Is there any value to hepatitis B virus genotype analysis?

Current Gastroenterology Reports

Volumn 14, Issue 1, 2012, Pages 37-46

  Tanwar, Sudeep ^a   Dusheiko, Geoffrey ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Genotype; Geography; Hepatitis B; Hepatocellular cancer; Interferon; Natural history; Nucleos(t)ide; Resistance; Seroconversion; Therapy; Transmission

Indexed keywords

ADEFOVIR; ALPHA INTERFERON; ANTIVIRUS AGENT; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; NUCLEOSIDE ANALOG; NUCLEOTIDE DERIVATIVE; PEGINTERFERON ALPHA; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; TELBIVUDINE; VIRUS DNA;

ANTIVIRAL RESISTANCE; ARTICLE; DISEASE COURSE; DISEASE SEVERITY; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; META ANALYSIS (TOPIC); MOLECULAR EPIDEMIOLOGY; NONHUMAN; PROMOTER REGION; SEROCONVERSION; TREATMENT OUTCOME; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS TRANSMISSION;

GENETIC VARIATION; GENOTYPE; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; PROGNOSIS;

EID: 84857614581     PISSN: 15228037     EISSN: 1534312X     Source Type: Journal    
DOI: 10.1007/s11894-011-0233-5     Document Type: Article

References (106)

1. JH Kao DS Chen 2002 Global control of hepatitis B virus infection Lancet Infect Dis 2 395 403 12127351 10.1016/S1473-3099(02)00315-8 (Pubitemid 34693257)
2. G Fattovich F Bortolotti F Donato 2008 Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors J Hepatol 48 335 52 18096267 10.1016/j.jhep.2007.11.011 1:CAS:528: DC%2BD1cXlsF2isg%3D%3D
3. TJ Liang 2009 Hepatitis B: the virus and the disease Hepatology 49 Suppl S13 21 19399811 1:CAS:528:DC%2BD1MXlvFKqsL4%3D 10.1002/hep.22881 A broad overview of the lifecycle and replication of hepatitis B virus and spectrum of disease
4. BS Blumberg HJ Alter S Visnich 1965 A "new" antigen in leukemia sera JAMA 191 541 6 14239025 1:STN:280:DyaF2M%2FktlCntg%3D%3D 10.1001/jama.1965.03080070025007
5. E Orito M Mizokami Y Ina, et al. 1989 Host-independant evolution and a genetic classification of the hepadnavirus family based on nucleotide sequences Proc Natl Acad Sci USA 86 7059 62 2780562 1:CAS:528:DyaL1MXlslSqsbg%3D 10.1073/pnas.86.18.7059 (Pubitemid 19240866)
6. AM Courouce-Pauty JM Lemaire JF Roux 1978 New Hepatitis B surface antigen subtypesinside the ad category Vox Sang 35 304 8 80881 1:STN:280: DyaE1M%2Fhs1eksA%3D%3D 10.1111/j.1423-0410.1978.tb02939.x (Pubitemid 9005983)
7. H Okamoto F Tsuda H Sakugawa, et al. 1988 Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes J Gen Virol 69 2575 83 3171552 1:CAS:528:DyaL1MXktVWltr4%3D 10.1099/0022-1317-69-10- 2575
8. H Norder B Hammas S Lofdahl, et al. 1992 Comparision of the amino acid sequences of nine difference serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains J Gen Virol 73 1201 8 1588323 1:CAS:528:DyaK3sXitFSqs74%3D 10.1099/0022-1317-73-5-1201
9. L Stuyver S De Gendt C Van Geyt, et al. 2000 A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness J Gen Virol 81 67 74 10640543 1:CAS:528:DC%2BD3cXjvVKrsg%3D%3D (Pubitemid 30047907)
