Molecular events associated with ciclosporinA-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts

Journal of Periodontal Research

Volumn 47, Issue 2, 2012, Pages 149-158

  Sobral, L M ^a   Aseredo, F ^a   Agostini, M ^a   Bufalino, A ^a   Pereira, M C C ^a   Graner, E ^a   Coletta, R D ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Ciclosporin A; Extracellular matrix; Gingival overgrowth; Proliferation; Smad7; Transforming growth factor 1

Indexed keywords

ANTIMETABOLITE; BROXURIDINE; COLLAGEN TYPE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLOSPORIN; DIAGNOSTIC AGENT; GELATINASE A; MMP2 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; SMAD2 PROTEIN; SMAD2 PROTEIN, HUMAN; SMAD7 PROTEIN; SMAD7 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CULTURE TECHNIQUE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GINGIVA; GINGIVA OVERGROWTH; HUMAN; MALE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTIMETABOLITES; APOPTOSIS; BROMODEOXYURIDINE; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; COLLAGEN TYPE I; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLOSPORINE; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE EXPRESSION REGULATION; GINGIVA; GINGIVAL OVERGROWTH; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84857449637     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2011.01412.x     Document Type: Article

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