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Volumn 279, Issue 1732, 2012, Pages 1249-1258

The role of robustness in phenotypic adaptation and innovation

Author keywords

Conflict; Genotype networks; Genotype space

Indexed keywords

ADAPTATION; EVOLUTIONARY BIOLOGY; INNOVATION; MUTATION; PHENOTYPIC PLASTICITY; PROTEIN;

EID: 84857510399     PISSN: 09628452     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rspb.2011.2293     Document Type: Review
Times cited : (101)

References (75)
  • 1
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • (doi:10.1038/nrg1471)
    • Kitano, H. 2004 Biological robustness. Nat. Rev. Genet. 5, 826-837. (doi:10.1038/nrg1471)
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 826-837
    • Kitano, H.1
  • 2
    • 4544346660 scopus 로고    scopus 로고
    • Robustness of cellular functions
    • (doi:10.1016/j.cell.2004.09.008)
    • Stelling, J., Sauer, U., Szallasi, Z., Doyle, F. J. & Doyle, J. 2004 Robustness of cellular functions. Cell 118, 675-685. (doi:10.1016/j.cell.2004.09.008)
    • (2004) Cell , vol.118 , pp. 675-685
    • Stelling, J.1    Sauer, U.2    Szallasi, Z.3    Doyle, F.J.4    Doyle, J.5
  • 3
    • 14344263352 scopus 로고    scopus 로고
    • Distributed robustness versus redundancy as causes of mutational robustness
    • (doi:10.1002/bies.20170)
    • Wagner, A. 2005 Distributed robustness versus redundancy as causes of mutational robustness. Bioessays 27, 176-188. (doi:10.1002/bies.20170)
    • (2005) Bioessays , vol.27 , pp. 176-188
    • Wagner, A.1
  • 5
    • 0034667684 scopus 로고    scopus 로고
    • Plasticity, evolvability, and modularity in RNA
    • (doi:10.1002/1097-010X(20001015) 288:3,242::AID-JEZ5.3.0.CO;2-O)
    • Ancel, L. W. & Fontana, W. 2000 Plasticity, evolvability, and modularity in RNA. J. Exp. Zool./Mol. Dev. Evol. 288, 242-283. (doi:10.1002/1097-010X(20001015) 288:3,242::AID-JEZ5.3.0.CO;2-O)
    • (2000) J. Exp. Zool./Mol. Dev. Evol. , vol.288 , pp. 242-283
    • Ancel, L.W.1    Fontana, W.2
  • 6
    • 77949386270 scopus 로고    scopus 로고
    • 2010Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast
    • (doi:10.1371/journal.pone.0009035)
    • Lehner, B. 2010Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. PLoS ONE 5, e9035. (doi:10.1371/journal.pone.0009035)
    • PLoS ONE , vol.5
    • Lehner, B.1
  • 7
    • 69449106377 scopus 로고    scopus 로고
    • Robustness: Mechanisms and consequences
    • (doi:10. 1016/j.tig.2009.07.005)
    • Masel, J. & Siegal, M. L. 2009 Robustness: mechanisms and consequences. Trends Genet. 25, 395-403. (doi:10. 1016/j.tig.2009.07.005)
    • (2009) Trends Genet , vol.25 , pp. 395-403
    • Masel, J.1    Siegal, M.L.2
  • 8
    • 0036776075 scopus 로고    scopus 로고
    • A single mode of canalization
    • (doi:10.1016/ S0169-5347(02)02596-X)
    • Meiklejohn, C. & Hartl, D. 2002 A single mode of canalization. Trends Ecol. Evol. 17, 468-473. (doi:10.1016/ S0169-5347(02)02596-X)
    • (2002) Trends Ecol. Evol. , vol.17 , pp. 468-473
    • Meiklejohn, C.1    Hartl, D.2
  • 9
    • 62349105350 scopus 로고    scopus 로고
    • Congruent evolution of genetic and environmental robustness in micro-RNA
    • (doi:10.1093/molbev/msp008)
    • Szollosi, G. J. & Derenyi, I. 2009 Congruent evolution of genetic and environmental robustness in micro-RNA. Mol. Biol. Evol. 26, 867-874. (doi:10.1093/molbev/msp008)
    • (2009) Mol. Biol. Evol. , vol.26 , pp. 867-874
    • Szollosi, G.J.1    Derenyi, I.2
  • 10
    • 33749392167 scopus 로고    scopus 로고
    • Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli
    • (doi:10.1186/1471-2164-7-237)
    • Cooper, T. F., Morby, A. P.,Gunn, A.&Schneider, D. 2006 Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli. BMC Genomics 7, 237. (doi:10.1186/1471-2164-7-237)
    • (2006) BMC Genomics , vol.7 , pp. 237
    • Cooper, T.F.1    Morby, A.P.2    Gunn, A.3    Schneider, D.4
  • 11
    • 0344824018 scopus 로고    scopus 로고
    • Quantitative trait symmetry independent of Hsp90 buffering: Distinct modes of genetic canalization and developmental stability
    • (doi:10.1073/ pnas.1835613100)
