09.027     Document Type: Article
Times cited : (32)

References (55)
  • 2
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty G., and Wagner E.F. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2 (2002) 389-406
    • (2002) Dev. Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 3
    • 0242334002 scopus 로고    scopus 로고
    • MAP kinases in chondrocyte differentiation
    • Stanton L.A., Underhill T.M., and Beier F. MAP kinases in chondrocyte differentiation. Dev. Biol. 263 (2003) 165-175
    • (2003) Dev. Biol. , vol.263 , pp. 165-175
    • Stanton, L.A.1    Underhill, T.M.2    Beier, F.3
  • 4
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 423 (2003) 332-336
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 5
    • 1642545091 scopus 로고    scopus 로고
    • Essential role of hypertrophic chondrocytes in endochondral bone development
    • Chung U.I. Essential role of hypertrophic chondrocytes in endochondral bone development. Endocr. J 51 (2004) 19-24
    • (2004) Endocr. J , vol.51 , pp. 19-24
    • Chung, U.I.1
  • 6
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp A., Lee K., Lanske B., Segre G.V., Kronenberg H.M., and Tabin C.J. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273 (1996) 613-622
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 7
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B., Hammerschmidt M., and McMahon A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13 (1999) 2072-2086
    • (1999) Genes Dev. , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 8
    • 0035895905 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
    • Zhen X., Wei L., Wu Q., Zhang Y., and Chen Q. Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone. J. Biol. Chem. 276 (2001) 4879-4885
    • (2001) J. Biol. Chem. , vol.276 , pp. 4879-4885
    • Zhen, X.1    Wei, L.2    Wu, Q.3    Zhang, Y.4    Chen, Q.5
  • 9
    • 0035957924 scopus 로고    scopus 로고
    • Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells
    • Watanabe H., de Caestecker M.P., and Yamada Y. Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. J. Biol. Chem. 276 (2001) 14466-14473
    • (2001) J. Biol. Chem. , vol.276 , pp. 14466-14473
    • Watanabe, H.1    de Caestecker, M.P.2    Yamada, Y.3
  • 10
    • 1542314840 scopus 로고    scopus 로고
    • p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation
    • Stanton L.A., Sabari S., Sampaio A.V., Underhill T.M., and Beier F. p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation. Biochem. J 378 (2004) 53-62
    • (2004) Biochem. J , vol.378 , pp. 53-62
    • Stanton, L.A.1    Sabari, S.2    Sampaio, A.V.3    Underhill, T.M.4    Beier, F.5
  • 11
    • 19044390915 scopus 로고    scopus 로고
    • Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis
    • Wang G., and Beier F. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. J. Bone Miner. Res. 20 (2005) 1022-10231
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 1022-10231
    • Wang, G.1    Beier, F.2
  • 12
    • 0035046919 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells
    • Gallea S., Lallemand F., Atfi A., Rawadi G., Ramez V., Spinella-Jaegle S., Kawai S., Faucheu C., Huet L., Baron R., and Roman-Roman S. Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone 28 (2001) 491-498
    • (2001) Bone , vol.28 , pp. 491-498
    • Gallea, S.1    Lallemand, F.2    Atfi, A.3    Rawadi, G.4    Ramez, V.5    Spinella-Jaegle, S.6    Kawai, S.7    Faucheu, C.8    Huet, L.9    Baron, R.10    Roman-Roman, S.11
  • 13
    • 0038185348 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation
    • Hu Y., Chan E., Wang S.X., and Li B. Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology 144 (2003) 2068-2074
    • (2003) Endocrinology , vol.144 , pp. 2068-2074
    • Hu, Y.1    Chan, E.2    Wang, S.X.3    Li, B.4
  • 14
    • 0033965158 scopus 로고    scopus 로고
    • The p38 signal transduction pathway: activation and function
    • Ono K., and Han J. The p38 signal transduction pathway: activation and function. Cell. Signal. 12 (2000) 1-13
    • (2000) Cell. Signal. , vol.12 , pp. 1-13
    • Ono, K.1    Han, J.2
  • 15
    • 0036803602 scopus 로고    scopus 로고
    • In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance
    • Shi Y., and Gaestel M. In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance. Biol. Chem. 383 (2002) 1519-1536
    • (2002) Biol. Chem. , vol.383 , pp. 1519-1536
    • Shi, Y.1    Gaestel, M.2
  • 16
    • 0030769809 scopus 로고    scopus 로고
    • Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo
    • Sims N.A., White C.P., Sunn K.L., Thomas G.P., Drummond M.L., Morrison N.A., Eisman J.A., and Gardiner E.M. Human and murine osteocalcin gene expression: conserved tissue restricted expression and divergent responses to 1,25-dihydroxyvitamin D3 in vivo. Mol. Endocrinol. 11 (1997) 1695-1708
    • (1997) Mol. Endocrinol. , vol.11 , pp. 1695-1708
    • Sims, N.A.1    White, C.P.2    Sunn, K.L.3    Thomas, G.P.4    Drummond, M.L.5    Morrison, N.A.6    Eisman, J.A.7    Gardiner, E.M.8
  • 17
    • 0027246006 scopus 로고
    • Induction of bone-related proteins, osteocalcin and osteopontin, and their matrix ultrastructural localization with development of chondrocyte hypertrophy in vitro
    • Lian J.B., McKee M.D., Todd A.M., and Gerstenfeld L.C. Induction of bone-related proteins, osteocalcin and osteopontin, and their matrix ultrastructural localization with development of chondrocyte hypertrophy in vitro. J. Cell. Biochem. 52 (1993) 206-219
    • (1993) J. Cell. Biochem. , vol.52 , pp. 206-219
    • Lian, J.B.1    McKee, M.D.2    Todd, A.M.3    Gerstenfeld, L.C.4
  • 18
    • 0033014044 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation by Cbfa1
    • Kim I.S., Otto F., Zabel B., and Mundlos S. Regulation of chondrocyte differentiation by Cbfa1. Mech. Dev. 80 (1999) 159-170
    • (1999) Mech. Dev. , vol.80 , pp. 159-170
    • Kim, I.S.1    Otto, F.2    Zabel, B.3    Mundlos, S.4
  • 19
    • 0034610058 scopus 로고    scopus 로고
    • A fundamental transcription factor for bone and cartilage
    • Komori T. A fundamental transcription factor for bone and cartilage. Biochem. Biophys. Res. Commun. 276 (2000) 813-816
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 813-816
    • Komori, T.1
  • 23
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    • Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 24
    • 14244265834 scopus 로고    scopus 로고
    • Minireview: transcriptional regulation in development of bone
    • Kobayashi T., and Kronenberg H. Minireview: transcriptional regulation in development of bone. Endocrinology 146 (2005) 1012-1017
    • (2005) Endocrinology , vol.146 , pp. 1012-1017
    • Kobayashi, T.1    Kronenberg, H.2
  • 25
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., and de Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108 (2002) 17-29
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    de Crombrugghe, B.7
  • 26
    • 0029820144 scopus 로고    scopus 로고
    • Expression of bone-specific genes by hypertrophic chondrocytes: implication of the complex functions of the hypertrophic chondrocyte during endochondral bone development
    • Gerstenfeld L.C., and Shapiro F.D. Expression of bone-specific genes by hypertrophic chondrocytes: implication of the complex functions of the hypertrophic chondrocyte during endochondral bone development. J. Cell. Biochem. 62 (1996) 1-9
    • (1996) J. Cell. Biochem. , vol.62 , pp. 1-9
    • Gerstenfeld, L.C.1    Shapiro, F.D.2
  • 27
    • 0030272737 scopus 로고    scopus 로고
    • Expression of matrix proteins during the development of mineralized tissues
    • Sommer B., Bickel M., Hofstetter W., and Wetterwald A. Expression of matrix proteins during the development of mineralized tissues. Bone 19 (1996) 371-380
    • (1996) Bone , vol.19 , pp. 371-380
    • Sommer, B.1    Bickel, M.2    Hofstetter, W.3    Wetterwald, A.4
  • 28
    • 0027931452 scopus 로고
    • Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo
    • Nakase T., Takaoka K., Hirakawa K., Hirota S., Takemura T., Onoue H., Takebayashi K., Kitamura Y., and Nomura S. Alterations in the expression of osteonectin, osteopontin and osteocalcin mRNAs during the development of skeletal tissues in vivo. Bone Miner. 26 (1994) 109-122
    • (1994) Bone Miner. , vol.26 , pp. 109-122
    • Nakase, T.1    Takaoka, K.2    Hirakawa, K.3    Hirota, S.4    Takemura, T.5    Onoue, H.6    Takebayashi, K.7    Kitamura, Y.8    Nomura, S.9
  • 29
    • 0026659978 scopus 로고
    • In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections
    • Ikeda T., Nomura S., Yamaguchi A., Suda T., and Yoshiki S. In situ hybridization of bone matrix proteins in undecalcified adult rat bone sections. J. Histochem. Cytochem. 40 (1992) 1079-1088
    • (1992) J. Histochem. Cytochem. , vol.40 , pp. 1079-1088
    • Ikeda, T.1    Nomura, S.2    Yamaguchi, A.3    Suda, T.4    Yoshiki, S.5
  • 30
    • 7644228337 scopus 로고    scopus 로고
    • Identification of the putative collagen X gene from the pufferfish Fugu rubripes
    • Woods A., James C., Underhill T.M., and Beier F. Identification of the putative collagen X gene from the pufferfish Fugu rubripes. Gene 342 (2004) 77-83
    • (2004) Gene , vol.342 , pp. 77-83
    • Woods, A.1    James, C.2    Underhill, T.M.3    Beier, F.4
  • 31
    • 27644453166 scopus 로고    scopus 로고
    • Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    • James C.G., Appleton C.T.G., Ulici V., Underhill T.M., and Beier F. Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol. Biol. Cell 16 (2005) 5316-5333
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5316-5333
    • James, C.G.1    Appleton, C.T.G.2    Ulici, V.3    Underhill, T.M.4    Beier, F.5
  • 33
    • 33744956176 scopus 로고    scopus 로고
    • RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner
    • Woods A., and Beier F. RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner. J. Biol. Chem. 281 (2006) 13134-13140
    • (2006) J. Biol. Chem. , vol.281 , pp. 13134-13140
    • Woods, A.1    Beier, F.2
  • 34
    • 33749548543 scopus 로고    scopus 로고
    • The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin gene transcription
    • James C.G., Woods A., Underhill T.M., and Beier F. The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin gene transcription. BMC Mol. Biol. 7 (2006) 30
    • (2006) BMC Mol. Biol. , vol.7 , pp. 30
    • James, C.G.1    Woods, A.2    Underhill, T.M.3    Beier, F.4
  • 35
    • 2442644183 scopus 로고    scopus 로고
    • p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation
    • Halawani D., Mondeh R., Stanton L.A., and Beier F. p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation. Oncogene 23 (2004) 3726-3731
    • (2004) Oncogene , vol.23 , pp. 3726-3731
    • Halawani, D.1    Mondeh, R.2    Stanton, L.A.3    Beier, F.4
  • 36
    • 1842581698 scopus 로고    scopus 로고
    • RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation
    • Wang G., Woods A., Sabari S., Pagnotta L., Stanton L.A., and Beier F. RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. J. Biol. Chem. 279 (2004) 13205-13214
    • (2004) J. Biol. Chem. , vol.279 , pp. 13205-13214
    • Wang, G.1    Woods, A.2    Sabari, S.3    Pagnotta, L.4    Stanton, L.A.5    Beier, F.6
  • 37
    • 0033051415 scopus 로고    scopus 로고
    • High density micromass cultures of embryonic limb bud mesenchymal cells: an in vitro model of endochondral skeletal development. PG-262-9
    • Mello M.A., and Tuan R.S. High density micromass cultures of embryonic limb bud mesenchymal cells: an in vitro model of endochondral skeletal development. PG-262-9. In Vitro Cell. Dev. Biol. Anim. 35 (1999) 262-269
    • (1999) In Vitro Cell. Dev. Biol. Anim. , vol.35 , pp. 262-269
    • Mello, M.A.1    Tuan, R.S.2
  • 38
    • 33646350024 scopus 로고    scopus 로고
    • Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation
    • Qiao M., Shapiro P., Fosbrink M., Rus H., Kumar R., and Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J. Biol. Chem. 281 (2006) 7118-7128
    • (2006) J. Biol. Chem. , vol.281 , pp. 7118-7128
    • Qiao, M.1    Shapiro, P.2    Fosbrink, M.3    Rus, H.4    Kumar, R.5    Passaniti, A.6
  • 39
    • 16544371756 scopus 로고    scopus 로고
    • Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2
    • Fujita T., Fukuyama R., Enomoto H., and Komori T. Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2. J. Cell. Biochem. 93 (2004) 374-383
    • (2004) J. Cell. Biochem. , vol.93 , pp. 374-383
    • Fujita, T.1    Fukuyama, R.2    Enomoto, H.3    Komori, T.4
  • 40
    • 0034635477 scopus 로고    scopus 로고
    • MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1
    • Xiao G., Jiang D., Thomas P., Benson M.D., Guan K., Karsenty G., and Franceschi R.T. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. J. Biol. Chem. 275 (2000) 4453-4459
