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Volumn 8, Issue 2, 2012, Pages 144-154

Genetic basis, nutritional challenges and adaptive responses in the prenatal origin of obesity and type-2 diabetes

Author keywords

Intrauterine growth retardation; Nutrition; Obesity; Postnatal growth; Prenatal programming; Type 2 diabetes

Indexed keywords

BODY MASS; DNA SEQUENCE; EPIGENETICS; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOME; GENOTYPE; HUMAN; INSULIN RESISTANCE; INTRAUTERINE GROWTH RETARDATION; MALNUTRITION; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITION; NUTRITIONAL STATUS; OBESITY; PERINATAL PERIOD; PHENOTYPE; PHYSICAL ACTIVITY; PRENATAL EXPOSURE; PRENATAL GROWTH; PRENATAL PERIOD; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; STARVATION; TIME; UTERUS;

EID: 84857751360     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/157339912799424537     Document Type: Review
Times cited : (26)

References (170)
  • 1
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 2
    • 77949430552 scopus 로고    scopus 로고
    • Metabolic syndrome as a risk factor for diabetes
    • Aschner P. Metabolic syndrome as a risk factor for diabetes. Expert Rev Cardiovasc Ther 2010; 8: 407-12.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 407-412
    • Aschner, P.1
  • 3
    • 67650072947 scopus 로고    scopus 로고
    • Metabolic syndrome and diabetes; alone and in combination; as predictors of cardiovascular disease mortality among men
    • Church TS, Thompson AM, Katzmarzyk PT et al. Metabolic syndrome and diabetes; alone and in combination; as predictors of cardiovascular disease mortality among men. Diabetes Care 2009; 32: 1289-94.
    • (2009) Diabetes Care , vol.32 , pp. 1289-1294
    • Church, T.S.1    Thompson, A.M.2    Katzmarzyk, P.T.3
  • 5
    • 0023879112 scopus 로고
    • Stone agers in the fast lane: Chronic degenerative diseases in evolutionary perspective
    • Eaton SB, Konner M, Shostak M. Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective. Am J Med 1988; 84: 739-49.
    • (1988) Am J Med , vol.84 , pp. 739-749
    • Eaton, S.B.1    Konner, M.2    Shostak, M.3
  • 7
    • 79959785542 scopus 로고    scopus 로고
    • Fetal programming of adipose tissue: Effects of intrauterine growth restriction and maternal obesity/high-fat diet
    • Desai M, Ross MG. Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet. Semin Reprod Med 2011; 29: 237-45.
    • (2011) Semin Reprod Med , vol.29 , pp. 237-245
    • Desai, M.1    Ross, M.G.2
  • 8
    • 0031937282 scopus 로고    scopus 로고
    • Programming by early nutrition: An experimental approach
    • Lucas A. Programming by early nutrition: an experimental approach. J Nutr 1998; 128: 401-6.
    • (1998) J Nutr , vol.128 , pp. 401-406
    • Lucas, A.1
  • 9
    • 0035707430 scopus 로고    scopus 로고
    • Animal models and programming of the metabolic syndrome
    • Bertram CE, Hanson MA. Animal models and programming of the metabolic syndrome. Br Med Bull 2001; 60: 103-21.
    • (2001) Br Med Bull , vol.60 , pp. 103-121
    • Bertram, C.E.1    Hanson, M.A.2
  • 10
    • 46449111527 scopus 로고    scopus 로고
    • Developmental programming of hypertension: Insight from animal models of nutritional manipulation
    • Ojeda NB, Grigore D, Alexander BT. Developmental programming of hypertension: insight from animal models of nutritional manipulation. Hypertension 2008; 52: 44-50.
    • (2008) Hypertension , vol.52 , pp. 44-50
    • Ojeda, N.B.1    Grigore, D.2    Alexander, B.T.3
  • 11
    • 70349239072 scopus 로고    scopus 로고
    • Early nutrition and later obesity: Animal models provide insights into mechanisms
    • Metges CC. Early nutrition and later obesity: animal models provide insights into mechanisms. Adv Exp Med Biol 2009; 646: 105-12.
    • (2009) Adv Exp Med Biol , vol.646 , pp. 105-112
    • Metges, C.C.1
  • 12
    • 43049100073 scopus 로고    scopus 로고
    • Models of "obesity" in large animals and birds
    • Clarke IJ. Models of "obesity" in large animals and birds. Frontiers Horm Res 2008; 36: 107-17.
    • (2008) Frontiers Horm Res , vol.36 , pp. 107-117
    • Clarke, I.J.1
  • 13
    • 33847068799 scopus 로고    scopus 로고
    • Advances in swine biomedical model genomics
    • Lunney JK. Advances in swine biomedical model genomics. Intern J Biol Sci 2007; 3: 179-84.
    • (2007) Intern J Biol Sci , vol.3 , pp. 179-184
    • Lunney, J.K.1
  • 14
    • 54049096872 scopus 로고    scopus 로고
    • A commentary on domestic animals as dual-purpose models that benefit agricultural and biomedical research
    • Ireland JJ, Roberts RM, Palmer GH, Bauman DE, Bazer FW. A commentary on domestic animals as dual-purpose models that benefit agricultural and biomedical research. J Anim Sci 2008; 86: 2797-805.
    • (2008) J Anim Sci , vol.86 , pp. 2797-2805
    • Ireland, J.J.1    Roberts, R.M.2    Palmer, G.H.3    Bauman, D.E.4    Bazer, F.W.5
  • 15
    • 78650253563 scopus 로고    scopus 로고
    • Hyperlipidic hypercholesterolemic diet in prepubertal rabbits affects gene expression in the embryo, restricts fetal growth and increases offspring susceptibility to obesity
    • Picone O, Laigrec P, Fortun-Lamothe L et al. Hyperlipidic hypercholesterolemic diet in prepubertal rabbits affects gene expression in the embryo, restricts fetal growth and increases offspring susceptibility to obesity. Theriogenology 2011; 75: 287-99.
    • (2011) Theriogenology , vol.75 , pp. 287-299
    • Picone, O.1    Laigrec, P.2    Fortun-Lamothe, L.3
  • 16
    • 77954656164 scopus 로고    scopus 로고
    • Sex and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep
    • Poore KR, Boullin JP, Cleal JK et al. Sex and age-specific effects of nutrition in early gestation and early postnatal life on hypothalamo-pituitary-adrenal axis and sympathoadrenal function in adult sheep. J Physiol 2010; 588: 2219-37.
    • (2010) J Physiol , vol.588 , pp. 2219-2237
    • Poore, K.R.1    Boullin, J.P.2    Cleal, J.K.3
  • 17
    • 0036240298 scopus 로고    scopus 로고
    • Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo-pituitary adrenal axis in sheep during late gestation
    • Edwards LJ, McMillen IC. Impact of maternal undernutrition during the periconceptional period, fetal number, and fetal sex on the development of the hypothalamo-pituitary adrenal axis in sheep during late gestation. Biol Reprod 2002; 66: 1562-9.
    • (2002) Biol Reprod , vol.66 , pp. 1562-1569
    • Edwards, L.J.1    McMillen, I.C.2
  • 18
  • 19
    • 34547209264 scopus 로고    scopus 로고
    • Mismatched pre and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood
    • Cleal JK, Poore KR, Boullin JP et al. Mismatched pre and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc Natl Acad Sci USA 2007; 104: 9529-33.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9529-9533
    • Cleal, J.K.1    Poore, K.R.2    Boullin, J.P.3
  • 20
    • 34748871475 scopus 로고    scopus 로고
    • The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep
    • Cleal JK, Poore KR, Newman JP, Noakes DE, Hanson MA, Green LR. The effect of maternal undernutrition in early gestation on gestation length and fetal and postnatal growth in sheep. Pediatr Res 2007; 62: 422-7.
