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Volumn 302, Issue 5, 2012, Pages

2-Hydroxyestradiol slows progression of experimental polycystic kidney disease

Author keywords

Estrogen; Gender; Hydroxyestradiol p21; Hypoxia inducible factor 1 ; Mammalian target of rapamycin 2

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; ESTRADIOL; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P21;

EID: 84857699451     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00265.2011     Document Type: Article
Times cited : (12)

References (76)
  • 2
    • 0034959984 scopus 로고    scopus 로고
    • Angiogenesis in autosomaldominant polycystic kidney disease
    • Bello-Reuss E, Holubec K, Rajaraman S. Angiogenesis in autosomaldominant polycystic kidney disease. Kidney Int 60: 37-45, 2001.
    • (2001) Kidney Int , vol.60 , pp. 37-45
    • Bello-Reuss, E.1    Holubec, K.2    Rajaraman, S.3
  • 3
    • 0037133954 scopus 로고    scopus 로고
    • PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
    • Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109: 157-168, 2002.
    • (2002) Cell , vol.109 , pp. 157-168
    • Bhunia, A.K.1    Piontek, K.2    Boletta, A.3    Liu, L.4    Qian, F.5    Xu, P.N.6    Germino, F.J.7    Germino, G.G.8
  • 6
    • 0037058639 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells
    • Carothers AM, Hughes SA, Ortega D, Bertagnolli MM. 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. Cancer Lett 187: 77-86, 2002.
    • (2002) Cancer Lett , vol.187 , pp. 77-86
    • Carothers, A.M.1    Hughes, S.A.2    Ortega, D.3    Bertagnolli, M.M.4
  • 7
    • 0033840090 scopus 로고    scopus 로고
    • Liver involvement in autosomal- dominant polycystic kidney disease: Therapeutic dilemma
    • Chauveau D, Fakhouri F, Grunfeld JP. Liver involvement in autosomal- dominant polycystic kidney disease: therapeutic dilemma. J Am Soc Nephrol 11: 1767-1775, 2000.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 1767-1775
    • Chauveau, D.1    Fakhouri, F.2    Grunfeld, J.P.3
  • 9
    • 12644271201 scopus 로고    scopus 로고
    • Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats
    • Cowley BD Jr, Rupp JC, Muessel MJ, Gattone VH 2nd. Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats. Am J Kidney Dis 29: 265-272, 1997.
    • (1997) Am J Kidney Dis , vol.29 , pp. 265-272
    • Cowley Jr., B.D.1    Rupp, J.C.2    Muessel, M.J.3    Gattone II, V.H.4
  • 10
    • 44449161505 scopus 로고    scopus 로고
    • Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes
    • D'Eon TM, Rogers NH, Stancheva ZS, Greenberg AS. Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes. Obesity (Silver Spring) 16: 1284-1288, 2008.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1284-1288
    • D'eon, T.M.1    Rogers, N.H.2    Stancheva, Z.S.3    Greenberg, A.S.4
  • 11
    • 0034990298 scopus 로고    scopus 로고
    • Estrogen-induced cardiorenal protection: Potential cellular, biochemical, and molecular mechanisms
    • Dubey RK, Jackson EK. Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms. Am J Physiol Renal Physiol 280: F365-F388, 2001.
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Dubey, R.K.1    Jackson, E.K.2
  • 12
    • 27744592317 scopus 로고    scopus 로고
    • What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)?
    • Edelstein CL. What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)? Cell Cycle 4: 1550-1554, 2005.
    • (2005) Cell Cycle , vol.4 , pp. 1550-1554
    • Edelstein, C.L.1
  • 14
    • 0036267868 scopus 로고    scopus 로고
    • Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: A longitudinal study
    • Fick-Brosnahan GM, Belz MM, McFann KK, Johnson AM, Schrier RW. Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study. Am J Kidney Dis 39: 1127-1134, 2002.
    • (2002) Am J Kidney Dis , vol.39 , pp. 1127-1134
    • Fick-Brosnahan, G.M.1    Belz, M.M.2    McFann, K.K.3    Johnson, A.M.4    Schrier, R.W.5
  • 16
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277: 38205-38211, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 18
    • 67649872366 scopus 로고    scopus 로고
    • Late progression of renal pathology and cyst enlargement is reduced by rapamycin in a mouse model of nephronophthisis
    • Gattone VH 2nd, Sinders RM, Hornberger TA, Robling AG. Late progression of renal pathology and cyst enlargement is reduced by rapamycin in a mouse model of nephronophthisis. Kidney Int 76: 178-182, 2009.
    • (2009) Kidney Int , vol.76 , pp. 178-182
