Evidence for the contribution of the hemozoin synthesis pathway of the murine plasmodium yoelii to the resistance to artemisinin-related drugs

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Witkowski, Benoit ^a,b   Lelièvre, Joel ^a,b,e   Nicolau Travers, Marie Laure ^a,b   Iriart, Xavier ^b,c   Soh, Patrice Njomnang ^a,b   Bousejra ElGarah, Fatima ^a   Meunier, Bernard ^a,d   Berry, Antoine ^b,c   Benoit Vical, Françoise ^a,b  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

^c UMR 152 IRD Universite Paul Sabatier   (France)

^d GlaxoSmithKline R and D Parque Tecnológico de Madrid ^*

^e GLAXOSMITHKLINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; ARTEMISININ; ARTEMISONE; ARTESUNATE; ATOVAQUONE; CHLOROQUINE; GLUTATHIONE; HEME DETOXIFICATION PROTEIN; HEMOZOIN; MEFLOQUINE; MESSENGER RNA; PROTOZOAL PROTEIN; PYRIMETHAMINE PLUS SULFADOXINE; QUININE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; HDP PROTEIN, PLASMODIUM FALCIPARUM; HEME; HEMOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPIFLUORESCENCE MICROSCOPY; FEMALE; GENE; GENE DOSAGE; INTERMETHOD COMPARISON; MDR1 GENE; MOUSE; NONHUMAN; PLASMODIUM YOELII; PRESSURE MEASUREMENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PYMDR1 GENE; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECT; DRUG RESISTANCE; LYSOSOME; METABOLISM; MOLECULAR GENETICS; MULTIDRUG RESISTANCE;

MURINAE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII;

AMINO ACID SEQUENCE; ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG RESISTANCE; DRUG RESISTANCE, MULTIPLE; FEMALE; HEME; HEMEPROTEINS; LYSOSOMES; MICE; MOLECULAR SEQUENCE DATA; PLASMODIUM YOELII; PROTOZOAN PROTEINS;

EID: 84857698357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032620     Document Type: Article

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