    • (2007) Pediatr Res , vol.62 , pp. 422-427
    • Cleal, J.K.1    Poore, K.R.2    Newman, J.P.3    Noakes, D.E.4    Hanson, M.A.5    Green, L.R.6
  • 21
    • 0015356172 scopus 로고
    • Of pigs and men and research: A review of applications and analogies of the pig (Sus scrofa) in human medical research
    • Douglas WR. Of pigs and men and research: a review of applications and analogies of the pig (Sus scrofa) in human medical research. Space Life Sci 1972; 3: 226-34.
    • (1972) Space Life Sci , vol.3 , pp. 226-234
    • Douglas, W.R.1
  • 22
    • 0016795172 scopus 로고
    • Swine lipoproteins and atherosclerosis: Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding
    • Mahley RW, Weisgraber KH, Inneraty T, Brewer HB Jr, Assmann G. Swine lipoproteins and atherosclerosis: changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry 1975; 14: 2817-23.
    • (1975) Biochemistry , vol.14 , pp. 2817-2823
    • Mahley, R.W.1    Weisgraber, K.H.2    Inneraty, T.3    Brewer Jr., H.B.4    Assmann, G.5
  • 23
    • 0026583881 scopus 로고
    • Evidence for an altered lipid metabolic state in circulating blood monocytes under conditions of hyperlipemia in swine and implications in arterial lipid metabolism
    • Bell FP, Gerrity RG. Evidence for an altered lipid metabolic state in circulating blood monocytes under conditions of hyperlipemia in swine and implications in arterial lipid metabolism. Arterioscler Thromb 1992; 12: 155-62.
    • (1992) Arterioscler Thromb , vol.12 , pp. 155-162
    • Bell, F.P.1    Gerrity, R.G.2
  • 24
    • 27744562461 scopus 로고    scopus 로고
    • Resistin: Yet another adipokine tells us that men are not mice
    • Arner P. Resistin: yet another adipokine tells us that men are not mice. Diabetologia 2005; 48: 2203-05.
    • (2005) Diabetologia , vol.48 , pp. 2203-2205
    • Arner, P.1
  • 25
    • 38949085542 scopus 로고    scopus 로고
    • The development of porcine models of obesity and the metabolic syndrome
    • Spurlock ME, Gabler NK. The development of porcine models of obesity and the metabolic syndrome. J Nutr 2008; 138: 397-402.
    • (2008) J Nutr , vol.138 , pp. 397-402
    • Spurlock, M.E.1    Gabler, N.K.2
  • 26
    • 0035031743 scopus 로고    scopus 로고
    • The obese Göttingen minipig as a model of the metabolic syndrome. Dietary effects on obesity; insulin sensitivity; and growth hormone profile
    • Johansen T, Hansen HS, Richelsen B, Malmlöf R. The obese Göttingen minipig as a model of the metabolic syndrome. Dietary effects on obesity; insulin sensitivity; and growth hormone profile. Comp Med 2001; 51: 150-5.
    • (2001) Comp Med , vol.51 , pp. 150-155
    • Johansen, T.1    Hansen, H.S.2    Richelsen, B.3    Malmlöf, R.4
  • 27
    • 38449097784 scopus 로고    scopus 로고
    • Gender-associated differences in metabolic syndrome-related parameters in Göttingen minipigs
    • Christoffersen BO, Grand N, Golozoubova V, Svendsen O, Raun K. Gender-associated differences in metabolic syndrome-related parameters in Göttingen minipigs. Comp Med 2007; 57: 493-504.
    • (2007) Comp Med , vol.57 , pp. 493-504
    • Christoffersen, B.O.1    Grand, N.2    Golozoubova, V.3    Svendsen, O.4    Raun, K.5
  • 29
    • 33646479329 scopus 로고    scopus 로고
    • Components of Metabolic Syndrome and Coronary Artery Disease in Female Ossabaw Swine Fed Excess Atherogenic Diet
    • Dyson MC, Alloosh M, Vuchetich JP, Mokelke EA, Sturek M. Components of Metabolic Syndrome and Coronary Artery Disease in Female Ossabaw Swine Fed Excess Atherogenic Diet. Comp Med 2006; 56: 35-45
    • (2006) Comp Med , vol.56 , pp. 35-45
    • Dyson, M.C.1    Alloosh, M.2    Vuchetich, J.P.3    Mokelke, E.A.4    Sturek, M.5
  • 31
    • 0036304218 scopus 로고    scopus 로고
    • The effect of dietary protein content and feeding level on the rate of protein deposition and energy utilization in growing Iberian pigs from 15 to 50kg body weight
    • Nieto R, Miranda A, García MA, Aguilera JF. The effect of dietary protein content and feeding level on the rate of protein deposition and energy utilization in growing Iberian pigs from 15 to 50kg body weight. Br J Nutr 2002; 88: 39-49.
    • (2002) Br J Nutr , vol.88 , pp. 39-49
    • Nieto, R.1    Miranda, A.2    García, M.A.3    Aguilera, J.F.4
  • 32
    • 0346997315 scopus 로고    scopus 로고
    • Sustained utilization of Iberian pig breed
    • López-Bote C. Sustained utilization of Iberian pig breed. Meat Sci 1998; 49: S17-S27.
    • (1998) Meat Sci , vol.49
    • López-Bote, C.1
  • 33
    • 77953264606 scopus 로고    scopus 로고
    • Comparison of Mangalica and Hungarian Large White pigs at identical bodyweight: Backfat histology
    • Szabó A, Viski A, Egyházi Z, Házas Z, Horn P, Romvári R. Comparison of Mangalica and Hungarian Large White pigs at identical bodyweight: Backfat histology. Archiv fur Tierzucht 2010; 53: 141-146.
    • (2010) Archiv Fur Tierzucht , vol.53 , pp. 141-146
    • Szabó, A.1    Viski, A.2    Egyházi, Z.3    Házas, Z.4    Horn, P.5    Romvári, R.6
  • 34
    • 34250005228 scopus 로고    scopus 로고
    • Serum profile of metabolites and hormones in obese (Iberian) and lean (Landrace) growing gilts fed balanced or lysine deficient diets
    • Fernandez-Figares I, Lachica M, Nieto R, Rivera-Ferre MG, Aguilera JF. Serum profile of metabolites and hormones in obese (Iberian) and lean (Landrace) growing gilts fed balanced or lysine deficient diets. Livestock Sci 2007; 110: 73-81.
    • (2007) Livestock Sci , vol.110 , pp. 73-81
    • Fernandez-Figares, I.1    Lachica, M.2    Nieto, R.3    Rivera-Ferre, M.G.4    Aguilera, J.F.5
  • 35
    • 58549089577 scopus 로고    scopus 로고
    • Comparison of luteinizing hormone, leptin and progesterone levels in the systemic circulation (Vena jugularis) and near the ovarian circulation (Vena cava caudalis) during the oestrous cycle in mangalica and landrace gilts
    • Brüssow KP, Schneider F, Tuchscherer A, Egerszegi I, Rátky J. Comparison of luteinizing hormone, leptin and progesterone levels in the systemic circulation (Vena jugularis) and near the ovarian circulation (Vena cava caudalis) during the oestrous cycle in mangalica and landrace gilts. J Reprod Dev 2008; 54: 431-8.
    • (2008) J Reprod Dev , vol.54 , pp. 431-438
    • Brüssow, K.P.1    Schneider, F.2    Tuchscherer, A.3    Egerszegi, I.4    Rátky, J.5
  • 36
    • 20844438188 scopus 로고    scopus 로고
    • Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross
    • Ovilo C, Fernandez A, Noguera JL et al. Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross. Genet Res 2005; 85: 57-67.
