EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats

Kidney International

Volumn 64, Issue 5, 2003, Pages 1573-1579

  Torres, Vicente E ^a   Sweeney Jr , William E ^b   Wang, Xiaofang ^b   Qian, Qi ^b   Harris, Peter C ^b   Frost, Philip ^b   Avner, Ellis D ^b  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

EGF receptor; EKB 569; EKI 785; HanSPRD rat; Polycystic kidney disease

Indexed keywords

EKI 785; EPIDERMAL GROWTH FACTOR RECEPTOR; PELITINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BIOAVAILABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; FEEDING; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KIDNEY FIBROSIS; KIDNEY MASS; KIDNEY POLYCYSTIC DISEASE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; TUMOR VOLUME; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; WILD TYPE;

EID: 0142249413     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2003.00256.x     Document Type: Article

References (44)

1. QIAN Q, HARRIS PC, TORRES VE: Treatment prospects for autosomal dominant polycystic kidney disease. Kidney Int 59:2005-2022, 2001
2. DAVIS ID, MACRAE DELL K, SWEENEY WE, et al: Can progression of autosomal dominant or autosomal recessive polycystic kidney disease be prevented? Semin Nephrol 21:430-440, 2001
3. GATTONE VI: Defective epidermal growth factor gene expression in mice with polycystic kidney disease. Develop Biol 138:225-230, 1990
4. HORIKOSHI S, KUBOTA S, MARTIN G, et al: Epidermal growth factor (EGF) expression in the congenital polycystic mouse kidney. Kidney Int 39:57-62, 1991
5. NAKAMURA T, EBIHARA I, NAGAOKA I, et al: Growth factor gene expression in kidney of murine polycystic kidney disease. J Am Soc Nephrol 3:1378-1386, 1993
6. COWLEY BJ, RUPP J: Abnormal expression of epidermal growth factor and sulfated glycoprotein SGP-2 messenger RNA in a rat model of autosomal dominant polycystic kidney diseas. J Am Soc Nephrol 6:1679-1681, 1995
7. MUNEMURA C, UEMASU J, KAWASAKI H: Epidermal growth factor and endothelin in cyst fluid from autosomal dominant polycystic kidney disease cases: possible evidence of heterogeneity in cystogenesis. Am J Kidney Dis 24:561-568, 1994
8. MOSKOWITZ D, BONAR S, LIU W, et al: Epidermal growth factor precursor is present in a variety of human renal cyst fluids. J Urol 153:578-583, 1995
9. LAKSHMANAN J, EYSSELEIN V: Hereditary error in epidermal growth factor prohormone metabolism in a rat model of autosomal dominant polycystic kidney disease. Biochem Biophys Res Commun J 97:1083-1093, 1993
10. KLINGEL R, DIPPOLD W, STORKEL S, et al: Expression of differentiation antigens and growth-related genes in normal kidney, autosomal dominant polycystic kidney disease, and renal cell carcinoma. Am J Kidney Dis 19:22-30, 1992
11. LEE D, CHAN K, CHAN S: Expression of transforming growth factor α and epidermal growth factor receptor in adult polycystic kidney disease. J Urol 159:291-296, 1998
12. NEUFELD T, DOUGLASS D, GRANT M, et al: In vitro formation and expansion of cysts derived from human renal cortex epithelial cells. Kidney Int 41:1222-1236, 1992
13. PUGH J, SWEENEY WJ, AVNER E: Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture. Kidney Int 47: 774-781, 1995
14. SWEENEY W, FUTEY L, FROST P, et al: In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor. Kidney Int 56:406-413, 1999
15. LOWDEN D, LINDERMANN G, MERLINO G, et al: Renal cysts in transgenic mice expressing transforming growth factor-α. J Lab Clin Med 124:386-394, 1994
16. STOCKLIN E, BOTTERI F, GRONER B: An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice. J Cell Biol 122:199-208, 1993
17. SCHAFFNER DL, BARRIOS R, MASSEY C, et al: Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys. Am J Pathol 142: 1051-1060, 1993
18. DU J, WILSON P: Abnormal polarization of EGF receptors and autocrine stimulation of cyst epithelial growth in human ADPKD. Am J Physiol 269:C487-C495, 1995