    • Milton, C. C., Huynh, B., Batterham, P., Rutherford, S. L. & Hoffmann, A. A. 2003 Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability. Proc. Natl Acad. Sci. USA 100, 13 396-13 401. (doi:10.1073/ pnas.1835613100)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 13396-13401
    • Milton, C.C.1    Huynh, B.2    Batterham, P.3    Rutherford, S.L.4    Hoffmann, A.A.5
  • 12
    • 34447546660 scopus 로고    scopus 로고
    • The distribution of fitness effects of new mutations
    • (doi:10.1038/nrg2146)
    • Eyre-Walker, A. & Keightley, P. D. 2007 The distribution of fitness effects of new mutations. Nat. Rev. Genet. 8, 610-618. (doi:10.1038/nrg2146)
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 610-618
    • Eyre-Walker, A.1    Keightley, P.D.2
  • 13
    • 34249848425 scopus 로고    scopus 로고
    • Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila
    • (doi:10.1073/pnas.0701572104)
    • Sawyer, S. A., Parsch, J., Zhang, Z. & Hartl, D. L. 2007 Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila. Proc. Natl Acad. Sci. USA 104, 6504-6510. (doi:10.1073/pnas.0701572104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6504-6510
    • Sawyer, S.A.1    Parsch, J.2    Zhang, Z.3    Hartl, D.L.4
  • 14
    • 77954743785 scopus 로고    scopus 로고
    • Mutational effects and the evolution of new protein functions
    • (doi:10.1038/nrg2808)
    • Soskine, M. & Tawfik, D. S. 2010 Mutational effects and the evolution of new protein functions. Nat. Rev. Genet. 11, 572-582. (doi:10.1038/nrg2808)
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 572-582
    • Soskine, M.1    Tawfik, D.S.2
  • 15
    • 0034765995 scopus 로고    scopus 로고
    • Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae
    • Wloch, D. M., Szafraniec, K., Borts, R. H. & Korona, R. 2001 Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae. Genetics 159, 441-452.
    • (2001) Genetics , vol.159 , pp. 441-452
    • Wloch, D.M.1    Szafraniec, K.2    Borts, R.H.3    Korona, R.4
  • 16
    • 80052796115 scopus 로고    scopus 로고
    • A theory of transformative change in living systems. Oxford, UK: Oxford University Press
    • Wagner, A. 2011 The origins of evolutionary innovations. A theory of transformative change in living systems. Oxford, UK: Oxford University Press.
    • (2011) The Origins of Evolutionary Innovations
    • Wagner, A.1
  • 17
    • 77955844575 scopus 로고    scopus 로고
    • Robustness and evolvability
    • (doi:10.1016/j.tig. 2010.06.002)
    • Masel, J. & Trotter, M. V. 2010 Robustness and evolvability. Trends Genet. 26, 406-414. (doi:10.1016/j.tig. 2010.06.002)
    • (2010) Trends Genet , vol.26 , pp. 406-414
    • Masel, J.1    Trotter, M.V.2
  • 18
    • 77953623874 scopus 로고    scopus 로고
    • Enzyme promiscuity: A mechanistic and evolutionary perspective
    • (eds R. D. Kornberg, C. R. H. Raetz, J. E. Rothman & J. W. Thorner, Palo Alto, CA: Annual Reviews, (doi:10.1146/annurev-biochem-030409-143718)
    • Khersonsky, O. & Tawfik, D. S. 2010 Enzyme promiscuity: a mechanistic and evolutionary perspective. In Annual Review of Biochemistry (eds R. D. Kornberg, C. R. H. Raetz, J. E. Rothman & J. W. Thorner), vol. 79, pp. 471-505. Palo Alto, CA: Annual Reviews. (doi:10.1146/annurev-biochem-030409-143718)
    • (2010) Annual Review of Biochemistry , vol.79 , pp. 471-505
    • Khersonsky, O.1    Tawfik, D.S.2
  • 19
    • 80052796317 scopus 로고    scopus 로고
    • The molecular origins of evolutionary innovations
    • (doi:10.1016/j. tig.2011.06.002)
    • Wagner, A. 2011 The molecular origins of evolutionary innovations. Trends Genet. 27, 397-410. (doi:10.1016/j. tig.2011.06.002)
    • (2011) Trends Genet , vol.27 , pp. 397-410
    • Wagner, A.1
  • 20
    • 81155160112 scopus 로고    scopus 로고
    • Genotype networks shed light on evolutionary constraints
    • (doi:10.1016/j.tree.2011.07.001)
    • Wagner, A. 2011 Genotype networks shed light on evolutionary constraints. Trends Ecol. Evol. 26, 577-584. (doi:10.1016/j.tree.2011.07.001)
    • (2011) Trends Ecol. Evol. , vol.26 , pp. 577-584
    • Wagner, A.1
  • 21
    • 37249030834 scopus 로고    scopus 로고
    • Is evolvability evolvable?
