A molecular marker for chloroquine-resistant falciparum malaria

New England Journal of Medicine

Volumn 344, Issue 4, 2001, Pages 299-302

  Warhurst, D C ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; GENE PRODUCT; PROTEIN FMDR1; PROTEIN PFCRT; PROTEIN PGH1; UNCLASSIFIED DRUG; VERAPAMIL;

CHROMOSOME 5; CHROMOSOME 7; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; MALARIA; MALARIA FALCIPARUM; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW;

ANIMALS; CHLOROQUINE; DRUG RESISTANCE; GENETIC MARKERS; HUMANS; LYSOSOMES; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POINT MUTATION; RABBITS;

EID: 0035945673     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200101253440411     Document Type: Review

References (16)

1. Increased susceptibility to malaria during the early postpartum period
2. Drug resistance in malaria parasites of animals and man
3. Impact of chloroquine resistance on malaria mortality
4. Gametocytes, chloroquine pressure, and the relative parasite survival advantage of resistant strains of falciparum malaria in west Africa
5. Lysosomes, pH and the anti-malarial action of chloroquine
6. Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites
7. Studies on modes of action of chloroquine, quinacrine, and quinine and on chloroquine resistance
8. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil
9. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum
10. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross
11. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
12. Mechanism of chloroquine-resistance in malaria
13. Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr 1 gene
14. A molecular marker for chloroquine-resistant falciparum malaria
15. Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine
16. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum