Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: A longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline

Journal of Hepatology

Volumn 43, Issue 3, 2005, Pages 411-417

  Chu, Chia Ming ^a   Liaw, Yun Fan ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Chronic hepatitis B; Cirrhosis; HBeAg seroconversion; HBV genotype: reactivation of hepatitis B

Indexed keywords

ALANINE AMINOTRANSFERASE;

AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HUMAN; INFECTION RISK; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; SCHOOL CHILD; SEROCONVERSION; STATISTICAL SIGNIFICANCE; VIRUS INFECTION; VIRUS REACTIVATION;

ADULT; ALANINE TRANSAMINASE; DISEASE PROGRESSION; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS B ANTIGENS; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HUMANS; LIVER CIRRHOSIS; LONGITUDINAL STUDIES; MALE; PROBABILITY; RETROSPECTIVE STUDIES; RISK;

EID: 23444443850     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.03.018     Document Type: Article

References (35)

1. A. Bartholomeusz, and S. Schaefer Hepatitis B virus genotypes: comparison of genotyping methods Rev Med Virol 14 2004 3 16
2. J.H. Kao Hepatitis B viral genotypes: clinical relevance and molecular characteristics J Gastroenterol Hepatol 17 2002 643 650
3. M. Lindh, C. Hannoun, A.P. Dhillon, G. Norkrans, and P. Horal Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers J Infect Dis 179 1999 775 782
4. J.H. Kao, P.J. Chen, M.Y. Lai, and D.S. Chen Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B Gastroenterology 118 2000 554 559
5. E. Orito, M. Mizokami, H. Sakugawa, K. Michitaka, K. Ishikawa, and T. Ichida A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group Hepatology 33 2001 218 223
6. J.H. Kao, P.J. Chen, M.Y. Lai, and D.S. Chen Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection J Clin Microbiol 40 2002 1207 1209
7. M. Kobayashi, Y. Arase, K. Ikeda, A. Tsubota, Y. Suzuki, and S. Saitoh Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C J Gastroenterol 37 2002 35 39
8. T. Nakayoshi, T. Maeshiro, T. Nakayoshi, H. Nakasone, H. Sakugawa, and F. Kinjo Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: a prospective study J Med Virol 70 2003 350 354
9. H. Sumi, O. Yokosuka, N. Seki, M. Arai, F. Imazeki, and T. Kurihara Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease Hepatology 37 2003 19 26
10. C.M. Lee, C.H. Chen, S.N. Lu, H.D. Tung, W.J. Chou, and J.H. Wang Prevalence and clinical implications of hepatitis B virus genotypes in southern Taiwan Scand J Gastroenterol 38 2003 95 101
11. J.H. Kao, P.J. Chen, M.Y. Lai, and D.S. Chen Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers J Med Virol 72 2004 363 369
12. M.F. Yuen, E. Sablon, H.J. Yuan, D.K. Wong, C.K. Hui, and B.C. Wong Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma Hepatology 37 2003 562 567
13. H.L. Chan, M.L. Wong, A.Y. Hui, A.M. Chim, A.M. Tse, and L.C. Hung Hepatitis B virus genotype has no impact on hepatitis B e antigen seroconversion after lamivudine treatment World J Gastroenterol 9 2003 2695 2697
14. C.J. Chu, M. Hussain, and A.S. Lok Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C Gastroenterology 122 2002 1756 1762
15. H.L. Chan, S.W. Tsang, M.L. Wong, C.H. Tse, N.W. Leung, and F.K. Chan Genotype B hepatitis B virus is associated with severe icteric flare-up of chronic hepatitis B virus infection in Hong Kong Am J Gastroenterol 97 2002 2629 2633