10. P Arauz-Ruiz H Norder BH Robertson LO Magnius 2002 Genotype H: a new Amerindian genotype of hepatitis B virus revealed in central America J Gen Virol 83 2059 73 12124470 1:CAS:528:DC%2BD38XlvVCrsLg%3D (Pubitemid 34846468)
11. TT Tran TN Trinh K Abe 2008 New complex recombinant genotype of hepatitis B virus identified in Vietnam J Virol 82 5657 63 18353958 10.1128/JVI.02010-07 1:CAS:528:DC%2BD1cXhtlY%3D (Pubitemid 350309167)
12. K Tatematsu Y Tanaka F Kurbanov, et al. 2009 A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J J Virol 83 10538 47 19640977 1:CAS:528:DC%2BD1MXhtlClsbbJ 10.1128/JVI.00462-09
13. KI Ohba M Mizokami T Ohno, et al. 1995 Relationships between serotypes and genotypes of hepatitis B virus: Genetic classification of HBV by use of surface genes Virus Research 39 1 25 34 8607280 1:CAS:528:DyaK2MXpsFSisb0%3D 10.1016/S0168-1702(95)00069-0
14. BS Guirgis RO Abbas HM Azzazy 2010 Hepatitis B virus genotyping: current methods and clinical implications Int J Infect Dis 14 11 e941 53 20674432 1:CAS:528:DC%2BC3cXhs1ars7rE 10.1016/j.ijid.2010.03.020 A concise outline of the current genotyping techniques including their advantages and limitations
15. Y Ma Y Ding F Juan XG Dou 2011 Genotyping the hepatitis B virus with a fragment of the HBV DNA polymerase gene in Shenyang, China Virol J 8 315 315 21693069 1:CAS:528:DC%2BC3MXot1GmtLY%3D 10.1186/1743-422X-8-315
16. SZ Jiang ZY Gao T Li, et al. 2009 T3098C and T53C mutations of HBV genotype C is associated with HBV infection progress Biomed Environ Sci 22 6 511 7 20337225 1:CAS:528:DC%2BC3cXhsFCks7g%3D 10.1016/S0895-3988(10)60009-8
17. J Ou O Laub W Rutter 1986 Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen Proc Natl Acad Sci USA 83 1578 82 3006057 1:CAS:528: DyaL28XhvVSrtbY%3D 10.1073/pnas.83.6.1578 (Pubitemid 16018607)
18. WF Carman MR Jacyna S Hadziyannis, et al. 1989 Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection Lancet 2 588 91 2570285 1:STN:280:DyaL1MzmtlOqsw%3D%3D 10.1016/S0140-6736(89)90713-7 (Pubitemid 19216208)
19. J-S Li S-P Tong Y-M Wen, et al. 1993 Hepatitis B virus genotype A rarely circulates as an HBe- minus mutant: Possible contribution of a single nucleotide in the precore region J Virol 67 5402 10 8350403 1:CAS:528:DyaK3sXmsVGgurg%3D (Pubitemid 23241374)
20. A Mangia YH Chung JH Hoofnagle, et al. 1996 Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg Dig Dis Sci 41 12 2447 52 9011456 1:STN:280:DyaK2s7kvVKmsQ%3D%3D 10.1007/BF02100141 (Pubitemid 27041801)
21. LJ Stuyver SA Locarnini A Lok, et al. 1901 Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region Hepatology 33 3 751 7 10.1053/jhep.2001.22166
22. HL Chan M Hussain AS Lok 1999 Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion Hepatology 29 3 976 84 10051506 1:CAS:528:DyaK1MXhvFyjsbw%3D 10.1002/hep.510290352 (Pubitemid 29109618)
23. K Takahashi Y Akahane K Hino, et al. 1998 Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates Arch Virol 143 12 2313 26 9930189 1:CAS:528:DyaK1MXhslaiur0%3D 10.1007/s007050050463 (Pubitemid 29020107)
