Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg

Digestive Diseases and Sciences

Volumn 41, Issue 12, 1996, Pages 2447-2452

  Mangia, Alessandra ^b   Chung, Young Hwa ^c   Hoofnagle, Jay H ^c   Birkenmeyer, Larry ^c   Mushahwar, Isa ^c   Di Bisceglie, Adrian M ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c St Louis Univ Hlth Sci Center ^*

Author keywords

HBeAg negative; hepatitis B; variant

Indexed keywords

HEPATITIS B ANTIGEN;

ADULT; ARTICLE; CHRONIC HEPATITIS; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEPATITIS B; HUMAN; MALE; MUTATION; PRIORITY JOURNAL;

ADULT; ASIAN AMERICANS; BASE SEQUENCE; CARRIER STATE; CHRONIC DISEASE; COHORT STUDIES; DNA, VIRAL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNOGLOBULIN M; INCIDENCE; MALE; MIDDLE AGED; SEROLOGIC TESTS; UNITED STATES;

EID: 0030455289     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02100141     Document Type: Article

References (19)

1. Hoofnagle JH, Shafritz DA, Popper H: Chronic type B hepatitis and the "healthy" HBsAg carrier state. Hepatology 7:758-763, 1987
2. Bonino F, Rosina F, Rizzetto M, Rizzi R, Chiaberge E, Tardanico R, Callea F, Verme G: Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBe. Gastroenterology 90:1268-1273, 1986
3. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC: Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2:588-591, 1989
4. Brunetto MR, Giarin E, Oliveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, Saracco G, Verme G, Will H, Bonino F: Wild-type and e antigen-deficient hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 88:4186-4190, 1991
5. Kosaka Y, Takase K, Kojima M, Shimizu M, Inoue K, Toshiba M, Tanaka S, et al.: Fulminant hepatitis B: induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen. Gastroenterology 100:1087-1094, 1991
6. Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben-Porath E: A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis B. N Engl J Med 324:1705-1709, 1991
7. Di Bisceglie AM, Fong T-L, Fried MW, Swain MG, Baker B, Korenman J, Bergasa NV, Waggoner JG, Park Y, Hoofnagle JH: A randomized, controlled trial of recombinant α-interferon therapy for chronic hepatitis B. Am J Gastroenterol 88:1887-1892, 1993
8. Kaneko S, Feinstone S, Miller RH: Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique. J Clin Microbiol 17:1930-1933, 1989
9. Birkenmeyer LG, Mushahwar IK: DNA probe amplification methods. J Virol Methods 35:117-126, 1991
10. Omata M, Ebara T, Yokosuka O, Hosoda K, Ohto M: Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 324:1699-1704, 1991
11. Laskus T, Persing DH, Nowicki MJ, Mosley JW, Rakela J: Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 105:1171-1178, 1993
12. Laskus T, Rakela J, Persing DH: Nucleotide sequence analysis of precore and proximal core regions in patients with chronic hepatitis B treated with interferon. Dig Dis Sci 40:1-7, 1995
13. Li J-S, Tong S-P, Wen Y-M, Vitvitski L, Zhang Q, Trepo C: Hepatitis B virus genotype A rarely circulates as an HBeAg-minus mutant: Possible contribution of a single nucleotide in the precore region. J Virol 67:5402-5410, 1993
14. Naoumov NV, Thomas MG, Mason AL, Chokshi S, Bodicky CJ, Farzaneh F, Williams R, Perrillo RP: Genomic variations in the hepatitis B core gene: A possible factor influencing response to interferon alfa treatment. Gastroenterology 108:505-514, 1995
15. Davis GL, Hoofnagle JH, Waggoner JG: Spontaneous reactivation of chronic hepatitis B virus infection. Gastroenterology 86:230-235, 1984
16. Li JS, Ton SP, Wen YM, Vitvitski L, Zhang Q, Trepo C: Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: A possible contribution of a single nucleotide in the precore region. J Virol 67:5402-5410, 1993
17. Akarca US, Greene S, Lok ASF: Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members. Hepatology 19:1366-1370, 1994
18. Tur-Kaspa R, Klein A, Aharonson S: Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology 16:1338-1342, 1992
19. Marinos G, Smith HM, Naoumov NV, Williams R: Quantitative assessment of serum IgM Anti-HBc in the natural course and during interferon treatment of chronic hepatitis B virus infection. Hepatology 19:303-311, 1994