    • Gattone II, V.H.1    Sinders, R.M.2    Hornberger, T.A.3    Robling, A.G.4
  • 19
    • 0142073812 scopus 로고    scopus 로고
    • Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
    • Gattone VH 2nd, Wang X, Harris PC, Torres VE. Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat Med 9: 1323-1326, 2003.
    • (2003) Nat Med , vol.9 , pp. 1323-1326
    • Gattone II, V.H.1    Wang, X.2    Harris, P.C.3    Torres, V.E.4
  • 21
    • 33746655373 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in the kidney
    • Haase VH. Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol 291: F271-F281, 2006.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Haase, V.H.1
  • 22
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 280: 26089-26093, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 24
    • 34248166505 scopus 로고    scopus 로고
    • Polycystic kidney disease
    • Igarashi P, Somlo S. Polycystic kidney disease. J Am Soc Nephrol 18: 1371-1373, 2007.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1371-1373
    • Igarashi, P.1    Somlo, S.2
  • 25
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 4: 648-657, 2002.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 26
    • 1542379706 scopus 로고    scopus 로고
    • The impact of gender on progression of renal disease: Potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection
    • Kang DH, Yu ES, Yoon KI, Johnson R. The impact of gender on progression of renal disease: potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection. Am J Pathol 164: 679-688, 2004.
    • (2004) Am J Pathol , vol.164 , pp. 679-688
    • Kang, D.H.1    Yu, E.S.2    Yoon, K.I.3    Johnson, R.4
  • 29
    • 0033033630 scopus 로고    scopus 로고
    • The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis
    • Kim YG, Alpers CE, Brugarolas J, Johnson RJ, Couser WG, Shankland SJ. The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis. Kidney Int 55: 2349-2361, 1999.
    • (1999) Kidney Int , vol.55 , pp. 2349-2361
    • Kim, Y.G.1    Alpers, C.E.2    Brugarolas, J.3    Johnson, R.J.4    Couser, W.G.5    Shankland, S.J.6
  • 31
    • 33748307456 scopus 로고    scopus 로고
    • Altered endothelial nitric oxide synthase targeting and conformation and caveolin-1 expression in the diabetic kidney
    • Komers R, Schutzer WE, Reed JF, Lindsley JN, Oyama TT, Buck DC, Mader SL, Anderson S. Altered endothelial nitric oxide synthase targeting and conformation and caveolin-1 expression in the diabetic kidney. Diabetes 55: 1651-1659, 2006.
    • (2006) Diabetes , vol.55 , pp. 1651-1659
    • Komers, R.1    Schutzer, W.E.2    Reed, J.F.3    Lindsley, J.N.4    Oyama, T.T.5    Buck, D.C.6    Mader, S.L.7    Anderson, S.8
  • 32
    • 0035171012 scopus 로고    scopus 로고
    • The pck rat: A new model that resembles human autosomal dominant polycystic kidney and liver disease
    • Lager DJ, Qian Q, Bengal RJ, Ishibashi M, Torres VE. The pck rat: a new model that resembles human autosomal dominant polycystic kidney and liver disease. Kidney Int 59: 126-136, 2001.
    • (2001) Kidney Int , vol.59 , pp. 126-136
    • Lager, D.J.1    Qian, Q.2    Bengal, R.J.3    Ishibashi, M.4    Torres, V.E.5
  • 33
    • 72049105867 scopus 로고    scopus 로고
    • The role of the mammalian target of rapamycin (mTOR) in renal disease
    • Lieberthal W, Levine JS. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 20: 2493-2502, 2009.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2493-2502
    • Lieberthal, W.1    Levine, J.S.2
  • 36
    • 84863716997 scopus 로고    scopus 로고
    • Regulation of LKB1 expression by sex hormones in adipocytes
    • Aug 30. doi 10.1038/ijo.2011.172 (Epub ahead of print)
    • McInnes KJ, Brown KA, Hunger NI, Simpson ER. Regulation of LKB1 expression by sex hormones in adipocytes. Int J Obes (Lond) 2011 Aug 30. doi 10.1038/ijo.2011.172 (Epub ahead of print).
    • (2011) Int J Obes (Lond)
    • McInnes, K.J.1    Brown, K.A.2    Hunger, N.I.3    Simpson, E.R.4
  • 37
    • 0742269867 scopus 로고    scopus 로고
    • New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent
    • Mooberry SL. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Curr Opin Oncol 15: 425-430, 2003.
    • (2003) Curr Opin Oncol , vol.15 , pp. 425-430
    • Mooberry, S.L.1
  • 38
    • 23944485127 scopus 로고    scopus 로고
    • Provenance of the protective property of p21
    • Nath KA. Provenance of the protective property of p21. Am J Physiol Renal Physiol 289: F512-F513, 2005.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Nath, K.A.1
