Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3752-3755

  Kawaguchi, Mitsuyasu ^a,b   Terai, Takuya ^a,b   Utata, Rei ^c   Kato, Miki ^c   Tsuganezawa, Keiko ^c   Tanaka, Akiko ^c   Kojima, Hirotatsu ^a   Okabe, Takayoshi ^a   Nagano, Tetsuo ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c RIKEN   (Japan)

Author keywords

ASK1; Fluorescence correlation spectroscopy; Kinase inhibitor; Staurosporine

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; STAUROSPORINE; TETRAMETHYLRHODAMINE;

ARTICLE; CRYSTAL STRUCTURE; DRUG SCREENING; ENDOPLASMIC RETICULUM; FLUORESCENCE CORRELATION SPECTROSCOPY; OXIDATIVE STRESS;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE POLARIZATION; FLUORESCENT DYES; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MAP KINASE KINASE KINASE 5; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; SPECTROMETRY, FLUORESCENCE; STAUROSPORINE;

EID: 44849143696     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.040     Document Type: Article

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