    • (doi:10.1038/nrg2278)
    • Pigliucci, M. 2008 Is evolvability evolvable? Nat. Rev. Genet. 9, 75-82. (doi:10.1038/nrg2278)
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 75-82
    • Pigliucci, M.1
  • 22
    • 84857550562 scopus 로고    scopus 로고
    • Old proteins and DNA, new tricks: Molecular evolution of antifreeze proteins in polar fishes
    • (doi:10.1016/j.cbpa.2006.01.059)
    • Cheng, C. 2006 Old proteins and DNA, new tricks: molecular evolution of antifreeze proteins in polar fishes. Comp. Biochem. Physiol. A-Mol. Integr. Physiol. 143, S61-S64. (doi:10.1016/j.cbpa.2006.01.059)
    • (2006) Comp. Biochem. Physiol. A-Mol. Integr. Physiol. , vol.143
    • Cheng, C.1
  • 24
    • 0025745163 scopus 로고
    • Modeling neutral and selective evolution of protein folding
    • (doi:10.1098/rspb.1991.0081)
    • Lipman, D. & Wilbur, W. 1991 Modeling neutral and selective evolution of protein folding. Proc. R. Soc. Lond. B 245, 7-11. (doi:10.1098/rspb.1991.0081)
    • (1991) Proc. R. Soc. Lond. B , vol.245 , pp. 7-11
    • Lipman, D.1    Wilbur, W.2
  • 25
    • 0028196714 scopus 로고
    • From sequences to shapes and back: A case-study in RNA secondary structures
    • (doi:10.1098/rspb.1994.0040)
    • Schuster, P., Fontana, W., Stadler, P. & Hofacker, I. 1994 From sequences to shapes and back: a case-study in RNA secondary structures. Proc. R. Soc. Lond. B 255, 279-284. (doi:10.1098/rspb.1994.0040)
    • (1994) Proc. R. Soc. Lond. B , vol.255 , pp. 279-284
    • Schuster, P.1    Fontana, W.2    Stadler, P.3    Hofacker, I.4
  • 27
    • 0029893918 scopus 로고    scopus 로고
    • A brief history of hemoglobins: Plant, animal, protist, and bacteria
    • (doi:10.1073/pnas.93.12.5675)
    • Hardison, R. C. 1996 A brief history of hemoglobins: plant, animal, protist, and bacteria. Proc. Natl Acad. Sci. USA 93, 5675-5679. (doi:10.1073/pnas.93.12.5675)
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5675-5679
    • Hardison, R.C.1
  • 28
    • 0037373550 scopus 로고    scopus 로고
    • Connectivity of neutral networks, overdispersion, and structural conservation in protein evolution
    • (doi:10.1007/s00239-002-2350-0)
    • Bastolla, U., Porto, M., Roman, H. E. & Vendruscolo, M. 2003 Connectivity of neutral networks, overdispersion, and structural conservation in protein evolution. J. Mol. Evol. 56, 243-254. (doi:10.1007/s00239-002-2350-0)
    • (2003) J. Mol. Evol. , vol.56 , pp. 243-254
    • Bastolla, U.1    Porto, M.2    Roman, H.E.3    Vendruscolo, M.4
  • 29
    • 0036308741 scopus 로고    scopus 로고
    • Enzyme function less conserved than anticipated
    • (doi:10.1016/ S0022-2836(02)00016-5)
    • Rost, B. 2002 Enzyme function less conserved than anticipated. J. Mol. Biol. 318, 595-608. (doi:10.1016/ S0022-2836(02)00016-5)
    • (2002) J. Mol. Biol. , vol.318 , pp. 595-608
    • Rost, B.1
  • 30
    • 0032698873 scopus 로고    scopus 로고
    • Protein folds, functions and evolution
    • (doi:10.1006/jmbi.1999.3054)
    • Thornton, J., Orengo, C., Todd, A. & Pearl, F. 1999 Protein folds, functions and evolution. J. Mol. Biol. 293, 333-342. (doi:10.1006/jmbi.1999.3054)
    • (1999) J. Mol. Biol. , vol.293 , pp. 333-342
    • Thornton, J.1    Orengo, C.2    Todd, A.3    Pearl, F.4