24. M Friedt P Gerner E Lausch, et al. 1999 Mutations in the basic core promotor and the precore region of hepatitis B virus and their selection in children with fulminant and chronic hepatitis B Hepatology 29 4 1252 8 10094972 1:CAS:528:DyaK1MXisVKgtr8%3D 10.1002/hep.510290418 (Pubitemid 29168762)
25. M Lindh C Hannoun AP Dhillon, et al. 1999 Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers J Infect Dis 179 4 775 82 10068571 1:CAS:528:DyaK1MXitlSlsrk%3D 10.1086/314688 (Pubitemid 29159321)
26. M Lindh C Gustavson K Mårdberg, et al. 1998 Mutation of nucleotide 1,762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damage in hepatitis B e antigen carriers J Med Virol 55 3 185 90 9624604 1:CAS:528:DyaK1cXjvFSmtr8%3D 10.1002/(SICI)1096-9071(199807)55: 3<185::AID-JMV1>3.0.CO;2-Y (Pubitemid 28270761)
27. EY Cho CS Choi JH Cho HC Kim 2011 Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection Gut Liver 5 1 70 6 21461076 1:CAS:528:DC%2BC3MXnsFOhsbY%3D 10.5009/gnl.2011.5.1.70
28. JH Lee KH Han JM Lee, et al. 2011 Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection Clin Vaccine Immunol 18 6 914 21 21490166 1:CAS:528:DC%2BC3MXnsFOjtrk%3D 10.1128/CVI.00474-10
29. PD Swenson C Van Geyt ER Alexander, et al. 2001 Hepatitis B virus genotypes and HBsAg subtypes in refugees and injection drug users in the United States determined by LiPA and monoclonal EIA J Med Virol 64 3 299 304 10.1002/jmv.1051 (Pubitemid 32565126)
30. F Kurbanov Y Tanaka M Mizokami 2010 Geographical and genetic diversity of the human hepatitis B virus Hepatol Res 40 14 30 20156297 10.1111/j.1872-034X. 2009.00601.x Comprehensive review of the geographical distribution of genetic variants of hepatitis B and criteria for the identification of new genotypes and subtypes
31. IE Andernach C Nolte JW Pape CP Muller 2009 Slave trade and hepatitis B virus genotypes and subgenotypes in Haiti and Africa Emerg Infect Dis 15 8 1222 8 19751583 10.3201/eid1508.081642
32. T Dupinay K Restorp P Leutscher, et al. 2010 High prevalence of hepatitis B virus genotype E in Northern Madagascar indicates a West-African lineage J Med Virol 82 9 1515 26 20648605 10.1002/jmv.21865
33. IE Andernach JM Hubschen CP Muller 2009 Hepatitis B virus: the genotype E puzzle Rev Med Virol 19 4 231 40 19475565 10.1002/rmv.618
34. P Garmiri A Loua N Haba, et al. 2009 Deletions and recombinations in the core region of hepatitis B virus genotype E strains from asymptomatic blood donors in Guinea, west Africa J Gen Virol 90 Pt 10 2442 51 19535503 1:CAS:528:DC%2BD1MXht1Ghu7fP 10.1099/vir.0.012013-0
35. Hu XL, Margolis HS, Purcell RH, et al.: Identification of hepatitis B virus indigenous to chimpanzees. Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1661-4. (Pubitemid 30118499)
36. H Norder JW Ebert HA Fields, et al. 1996 Complete sequencing of a gibbon hepatitis B virus genome reveals a unique genotype distantly related to the chimpanzee hepatitis B virus Virology 218 1 214 23 8615024 1:CAS:528: DyaK28XitVCmur4%3D 10.1006/viro.1996.0181 (Pubitemid 26133099)