    • (2005) Genet Res , vol.85 , pp. 57-67
    • Ovilo, C.1    Fernandez, A.2    Noguera, J.L.3
  • 37
    • 78650993737 scopus 로고    scopus 로고
    • Hypothalamic expression of porcine leptin receptor (LEPR), neuropeptide Y (NPY), and cocaine and amphetamine-regulated transcript (CART) genes is influenced by LEPR genotype
    • Ovilo C, Fernández A, Fernández AI, et al. Hypothalamic expression of porcine leptin receptor (LEPR), neuropeptide Y (NPY), and cocaine and amphetamine-regulated transcript (CART) genes is influenced by LEPR genotype. Mamm Genome 2010; 21: 583-91.
    • (2010) Mamm Genome , vol.21 , pp. 583-591
    • Ovilo, C.1    Fernández, A.2    Fernández, A.I.3
  • 38
    • 62249108738 scopus 로고    scopus 로고
    • Single and joint-population analyses of two experimental pig crosses to confirm quantitative trait loci on Sus scrofa chromosome 6 and leptin receptor effects on fatness and growth traits
    • Muñoz G, Ovilo C, Silio L, Tomas A, Noguera JL, Rodriguez MC. Single and joint-population analyses of two experimental pig crosses to confirm quantitative trait loci on Sus scrofa chromosome 6 and leptin receptor effects on fatness and growth traits. J Anim Sci 2009; 87: 459-68.
    • (2009) J Anim Sci , vol.87 , pp. 459-468
    • Muñoz, G.1    Ovilo, C.2    Silio, L.3    Tomas, A.4    Noguera, J.L.5    Rodriguez, M.C.6
  • 39
    • 36049047748 scopus 로고    scopus 로고
    • A review of molecular contrasts between arresting and viable porcine attachment sites
    • Wessels JM, Linton NF, Croy A, Tayade C. A review of molecular contrasts between arresting and viable porcine attachment sites. Am J Reprod Immunol 2007; 58: 470-80.
    • (2007) Am J Reprod Immunol , vol.58 , pp. 470-480
    • Wessels, J.M.1    Linton, N.F.2    Croy, A.3    Tayade, C.4
  • 40
    • 0016716328 scopus 로고
    • Evaluation of various protein sequences on the nutritional carry-over from gestation to lactation with first-litter sows
    • Mahan DC, Mangan LT. Evaluation of various protein sequences on the nutritional carry-over from gestation to lactation with first-litter sows. J Nutr 1975; 105: 1291-98.
    • (1975) J Nutr , vol.105 , pp. 1291-1298
    • Mahan, D.C.1    Mangan, L.T.2
  • 41
    • 2342653484 scopus 로고    scopus 로고
    • Long-term, but not short-term, treatment with somatotropin during pregnancy in underfed pigs increases the body size of progeny at birth
    • Gatford KL, Boyce JM, Blackmore K, Smits RJ, Campbell RG, Owens PC. Long-term, but not short-term, treatment with somatotropin during pregnancy in underfed pigs increases the body size of progeny at birth. J Anim Sci 2004; 82, 93-101.
    • (2004) J Anim Sci , vol.82 , pp. 93-101
    • Gatford, K.L.1    Boyce, J.M.2    Blackmore, K.3    Smits, R.J.4    Campbell, R.G.5    Owens, P.C.6
  • 42
    • 33748562108 scopus 로고    scopus 로고
    • Intrauterine growth retardation: Implications for the animal sciences
    • Wu G, Bazer FW, Wallace JM, Spencer TE. Intrauterine growth retardation: Implications for the animal sciences. J Anim Sci 2006; 84: 2316-37.
    • (2006) J Anim Sci , vol.84 , pp. 2316-2337
    • Wu, G.1    Bazer, F.W.2    Wallace, J.M.3    Spencer, T.E.4
  • 43
    • 24944541833 scopus 로고    scopus 로고
    • Nutritional programming: Prenatal nutritional effects on the regulation of growth and metabolism
    • Metges CC, Hammon HM. Nutritional programming: prenatal nutritional effects on the regulation of growth and metabolism. J Anim Feed Sci 2005; 14: 15-30.
    • (2005) J Anim Feed Sci , vol.14 , pp. 15-30
    • Metges, C.C.1    Hammon, H.M.2
  • 44
    • 0036334715 scopus 로고    scopus 로고
    • Within-litter birth weight variation in the domestic pig and its relation to pre-weaning survival, weight gain, and variation in weaning weights
    • Milligan BN, Fraser D, Kramer DL. Within-litter birth weight variation in the domestic pig and its relation to pre-weaning survival, weight gain, and variation in weaning weights. Livest Prod Sci 2002; 76: 181-91.
    • (2002) Livest Prod Sci , vol.76 , pp. 181-191
    • Milligan, B.N.1    Fraser, D.2    Kramer, D.L.3
  • 45
    • 0019551580 scopus 로고
    • Skeletal muscle and adipose tissue cellularity in runt and normal birth weight swine
    • Powell SE, Aberle ED. Skeletal muscle and adipose tissue cellularity in runt and normal birth weight swine. J. Anim Sci 1981; 52: 748-56.
    • (1981) J. Anim Sci , vol.52 , pp. 748-756
    • Powell, S.E.1    Aberle, E.D.2
  • 46
    • 0141725461 scopus 로고    scopus 로고
    • Birth weight affects postnatal growth, body composition, and meat quality in pigs
    • Kuhn G, Rehfeldt C, Stabenow B, Nürnberg G, Ender K. Birth weight affects postnatal growth, body composition, and meat quality in pigs. Arch Anim Breed 2003; 46: 171-5.
    • (2003) Arch Anim Breed , vol.46 , pp. 171-175
    • Kuhn, G.1    Rehfeldt, C.2    Stabenow, B.3    Nürnberg, G.4    Ender, K.5
  • 47
    • 33749596816 scopus 로고    scopus 로고
    • Consequences of birth weight for postnatal growth performance and carcass quality in pigs as related to miogénesis
    • Rehfeldt C, Kuhn G. Consequences of birth weight for postnatal growth performance and carcass quality in pigs as related to miogénesis. J Anim Sci 2006; 84: 113-23.
    • (2006) J Anim Sci , vol.84 , pp. 113-123
    • Rehfeldt, C.1    Kuhn, G.2
  • 48
    • 70349566593 scopus 로고
    • Diabetes mellitus: A thrifty genotype rendered detrimental by progress?
    • Neel JV. Diabetes mellitus: a thrifty genotype rendered detrimental by progress? Am J Hum Gen. 1962; 14: 353-362.
    • (1962) Am J Hum Gen , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 49
    • 55049110154 scopus 로고    scopus 로고
    • The contribution of animal models to the study of obesity
    • Speakman J, Hambly C, Mitchell S, Król E. The contribution of animal models to the study of obesity. Lab Anim 2008; 42: 413-32.
    • (2008) Lab Anim , vol.42 , pp. 413-432
    • Speakman, J.1    Hambly, C.2    Mitchell, S.3    Król, E.4
  • 50
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661-78.
    • (2007) Nature , vol.447 , pp. 661-678
  • 51
    • 79951521421 scopus 로고    scopus 로고
    • Progress and promise of genomewide association studies for human complex trait genetics
    • Stranger BE, Stahl EA, Raj T. Progress and promise of genomewide association studies for human complex trait genetics. Genetics 2011; 187: 367-83.
    • (2011) Genetics , vol.187 , pp. 367-383
    • Stranger, B.E.1    Stahl, E.A.2    Raj, T.3
  • 52
    • 50449099144 scopus 로고    scopus 로고
    • Lessons from extreme human obesity: Monogenic disorders
    • Ranadive SA, Vaisse C. Lessons from extreme human obesity: monogenic disorders. Endocrinol Metabol Clin North Am 2008; 37: 733-51.