  • 31
    • 0032859140 scopus 로고    scopus 로고
    • Evolution of protein function, from a structural perspective
    • (doi:10.1016/S1367- 5931(99)00007-1)
    • Todd, A., Orengo, C. & Thornton, J. 1999 Evolution of protein function, from a structural perspective. Curr. Opin. Chem. Biol. 3, 548-556. (doi:10.1016/S1367- 5931(99)00007-1)
    • (1999) Curr. Opin. Chem. Biol. , vol.3 , pp. 548-556
    • Todd, A.1    Orengo, C.2    Thornton, J.3
  • 32
    • 0036900082 scopus 로고    scopus 로고
    • Quantifying the slightly deleterious mutation model of molecular evolution
    • Eyre-Walker, A., Keightley, P. D., Smith, N. G. C. & Gaffney, D. 2002 Quantifying the slightly deleterious mutation model of molecular evolution. Mol. Biol. Evol. 19, 2142-2149.
    • (2002) Mol. Biol. Evol. , vol.19 , pp. 2142-2149
    • Eyre-Walker, A.1    Keightley, P.D.2    Smith, N.G.C.3    Gaffney, D.4
  • 34
    • 16544384596 scopus 로고    scopus 로고
    • Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs
    • (doi:10.1038/ng1451)
    • Kern, A. D. & Kondrashov, F. A. 2004 Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs. Nat. Genet. 36, 1207-1212. (doi:10.1038/ng1451)
    • (2004) Nat. Genet. , vol.36 , pp. 1207-1212
    • Kern, A.D.1    Kondrashov, F.A.2
  • 35
    • 9444269272 scopus 로고    scopus 로고
    • Compensated deleterious mutations in insect genomes
    • (doi:10.1126/science. 1100522)
    • Kulathinal, R. J., Bettencourt, B. R. & Hartl, D. L. 2004 Compensated deleterious mutations in insect genomes. Science 306, 1553-1554.(doi:10.1126/science. 1100522)
    • (2004) Science , vol.306 , pp. 1553-1554
    • Kulathinal, R.J.1    Bettencourt, B.R.2    Hartl, D.L.3
  • 36
    • 21044446722 scopus 로고    scopus 로고
    • Rapid evolutionary escape by large populations from local fitness peaks is likely in nature
    • (doi:10. 1554/04-392)
    • Weinreich, D. M. & Chao, L. 2005 Rapid evolutionary escape by large populations from local fitness peaks is likely in nature. Evolution 59, 1175-1182. (doi:10. 1554/04-392)
    • (2005) Evolution , vol.59 , pp. 1175-1182
    • Weinreich, D.M.1    Chao, L.2
  • 37
    • 36348992094 scopus 로고    scopus 로고
    • Robustness and evolvability: A paradox resolved
    • (doi:10.1098/ rspb.2007.1137)
    • Wagner, A. 2008 Robustness and evolvability: a paradox resolved. Proc. R. Soc. B 275, 91-100. (doi:10.1098/ rspb.2007.1137)
    • (2008) Proc. R. Soc. B , vol.275 , pp. 91-100
    • Wagner, A.1
  • 38
    • 0033117461 scopus 로고    scopus 로고
    • Catalytic promiscuity and the evolution of new enzymatic activities
    • (doi:10.1016/S1074-5521 (99)80033-7)
    • O'Brien, P. J. & Herschlag, D. 1999 Catalytic promiscuity and the evolution of new enzymatic activities. Chem. Biol. 6, R91-R105. (doi:10.1016/S1074-5521 (99)80033-7)
    • (1999) Chem. Biol. , vol.6
    • O'Brien, P.J.1    Herschlag, D.2
  • 39
    • 64849101493 scopus 로고    scopus 로고
    • Protein dynamism and evolvability
    • (doi:10.1126/science. 1169375)
    • Tokuriki, N. & Tawfik, D. S. 2009 Protein dynamism and evolvability. Science 324, 203-207. (doi:10.1126/science. 1169375)
    • (2009) Science , vol.324 , pp. 203-207
    • Tokuriki, N.1    Tawfik, D.S.2
  • 41
