Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae

Genetics

Volumn 159, Issue 2, 2001, Pages 441-452

  Wloch, Dominika M ^a   Szafraniec, Krzysztof ^a   Borts, Rhona H ^b   Korona, Ryszard ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID ETHYL ESTER;

ANALYTIC METHOD; ARTICLE; BASE MISPAIRING; CALCULATION; CELL DIVISION; CONTROLLED STUDY; DNA REPAIR; FITNESS; FUNGUS GROWTH; FUNGUS MUTANT; FUNGUS MUTATION; GROWTH RATE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SCORING SYSTEM; SPONTANEOUS MUTATION; STATISTICAL ANALYSIS;

ETHYL METHANESULFONATE; MUTAGENS; MUTATION; PHENOTYPE; SACCHAROMYCES CEREVISIAE;

EID: 0034765995     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. The genome sequence of Drosophila melanogaster
2. Suitability of replacement markers for functional analysis studies in Saccharomyces cerevisiae
3. A general model for the evolution of recombination
4. The viability of near-normal irradiated chromosomes
5. A positive selection for mutants lacking orotidine 5′-phosphate decarboxylase activity in yeast
6. Some evolutionary consequences of deleterious mutations
7. The maintenence of genetic variation in life-history traits
8. Genetic loads and estimates of mutation rates in highly inbred plant populations
9. Mismatch repair systems in Saccharomyses cerevisiae
10. The origins, patterns and implications of human spontaneous mutation
11. The mutation load in Drosophila
12. Antagonistic pleiotropy, reversal of dominance, and genetic polymorphisms
13. High frequency of cryptic deleterious mutations in Caenorhabditis elegans
14. Estimation of the genomic mutation parameters in natural populations
15. On the experimental design and data analysis of mutation accumulation experiments
16. Rates of spontaneous mutation
17. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach
18. High genomic deleterious mutation rates in hominids
19. Evolution of recombination in a constant environment
20. Spontaneous mutational variances and covariances for fitness-related traits in Drosophila melanogaster
21. New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster
22. Muller's ratchet and mutational meltdowns
23. Ploidy regulation of gene expression
24. Properties of spontaneous mutations affecting quantitative traits
25. Initial sequencing and analysis of the human genome
26. Meiosis and the evolution of recombination at low mutation rates
27. A review of phenotypes in Saccharomyces cerevisiae
28. Deleterious mutation and the evolution of genetic life cycles
29. The distribution of mutation effects on viability in Drosophila melanogaster
30. Nature of mutational load in Drosophila
31. Genomic mutation rate for lifetime reproductive output and lifespan in Caenorhabditis elegans
32. Terumi Mukai and the riddle of deleterious mutation rates
33. Deleterious mutations and the evolution of sex
34. The mutational load with epistatic gene interactions in fitness
35. Biochemistry, and genetics of eukaryotic mismatch repair
36. Deleterious mutations and the evolution of sexual reproduction
37. Haploidy or diploidy: Which is better?
38. Genetic load of the yeast Saccharomyces cerevisiae under diverse environmental conditions
39. Unpredictable fitness transitions between haploid and diploid strains of genetically loaded yeast Saccharomyces cerevisiae
40. Risk of population extinction from new deleterious mutations
41. Mutation, selection, and the maintenance of life-history, variation in natural population
42. Spontaneous deleterious mutation
43. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2 dependent mismatch repair
44. Pleiotropic plasma membrane ATPase mutations of Saccharomyces cerevisiae
45. Inferring parameters of mutation, selection and demography from patterns of synonymous site evolution in Drosophila
46. An estimate of the mutational damage in man from data on consanguinous marriages
47. The genetic structure of natural populations of Drosophila melanogaster. I. Spontaneous mutation rate of polygenes controlling viability
48. Mutation rate and dominance of genes affecting viability in Drosophila melanogaster
49. The relation of recombination to mutational advance
50. Transition from haploidy to diploidy
51. Isolation and characterisation of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins
52. Antagonistic pleiotropy, dominance and genetic variation
53. A review of the genetic effects of ethyl methanesulfonate
54. Rapid decline of fitness in panmictic populations of Drosophila melanogaster maintained under relaxed natural selection
55. Yeast genetics
56. Functional analysis of the genes of yeast chromosome V by genetic footprinting
57. Environmental stress and mutational load in diploid strains of the yeast Saccharomyces cerevisiae
58. The fitness effects of spontaneous mutations in Caenorhabditis elegans
59. The sequence of the human genome
60. Epistatic interactions of spontaneous mutations in haploid strains of the yeast Saccharomyces cerevisiae
61. Whole-genome effects of ethyl methanesulfonate-induced mutation on nine quantitative traits in outbred Drosophila melanogaster
62. Two-sample hypotheses
63. Estimates of the rate and distribution of fitness effects of spontaneous mutation in Saccharomyces cerevisiae