37. K Takahashi B Brotman S Usuda, et al. 2000 Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: Implications for an origin of HBV Virology 267 1 58 64 10648183 1:CAS:528:DC%2BD3cXmsFamtA%3D%3D 10.1006/viro.1999.0102 (Pubitemid 30094153)
38. DM MacDonald EC Holmes JC Lewis P Simmonds 2000 Detection of hepatitis B virus infection in wild-born chimpanzees (Pan troglodytes verus): Phylogenetic relationships with human and other primate genotypes J Virol 74 9 4253 7 10756039 1:CAS:528:DC%2BD3cXislGru7k%3D 10.1128/JVI.74.9.4253-4257.2000 (Pubitemid 30214432)
39. EE Mast HS Margolis AE Fiore, et al. 2005 A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization practices (ACIP) part 1: immunization of infants, children and adolescents MMWR Recomm Rep 54 RR-16 1 31 16371945
40. RP Beasley LY Hwang GC Lee, et al. 1983 Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine Lancet 2 8359 1099 102 6138642 1:STN:280: DyaL2c%2FjvVGgsQ%3D%3D 10.1016/S0140-6736(83)90624-4 (Pubitemid 14242389)
41. EE Mast CM Weinbaum AE Fiore, et al. 2006 A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization practices (ACIP) part 1: immunization of infants, children and adolescents MMWR Recomm Rep 55 RR16 1 25 17159833
42. SE Livingston J Simonetti L Bulkow, et al. 2007 Clearance of Hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D and F Gastroenterology 133 1452 7 17920063 1:CAS:528:DC%2BD2sXhsVGqtr%2FF 10.1053/j.gastro.2007.08.010 (Pubitemid 350029740)
43. JH Kao PJ Chen MY Lai DS Chen 2004 Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers J Med Virol 72 363 9 14748059 1:CAS:528:DC%2BD2cXhvVCjtL8%3D 10.1002/jmv.10534 (Pubitemid 38133976)
44. CJ Chu M Hussain AS Lok 2002 Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C Gastroenterology 122 1756 62 12055581 1:CAS:528:DC%2BD38Xlt12gsrc%3D 10.1053/gast.2002.33588 (Pubitemid 34651418)
45. WH Wen HL Chen YH Ni, et al. 2011 Secular trend of the viral genotype distribution in children with chronic hepatitis B virus infection after universal infant immunization Hepatology 53 2 429 36 21274864 10.1002/hep.24061 Study outlining the change in hepatitis B genotypes following the introduction of mass immunization in Taiwan and the consequences for vertical transmission
46. JM Sanchez-Tapias J Costa A Mas, et al. 2002 Influence of hepatitis B virus genotype on the long term outcome of chronic hepatitis B in western patients Gastroenterology 123 1848 56 12454842 10.1053/gast.2002.37041 (Pubitemid 35408309)
47. Yuen MF, Wong DK, Sablon E, et al.: HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects. Hepatology 2004;39:1694-701. [Published erratum appears in Hepatology 2004;40:767]. (Pubitemid 38702671)
48. SJ Hadziyannis 2011 Natural history of chronic hepatitis B in Euro-Mediterranean and African Countries J Hepatol 55 1 183 91 21238520 10.1016/j.jhep.2010.12.030
49. MC Kew A Kramvis MC Yu, et al. 2005 Increased hepatocarcinogenic potential of hepatitis B virus genotype in Bantu-speaking sub-Saaran Africans J Med Virol 75 513 21 15714494 1:CAS:528:DC%2BD2MXivFSgurw%3D 10.1002/jmv.20311 (Pubitemid 40293518)