    • 33846056835 scopus 로고    scopus 로고
    • fRNAdb: A platform for mining/annotating functional RNA candidates from non-coding RNA sequences
    • Database Issue, (doi:10.1093/nar/gkl837)
    • Kin, T. et al. 2007 fRNAdb: a platform for mining/annotating functional RNA candidates from non-coding RNA sequences. Nucleic Acids Res. (Database Issue) 35, D145-D148. (doi:10.1093/nar/gkl837)
    • (2007) Nucleic Acids Res , vol.35
    • Kin, T.1
  • 42
    • 60749114979 scopus 로고    scopus 로고
    • Neutral network sizes of biological RNA molecules can be computed and are not atypically small
    • (doi:10. 1186/1471-2105-9-464)
    • Jörg, T., Martin, O. & Wagner, A. 2008 Neutral network sizes of biological RNA molecules can be computed and are not atypically small. BMC Bioinform. 9, 464. (doi:10. 1186/1471-2105-9-464)
    • (2008) BMC Bioinform , vol.9 , pp. 464
    • Jörg, T.1    Martin, O.2    Wagner, A.3
  • 43
    • 0034698298 scopus 로고    scopus 로고
    • One sequence, two ribozymes: Implications for the emergence of new ribozyme folds
    • (doi:10.1126/science.289. 5478.448)
    • Schultes, E. & Bartel, D. 2000 One sequence, two ribozymes: implications for the emergence of new ribozyme folds. Science 289, 448-452. (doi:10.1126/science.289. 5478.448)
    • (2000) Science , vol.289 , pp. 448-452
    • Schultes, E.1    Bartel, D.2
  • 44
    • 39449136567 scopus 로고    scopus 로고
    • Molecular modeling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes
    • (doi:10.1038/emboj.2008.4)
    • Beckert, B., Nielsen, H., Einvik, C., Johansen, S. D., Westhof, E. & Masquida, B. 2008 Molecular modeling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes. EMBO J. 27, 667-678. (doi:10.1038/emboj.2008.4)
    • (2008) EMBO J , vol.27 , pp. 667-678
    • Beckert, B.1    Nielsen, H.2    Einvik, C.3    Johansen, S.D.4    Westhof, E.5    Masquida, B.6
  • 45
    • 0344874269 scopus 로고    scopus 로고
    • Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer
    • (doi:10.1261/rna. 5990203)
    • Huang, Z. & Szostak, J. W. 2003 Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer. RNA 9, 1456-1463. (doi:10.1261/rna. 5990203)
    • (2003) RNA , vol.9 , pp. 1456-1463
    • Huang, Z.1    Szostak, J.W.2
  • 46
    • 79957944389 scopus 로고    scopus 로고
    • Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme
    • (doi:10.1038/ nature10083)
    • Hayden, E., Ferrada, E. & Wagner, A. 2011 Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme. Nature 474, 92-95. (doi:10.1038/ nature10083)
    • (2011) Nature , vol.474 , pp. 92-95
    • Hayden, E.1    Ferrada, E.2    Wagner, A.3
  • 47
    • 55249126669 scopus 로고    scopus 로고
    • Cryptic genetic variation
    • (doi:10.1016/j.cub. 2008.08.011)
    • Gibson, G. & Reed, L. K. 2008 Cryptic genetic variation. Curr. Biol. 18, R989-R990. (doi:10.1016/j.cub. 2008.08.011)
    • (2008) Curr. Biol. , vol.18
    • Gibson, G.1    Reed, L.K.2
  • 48
    • 0029805902 scopus 로고    scopus 로고
    • Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(IIe) of the purple bacterium Azoarcus
    • Tanner, M. A. & Cech, T. R. 1996 Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(IIe) of the purple bacterium Azoarcus. RNA-A Publ. RNA Soc. 2, 74-83.