    • (2008) Endocrinol Metabol Clin North Am , vol.37 , pp. 733-751
    • Ranadive, S.A.1    Vaisse, C.2
  • 53
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague CT, Farooqi IS, Whitehead JP et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-8.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 54
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • Clement K, Vaisse C, Lahlou N et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1    Vaisse, C.2    Lahlou, N.3
  • 55
    • 0031662163 scopus 로고    scopus 로고
    • A frameshift mutation in human MC4R is associated with a dominant form of obesity
    • Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genet 1998; 20: 113-4.
    • (1998) Nature Genet , vol.20 , pp. 113-114
    • Vaisse, C.1    Clement, K.2    Guy-Grand, B.3    Froguel, P.4
  • 57
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity; adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity; adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998; 19: 155-7.
    • (1998) Nat Genet , vol.19 , pp. 155-157
    • Krude, H.1    Biebermann, H.2    Luck, W.3    Horn, R.4    Brabant, G.5    Gruters, A.6
  • 58
    • 0030949271 scopus 로고    scopus 로고
    • Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    • Jackson RS, Creemers JW, Ohagi S et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997; 16: 303-6.
    • (1997) Nat Genet , vol.16 , pp. 303-306
    • Jackson, R.S.1    Creemers, J.W.2    Ohagi, S.3
  • 59
    • 0034016043 scopus 로고    scopus 로고
    • Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
    • Holder JL Jr, Butte NF, Zinn AR. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum Mol Genet 2000; 9: 101-8.
    • (2000) Hum Mol Genet , vol.9 , pp. 101-108
    • Holder Jr., J.L.1    Butte, N.F.2    Zinn, A.R.3
  • 60
    • 33748742610 scopus 로고    scopus 로고
    • Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
    • Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR. Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons. Mol Endocrinol 2006; 20: 2483-92.
    • (2006) Mol Endocrinol , vol.20 , pp. 2483-2492
    • Kublaoui, B.M.1    Holder Jr., J.L.2    Gemelli, T.3    Zinn, A.R.4
  • 61
    • 0034653422 scopus 로고    scopus 로고
    • BDNF regulates eating behavior and locomotor activity in mice
    • Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 2000; 19: 1290-300.
    • (2000) EMBO J , vol.19 , pp. 1290-1300
    • Kernie, S.G.1    Liebl, D.J.2    Parada, L.F.3
  • 62
    • 33846613209 scopus 로고    scopus 로고
    • Functional characterization of human NTRK2 mutations identified in patients with severe early onset obesity
    • Gray J, Yeo G, Hung C et al. Functional characterization of human NTRK2 mutations identified in patients with severe early onset obesity. Int J Obes (Lond) 2006; 31: 359-64.
    • (2006) Int J Obes (Lond) , vol.31 , pp. 359-364
    • Gray, J.1    Yeo, G.2    Hung, C.3
  • 63
    • 47249142353 scopus 로고    scopus 로고
    • Polygenic obesity in humans
    • Hinney A, Hebebrand J. Polygenic obesity in humans. Obesity Facts 2008; 1: 35-42.
    • (2008) Obesity Facts , vol.1 , pp. 35-42
    • Hinney, A.1    Hebebrand, J.2
  • 64
    • 33749017409 scopus 로고    scopus 로고
    • The human obesity gene map: The 2005 update
    • Rankinen T, Zuberi A, Chagnon YC et al. The human obesity gene map: the 2005 update. Obesity 2006; 14: 529-644.
    • (2006) Obesity , vol.14 , pp. 529-644
    • Rankinen, T.1    Zuberi, A.2    Chagnon, Y.C.3
  • 65
    • 33646074794 scopus 로고    scopus 로고
    • Genetic basis of maturity onset diabetes of the young
    • Vaxillaire M, Froguel P. Genetic basis of maturity onset diabetes of the young. Endocrinol Metab Clin North Am 2006; 35: 371-84.
    • (2006) Endocrinol Metab Clin North Am , vol.35 , pp. 371-384
    • Vaxillaire, M.1    Froguel, P.2
  • 66
    • 70349557826 scopus 로고    scopus 로고
    • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    • Rung J, Cauchi S, Albrechtsen A et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 2009; 41: 1110-5.
    • (2009) Nat Genet , vol.41 , pp. 1110-1115
    • Rung, J.1    Cauchi, S.2    Albrechtsen, A.3
  • 68
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARG Pro12Ala polymorphism is associated with decreased risk of type-2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARG Pro12Ala polymorphism is associated with decreased risk of type-2 diabetes. Nat Genet 2000; 26: 76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 69
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn A.L., Weedon M.N., Owen K.R et al. Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003; 52: 568-72.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3
  • 70
    • 0347990586 scopus 로고    scopus 로고
    • Lipoprotein lipase is a gene for insulin resistance in Mexican Americans
    • Goodarzi MO, Guo X, Taylor KD et al. Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Diabetes 2004; 53: 214-20.
    • (2004) Diabetes , vol.53 , pp. 214-220
    • Goodarzi, M.O.1    Guo, X.2    Taylor, K.D.3
  • 71
    • 0036312406 scopus 로고    scopus 로고
    • Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type-2 diabetes in South Indians
    • Cassell PG, Jackson AE, North BV et al. Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type-2 diabetes in South Indians. Diabetes 2002; 51: 1622-8.
    • (2002) Diabetes , vol.51 , pp. 1622-1628
    • Cassell, P.G.1    Jackson, A.E.2    North, B.V.3
  • 72
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome wide association signals in U.K. samples reveals risk loci for type-2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome wide association signals in U.K. samples reveals risk loci for type-2 diabetes. Science 2007; 316: 1336-41.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 73
    • 34249888775 scopus 로고    scopus 로고
    • Genome wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes of BioMedical Research et al
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes of BioMedical Research et al. Genome wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316, 1331-6.
    • (2007) Science , vol.316 , pp. 1331-1336
  • 74
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, Willer CJ, Berndt SI et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010; 42: 937-48.
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 75
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • Voight BF, Scott LJ, Steinthorsdottir V et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010; 42: 579-89.
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 76
    • 42349106044 scopus 로고    scopus 로고
    • Meta analysis of genome wide association data and large scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini E, Scott LJ, Saxena R et al. Meta analysis of genome wide association data and large scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40: 638-45.
    • (2008) Nat Genet , vol.40 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3
  • 77
    • 66549087600 scopus 로고    scopus 로고
    • Genetic architecture of type 2 diabetes: Recent progress and clinical implications
    • Grant RW, Moore AF, Florez JC. Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care 2009; 32: 1107-14.
    • (2009) Diabetes Care , vol.32 , pp. 1107-1114
    • Grant, R.W.1    Moore, A.F.2    Florez, J.C.3
  • 78
    • 66849138608 scopus 로고    scopus 로고
    • Lipid profiles in middle-aged men and women after famine exposure during gestation: The Dutch Hunger Winter Families Study
    • Lumey LH, Stein AD, Kahn HS, Romijn JA. Lipid profiles in middle-aged men and women after famine exposure during gestation: the Dutch Hunger Winter Families Study. Am J Clin Nutr 2009; 89: 1737-43.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1737-1743
    • Lumey, L.H.1    Stein, A.D.2    Kahn, H.S.3    Romijn, J.A.4
  • 79
    • 0016440115 scopus 로고
    • The Dutch famine, 1944-1945, and the reproductive process. I. Effects on six indices at birth
    • Stein Z, Susser M. The Dutch famine, 1944-1945, and the reproductive process. I. Effects on six indices at birth. Pediatr Res 1975; 9: 70-6.