50. G Kimbi A Kramvis M Kew 2004 Distinctive sequence characteristics from subgenotype A1isolates of hepatitis B virus from South Africa J Gen Virol 85 1211 20 15105537 1:CAS:528:DC%2BD2cXktFert7k%3D 10.1099/vir.0.19749-0 (Pubitemid 38659784)
51. MC Kew 2010 Hepatocellular carcinoma in African Blacks: Recent progress in etiology and pathogenesis World J Hepatol 2 2 65 73 21160975
52. SE Livingston JP Simonetti BJ McMahon, et al. 2007 Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype F J Infect Dis 195 5 11 17152003 1:CAS:528:DC%2BD2sXpslSgsw%3D%3D 10.1086/509894 (Pubitemid 44958221)
53. F Saugauchi E Orito T Ichida, et al. 2003 Epidemiologic and virological characteristics of hepatitis B virus genotype B having the recombination with genotype C Gastroenterology 124 925 32 10.1053/gast.2003.50140 1:CAS:528:DC%2BD3sXjsFOju74%3D (Pubitemid 36389795)
54. A Ozasa Y Tanaka E Orito, et al. 2006 Influence of genotypesand precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection Hepatology 44 326 34 16871568 1:CAS:528:DC%2BD28XptVKmt7s%3D 10.1002/hep.21249 (Pubitemid 44214871)
55. CM Lee CH Chen SN Lu, et al. 2003 Prevalence an clinical implications of hepatitis B virus genotypes in southern Taiwan Scan J Gastroenterol 38 95 101 1:STN:280:DC%2BD3s%2Fps1Sjtw%3D%3D 10.1080/00365520310000500 (Pubitemid 36152871)
56. P Tangkijvanich V Mahachai P Komolmit, et al. 2005 Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand Word J Gastroenterol 11 15 2238 43 1:CAS:528:DC%2BD2MXksVymu7Y%3D (Pubitemid 40691330)
57. CM Chu YF Laiw 2005 Genotype C hepatitis B virusinfection is associated with higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels a baseline J Hepatol 43 411 7 16006001 1:CAS:528:DC%2BD2MXntVCkurk%3D 10.1016/j.jhep.2005.03.018 (Pubitemid 41111421)
58. MF Yuen E Sablon HJ Yuan, et al. 2003 Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma Hepatology 37 562 7 12601354 10.1053/jhep.2003.50098 (Pubitemid 36258778)
59. AM Zhang HF Wang HB Wang, et al. 2010 Association between HBV genotype and chronic/severe liver disease with HBV infection in Chinese patients Chin J Exp Clin Virol 24 3 178 80
60. HI Yang SH Yeh PJ Chen, et al. 2008 Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma Journal of the National Cancer Institute. 100 16 1134 43 18695135 1:CAS:528: DC%2BD1cXhtFKrsb7P 10.1093/jnci/djn243
61. E Orito M Mizokami H Sakugawa, et al. 2001 A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C Hepatology 33 1 218 23 11124839 1:CAS:528: DC%2BD3MXktFajsA%3D%3D 10.1053/jhep.2001.20532 (Pubitemid 32016905)
62. JH Kao PJ Chen MY Lai DS Chen 2000 Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B Gastroenterology 118 3 554 9 10702206 1:STN:280:DC%2BD3c7mslWjug%3D%3D 10.1016/S0016-5085(00)70261-7
63. Qin Y, Tang X, Garcia T, et al.: Hepatitis B virus genotype C isolates with wild-type core promoter sequence replicate less efficiently than genotype B isolates but possess higher virion secretion capacity. J Virol 2011;%20.
