Impact of hepatitis B virus (HBV) X gene mutations on hepatocellular carcinoma development in chronic HBV infection

Clinical and Vaccine Immunology

Volumn 18, Issue 6, 2011, Pages 914-921

  Lee, Jong Han ^a   Han, Kwang Hyub ^a   Lee, Jae Myun ^a   Park, Jeon Han ^a   Kim, Hyon Suk ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B VIRUS X PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC TRANSCRIPTION; GENOTYPE; HEPATITIS B; HUMAN; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; MUTATION RATE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIRUS CARCINOGENESIS; WILD TYPE;

ADULT; AMINO ACID SUBSTITUTION; CARCINOMA, HEPATOCELLULAR; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; MUTATION, MISSENSE; NF-KAPPA B; TRANS-ACTIVATORS; VIRULENCE FACTORS;

EID: 79957997336     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00474-10     Document Type: Article

References (32)

1. Aggarwal, B. B. 2004. Nuclear factor-κB: the enemy within. Cancer Cell 6:203-208.
2. Beasley, R. P., L. Y. Hwang, C. C. Lin, and C. S. Chien. 1981. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22,707 men in Taiwan. Lancet ii:1129-1133.
3. Billet, O., et al. 1995. In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation. J. Virol. 69:5912-5916.
4. Birrer, R. B., D. Birrer, and J. V. Klavins. 2003. Hepatocellular carcinoma and hepatitis virus. Ann. Clin. Lab. Sci. 33:39-54.
5. Bouchard, M. J., and R. J. Schneider. 2004. The enigmatic X gene of hepatitis B virus. J. Virol. 78:12725-12734.
6. Choi, C. S., et al. 2009. X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma. J. Med. Virol. 81:1721-1725.
7. Chou, Y. C., et al. 2008. Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut 57:91-97.
8. Fang, Z. L., et al. 2008. HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study. Am. J. Gastroenterol. 103:2254-2262.
9. Fang, Z. L., et al. 2009. The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis. J. Hepatol. 50:273-280.
10. Fang, Z. L., et al. 2002. Core promoter mutations [A(1762)T and G(1764)A] and viral genotype in chronic hepatitis B and hepatocellular carcinoma in Guangxi, China. J. Med. Virol. 68:33-40.
11. Gottlob, K., S. Pagano, M. Levrero, and A. Graessmann. 1998. Hepatitis B virus X protein transcription activation domains are neither required nor sufficient for cell transformation. Cancer Res. 58:3566-3570. (Pubitemid 28376552)
12. Kao, J. H., P. J. Chen, M. Y. Lai, and D. S. Chen. 2000. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 118:554-559.
13. Kao, J. H., P. J. Chen, M. Y. Lai, and D. S. Chen. 2003. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 124:327-334.
14. Karin, M. 2006. Nuclear factor-κB in cancer development and progression. Nature 441:431-436. (Pubitemid 44050137)
15. Kim, C. M., K. Koike, I. Saito, T. Miyamura, and G. Jay. 1991. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351:317-320. (Pubitemid 21896589)
16. Kim, H., et al. 2007. Molecular epidemiology of hepatitis B virus (HBV) genotypes and serotypes in patients with chronic HBV infection in Korea. Intervirology 50:52-57. (Pubitemid 46005272)
17. Kim, H. J., et al. 2008. Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection. J. Med. Virol. 80:1337-1343.
18. Lavanchy, D. 2004. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J. Viral Hepat. 11:97-107. (Pubitemid 38365759)
19. Liu, S., et al. 2009. Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. J. Natl. Cancer Inst. 101:1066-1082.
20. McMahon, B. J. 2009. The natural history of chronic hepatitis B virus infection. Hepatology 49:S45-S55.
21. Muroyama, R., et al. 2006. Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. J. Hepatol. 45:805-812. (Pubitemid 44646684)
22. Ohata, K., et al. 2003. Interferon alpha inhibits the nuclear factor κB activation triggered by X gene product of hepatitis B virus in human hepatoma cells. FEBS Lett. 553:304-308. (Pubitemid 37315621)
23. Okamoto, H., et al. 1994. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J. Virol. 68:8102-8110.
24. Perfumo, S., et al. 1992. Recognition efficiency of the hepatitis B virus polyadenylation signals is tissue specific in transgenic mice. J. Virol. 66:6819-6823.
25. Schaefer, S., et al. 1998. Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein. J. Gen. Virol. 79(Pt. 4):767-777.
26. Shinkai, N., et al. 2007. Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2. J. Clin. Microbiol. 45:3191-3197.
27. Sun, B., and M. Karin. 2008. NF-κB signaling, liver disease and hepatoprotective agents. Oncogene 27:6228-6244.
28. Tanaka, Y., et al. 2006. Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma. J. Hepatol. 45:646-653. (Pubitemid 44466666)
29. Yeh, C. T., C. H. Shen, D. I. Tai, C. M. Chu, and Y. F. Liaw. 2000. Identification and characterization of a prevalent hepatitis B virus X protein mutant in Taiwanese patients with hepatocellular carcinoma. Oncogene 19:5213-5220.
30. Yu, D. Y., et al. 1999. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J. Hepatol. 31:123-132.
31. Yun, C., et al. 2002. NF-κB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival. Cancer Lett. 184:97-104. (Pubitemid 34718111)
32. Zhang, H., et al. 2008. Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol. Sin. 29:473-480.