16. M.F. Yuen, E. Sablon, D.K. Wong, H.J. Yuan, B.C. Wong, and A.O. Chan Role of hepatitis B virus genotypes in chronic hepatitis B exacerbation Clin Infect Dis 37 2003 593 597
17. Y.S. Hsu, R.N. Chien, C.T. Yeh, I.S. Sheen, H.Y. Chiou, and C.M. Chu Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B Hepatology 35 2002 1522 1527
18. C.M. Chu, S.J. Hung, J. Lin, D.I. Tai, and Y.F. Liaw Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels Am J Med 116 2004 829 834
19. C.M. Chu, P. Karayiannis, M.J.F. Fowler, J. Monjardino, Y.F. Liaw, and H.C. Thomas Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum Hepatology 5 1985 431 434
20. A.S.F. Lok, and C.L. Lai A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children Hepatology 5 1988 1130 1133
21. D.S. Chen From hepatitis to hepatoma: lessons from type B viral hepatitis Science 262 1993 369 370
22. D.Y. Lin, I.S. Sheen, C.T. Chiu, S.M. Lin, Y.C. Kuo, and Y.F. Liaw Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study J Clin Ultrasound 21 1993 303 308
23. Y.F. Liaw, D.I. Tai, C.M. Chu, and T.J. Chen The development of cirrhosis in patients with chronic type B hepatitis: a prospective study Hepatology 8 1988 493 496
24. Y.C. Chen, I.S. Sheen, C.M. Chu, and Y.F. Liaw Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection Gastroenterology 123 2002 1084 1089
25. Y.F. Liaw, D.I. Tai, C.M. Chu, D.Y. Lin, I.S. Sheen, and T.J. Chen Early detection of hepatocellular carcinoma in patients with chronic type B hepatitis Gastroenterology 90 1986 263 267
26. M.F. Yuen, H.J. Yuan, C.K. Hui, D.K. Wong, W.M. Wong, and A.O. Chan A large population study of spontaneous HBeAg seroconversion and acute exacerbation of chronic hepatitis B infection: implication for antiviral therapy Gut 52 2003 416 419
27. Y.F. Liaw, C.M. Chu, I.J. Su, M.J. Huang, D.Y. Lin, and C.S. Chang-Chien Clinical and histological events preceding hepatitis B e antigen seroconversion in chronic type B hepatitis Gastroenterology 84 1983 216 219
28. A.S.F. Lok, C.L. Lai, P.C. Wu, E.K. Leung, and T.S. Lam Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection Gastroenterology 92 1987 1839 1843
29. C.M. Chu, I.S. Sheen, S.M. Lin, and Y.F. Liaw Sex difference in chronic hepatitis B virus infection: studies of serum HBeAg and alanine aminotransferase levels in 10,431 asymptomatic Chinese HBsAg carriers Clin Infect Dis 16 1993 709 713
30. C.H. Hung, S.N. Lu, J.H. Wang, C.M. Lee, T.M. Chen, and H.D. Tung Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis J Gastroenterol 38 2003 153 157
31. C. Aube, F. Oberti, N. Korali, M.A. Namour, D. Loisel, and J.Y. Tanguy Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis J Hepatol 30 1999 472 478
32. S. Gaiani, L. Gramantieri, N. Venturoli, F. Piscaglia, S. Siringo, and A. D'Errico What is the criterion for differentiating chronic hepatitis from compensated cirrhosis? A prospective study comparing ultrasonography and percutaneous liver biopsy J Hepatol 27 1997 979 985
33. M.F. Yuen, and C.L. Lai Natural history of chronic hepatitis B virus infection J Gastroenterol Hepatol 15 2000 E20 E24
34. C.M. Chu, C.T. Yeh, C.S. Lee, I.S. Sheen, and Y.F. Liaw Precore stop mutant in HBeAg-positive patients with chronic hepatitis B: clinical characteristics and correlation with the course of HBeAg-to-anti-HBe seroconversion J Clin Microbiol 40 2002 16 21
35. J.H. Kao, P.J. Chen, M.Y. Lai, and D.S. Chen Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers Gastroenterology 124 2003 327 334