  • 39
    • 33646948499 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease
    • Omori S, Hida M, Fujita H, Takahashi H, Tanimura S, Kohno M, Awazu M. Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease. J Am Soc Nephrol 17: 1604-1614, 2006.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1604-1614
    • Omori, S.1    Hida, M.2    Fujita, H.3    Takahashi, H.4    Tanimura, S.5    Kohno, M.6    Awazu, M.7
  • 40
    • 35748957484 scopus 로고    scopus 로고
    • p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: Roscovitine augments p21 levels
    • Park JY, Schutzer WE, Lindsley JN, Bagby SP, Oyama TT, Anderson S, Weiss RH. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels. BMC Nephrol 8: 12, 2007.
    • (2007) BMC Nephrol , vol.8 , pp. 12
    • Park, J.Y.1    Schutzer, W.E.2    Lindsley, J.N.3    Bagby, S.P.4    Oyama, T.T.5    Anderson, S.6    Weiss, R.H.7
  • 42
    • 0031801328 scopus 로고    scopus 로고
    • Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease
    • Ramasubbu K, Gretz N, Bachmann S. Increased epithelial cell proliferation and abnormal extracellular matrix in rat polycystic kidney disease. J Am Soc Nephrol 9: 937-945, 1998.
    • (1998) J Am Soc Nephrol , vol.9 , pp. 937-945
    • Ramasubbu, K.1    Gretz, N.2    Bachmann, S.3
  • 49
  • 50
    • 33749235323 scopus 로고    scopus 로고
    • Development of polycystic kidney disease in juvenile cystic kidney mice: Insights into pathogenesis, ciliary abnormalities, and common features with human disease
    • Smith LA, Bukanov NO, Husson H, Russo RJ, Barry TC, Taylor AL, Beier DR, Ibraghimov-Beskrovnaya O. Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease. J Am Soc Nephrol 17: 2821-2831, 2006.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2821-2831
    • Smith, L.A.1    Bukanov, N.O.2    Husson, H.3    Russo, R.J.4    Barry, T.C.5    Taylor, A.L.6    Beier, D.R.7    Ibraghimov-Beskrovnaya, O.8
  • 54
    • 18744406029 scopus 로고    scopus 로고
    • Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease
    • Tao Y, Kim J, Faubel S, Wu JC, Falk SA, Schrier RW, Edelstein CL. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci USA 102: 6954-6959, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6954-6959
    • Tao, Y.1    Kim, J.2    Faubel, S.3    Wu, J.C.4    Falk, S.A.5    Schrier, R.W.6    Edelstein, C.L.7
  • 55
    • 18744380752 scopus 로고    scopus 로고
    • Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
    • Tao Y, Kim J, Schrier RW, Edelstein CL. Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease. J Am Soc Nephrol 16: 46-51, 2005.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 46-51
    • Tao, Y.1    Kim, J.2    Schrier, R.W.3    Edelstein, C.L.4
  • 57
    • 44349189277 scopus 로고    scopus 로고
    • Caspase-3 gene deletion prolongs survival in polycystic kidney disease
    • Tao Y, Zafar I, Kim J, Schrier RW, Edelstein CL. Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J Am Soc Nephrol 19: 749-755, 2008.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 749-755
    • Tao, Y.1    Zafar, I.2    Kim, J.3    Schrier, R.W.4    Edelstein, C.L.5
  • 58
    • 0033529838 scopus 로고    scopus 로고
    • Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest
    • Tiainen M, Ylikorkala A, Makela TP. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96: 9248-9251, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9248-9251
    • Tiainen, M.1    Ylikorkala, A.2    Makela, T.P.3
  • 59
    • 0036839384 scopus 로고    scopus 로고
    • 2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy
    • Tofovic SP, Dubey R, Salah EM, Jackson EK. 2-Hydroxyestradiol attenuates renal disease in chronic puromycin aminonucleoside nephropathy. J Am Soc Nephrol 13: 2737-2747, 2002.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2737-2747
    • Tofovic, S.P.1    Dubey, R.2    Salah, E.M.3    Jackson, E.K.4
  • 60
    • 0035192862 scopus 로고    scopus 로고
    • 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats
    • Tofovic SP, Dubey RK, Jackson EK. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther 299: 973-977, 2001.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 973-977
    • Tofovic, S.P.1    Dubey, R.K.2    Jackson, E.K.3
  • 61
    • 21444459241 scopus 로고    scopus 로고
    • Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition
