Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Shalapour, Shabnam ^a   Deiser, Katrin ^a   Kühl, Anja A ^a   Glauben, Rainer ^a   Krug, Susanne M ^a   Fischer, André ^a   Sercan, Özen ^a,b   Chappaz, Stephane ^c   Bereswill, Stefan ^a   Heimesaat, Markus M ^a   Loddenkemper, Christoph ^a   Fromm, Michael ^a   Finke, Daniela ^c   Hämmerling, Günter J ^b   Arnold, Bernd ^b   Siegmund, Britta ^a   Schüler, Thomas ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CELL HYPERPLASIA; CELL SURVIVAL; CELLULAR DISTRIBUTION; COLITIS; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIGESTIVE SYSTEM FUNCTION DISORDER; HOMEOSTASIS; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOLOGY; EPITHELIUM CELL; GENE; GENETICS; HYPERPLASIA; INTESTINE; METABOLISM; PHENOTYPE; TRANSGENIC MOUSE;

MUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLITIS; EPITHELIAL CELLS; GENES, RAG-1; HOMEOSTASIS; HYPERPLASIA; INTERLEUKIN-7; INTESTINES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84857510565     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031939     Document Type: Article

References (41)

1. Jameson SC, (2002) Maintaining the norm: T-cell homeostasis. Nat Rev Immunol 2: 547-556.
2. Khaled AR, Durum SK, (2002) Lymphocide: cytokines and the control of lymphoid homeostasis. Nat Rev Immunol 2: 817-830.
3. Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, et al. (2004) Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21: 289-302.
4. Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, et al. (2001) Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7: 73-79.
5. Guimond M, Veenstra RG, Grindler DJ, Zhang H, Cui Y, et al. (2009) Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10: 149-157.
6. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, et al. (1995) Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181: 1519-1526.
7. Kieper WC, Tan JT, Bondi-Boyd B, Gapin L, Sprent J, et al. (2002) Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 195: 1533-1539.
8. Sawa S, Kamimura D, Jin GH, Morikawa H, Kamon H, et al. (2006) Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203: 1459-1470.
9. Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, et al. (1998) Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 187: 389-402.
10. Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R, (2002) Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 110: 1643-1650.
11. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, et al. (2007) IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol 178: 4737-4748.
12. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, et al. (2008) Systemic, but Not Intestinal, IL-7 Is Essential for the Persistence of Chronic Colitis. J Immunol 180: 383-390.
13. Watanabe M, Yamazaki M, Okamoto R, Ohoka S, Araki A, et al. (2003) Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. Curr Drug Targets Inflamm Allergy 2: 119-123.
14. Ponchel F, Cuthbert RJ, Goëb V, (2011) IL-7 and lymphopenia. Clin Chim Acta 412: 7-16.
15. Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, et al. (2009) gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15: 91-102.
16. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, et al. (2009) IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15: 103-113.
17. Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, et al. (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446: 557-561.
18. Xiao H, Gulen MF, Qin J, Yao J, Bulek K, et al. (2007) The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. Immunity 26: 461-475.
19. Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, et al. (2007) Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 446: 552-556.
20. Shalapour S, Deiser K, Sercan O, Tuckermann J, Minnich K, et al. (2010) Commensal microflora and interferon-gamma promote steady-state interleukin-7 production in vivo. Eur J Immunol 40: 2391-2400.
21. Jiang Q, Li WQ, Aiello FB, Mazzucchelli R, Asefa B, et al. (2005) Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev 16: 513-533.
22. Mertsching E, Burdet C, Ceredig R, (1995) IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro. Int Immunol 7: 401-414.
23. Li Y, Chen W, Ren J, Yu WH, Li Q, et al. (2003) DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. Cancer Biol Ther 2: 187-193.
24. van der Flier LG, Clevers H, (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 71: 241-260.
25. Izcue A, Coombes JL, Powrie F, (2009) Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 27: 313-338.
26. Feng T, Wang L, Schoeb TR, Elson CO, Cong Y, (2010) Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med 207: 1321-1332.
27. Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, et al. (2003) Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J Immunol 171: 1556-1563.
28. Sonnenberg GF, Fouser LA, Artis D, (2011) Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 12: 383-390.
29. Satoh-Takayama N, Lesjean-Pottier S, Vieira P, Sawa S, Eberl G, et al. (2010) IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med 207: 273-280.
30. Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, et al. (2010) Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes. Immunity 33: 736-751.
31. Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, et al. (2008) Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29: 947-957.
32. Sawa S, Lochner M, Satoh-Takayama N, Dulauroy S, Bérard M, et al. (2011) RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 12: 320-326.
33. Wilcox CM, Saag MS, (2008) Gastrointestinal complications of HIV infection: changing priorities in the HAART era. Gut 57: 861-870.
34. Buckley RH, (2004) Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu Rev Immunol 22: 625-655.
35. Tetsu O, McCormick F, (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422-426.
36. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281: 1509.
37. Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, et al. (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395: 698-702.
38. Kinzler KW, Vogelstein B, (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
39. Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, et al. (2007) Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12: 313-327.
40. Sportès C, Gress RE, Mackall CL, (2009) Perspective on potential clinical applications of recombinant human interleukin-7. Ann N Y Acad Sci 1182: 28-38.
41. Boyman O, Ramsey C, Kim DM, Sprent J, Surh CD, (2008) IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol 180: 7265-7275.