    • (1975) Pediatr Res , vol.9 , pp. 70-76
    • Stein, Z.1    Susser, M.2
  • 80
    • 0016436447 scopus 로고
    • The Dutch famine, 1944-1945, and the reproductive process. II. Interrelations of caloric rations and six indices at birth
    • Stein Z, Susser M. The Dutch famine, 1944-1945, and the reproductive process. II. Interrelations of caloric rations and six indices at birth. Pediatr Res 1975; 9: 76-83.
    • (1975) Pediatr Res , vol.9 , pp. 76-83
    • Stein, Z.1    Susser, M.2
  • 81
    • 0017305263 scopus 로고
    • Obesity in young men after famine exposure in utero and early infancy
    • Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976; 295: 349-53.
    • (1976) N Engl J Med , vol.295 , pp. 349-353
    • Ravelli, G.P.1    Stein, Z.A.2    Susser, M.W.3
  • 82
    • 78049318886 scopus 로고    scopus 로고
    • The Dutch Hunger Winter and the developmental origins of health and disease
    • Schulz LC. The Dutch Hunger Winter and the developmental origins of health and disease. Proc Natl Acad Sci USA 2010; 107: 16757-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16757-16758
    • Schulz, L.C.1
  • 83
    • 84857739284 scopus 로고
    • Effects of maternal malnutrition on fetal development
    • Smith CA. Effects of maternal malnutrition on fetal development. Am J Dis Child 1947; 73: 243.
    • (1947) Am J Dis Child , vol.73 , pp. 243
    • Smith, C.A.1
  • 84
    • 0002466723 scopus 로고
    • Overnutrition in prenatal and neonatal life: A problem?
    • Cochrane WA. Overnutrition in prenatal and neonatal life: a problem? Can Med Assoc J 1965; 93: 893-9.
    • (1965) Can Med Assoc J , vol.93 , pp. 893-899
    • Cochrane, W.A.1
  • 85
    • 0015676039 scopus 로고
    • Diabetes, pregnancy and obesity
    • Fisher DA. Diabetes, pregnancy and obesity. Calif Med 1973; 119:35-7.
    • (1973) Calif Med , vol.119 , pp. 35-37
    • Fisher, D.A.1
  • 89
    • 31844456075 scopus 로고    scopus 로고
    • Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover
    • Marliss EB, Chevalier S, Gougeon R et al. Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover. Diabetologia 2006; 49: 351-9.
    • (2006) Diabetologia , vol.49 , pp. 351-359
    • Marliss, E.B.1    Chevalier, S.2    Gougeon, R.3
  • 90
    • 0037306991 scopus 로고    scopus 로고
    • Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function
    • Bird IM, Zhang LB, Magness RR. Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function. Am J Physiol 2003; 284: 245-58.
    • (2003) Am J Physiol , vol.284 , pp. 245-258
    • Bird, I.M.1    Zhang, L.B.2    Magness, R.R.3
  • 91
    • 0038637784 scopus 로고    scopus 로고
    • Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia
    • Savvidou MD, Hingorani AD, Tsikas D, Frolich JC, Vallance P, Nicolaides KH. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. Lancet 2003; 361: 1511-7.
    • (2003) Lancet , vol.361 , pp. 1511-1517
    • Savvidou, M.D.1    Hingorani, A.D.2    Tsikas, D.3    Frolich, J.C.4    Vallance, P.5    Nicolaides, K.H.6
  • 92
    • 31044439034 scopus 로고    scopus 로고
    • Castracane VD Leptin in Pregnancy: An Update
    • Henson M, Castracane VD Leptin in Pregnancy: An Update. Biol Reprod 2006; 74: 218-29.
    • (2006) Biol Reprod , vol.74 , pp. 218-229
    • Henson, M.1
  • 93
    • 0024422746 scopus 로고
    • The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis
    • Barker DJ, Osmond C, Law CM. The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health 1989; 43: 237-40.
    • (1989) J Epidemiol Community Health , vol.43 , pp. 237-240
    • Barker, D.J.1    Osmond, C.2    Law, C.M.3
  • 94
    • 0027529974 scopus 로고
    • Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): Relation to reduced fetal growth
    • Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993; 36: 62-7.
    • (1993) Diabetologia , vol.36 , pp. 62-67
    • Barker, D.J.1    Hales, C.N.2    Fall, C.H.3    Osmond, C.4    Phipps, K.5    Clark, P.M.6
  • 95
    • 0031016126 scopus 로고    scopus 로고
    • Insulin resistance in short children with intrauterine growth retardation
    • Hofman PL, Cutfield WS, Robinson EM et al. Insulin resistance in short children with intrauterine growth retardation. J Clin Endocrinol Metab. 1997; 82: 402-6.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 402-406
    • Hofman, P.L.1    Cutfield, W.S.2    Robinson, E.M.3
  • 97
    • 33746911576 scopus 로고    scopus 로고
    • The Dutch famine and its long-term consequences for adult health
    • Roseboom T, de Rooij S, Painter R. The Dutch famine and its long-term consequences for adult health. Early Hum Dev 2006; 82: 485-91.
    • (2006) Early Hum Dev , vol.82 , pp. 485-491
    • Roseboom, T.1    de Rooij, S.2    Painter, R.3
  • 98
    • 60149112073 scopus 로고    scopus 로고
    • A fingerprint marker from early gestation associated with diabetes in middle age: The Dutch Hunger Winter Families Study
    • Kahn HS, Graff M, Stein AD, Lumey LH. A fingerprint marker from early gestation associated with diabetes in middle age: the Dutch Hunger Winter Families Study. Int J Epidemiol 2009; 38: 101-9.
    • (2009) Int J Epidemiol , vol.38 , pp. 101-109
    • Kahn, H.S.1    Graff, M.2    Stein, A.D.3    Lumey, L.H.4
  • 99
    • 0030926405 scopus 로고    scopus 로고
    • Fetal undernutrition and disease in later life
    • Barker JP, Clark PM. Fetal undernutrition and disease in later life. Rev Reprod 1997; 2: 105-12.
    • (1997) Rev Reprod , vol.2 , pp. 105-112
    • Barker, J.P.1    Clark, P.M.2
  • 102
    • 33846058958 scopus 로고    scopus 로고
    • Beedle AS Early life events and their consequences for later disease: A life history and evolutionary perspective
    • Gluckman PD, Hanson MA, Beedle AS Early life events and their consequences for later disease: a life history and evolutionary perspective. Am J Hum Biol 2007; 19: 1-19.
    • (2007) Am J Hum Biol , vol.19 , pp. 1-19
    • Gluckman, P.D.1    Hanson, M.A.2
  • 103
    • 20344379701 scopus 로고    scopus 로고
    • Environmental influences during development and their later consequences for health and disease: Implications for the interpretation of empirical studies
    • Gluckman PD, Hanson MA, Spencer HG, Bateson P. Environmental influences during development and their later consequences for health and disease: implications for the interpretation of empirical studies. Proc Royal Soc Biol 2005; 272: 671-7.
    • (2005) Proc Royal Soc Biol , vol.272 , pp. 671-677
    • Gluckman, P.D.1    Hanson, M.A.2    Spencer, H.G.3    Bateson, P.4
  • 105
    • 0037974465 scopus 로고    scopus 로고
    • Sedentary behaviour during postnatal life is determined by the prenatal environment Band exacerbated by postnatal hypercaloric nutrition
    • Vickers MH, Breier BH, McCarthy D, Gluckman PD. Sedentary behaviour during postnatal life is determined by the prenatal environment Band exacerbated by postnatal hypercaloric nutrition. Am J Physiol Regul Integr Comp Physiol 2003; 285: 271-3.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285 , pp. 271-273
    • Vickers, M.H.1    Breier, B.H.2    McCarthy, D.3    Gluckman, P.D.4
  • 106
    • 6944246725 scopus 로고    scopus 로고
    • Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat
    • Bellinger L, Lilley C, Langley-Evans SC. Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat. Br J Nutr 2004; 92: 513-20.