    • (1996) RNA-A Publ. RNA Soc. , vol.2 , pp. 74-83
    • Tanner, M.A.1    Cech, T.R.2
  • 49
    • 0026649231 scopus 로고
    • Directed evolution of an RNA enzyme
    • (doi:10.1126/ science.1496376)
    • Beaudry, A. A. & Joyce, G. F. 1992 Directed evolution of an RNA enzyme. Science 257, 635-641. (doi:10.1126/ science.1496376)
    • (1992) Science , vol.257 , pp. 635-641
    • Beaudry, A.A.1    Joyce, G.F.2
  • 50
    • 36749042777 scopus 로고    scopus 로고
    • Latent evolutionary potentials under the neutral mutational drift of an enzyme
    • (doi:10.2976/ 1.2739115)
    • Amitai, G., Gupta, R. D. & Tawfik, D. S. 2007 Latent evolutionary potentials under the neutral mutational drift of an enzyme. HFSP J. 1, 67-78. (doi:10.2976/ 1.2739115)
    • (2007) HFSP J , vol.1 , pp. 67-78
    • Amitai, G.1    Gupta, R.D.2    Tawfik, D.S.3
  • 51
    • 34447559360 scopus 로고    scopus 로고
    • Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
    • (doi:10.1186/1745-6150-2-17)
    • Bloom, J. D., Romero, P. A., Lu, Z. & Arnold, F. H. 2007 Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. Biol. Direct 2, 17. (doi:10.1186/1745-6150-2-17)
    • (2007) Biol. Direct , vol.2 , pp. 17
    • Bloom, J.D.1    Romero, P.A.2    Lu, Z.3    Arnold, F.H.4
  • 52
    • 33847268619 scopus 로고    scopus 로고
    • Circuit topology and the evolution of robustness in complex regulatory gene networks
    • (doi:10.1371/journal.pcbi.0030015)
    • Ciliberti, S., Martin, O. C. & Wagner, A. 2007 Circuit topology and the evolution of robustness in complex regulatory gene networks. PLoS Comput. Biol. 3, e15. (doi:10.1371/journal.pcbi.0030015)
    • (2007) PLoS Comput. Biol. , vol.3
    • Ciliberti, S.1    Martin, O.C.2    Wagner, A.3
  • 53
    • 35348892535 scopus 로고    scopus 로고
    • Innovation and robustness in complex regulatory gene networks
    • (doi:10.1073/ pnas.0705396104)
    • Ciliberti, S., Martin, O. C. & Wagner, A. 2007 Innovation and robustness in complex regulatory gene networks. Proc. Natl Acad. Sci. USA 104, 13 591-13 596. (doi:10.1073/ pnas.0705396104)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13591-13596
    • Ciliberti, S.1    Martin, O.C.2    Wagner, A.3
  • 54
    • 0029772552 scopus 로고    scopus 로고
    • Emergence of preferred structures in a simple model of protein folding
    • (doi:10.1126/science.273. 5275.666)
    • Li, H., Helling, R., Tang, C. & Wingreen, N. 1996 Emergence of preferred structures in a simple model of protein folding. Science 273, 666-669. (doi:10.1126/science.273. 5275.666)
    • (1996) Science , vol.273 , pp. 666-669
    • Li, H.1    Helling, R.2    Tang, C.3    Wingreen, N.4
  • 55
    • 77952295145 scopus 로고    scopus 로고
    • Genotype networks in metabolic reaction spaces
    • (doi:10.1186/1752- 0509-4-30)
    • Samal, A., Rodrigues, J. F. M., Jost, J., Martin, O. C. & Wagner, A. 2010 Genotype networks in metabolic reaction spaces. BMC Syst. Biol. 4, 30. (doi:10.1186/1752- 0509-4-30)
    • (2010) BMC Syst. Biol. , vol.4 , pp. 30
    • Samal, A.1    Rodrigues, J.F.M.2    Jost, J.3    Martin, O.C.4    Wagner, A.5
  • 56
    • 0031105866 scopus 로고    scopus 로고
    • Generic properties of combinatory maps: Neutral networks of RNA secondary structures
    • (doi:10.1007/BF02462007)