64. TJ Liang KT Mok SI Liu, et al. 2010 Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma J Am Coll Surg 211 5 580 6 20851644 10.1016/j.jamcollsurg.2010.06.020
65. HL Chan AM Tse F Mo, et al. 2008 High viral load and hepatitis B virus subtype Ce are associated with increased risk of hepatocellular carcinoma J Clin Oncol 26 2 177 82 18182659 1:CAS:528:DC%2BD1cXitVWitr8%3D 10.1200/JCO.2007.13. 2043
66. S Liu H Zhang C Gu, et al. 2009 Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis J. Natl. Cancer Inst. 101 1066 82 19574418 1:CAS:528:DC%2BD1MXpvF2qtbY%3D 10.1093/jnci/djp180
67. JH Yin J Zhao HW Zhang, et al. 2010 HBV genotype C is independently associated with cirrhosis in community-based population World J Gastroenterol 16 3 379 83 20082486 1:CAS:528:DC%2BC3cXht1emsL4%3D 10.3748/wjg.v16.i3.379
68. X Ren Z Xu Y Liu, et al. 2010 Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis J Viral Hepat 17 12 887 95 20070500 1:STN:280:DC%2BC3cbmtlansg%3D%3D 10.1111/j.1365-2893.2009.01254.x A study of patients with hepatitis B and acute -on-chronic liver failure which gives credence to the concept that both hepatitis B genotype and BCP/PC mutations are associated with more severe disease phenotype
69. EY Cho HC Kim CS Choi, et al. 2010 Nucleotide changes related to hepatocellular carcinoma in the enhancer 1/x-promoter of hepatitis B virus subgenotype C2 in cirrhotic patients Cancer Sci 101 8 1905 12 20550526 1:CAS:528:DC%2BC3cXhtVCktbjK 10.1111/j.1349-7006.2010.01612.x
70. Zacharakis GH, Koskinas J, Kotsiou S, et al.: Natural history of chronic HBV infection: a cohort with up to 12 years follow-up in North Greece (part of the Interrg I-II/EC-Project). J Med Virol 2005;173-179. (Pubitemid 41285783)
71. S Sharma B Sharma B Singla, et al. 2010 Clinical significance of genotypes and precore/basal core promoter mutations in HBV related chronic liver disease patients in North India Dig Dis Sci 55 794 802 20043209 1:CAS:528:DC%2BC3cXitVKisb8%3D 10.1007/s10620-009-1083-y
72. VA Arankalle S Gandhi KS Lole, et al. 2011 An outbreak of hepatitis B with high mortality in India: association with precore, basal core promoter mutants and improperly sterilized syringes J Viral Hepat 18 4 e20 8 21108697 1:STN:280:DC%2BC3M3lsFOrtA%3D%3D 10.1111/j.1365-2893.2010.01391.x
73. S Suzuki F Sugauchi E Orito, et al. 2003 Distribution of hepatitis B virus (HBV) genotypes among HBV carriers in the Cote d'Ivoire: complete genome sequence and phylogenetic relatedness of HBV genotype E J Med Virol 69 459 65 12601751 1:CAS:528:DC%2BD3sXisVOitrc%3D 10.1002/jmv.10331 (Pubitemid 36249857)
74. H Kato E Orito RG Gish, et al. 2002 Hepatitis B e antigen in sera from individuals infected with hepatitis B virus of genotype G Hepatology 35 922 9 11915040 1:CAS:528:DC%2BD38XjtFSksbo%3D 10.1053/jhep.2002.32096 (Pubitemid 34258388)
75. K Lacombe V Massari PM Girard, et al. 2006 Major role of hepatitis B genotypes in liver fibrosis during coinfection with HIV AID 20 3 419 27 10.1097/01.aids.0000200537.86984.0e
76. DY Dao J Balko N Attar, et al. 2011 Hepatitis B virus genotype G: Prevalence and impact in patients co-infected with human immunodeficiency virus J Med Virol 83 9 1551 8 21739445 10.1002/jmv.22160
77. S Schaefer 2005 Hepatitis B virus: significance of genotypes J Viral Hepat 12 111 24 15720525 1:STN:280:DC%2BD2M%2Fpt1Chtg%3D%3D 10.1111/j.1365-2893. 2005.00584.x (Pubitemid 40342168)