    • (2004) Br J Nutr , vol.92 , pp. 513-520
    • Bellinger, L.1    Lilley, C.2    Langley-Evans, S.C.3
  • 107
    • 1642349297 scopus 로고    scopus 로고
    • Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice
    • Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci 2004; 24: 2797-805.
    • (2004) J Neurosci , vol.24 , pp. 2797-2805
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 108
    • 1842536210 scopus 로고    scopus 로고
    • Trophic action of leptin on hypothalamic neurons that regulate feeding
    • Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004; 304: 108-10.
    • (2004) Science , vol.304 , pp. 108-110
    • Bouret, S.G.1    Draper, S.J.2    Simerly, R.B.3
  • 109
    • 4544366928 scopus 로고    scopus 로고
    • Living with the past: Evolution, development, and patterns of disease
    • Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science 2004; 305:1733-6.
    • (2004) Science , vol.305 , pp. 1733-1736
    • Gluckman, P.D.1    Hanson, M.A.2
  • 110
    • 15544369982 scopus 로고    scopus 로고
    • Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming
    • McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 2005; 85: 571-633.
    • (2005) Physiol Rev , vol.85 , pp. 571-633
    • McMillen, I.C.1    Robinson, J.S.2
  • 111
    • 0030888463 scopus 로고    scopus 로고
    • Effects of the intrauterine environment on childhood growth
    • Strauss RS Effects of the intrauterine environment on childhood growth. Br Med Bull 1997; 53: 81-95.
    • (1997) Br Med Bull , vol.53 , pp. 81-95
    • Strauss, R.S.1
  • 112
    • 34249039682 scopus 로고    scopus 로고
    • Glucose regulation in young adults with very low birth weight
    • Hovi P, Andersson S, Eriksson JG et al. Glucose regulation in young adults with very low birth weight. N Engl J Med 2007; 356: 2053-63.
    • (2007) N Engl J Med , vol.356 , pp. 2053-2063
    • Hovi, P.1    Andersson, S.2    Eriksson, J.G.3
  • 116
    • 77956090597 scopus 로고    scopus 로고
    • Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: A 15-year follow-up study
    • Tam WH, Ma RC, Yang X et al. Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study. Diabetes Care 2010; 33: 1382-4.
    • (2010) Diabetes Care , vol.33 , pp. 1382-1384
    • Tam, W.H.1    Ma, R.C.2    Yang, X.3
  • 117
    • 34548384252 scopus 로고    scopus 로고
    • Pettitt DJ Childhood obesity and metabolic imprinting: The ongoing effects of maternal hyperglycemia
    • Hillier TA, Pedula KL, Schmidt MM, Mullen JA, Charles MA, Pettitt DJ Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia. Diabetes Care 2007; 30: 2287-92.
    • (2007) Diabetes Care , vol.30 , pp. 2287-2292
    • Hillier, T.A.1    Pedula, K.L.2    Schmidt, M.M.3    Mullen, J.A.4    Charles, M.A.5
  • 118
    • 77951974181 scopus 로고    scopus 로고
    • Maternal obesity upregulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta
    • Zhu MJ, Dua M, Nathanielsz PW, Ford SP. Maternal obesity upregulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta. Placenta 2010; 31: 387-91.
    • (2010) Placenta , vol.31 , pp. 387-391
    • Zhu, M.J.1    Dua, M.2    Nathanielsz, P.W.3    Ford, S.P.4
  • 119
    • 34447524124 scopus 로고    scopus 로고
    • Regulation of placental nutrient transport - a review
    • Jones HN, Powell TL, Jonsson T. Regulation of placental nutrient transport - a review. Placenta 2007; 28: 763-74.
    • (2007) Placenta , vol.28 , pp. 763-774
    • Jones, H.N.1    Powell, T.L.2    Jonsson, T.3
  • 120
    • 78650510827 scopus 로고    scopus 로고
    • Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth
    • Higgins L., Greenwood SL, Wareing M, Sibley CP, Mills TA. Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth. Placenta 2011; 32: 1-7.
    • (2011) Placenta , vol.32 , pp. 1-7
    • Higgins, L.1    Greenwood, S.L.2    Wareing, M.3    Sibley, C.P.4    Mills, T.A.5
  • 121
    • 77956206292 scopus 로고    scopus 로고
    • Obesity, insulin resistance, and pregnancy outcome
    • Catalano PM. Obesity, insulin resistance, and pregnancy outcome. Reproduction 2010; 140: 365-71
    • (2010) Reproduction , vol.140 , pp. 365-371
    • Catalano, P.M.1
  • 122
    • 80053537077 scopus 로고    scopus 로고
    • Nutrition during pregnancy and the effect of carbohydrates on the offspring's metabolic profile: In search of the Perfect Maternal Diet
    • Tzanetakou IP, Mikhailidis DP, Perrea DN. Nutrition during pregnancy and the effect of carbohydrates on the offspring's metabolic profile: in search of the Perfect Maternal Diet. Open Cardiovasc Med J 2011; 5: 103-9.
    • (2011) Open Cardiovasc Med J , vol.5 , pp. 103-109
    • Tzanetakou, I.P.1    Mikhailidis, D.P.2    Perrea, D.N.3
  • 123
    • 0015534691 scopus 로고
    • Influence of maternal protein and energy nutrition during gestation on progeny performance in swine
    • Pond WG. Influence of maternal protein and energy nutrition during gestation on progeny performance in swine. J Anim Sci 1973; 36: 175-82.
    • (1973) J Anim Sci , vol.36 , pp. 175-182
    • Pond, W.G.1
  • 124
    • 0016054615 scopus 로고
    • Blood and tissue traits in pigs at birth and at 3 weeks from gilts fed low or high energy diets during gestation
    • Buitrago JA, Walker EF, Snyder WI, Pond WG. Blood and tissue traits in pigs at birth and at 3 weeks from gilts fed low or high energy diets during gestation. J Anim Sci 1974; 38: 766-71.
    • (1974) J Anim Sci , vol.38 , pp. 766-771
    • Buitrago, J.A.1    Walker, E.F.2    Snyder, W.I.3    Pond, W.G.4
  • 125
    • 2342514770 scopus 로고    scopus 로고
    • Effect of early gestation feeding, birth weight, and gender of progeny on muscle fiber characteristics of pigs at slaughter
    • Bee G. Effect of early gestation feeding, birth weight, and gender of progeny on muscle fiber characteristics of pigs at slaughter. J Anim Sci 2004; 82: 826-36.
    • (2004) J Anim Sci , vol.82 , pp. 826-836
    • Bee, G.1
  • 126
    • 33750597519 scopus 로고    scopus 로고
    • The importance of catchup growth after early malnutrition for the programming of obesity in male rat
    • Bieswal F, Ahn MT, Reusens B et al. The importance of catchup growth after early malnutrition for the programming of obesity in male rat. Obesity (Silver Spring) 2006; 14: 1330-43.
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1330-1343
    • Bieswal, F.1    Ahn, M.T.2    Reusens, B.3
  • 127
    • 0017701317 scopus 로고
    • Alterations in the rate of fetal and placental development as a consequence of early maternal protein/calorie restriction
    • Van Marthens E. Alterations in the rate of fetal and placental development as a consequence of early maternal protein/calorie restriction. Biol Neonate 1977; 31: 324-32.
    • (1977) Biol Neonate , vol.31 , pp. 324-332
    • van Marthens, E.1
  • 128
    • 62749124309 scopus 로고    scopus 로고
    • The effect of energy restriction during pregnancy on obesity-related peptide hormones in rat offspring
    • Hietaniemi M, Malo E, Jokela M, Santaniemi M, Ukkola O, Kesäniemi YA. The effect of energy restriction during pregnancy on obesity-related peptide hormones in rat offspring. Peptides 2009; 30: 705-9.
    • (2009) Peptides , vol.30 , pp. 705-709
    • Hietaniemi, M.1    Malo, E.2    Jokela, M.3    Santaniemi, M.4    Ukkola, O.5    Kesäniemi, Y.A.6
  • 129
    • 0028158572 scopus 로고
    • Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets
    • Langley SC, Jackson AA. Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin Sci (Lond) 1994; 86: 217-22.
    • (1994) Clin Sci (Lond) , vol.86 , pp. 217-222
    • Langley, S.C.1    Jackson, A.A.2
  • 130
    • 0030886421 scopus 로고    scopus 로고
    • Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation
    • Burns SP, Desai M, Cohen RD et al. Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest 1997; 100: 1768-74.
    • (1997) J Clin Invest , vol.100 , pp. 1768-1774
    • Burns, S.P.1    Desai, M.2    Cohen, R.D.3
  • 131
    • 0036834977 scopus 로고    scopus 로고
    • Early programming of glucose-insulin metabolism
    • Ozanne SE, Hales CN. Early programming of glucose-insulin metabolism. Trends Endocrinol Metab 2002; 13: 368-73.
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 368-373
    • Ozanne, S.E.1    Hales, C.N.2
  • 132
    • 4143102679 scopus 로고    scopus 로고
    • Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferator-activated receptors in the liver and adipose tissue of the offspring
    • Burdge GC, Phillips ES, Dunn RL, Jackson AA, Lillycrop KA. Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferator-activated receptors in the liver and adipose tissue of the offspring. Nutr Res 2004; 24: 639-46.
    • (2004) Nutr Res , vol.24 , pp. 639-646
    • Burdge, G.C.1    Phillips, E.S.2    Dunn, R.L.3    Jackson, A.A.4    Lillycrop, K.A.5
  • 133
    • 26844503967 scopus 로고    scopus 로고
    • Fetal programming of appetite by exposure to a maternal low-protein diet in the rat
    • Bellinger L, Langley-Evans SC. Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. Clin Sci (Lond) 2005; 109: 413-20.
    • (2005) Clin Sci (Lond) , vol.109 , pp. 413-420
    • Bellinger, L.1    Langley-Evans, S.C.2
  • 134
    • 79955814335 scopus 로고    scopus 로고
    • Limited and excess dietary protein during gestation affects growth and compositional traits in gilts and impairs offspring fetal growth
    • Rehfeldt C, Lang IS, Görs S et al. Limited and excess dietary protein during gestation affects growth and compositional traits in gilts and impairs offspring fetal growth. J Anim Sci 2011; 89: 329-41.
    • (2011) J Anim Sci , vol.89 , pp. 329-341
    • Rehfeldt, C.1    Lang, I.S.2    Görs, S.3
  • 135
    • 0033591379 scopus 로고    scopus 로고
    • Impact of a cholesterol enriched diet on maternal and fetal plasma lipids and fetal deposition in pregnant rabbits
    • Montoudis A, Simoneau L, Brissette L, Forest JC, Savard R, Lafond J. Impact of a cholesterol enriched diet on maternal and fetal plasma lipids and fetal deposition in pregnant rabbits. Life Sci 1999; 64: 2439-50.
    • (1999) Life Sci , vol.64 , pp. 2439-2450
    • Montoudis, A.1    Simoneau, L.2    Brissette, L.3    Forest, J.C.4    Savard, R.5    Lafond, J.6
  • 136
    • 0035875163 scopus 로고    scopus 로고
    • Abnormal aortic fatty acid composition and small artery function in offspring of rats fed a high fat diet in pregnancy
    • Ghosh P, Bitsanis D, Ghebremeskel K, Crawford MA, Poston L. Abnormal aortic fatty acid composition and small artery function in offspring of rats fed a high fat diet in pregnancy. J Physiol 2001; 533: 815-22.
    • (2001) J Physiol , vol.533 , pp. 815-822
    • Ghosh, P.1    Bitsanis, D.2    Ghebremeskel, K.3    Crawford, M.A.4    Poston, L.5
  • 137
    • 70349627249 scopus 로고    scopus 로고
    • Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring
    • Page KC, Malik RE, Ripple JA, Anday EK. Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring. Am J Physiol Regul Integr Comp Physiol 2009; 297: 1049-57.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297 , pp. 1049-1057
    • Page, K.C.1    Malik, R.E.2    Ripple, J.A.3    Anday, E.K.4
  • 138
    • 77955852369 scopus 로고    scopus 로고
    • Fructose and saturated fats predispose hyperinsulinemia in lean male rat offspring
    • Chen CY, Crott J, Liu Z, Smith DE. Fructose and saturated fats predispose hyperinsulinemia in lean male rat offspring. Eur J Nutr 2010; 49: 337-43.
    • (2010) Eur J Nutr , vol.49 , pp. 337-343
    • Chen, C.Y.1    Crott, J.2    Liu, Z.3    Smith, D.E.4
  • 139
    • 38549129216 scopus 로고    scopus 로고
    • Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease
    • Watkins AJ, Ursell E, Panton R et al. Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease. Biol Reprod 2008; 78: 299-306.
    • (2008) Biol Reprod , vol.78 , pp. 299-306
    • Watkins, A.J.1    Ursell, E.2    Panton, R.3
  • 141
    • 33845296557 scopus 로고    scopus 로고
    • Modelling the developmental origins of health and disease in the early embryo
    • Sinclair KD, Singh R. Modelling the developmental origins of health and disease in the early embryo. Theriogenology 2007; 67: 43-53.
    • (2007) Theriogenology , vol.67 , pp. 43-53
    • Sinclair, K.D.1    Singh, R.2
  • 142
    • 0032539468 scopus 로고    scopus 로고
    • Glucose tolerance in adults after prenatal exposure to famine
    • Ravelli AC, van der Meulen JH, Michels RP et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998; 351: 173-7.
    • (1998) Lancet , vol.351 , pp. 173-177
    • Ravelli, A.C.1    van der Meulen, J.H.2    Michels, R.P.3
  • 143
    • 21944442058 scopus 로고    scopus 로고
    • Prenatal exposure to the Dutch famine and disease in later life: An overview
    • Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol 2005; 20: 345-52.
    • (2005) Reprod Toxicol , vol.20 , pp. 345-352
    • Painter, R.C.1    Roseboom, T.J.2    Bleker, O.P.3
  • 144
    • 0033802933 scopus 로고    scopus 로고
    • Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams
    • Plagemann A, Harder T, Rake A, Melchior K, Rohde W, Dorner G. Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams. J Nutr 2000; 130: 2582-9.
    • (2000) J Nutr , vol.130 , pp. 2582-2589
    • Plagemann, A.1    Harder, T.2    Rake, A.3    Melchior, K.4    Rohde, W.5    Dorner, G.6
  • 145
    • 61549128665 scopus 로고    scopus 로고
    • Epigenetics and obesity
    • Stoger R. Epigenetics and obesity. Pharmacogenomics 2008; 9: 1851-60.
    • (2008) Pharmacogenomics , vol.9 , pp. 1851-1860
    • Stoger, R.1
  • 146
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003; 33: 245-54.
    • (2003) Nat Genet , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 147
    • 79957575898 scopus 로고    scopus 로고
    • Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming
    • Gordon L, Joo JH, Andronikos R et al. Expression discordance of monozygotic twins at birth: effect of intrauterine environment and a possible mechanism for fetal programming. Epigenetics 2011; 6: 579-92.
    • (2011) Epigenetics , vol.6 , pp. 579-592
    • Gordon, L.1    Joo, J.H.2    Andronikos, R.3
  • 148
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002; 16: 6-21.
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 149
    • 70350674919 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: An epigenetic model of obesity and the metabolic syndrome
    • Plagemann A, Harder T, Brunn M et al. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol 2009; 587: 4963-76.