    • Reidys, C., Stadler, P. & Schuster, P. 1997 Generic properties of combinatory maps: neutral networks of RNA secondary structures. Bull. Math. Biol. 59, 339-397. (doi:10.1007/BF02462007)
    • (1997) Bull. Math. Biol. , vol.59 , pp. 339-397
    • Reidys, C.1    Stadler, P.2    Schuster, P.3
  • 57
    • 0037161813 scopus 로고    scopus 로고
    • Endosymbiotic bacteria: GroEL buffers against deleterious mutations
    • (doi:10.1038/417398a)
    • Fares, M. A., Ruiz-Gonzalez, M. X., Moya, A., Elena, S. F. & Barrio, E. 2002 Endosymbiotic bacteria: GroEL buffers against deleterious mutations. Nature 417, 398. (doi:10.1038/417398a)
    • (2002) Nature , vol.417 , pp. 398
    • Fares, M.A.1    Ruiz-Gonzalez, M.X.2    Moya, A.3    Elena, S.F.4    Barrio, E.5
  • 58
    • 0037040541 scopus 로고    scopus 로고
    • Protein folding: Molecular chaperones in the cytosol from nascent chain to folded protein
    • (doi:10. 1126/science.1068408)
    • Hartl, F. U. & Hayer-Hartl, M. 2002 Protein folding: molecular chaperones in the cytosol from nascent chain to folded protein. Science 295, 1852-1858. (doi:10. 1126/science.1068408)
    • (2002) Science , vol.295 , pp. 1852-1858
    • Hartl, F.U.1    Hayer-Hartl, M.2
  • 59
    • 66649132872 scopus 로고    scopus 로고
    • Chaperonin overexpression promotes genetic variation and enzyme evolution
    • (doi:10.1038/nature08009)
    • Tokuriki, N. & Tawfik, D. S. 2009 Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature 459, 668-673. (doi:10.1038/nature08009)
    • (2009) Nature , vol.459 , pp. 668-673
    • Tokuriki, N.1    Tawfik, D.S.2
  • 60
  • 62
    • 0041673352 scopus 로고    scopus 로고
    • Structural determinant of protein designability
    • (doi:10.1103/PhysRevLett.90.218101)
    • England, J. L. & Shakhnovich, E. I. 2003 Structural determinant of protein designability. Phys. Rev. Lett. 90, 218101. (doi:10.1103/PhysRevLett.90.218101)
    • (2003) Phys. Rev. Lett. , vol.90 , pp. 218101
    • England, J.L.1    Shakhnovich, E.I.2
  • 63
    • 44949206468 scopus 로고    scopus 로고
    • Protein robustness promotes evolutionary innovations on large evolutionary time scales
    • (doi:10. 1098/rspb.2007.1617)
    • Ferrada, E. & Wagner, A. 2008 Protein robustness promotes evolutionary innovations on large evolutionary time scales. Proc. R. Soc. B 275, 1595-1602. (doi:10. 1098/rspb.2007.1617)
    • (2008) Proc. R. Soc. B , vol.275 , pp. 1595-1602
    • Ferrada, E.1    Wagner, A.2
  • 64
    • 0034542564 scopus 로고    scopus 로고
    • The evolution ofmutation rates: Separating causes fromconsequences
    • (doi:10.1002/1521- 1878(200012)22:12,1057::AID-BIES3.3.0.CO;2-W)
    • Sniegowski, P., Gerrish, P., Johnson, T. & Shaver, A. 2000 The evolution ofmutation rates: separating causes fromconsequences. Bioessays 22, 1057-1066. (doi:10.1002/1521- 1878(200012)22:12,1057::AID-BIES3.3.0.CO;2-W)
    • (2000) Bioessays , vol.22 , pp. 1057-1066
    • Sniegowski, P.1    Gerrish, P.2    Johnson, T.3    Shaver, A.4
  • 66
    • 0032555135 scopus 로고    scopus 로고
    • Evolvability
    • (doi:10.1073/pnas.95. 15.8420)
    • Kirschner, M. & Gerhart, J. 1998 Evolvability. Proc. Natl Acad. Sci. USA 95, 8420-8427. (doi:10.1073/pnas.95. 15.8420)
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 8420-8427
    • Kirschner, M.1    Gerhart, J.2
  • 67
    • 77649317480 scopus 로고    scopus 로고
    • Sunderland, MA: Sinauer
    • Futuyma, D. J. 2009 Evolution. Sunderland, MA: Sinauer.
