Arsenite reduces insulin secretion in rat pancreatic β-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25

Toxicology and Applied Pharmacology

Volumn 231, Issue 3, 2008, Pages 291-299

  Díaz Villaseñor, Andrea ^a   Burns, Anna L ^a,b   Salazar, Ana María ^a   Sordo, Monserrat ^a   Hiriart, Marcia ^a   Cebrián, Mariano E ^c   Ostrosky Wegman, Patricia ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Arsenic; Calcium; Calpains; Insulin; SNAP 25; Type 2 diabetes

Indexed keywords

ARSENIC TRIOXIDE; CALCIUM; CALPAIN 10; GLUCOSE; INSULIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; EXOCYTOSIS; INSULIN RELEASE; INSULIN SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN DEGRADATION; RAT;

ANIMALS; ARSENITES; CALCIUM; CALPAIN; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; INSULIN; INSULIN-SECRETING CELLS; PEPTIDE HYDROLASES; RATS; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;

RATTUS;

EID: 50849136166     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.05.018     Document Type: Article

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