    • (2000) J. Biol. Chem. , vol.275 , pp. 4453-4459
    • Xiao, G.1    Jiang, D.2    Thomas, P.3    Benson, M.D.4    Guan, K.5    Karsenty, G.6    Franceschi, R.T.7
  • 41
    • 2342547689 scopus 로고    scopus 로고
    • Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage
    • Alsalameh S., Amin R., Gemba T., and Lotz M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum. 50 (2004) 1522-1532
    • (2004) Arthritis Rheum. , vol.50 , pp. 1522-1532
    • Alsalameh, S.1    Amin, R.2    Gemba, T.3    Lotz, M.4
  • 42
    • 16844370419 scopus 로고    scopus 로고
    • Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development
    • Colnot C., de la Fuente L., Huang S., Hu D., Lu C., St-Jacques B., and Helms J.A. Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132 (2005) 1057-1067
    • (2005) Development , vol.132 , pp. 1057-1067
    • Colnot, C.1    de la Fuente, L.2    Huang, S.3    Hu, D.4    Lu, C.5    St-Jacques, B.6    Helms, J.A.7
  • 44
    • 26844502418 scopus 로고    scopus 로고
    • Transcriptional control of chondrocyte fate and differentiation
    • Lefebvre V., and Smits P. Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res. C. Embryo Today 75 (2005) 200-212
    • (2005) Birth Defects Res. C. Embryo Today , vol.75 , pp. 200-212
    • Lefebvre, V.1    Smits, P.2
  • 47
    • 0035135642 scopus 로고    scopus 로고
    • Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
    • Chung U.I., Schipani E., McMahon A.P., and Kronenberg H.M. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J. Clin. Invest 107 (2001) 295-304
    • (2001) J. Clin. Invest , vol.107 , pp. 295-304
    • Chung, U.I.1    Schipani, E.2    McMahon, A.P.3    Kronenberg, H.M.4
  • 48
    • 0031406262 scopus 로고    scopus 로고
    • Expression of Indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis
    • Iwasaki M., Le A.X., and Helms J.A. Expression of Indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis. Mech. Dev. 69 (1997) 197-202
    • (1997) Mech. Dev. , vol.69 , pp. 197-202
    • Iwasaki, M.1    Le, A.X.2    Helms, J.A.3
  • 49
    • 29744468220 scopus 로고    scopus 로고
    • Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation
    • Razzaque M.S., Soegiarto D.W., Chang D., Long F., and Lanske B. Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J. Pathol. 207 (2005) 453-461
    • (2005) J. Pathol. , vol.207 , pp. 453-461
    • Razzaque, M.S.1    Soegiarto, D.W.2    Chang, D.3    Long, F.4    Lanske, B.5
  • 50
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long F., Chung U.-i., Ohba S., McMahon J., Kronenberg H.M., and McMahon A.P. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131 (2004) 1309-1318
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.-i.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 51
    • 31044432518 scopus 로고    scopus 로고
    • Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation
    • Zhang R., Murakami S., Coustry F., Wang Y., and de Crombrugghe B. Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. Proc. Natl. Acad. Sci. 103 (2006) 365-370
    • (2006) Proc. Natl. Acad. Sci. , vol.103 , pp. 365-370
    • Zhang, R.1    Murakami, S.2    Coustry, F.3    Wang, Y.4    de Crombrugghe, B.5
  • 52
    • 14744271227 scopus 로고    scopus 로고
    • Regulation of Indian hedgehog mRNA levels in chondrocytic cells by ERK1/2 and p38 mitogen-activated protein kinases
    • Lai L.P., DaSilva K.A., and Mitchell J. Regulation of Indian hedgehog mRNA levels in chondrocytic cells by ERK1/2 and p38 mitogen-activated protein kinases. J. Cell. Physiol. 203 (2005) 177-185
    • (2005) J. Cell. Physiol. , vol.203 , pp. 177-185
    • Lai, L.P.1    DaSilva, K.A.2    Mitchell, J.3
  • 53
    • 0142153787 scopus 로고    scopus 로고
    • The hedgehog signaling network
    • Cohen Jr. M.M. The hedgehog signaling network. Am. J. Med. Genet., A 123 (2003) 5-28
    • (2003) Am. J. Med. Genet., A , vol.123 , pp. 5-28
    • Cohen Jr., M.M.1
  • 54
    • 22644447278 scopus 로고    scopus 로고
    • Regulation of skeletal development by the Runx family of transcription factors
    • Komori T. Regulation of skeletal development by the Runx family of transcription factors. J. Cell. Biochem. 95 (2005) 445-453
    • (2005) J. Cell. Biochem. , vol.95 , pp. 445-453
    • Komori, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.