Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion

Hepatology

Volumn 29, Issue 3, 1999, Pages 976-984

  Chan, Henry L Y ^a,b   Hussain, Munira ^a   Lok, Anna S F ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B(E) ANTIGEN;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE MUTATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER DISEASE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SCHOOL CHILD; SEQUENCE ANALYSIS; SEROCONVERSION; STATISTICAL ANALYSIS; STOP CODON;

EID: 0032979682     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290352     Document Type: Article

References (14)

1. Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto S, Omi S, et al. Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region. Gastroenterology 1990;99:1113-1119.
2. Brunetto MR, Giarin MM, Oliveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci U S A 1991;88:4186-4190.
3. Carman WF, Hadziyannis S, McGarvey MJ, Jacyna MR, Karayiannis P, Makris A, Thomas HC. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989;ii:588-590.
4. Lok ASF, Akarca U, Greene S. Mutations in the pre-core region of hepatitits B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci U S A 1994;91:4077-4081.
5. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990;64:1298-1303.
6. Takeda K, Akahane Y, Suzuki H, Okamoto H, Tsuda F, Miyakawa Y, Mayumi M. Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with Interferon therapy. HEPATOLOGY 1990;12:1284-1289.
7. Hamasaki K, Nakata K, Nagayama Y, Ohtsuru A, Daikoku M, Taniguchi K, Tsutsumi T, et al. Changes in the prevalence of HBeAg-negative mutants hepatitis B virus during the course of chronic hepatitis B. HEPATOLOGY 1994;20:8-14.
8. Li JS, Tong SP, Wen YM, Vitvitski L, Zhang Q, Trepo C. Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J Virol 1993;67:5402-5410.
9. Rodriguez-Frias F, Buti M, Jardi R, Cotrina M, Viladomiu L, Esteban R, Guardia J. Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. HEPATOLOGY 1995;22:1641-1647.
10. Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - large-scaled analysis using a new genotyping method. J Infect Dis 1997;175:1285-1293.
11. Lok ASF, Akarca US, Greene S. Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance. HEPATOLOGY 1995;21:19-24.
12. Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka T, et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994;68:8102-8110.
13. Kidd-Ljunggren K, Oberg M, Kidd AH. Hepatitis B virus X gene 1751 to 1764 mutations: implications for HBeAg status and disease. J Gen Virol 1997;78:1469-1478.
14. Kurosaki M, Enomoto N, Asahina Y, Sakuma I, Ikeda T, Tozuka S, Izumi N, et al. Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B. J Med Virol 1996;49:115-123.