Association between hepatitis B virus X gene mutations and clinical status in patients with chronic hepatitis B infection

Gut and Liver

Volumn 5, Issue 1, 2011, Pages 70-76

  Cho, Eun Young ^a   Choi, Chang Soo ^a   Cho, Ji Hyun ^a   Kim, Haak Cheoul ^a  

^a Wonkwang University Hospital   (South Korea)

Author keywords

Cirrhosis; Hepatitis B virus; Hepatocellular carcinoma; Liver disease; X mutation

Indexed keywords

HEPATITIS B(E) ANTIGEN;

ADULT; ARTICLE; CANCER PATIENT; CHRONIC DISEASE; CLINICAL ASSESSMENT; FEMALE; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PREVALENCE;

EID: 79952949689     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2011.5.1.70     Document Type: Article

References (43)

1. Lee WM. Hepatitis B virus infection. N Engl J Med 1997;337:1733-1745. (Pubitemid 27527771)
2. Ganem D, Varmus HE. The molecular biology of the hepatitis B viruses. Annu Rev Biochem 1987;56:651-693.
3. Schaller H, Fischer M. Transcriptional control of hepadnavirus gene expression. Curr Top Microbiol Immunol 1991;168:21-39.
4. Mayans MV, Calvet X, Bruix J, et al. Risk factors for hepatocellular carcinoma in Catalonia, Spain. Int J Cancer 1990;46:378-381. (Pubitemid 20291088)
5. London WT, Evans AA, McGlynn K, et al. Viral, host and environmental risk factors for hepatocellular carcinoma: a prospective study in Haimen City, China. Intervirology 1995;38:155-161. (Pubitemid 26009386)
6. Omata M, Ehata T, Yokosuka O, Hosoda K, Ohto M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991;324:1699-1704.
7. Fattovich G, Brollo L, Alberti A, Pontisso P, Giustina G, Realdi G. Long-term follow-up of anti-HBe-positive chronic active hepatitis B. Hepatology 1988;8:1651-1654. (Pubitemid 19021903)
8. Lindh M, Horal P, Dhillon AP, Norkrans G. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B. J Viral Hepat 2000;7:258-267.
9. Thomas HC, Brown D, Routhier G, et al. Inducer and suppressor T-cells in hepatitis B virus-induced liver disease. Hepatology 1982;2:202-204. (Pubitemid 12083681)
10. Eddleston AL, Mondelli M. Immunopathological mechanisms of liver cell injury in chronic hepatitis B virus infection. J Hepatol 1986;3 Suppl 2:S17-S23. (Pubitemid 17063406)
11. Omata M, Yokosuka O, Imazeki F, et al. Correlation of hepatitis B virus DNA and antigens in the liver. A study in chronic liver disease. Gastroenterology 1987;92:192-196.
12. Tanaka Y, Mukaide M, Orito E, et al. Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma. J Hepatol 2006;45:646-653. (Pubitemid 44466666)
13. Kim JK, Chang HY, Lee JM, et al. Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma. J Med Virol 2009;81:1002-1008.
14. Chou YC, Yu MW, Wu CF, et al. Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut 2008;57:91-97.
15. Yuen MF, Tanaka Y, Shinkai N, et al. Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels. Gut 2008;57:98-102.
16. Shinkai N, Tanaka Y, Ito K, et al. Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2. J Clin Microbiol 2007;45:3191-3197. (Pubitemid 47585639)
17. Gu JM, Lim SO, Oh SJ, Yoon SM, Seong JK, Jung G. HBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species. Virus Res 2008;133:167-177.
18. Shirakata Y, Koike K. Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential. J Biol Chem 2003;278:22071-22078. (Pubitemid 36792617)
19. Kim S, Kim HY, Lee S, et al. Hepatitis B virus X protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners. J Virol 2007;81:1714-1726. (Pubitemid 46214446)
20. Lee MO, Choi YH, Shin EC, et al. Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection. J Hepatol 2002;37:380-386.