    • (2009) Evolution
    • Futuyma, D.J.1
  • 68
    • 75149186552 scopus 로고    scopus 로고
    • Mutational robustness can facilitate adaptation
    • (doi:10.1038/nature08694)
    • Draghi, J., Parsons, T., Wagner, G. P. & Plotkin, J. 2010 Mutational robustness can facilitate adaptation. Nature 463, 353-355. (doi:10.1038/nature08694)
    • (2010) Nature , vol.463 , pp. 353-355
    • Draghi, J.1    Parsons, T.2    Wagner, G.P.3    Plotkin, J.4
  • 69
    • 39749111957 scopus 로고    scopus 로고
    • Evolution of evolvability in a developmental model
    • (doi:10.1111/j.1558-5646.2007.00303.x)
    • Draghi, J. & Wagner, G. R. 2008 Evolution of evolvability in a developmental model. Evolution 62, 301-315. (doi:10.1111/j.1558-5646.2007.00303.x)
    • (2008) Evolution , vol.62 , pp. 301-315
    • Draghi, J.1    Wagner, G.R.2
  • 70
    • 79955654559 scopus 로고    scopus 로고
    • Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits
    • (doi:10.1111/j. 1420-9101.2011.02261.x)
    • Espinosa-Soto, C., Martin, O. C. M. & Wagner, A. 2010 Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits. J. Evol. Biol. 24, 1284-1297. (doi:10.1111/j. 1420-9101.2011.02261.x)
    • (2010) J. Evol. Biol. , vol.24 , pp. 1284-1297
    • Espinosa-Soto, C.1    Martin, O.C.M.2    Wagner, A.3
  • 71
    • 80052791131 scopus 로고    scopus 로고
    • Genotype networks in sulfur metabolism
    • (doi:10. 1186/1752-0509-5-39)
    • Rodrigues, J. F. & Wagner, A. 2011 Genotype networks in sulfur metabolism. BMC Syst. Biol. 5, 39. (doi:10. 1186/1752-0509-5-39)
    • (2011) BMC Syst. Biol. , vol.5 , pp. 39
    • Rodrigues, J.F.1    Wagner, A.2
  • 72
    • 27844567907 scopus 로고    scopus 로고
    • Evolution of mutational robustness in an RNA virus
    • (doi:10.1371/ journal.pbio.0030381)
    • Montville, R., Froissart, R., Remold, S. K., Tenaillon, O. & Turner, P. E. 2005 Evolution of mutational robustness in an RNA virus. PLoS Biol. 3, 1939-1945. (doi:10.1371/ journal.pbio.0030381)
    • (2005) PLoS Biol , vol.3 , pp. 1939-1945
    • Montville, R.1    Froissart, R.2    Remold, S.K.3    Tenaillon, O.4    Turner, P.E.5
  • 73
    • 33745614283 scopus 로고    scopus 로고
    • In silico predicted robustness of viroids RNA secondary structures. I. The effect of single mutations
    • (doi:10.1093/molbev/msl005)
    • Sanjuan, R., Forment, J. & Elena, S. F. 2006 In silico predicted robustness of viroids RNA secondary structures. I. The effect of single mutations. Mol. Biol. Evol. 23, 1427-1436. (doi:10.1093/molbev/msl005)
    • (2006) Mol. Biol. Evol. , vol.23 , pp. 1427-1436
    • Sanjuan, R.1    Forment, J.2    Elena, S.F.3
  • 74
    • 0033567123 scopus 로고    scopus 로고
    • Viral RNA and evolved mutational robustness
    • (doi:10.1002/(SICI)1097-010X(19990 815)285:2,119::AID-JEZ4.3.0.CO;2-D)
    • Wagner, A. & Stadler, P. 1999 Viral RNA and evolved mutational robustness. J. Exp. Zool./Mol. Dev. Evol. 285, 119-127. (doi:10.1002/(SICI)1097-010X(19990 815)285:2,119::AID-JEZ4.3.0.CO;2-D)
    • (1999) J. Exp. Zool./Mol. Dev. Evol. , vol.285 , pp. 119-127
    • Wagner, A.1    Stadler, P.2
  • 75
    • 48249115639 scopus 로고    scopus 로고
    • The ascent of the abundant: How mutational networks constrain evolution
    • (doi:10. 1371/journal.pcbi.1000110)
    • Cowperthwaite, M. C., Economo, E. P., Harcombe, W. R., Miller, E. L. & Meyers, L. A. 2008 The ascent of the abundant: how mutational networks constrain evolution. PLoS Comput. Biol. 4, e1000110. (doi:10. 1371/journal.pcbi.1000110)
    • (2008) PLoS Comput. Biol. , vol.4
    • Cowperthwaite, M.C.1    Economo, E.P.2    Harcombe, W.R.3    Miller, E.L.4    Meyers, L.A.5


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