19. ORELLANA S, SWEENEY W, NEFF C, et al: Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. Kidney Int 47:490-499, 1995
20. SWEENEY W, JR, AVNER E: Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease. Am J Physiol 275:F387-F394, 1998
21. NAKANISHI K, SWEENEY W, JR, AVNER ED: Segment-specificc-ErbB2 expression in human autosomal recessive polycystic kidney disease. J Am Soc Nephrol 12:379-384, 2001
22. RICHARDS W, SWEENEY W, YODER B, et al: Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. J Clin Invest 101:935-939, 1998
23. SWEENEY WE, JR, CHEN Y, NAKANISH K, et al: Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int 57:33-40, 2000
24. KASPAREIT-RITTINGHAUSEN J, RAPP K, DEERBERG F, et al: Hereditary polycystic kidney disease associated with osteorenal syndrome in rats. Vet Pathol 26:195-201, 1989
25. COWLEY B, JR, GUDAPATY S, KRAYBILL A, et al: Autosomal dominant polycystic kidney disease in the rat. Kidney Int 43:522-534, 1993
26. DISCAFANI CM, CARROLL ML, FLOYD MB, JR, et al: Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6- quinazolinyl]-2-butynamide (CL-387,785). Biochem Pharmacol 57:917-925, 1999
27. TORRANCE CJ, JACKSON PE, MONTGOMERY E, et al: Combinatorial chemoprevention of intestinal neoplasia. Nat Med 6:1024-1028, 2000
28. TERZI F, BURTFN M, HEKMATI M, et al: Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest 106:225-234, 2000
29. NORMAN J, BADIE-DEZFOOLY B, NORD E, et al: EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II. Am J Physiol 253:F299-F309, 1987
30. STANTON RC, SEIFTER JL: Epidermal growth factor rapidly activates the hexose monophosphate shunt in kidney cells. Am J Physiol 254:C267-C271, 1988
31. HUMES HD, BEALS TF, CIESLINSKI DA, et al: Effects of transforming growth factor-β, transforming growth factor-α, and other growth factors on renal proximal tubule cells. Lab Invest 64:538-545, 1991
32. HARRIS RC, DANIEL TO: Epidermal growth factor binding, stimulation of phosphorylation, and inhibition of gluconeogenesis in rat proximal tubule. J Cell Physiol 139:383-391, 1989
33. RALL LB, SCOTT J, BELL GI, et al: Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues. Nature 313:228-231, 1985
34. HARRIS RC: Potential physiologic roles for epidermal growth factor in the kidney. Am J Kidney Dis 17:627-630, 1991
35. XIAN CJ: Expression of transforming growth factor-alpha mRNA and peptide in rodent kidneys. Histochem Cell Biol 111:467-475, 1999
36. KEITH DS, TORRES VE, JOHNSON CM, et al: Effect of sodium chloride, enalapril, and losartan on the development of polycystic kidney disease in Han:SPRD rats. Am J Kidney Dis 24;491-498, 1994
37. OGBORN M, SAREEN S, PINETTE G: Cilazapril delays progression of hypertension and uremia in rat polycystic kidney disease. Am J Kidney Dis 26:942-946, 1995
38. KENNEFICK T, AL-NIMRI M, OYAMA T, et al: Hypertension and renal injury in experimental polycystic kidney disease. Kidney Int 56:2181-2190, 1999
39. HUMES HD, CIESLINSKI DA, COIMBRA TM, et al: Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure. J Clin Invest 84:1757-1761, 1989
40. COIMBRA TM, CIESLINSKI DA, HUMES HD: Epidermal growth factor accelerates renal repair in mercuric chloride nephrotoxicity. Am J Physiol 259:F438-F443, 1990
41. MILLER SB, ROGERS SA, ESTES CE, et al: Increased distal nephron EGF content and altered distribution of peptide in compensatory renal hypertrophy. Am J Physiol 262:F1032-F1038, 1992
42. TERZI F, BURTIN M, FRIEDLANDER G: Early molecular mechanisms in the progression of renal failure: Role of growth factors and protooncogenes. Kidney Int 53(Suppl 65):S68-S73, 1998
43. UHLMAN DL, NGUYEN P, MANIVEL JC, et al: Epidermal growth factor receptor and transforming growth factor alpha expression in papillary and nonpapillary renal cell carcinoma: correlation with metastatic behavior and prognosis. Clin Cancer Res 1:913-920, 1995
44. WARD CJ, HOGAN MC, ROSSETTI S, et al: The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Nat Genet 30:259-269, 2002