78. D Kiesslich MA Crispim C Santos, et al. 2009 Influence of hepatitis B virus (HBV) genotype on the clinical course of disease in patients coinfected with HBV and hepatitis delta virus J Infect Dis 199 11 1608 11 19388852 1:CAS:528:DC%2BD1MXmvVOmtbg%3D 10.1086/598955
79. AS Lok BJ McMahon 2009 Chronic hepatitis B: update 2009 Hepatology 50 3 661 2 19714720 10.1002/hep.23190
80. YF Liaw N Leung JH Kao, et al. 2008 Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update Hepatol Int 2 263 83 19669255 10.1007/s12072-008-9080-3
81. European Association For The Study Of The Liver 2009 EASL clinical practice guidelines: management of chronic hepatitis B J Hepatol 50 227 42 10.1016/j.jhep.2008.10.001
82. JH Kao NH Wu PJ Chen, et al. 2000 Hepatitis B genotypes and the response to interferon therapy J Hepatol 33 998 1002 11131465 1:CAS:528: DC%2BD3cXovVKjsbg%3D 10.1016/S0168-8278(00)80135-X
83. J Hou R Schilling HLA Janssen 2001 Molecular characteristics of hepatitis B virus genotype A confer a higher response to interferon treatment J Hepatol 34 1 15
84. CT Wai CJ Chu M Hussain AS Lok 2002 HBV genotype B is associated with better response to interferon therapy in HBeAg(+) chronic hepatitis than genotype C Hepatology 36 1425 30 12447868 1:CAS:528:DC%2BD38Xps1ylurk%3D (Pubitemid 35403533)
85. A Erhardt D Blondin K Hauck, et al. 2005 Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D Gut 54 1009 13 15951551 1:CAS:528:DC%2BD2MXmsFKqtrg%3D 10.1136/gut.2004.060327 (Pubitemid 40873918)
86. WG Cooksley T Piratvisuth SD Lee, et al. 2003 Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B J Viral Hepat. 10 4 298 305 12823597 1:STN:280: DC%2BD3szksVOquw%3D%3D 10.1046/j.1365-2893.2003.00450.x (Pubitemid 36801917)
87. A Craxi WG Cooksley 2003 Pegylated interferons for chronic hepatitis B Antiviral Res. 60 2 87 9 14638403 1:CAS:528:DC%2BD3sXpt1eqsro%3D 10.1016/j.antiviral.2003.08.015 (Pubitemid 37452451)
88. CH Chen CM Lee CH Hung, et al. 2011 Hepatitis B virus genotype B results in better immediate, late and sustained responses to peginterferon-alfa in hepatitis-B-e-antigen-positive patients J Gastroenterol Hepatol 26 3 461 8 21332543 1:CAS:528:DC%2BC3MXks1amu7w%3D 10.1111/j.1440-1746.2010.06429.x A recent study which emphasises the importance of hepatitis B genotype in treatment response to peginterferon
89. HL Janssen M van Zonneveld H Senturk, et al. 2005 HBV 99-01 study group; Rotterdam foundation for liver research. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial Lancet 365 123 9 15639293 1:CAS:528:DC%2BD2MXhvF2gsQ%3D%3D 10.1016/S0140-6736(05)17701-0 (Pubitemid 40091801)
90. HJ Flink M van Zonneveld BE Hansen, et al. 2006 HBV 99-01 Study Group. Treatment with Peg-interferon alpha-2b for HBeAg-positive chronic hepatitis B: HBsAg loss is associated with HBV genotype Am J Gastroenterol 101 297 303 16454834 1:CAS:528:DC%2BD28XitFSgtr4%3D 10.1111/j.1572-0241.2006.00418.x (Pubitemid 43381671)
91. JH Kao NH Wu PJ Chen, et al. 2000 Hepatitis B genotypes and the response to interferon therapy J Hepatol 33 6 998 1002 11131465 1:CAS:528: DC%2BD3cXovVKjsbg%3D 10.1016/S0168-8278(00)80135-X
92. J Wiegand D Hasenclever HL Tillmann 2008 Should treatment of hepatitis B depend on hepatitis B virus genotypes? A hypothesis generated from an explorative analysis of published evidence Antivir Ther 13 211 20 18505172 1:CAS:528:DC%2BD1cXlslWmtb4%3D An overview and meta-analysis of the literature on hepatitis B treatment with interferon or nucleos(tide) analogues (Pubitemid 351535372)