    • Tofovic SP, Salah EM, Dubey RK, Melhem MF, Jackson EK. Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition. J Cardiovasc Pharmacol 46: 25-35, 2005.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 25-35
    • Tofovic, S.P.1    Salah, E.M.2    Dubey, R.K.3    Melhem, M.F.4    Jackson, E.K.5
  • 62
    • 0031916990 scopus 로고    scopus 로고
    • Renal concentration of alpha-tocopherol: Dependence on gender and lack of effect on polycystic kidney disease in Han:SPRD rats
    • Torres VE, Bengal RJ, Nickander KK, Grande JP, Low PA. Renal concentration of alpha-tocopherol: dependence on gender and lack of effect on polycystic kidney disease in Han:SPRD rats. Am J Kidney Dis 31: 687-693, 1998.
    • (1998) Am J Kidney Dis , vol.31 , pp. 687-693
    • Torres, V.E.1    Bengal, R.J.2    Nickander, K.K.3    Grande, J.P.4    Low, P.A.5
  • 63
    • 33845989853 scopus 로고    scopus 로고
    • Polycystic kidney disease: Genes, proteins, animal models, disease mechanisms and therapeutic opportunities
    • Torres VE, Harris PC. Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities. J Intern Med 261: 17-31, 2007.
    • (2007) J Intern Med , vol.261 , pp. 17-31
    • Torres, V.E.1    Harris, P.C.2
  • 66
    • 33644859253 scopus 로고    scopus 로고
    • Inhibition of mTOR with sirolimus slows disease progression in Han: SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)
    • Wahl PR, Serra AL, Le Hir M, Molle KD, Hall MN, Wuthrich RP. Inhibition of mTOR with sirolimus slows disease progression in Han: SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant 21: 598-604, 2006.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 598-604
    • Wahl, P.R.1    Serra, A.L.2    le Hir, M.3    Molle, K.D.4    Hall, M.N.5    Wuthrich, R.P.6
  • 68
    • 33748943989 scopus 로고    scopus 로고
    • Evidence of angiogenesis and microvascular regression in autosomal-dominant polycystic kidney disease kidneys: A corrosion cast study
    • Wei W, Popov V, Walocha JA, Wen J, Bello-Reuss E. Evidence of angiogenesis and microvascular regression in autosomal-dominant polycystic kidney disease kidneys: a corrosion cast study. Kidney Int 70: 1261-1268, 2006.
    • (2006) Kidney Int , vol.70 , pp. 1261-1268
    • Wei, W.1    Popov, V.2    Walocha, J.A.3    Wen, J.4    Bello-Reuss, E.5
  • 69
    • 33644657042 scopus 로고    scopus 로고
    • Kidney cancer: Identification of novel targets for therapy
    • Weiss RH, Lin PY. Kidney cancer: identification of novel targets for therapy. Kidney Int 69: 224-232, 2006.
    • (2006) Kidney Int , vol.69 , pp. 224-232
    • Weiss, R.H.1    Lin, P.Y.2
  • 70
    • 33947358664 scopus 로고    scopus 로고
    • Cystic disease of the kidney
    • Wilson PD, Goilav B. Cystic disease of the kidney. Annu Rev Pathol 2: 341-368, 2007.
    • (2007) Annu Rev Pathol , vol.2 , pp. 341-368
    • Wilson, P.D.1    Goilav, B.2
  • 71
    • 21244506269 scopus 로고    scopus 로고
    • High-dose estrogen and clinical selective estrogen receptor modulators induce growth arrest, p21, and p53 in primate ovarian surface epithelial cells
    • Wright JW, Stouffer RL, Rodland KD. High-dose estrogen and clinical selective estrogen receptor modulators induce growth arrest, p21, and p53 in primate ovarian surface epithelial cells. J Clin Endocrinol Metab 90: 3688-3695, 2005.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3688-3695
    • Wright, J.W.1    Stouffer, R.L.2    Rodland, K.D.3
  • 72
    • 77950896568 scopus 로고    scopus 로고
    • Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
    • Yao Y, Li H, Gu Y, Davidson NE, Zhou Q. Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling. Carcinogenesis 31: 382-387, 2010.
    • (2010) Carcinogenesis , vol.31 , pp. 382-387
    • Yao, Y.1    Li, H.2    Gu, Y.3    Davidson, N.E.4    Zhou, Q.5
  • 75
    • 33846561588 scopus 로고    scopus 로고
    • 2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats
    • Zhang X, Jia Y, Jackson EK, Tofovic SP. 2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats. J Cardiovasc Pharmacol 49: 56-63, 2007.
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 56-63
    • Zhang, X.1    Jia, Y.2    Jackson, E.K.3    Tofovic, S.P.4
  • 76
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER- 2/neu-overexpressing cells
    • Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER- 2/neu-overexpressing cells. Nat Cell Biol 3: 245-252, 2001.
    • (2001) Nat Cell Biol , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6


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