21. Lara-Pezzi E, Majano PL, Gómez-Gonzalo M, et al. The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes. Hepatology 1998;28:1013-1021. (Pubitemid 28450262)
22. Koike K. Hepatitis B virus X gene is implicated in liver carcinogenesis. Cancer Lett 2009;286:60-68.
23. Bock CT, Toan NL, Koeberlein B, et al. Subcellular mislocalization of mutant hepatitis B X proteins contributes to modulation of STAT/SOCS signaling in hepatocellular carcinoma. Intervirology 2008;51:432-443.
24. Kim HJ, Park JH, Jee Y, et al. Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection. J Med Virol 2008;80:1337-1343. (Pubitemid 351897403)
25. Takahashi K, Akahane Y, Hino K, Ohta Y, Mishiro S. Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates. Arch Virol 1998;143:2313-2326. (Pubitemid 29020107)
26. Sung JJ, Tsui SK, Tse CH, et al. Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus. J Virol 2008;82:3604-3611. (Pubitemid 351429936)
27. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG. The CLUSTAL-X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 1997;25:4876-4882. (Pubitemid 28022245)
28. Kimura M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 1980;16:111-120. (Pubitemid 11166431)
29. Dong Q, Chan HL, Liu Z, et al. A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities. Biochem Biophys Res Commun 2008;374:773-776.
30. Stemler M, Weimer T, Tu ZX, et al. Mapping of B-cell epitopes of the human hepatitis B virus X protein. J Virol 1990;64:2802-2809. (Pubitemid 20171269)
31. Muroyama R, Kato N, Yoshida H, et al. Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma. J Hepatol 2006;45:805-812. (Pubitemid 44646684)
32. Choi CS, Cho EY, Park R, Kim SJ, Cho JH, Kim HC. X gene mutations in hepatitis B patients with cirrhosis, with and without hepatocellular carcinoma. J Med Virol 2009;81:1721-1725.
33. Yuh CH, Chang YL, Ting LP. Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J Virol 1992;66:4073-4084.
34. López-Cabrera M, Letovsky J, Hu KQ, Siddiqui A. Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: trans-activation and repression by CCAAT/enhancer binding protein. Proc Natl Acad Sci U S A 1990;87:5069-5073.
35. Lee H, Kim HT, Yun Y. Liver-specific enhancer II is the target for the p53-mediated inhibition of hepatitis B viral gene expression. J Biol Chem 1998;273:19786-19791. (Pubitemid 28367039)
36. Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Bréchot C. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999;18:4848-4859. (Pubitemid 29423568)
37. Wang Z, Tanaka Y, Huang Y, et al. Clinical and virological characteristics of hepatitis B virus subgenotypes Ba, C1, and C2 in China. J Clin Microbiol 2007;45:1491-1496. (Pubitemid 46762403)
38. Miyakawa Y, Okamoto H, Mayumi M. The molecular basis of hepatitis B e antigen (HBeAg)-negative infections. J Viral Hepat 1997;4:1-8. (Pubitemid 127733513)
39. Kidd AH, Kidd-Ljunggren K. A revised secondary structure model for the 3′-end of hepatitis B virus pregenomic RNA. Nucleic Acids Res 1996;24:3295-3301. (Pubitemid 26294437)
40. Jammeh S, Tavner F, Watson R, Thomas HC, Karayiannis P. Effect of basal core promoter and pre-core mutations on hepatitis B virus replication. J Gen Virol 2008;89(Pt 4):901-909.
41. Lin X, Xu X, Huang QL, et al. Biological impacts of "hot-spot" mutations of hepatitis B virus X proteins are genotype B and C differentiated. World J Gastroenterol 2005;11:4703-4708.
42. Liu S, Zhang H, Gu C, et al. Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. J Natl Cancer Inst 2009;101:1066-1082.
43. Günther S, Piwon N, Iwanska A, Schilling R, Meisel H, Will H. Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease. J Virol 1996;70:8318-8331. (Pubitemid 26378406)