93. P Marcellin F Bonino GK Lau, et al. 2009 Peginterferon alfa-2a in HBeAg-negative Chronic Hepatitis B Study Group. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a Gastroenterology 136 2169 79 19303414 1:CAS:528:DC%2BD1MXotVeqtbw%3D 10.1053/j.gastro.2009.03.006
94. A Erhardt T Göbel A Ludwig, et al. 2009 Response to antiviral treatment in patients infected with hepatitis B virus genotypes E-H J Med Virol 81 1716 20 19697400 1:CAS:528:DC%2BD1MXhtFGrur3O 10.1002/jmv.21588
95. BE Hansen EH Buster EW Steyerberg, et al. 2010 Prediction of the response to peg-interferon-alfa in patients with HBeAg positive chronic hepatitis B using decline of HBV DNA during treatment J Med Virol 82 7 1135 42 20513075 1:CAS:528:DC%2BC3cXns1Citbo%3D 10.1002/jmv.21778
96. TH Hsieh TC Tseng CJ Liu, et al. 2009 Hepatitis B virus genotype B has an earlier emergence of lamivudine resistance than genotype C Antivir Ther 14 1157 63 20032545 1:CAS:528:DC%2BC3cXitVyqu74%3D 10.3851/IMP1454
97. J Inoue Y Ueno Y Wakui, et al. 2011 Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern Journal of Viral Hepatitis. 18 3 206 15 20367795 1:STN:280:DC%2BC3M7nt1Kktw%3D%3D 10.1111/j.1365-2893.2010.01301.x
98. K Wursthorn M Jung A Riva, et al. 2010 Kinetics of hepatitis B surface antigen decline during 3 years of telbivudine treatment in hepatitis B e antigen-positive patients Hepatology 52 5 1611 20 20931556 1:CAS:528: DC%2BC3cXhsFOnsrrO 10.1002/hep.23905
99. TH Hsieh TC Tseng CJ Liu, et al. 2009 Hepatitis B virus genotype B has an earlier emergence of lamivudine resistance than genotype C Antivir Ther 14 8 1157 63 20032545 1:CAS:528:DC%2BC3cXitVyqu74%3D 10.3851/IMP1454
100. D Tabernero MJ Sanchez M Homs, et al. 2010 Main mutations in the hepatitis B virus basic core promoter (A1762T/G1764A) before HBeAg loss are markers that identify patients who will require long-term treatment Aliment Pharmacol Ther 32 1 97 104 20374224 1:CAS:528:DC%2BC3cXptV2nsbw%3D
101. S Fujisaki Y Yokomaku T Shiino, et al. 2011 Outbreak of infections by hepatitis B virus genotype A and transmission of genetic drug resistance in patients coinfected with HIV-1 in Japan J Clin Microbiol 49 3 1017 24 21248087 1:CAS:528:DC%2BC3MXlt1Wju7o%3D 10.1128/JCM.02149-10
102. C Wei YT Chong JZ Wen, et al. 2011 Characterization of hepatitis virus B isolated from a multi-drug refractory patient Virus Research. 155 1 254 8 20970466 10.1016/j.virusres.2010.10.018 1:CAS:528:DC%2BC3cXhs1agtbvM
103. BJ McMahon 2009 The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B Hepatol Int 3 2 334 42 19669359 10.1007/s12072-008-9112-z
104. MF Yuen Y Tanaka DY Fong, et al. 2009 Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B J Hepatol 50 80 8 18977053 10.1016/j.jhep.2008.07.023
105. VW Wong SL Chan F Mo, et al. 2010 Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers J Clin Oncol 28 1660 5 20194845 1:CAS:528:DC%2BC3cXmtVyhurg%3D 10.1200/JCO.2009.26.2675
106. HI Yang M Sherman J Su, et al. 2010 Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection J Clin Oncol 28 2437 44 20368541 10.1200/JCO.2009.27.4456 A model based upon the REVEAL-HBV study cohort data identifying which viral and host factors are associated with the development of HBV associated HCC.