    • (2009) J Physiol , vol.587 , pp. 4963-4976
    • Plagemann, A.1    Harder, T.2    Brunn, M.3
  • 150
    • 36749093765 scopus 로고    scopus 로고
    • In vivo methylation patterns of the leptin promoter in human and mouse
    • Stöger R, In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics 2006; 1: 155-62.
    • (2006) Epigenetics , vol.1 , pp. 155-162
    • Stöger, R.1
  • 151
    • 0347123629 scopus 로고    scopus 로고
    • Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    • Waterland R.A., Jirtle R.L. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 2004, 20: 63-8.
    • (2004) Nutrition , vol.20 , pp. 63-68
    • Waterland, R.A.1    Jirtle, R.L.2
  • 153
    • 34247469154 scopus 로고    scopus 로고
    • Epigenetic regulation of transcription: A mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
    • Burdge GC, Hanson MA, Slater-Jefferies JL, Lillycrop KA Epigenetic regulation of transcription: A mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?. Br J Nutr 2007; 97: 1036-46.
    • (2007) Br J Nutr , vol.97 , pp. 1036-1046
    • Burdge, G.C.1    Hanson, M.A.2    Slater-Jefferies, J.L.3    Lillycrop, K.A.4
  • 154
    • 33847723947 scopus 로고    scopus 로고
    • Developmental origins of diabetes: The role of epigenetic mechanisms
    • Simmons RA. Developmental origins of diabetes: the role of epigenetic mechanisms. Curr Opin Endocrinol Diabetes Obes 2007; 14: 13-6.
    • (2007) Curr Opin Endocrinol Diabetes Obes , vol.14 , pp. 13-16
    • Simmons, R.A.1
  • 155
    • 0035716123 scopus 로고    scopus 로고
    • Fetal programming and the Leningrad Siege study
    • Stanner SA, Yudkin JS. Fetal programming and the Leningrad Siege study. Twin Res 2001; 4: 287-92.
    • (2001) Twin Res , vol.4 , pp. 287-292
    • Stanner, S.A.1    Yudkin, J.S.2
  • 156
    • 77957591910 scopus 로고    scopus 로고
    • Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood
    • Li Y, He Y, Qi L et al. Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes 2010; 59: 2400-6.
    • (2010) Diabetes , vol.59 , pp. 2400-2406
    • Li, Y.1    He, Y.2    Qi, L.3
  • 157
    • 79955596507 scopus 로고    scopus 로고
    • Exposure to the Chinese famine in early life and the risk of hypertension in adulthood
    • Li Y, Jaddoe VW, Qi L et al. Exposure to the Chinese famine in early life and the risk of hypertension in adulthood. J Hypertens 2011; 29: 1085-92.
    • (2011) J Hypertens , vol.29 , pp. 1085-1092
    • Li, Y.1    Jaddoe, V.W.2    Qi, L.3
  • 158
    • 79955624796 scopus 로고    scopus 로고
    • Exposure to the Chinese famine in early life and the risk of metabolic syndrome in adulthood
    • Li Y, Jaddoe VW, Qi L et al. Exposure to the Chinese famine in early life and the risk of metabolic syndrome in adulthood. Diabetes Care 2011; 34: 1014-8.
    • (2011) Diabetes Care , vol.34 , pp. 1014-1018
    • Li, Y.1    Jaddoe, V.W.2    Qi, L.3
  • 159
    • 0034620969 scopus 로고    scopus 로고
    • Association between postnatal catch-up growth and obesity in childhood: Prospective cohort study
    • Ong KK, Ahmed ML, Emmett PM, Preece MA, Dunger DB. Association between postnatal catch-up growth and obesity in childhood: Prospective cohort study. Br Med J 2000; 320: 967-71.
    • (2000) Br Med J , vol.320 , pp. 967-971
    • Ong, K.K.1    Ahmed, M.L.2    Emmett, P.M.3    Preece, M.A.4    Dunger, D.B.5
  • 161
    • 0037440740 scopus 로고    scopus 로고
    • The dangerous road of catch-up growth
    • Hales CN, Ozanne SE. The dangerous road of catch-up growth. J Physiol (Lond) 2003; 547: 5-10.
    • (2003) J Physiol (Lond) , vol.547 , pp. 5-10
    • Hales, C.N.1    Ozanne, S.E.2
  • 162
    • 33751532448 scopus 로고    scopus 로고
    • Early growth, and coronary heart disease and type 2 diabetes: Experiences from the Helsinki birth cohort studies
    • Eriksson JG. Early growth, and coronary heart disease and type 2 diabetes: Experiences from the Helsinki birth cohort studies. Int J Obes (Lond) 2006; 30: S18-22.
    • (2006) Int J Obes (Lond) , vol.30
    • Eriksson, J.G.1
  • 163
    • 33744952660 scopus 로고    scopus 로고
    • Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children
    • Ibañez L, Ong K, Dunger DB, de Zegher F. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. J Clin Endocrinol Metab 2006; 91: 2153-8.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2153-2158
    • Ibañez, L.1    Ong, K.2    Dunger, D.B.3    de Zegher, F.4
  • 164
    • 79951734205 scopus 로고    scopus 로고
    • Reproduction in females: The role of the early life environment
    • Sloboda DM, Hickey M, Hart R. Reproduction in females: the role of the early life environment. Hum Reprod Update. 2011; 17: 210-27.
    • (2011) Hum Reprod Update , vol.17 , pp. 210-227
    • Sloboda, D.M.1    Hickey, M.2    Hart, R.3
  • 165
    • 0034887287 scopus 로고    scopus 로고
    • Dysregulation of the adipoinsular axis-a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming
    • Vickers MH, Reddy S, Ikenasio BA, Breier BH. Dysregulation of the adipoinsular axis-a mechanism for the pathogenesis of hyperleptinemia and adipogenic diabetes induced by fetal programming. J Endocrinol 2001; 170: 323-32.
    • (2001) J Endocrinol , vol.170 , pp. 323-332
    • Vickers, M.H.1    Reddy, S.2    Ikenasio, B.A.3    Breier, B.H.4
  • 167
    • 24144486246 scopus 로고    scopus 로고
    • Role of premature leptin surge in obesity resulting from intrauterine undernutrition
    • Yura S, Itoh H, Sagawa N, Yamamoto H et al. Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metab 2005; 1: 371-8.
    • (2005) Cell Metab , vol.1 , pp. 371-378
    • Yura, S.1    Itoh, H.2    Sagawa, N.3    Yamamoto, H.4
  • 168
    • 80052664767 scopus 로고    scopus 로고
    • Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: Implication for the understanding of metabolic syndrome
    • Jousse C, Parry L, Lambert-Langlais S et al. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J 2011; 25: 3271-8.
    • (2011) FASEB J , vol.25 , pp. 3271-3278
    • Jousse, C.1    Parry, L.2    Lambert-Langlais, S.3
  • 169
    • 20444421276 scopus 로고    scopus 로고
    • Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation
    • Lecklin A, Dube MG, Torto RN, Kalra PS, Kalra SP. Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation. Peptides 2005; 26: 1176-87.
    • (2005) Peptides , vol.26 , pp. 1176-1187
    • Lecklin, A.1    Dube, M.G.2    Torto, R.N.3    Kalra, P.S.4    Kalra, S.P.5
  • 170
    • 33748448112 scopus 로고    scopus 로고
    • Metabolic programming: Fetal origins of obesity and metabolic syndrome in the adult
    • Ismail-Beigi F, Catalano PM, Hanson RW. Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult. Am J Physiol Endocrinol Metab 2006; 291: 439-40.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. 439-440
    • Ismail-Beigi, F.1    Catalano, P.M.2    Hanson, R.W.3


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