Regulation of LKB1 expression by sex hormones in adipocytes

International Journal of Obesity

Volumn 36, Issue 7, 2012, Pages 982-985

  McInnes, K J ^a   Brown, K A ^b,c   Hunger, N I ^b   Simpson, E R ^b,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

adipocytes; AMPK; androgen; LKB1; oestrogen

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FLUTAMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE LKB1; TESTOSTERONE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADIPOCYTES; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DIHYDROTESTOSTERONE; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; HUMANS; LIPOGENESIS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TESTOSTERONE;

MURINAE;

EID: 84863716997     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2011.172     Document Type: Article

References (13)

1. Poehlman ET. Transversing the menopause: change in energy expenditure and body composition. Coron Artery Dis 2005; 16: 511.
2. Liu YM, Ding JZ, Trudy TL, Longenecker JC, Nieto FJ, Golden SH et al. Relative androgen excess and increased cardiovascular risk after menopause: a hypothesized relation. Am J Epidemiol 2001; 154: 489-494.
3. McInnes KJ, Corbould A, Simpson ER, Jones ME. Regulation of adenosine 50,monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state. Endocrinol 2006; 147: 5907-5913.
4. Fisher CR, Graves KH, Parlow AF, Simpson ER. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 1998; 95: 6965-6970.
5. Simpson ER, Misso M, Hewitt KN, Hill RA, Boon WC, Jones ME et al. Estrogen-the good, the bad, and the unexpected. Endocr Rev 2005; 26: 322-330.
6. Jones MEE, Boon WC, McInnes K, Maffei L, Carani C, Simpson ER. Recognizing rare disorders: aromatase deficiency. Nat Clin Pract Endocrinol Metab 2007; 3: 414-421.
7. Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LGD, Neumann D et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 2003; 13: 2004-2008.
8. Brown KA, McInnes KJ, Hunger NI, Oakhill JS, Steinberg GR, Simpson ER. Subcellular localization of cyclic AMP-responsive element binding proteinregulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women. Cancer Res 2009; 69: 5392-5399.
9. Barros RPA, Gabbi C, Morani A, Warner M, Gustafsson JA. Participation of ER alpha and ER beta in glucose homeostasis in skeletal muscle and white adipose tissue. Am J Physiol-Endocrinol Metabol 2009; 297: E124-E133.
10. Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S et al. Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinol 2008; 149: 2361-2368.
11. Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril 2006; 85: 1319-1340.
12. Alessi DR, Sakamoto K, Bayascas JR. LKB1-dependent signaling pathways. Annu Rev Biochem 2006; 75: 137-163.
13. Carling D. LKB1: a sweet side to Peutz-Jeghers syndrome? Trends Mol Med 2006; 12: 144-147.