Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines

Journal of Periodontal Research

Volumn 42, Issue 6, 2007, Pages 580-588

  Sukkar, T Z ^a   Thomason, J M ^a   Cawston, T E ^a   Lakey, R ^a   Jones, D ^a   Catterall, J ^a   Seymour, R A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Collagen; Cyclosporin; Cytokine; Gingival fibroblast; Matrix metalloproteinase; Tissue inhibitor of metalloproteinase

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; NIFEDIPINE; ONCOSTATIN M; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DOWN REGULATION; FIBROBLAST; GINGIVA; GINGIVA OVERGROWTH; HUMAN; METABOLISM; PHYSIOLOGY;

CALCIUM CHANNEL BLOCKERS; CASE-CONTROL STUDIES; CELLS, CULTURED; CYCLOSPORINE; DOWN-REGULATION; FIBROBLASTS; GINGIVA; GINGIVAL OVERGROWTH; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; MATRIX METALLOPROTEINASE 1; NIFEDIPINE; ONCOSTATIN M; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 35348994495     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2007.00986.x     Document Type: Article

References (32)

1. Faulds D, Goa KL, Benfield P. Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 1993 45 : 953 1040.
2. Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol 1996 23 : 165 175.
3. Trackman PC, Kantarci A. A connective tissue metabolism and gingival overgrowth. Crit Rev Oral Biol Med 2004 15 : 165 175.
4. Thomason JM, Sloan P, Seymour RA. Immunolocalization of collagenase (MMP-1) and stromelysin (MMP-3) in the gingival tissues of organ transplant patients medicated with cyclosporin. J Clin Periodontol 1998 25 : 554 560.
5. Hyland PL, Traynor PS, Myrillas TT et al. The effects of cyclosporin on the collagenolytic activity of gingival fibroblasts. J Periodontol 2003 74 : 437 445.
6. Cotrim P, Martelli-Junior H, Graner E, Sauk JJ, Coletta RD. Cyclosporin A induces proliferation in human gingival fibroblasts via induction of transforming growth factor-beta1. J Periodontol 2003 74 : 1625 1633.
7. Gagliano N, Moscheni C, Dellavia C et al. Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro study. Biomed Pharmacother 2004 58 : 231 238.
8. Yamada H, Nishimura F, Naruishi K et al. Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts. J Periodontol 2000 71 : 955 960.
9. Bolzani G, Della Coletta R, Martelli Junior H, Martelli Junior H, Graner E. Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts. J Periodont Res 2000 35 : 51 58.
10. Tipton DA, Stricklin GP, Dabbous MK. Fibroblast heterogeneity in collagenolytic response to cyclosporine. J Cell Biochem 1991 46 : 152 165.
11. Cawston TE, Billington C, Cleaver C et al. The regulation of MMPs and TIMPs in cartilage turnover. Ann N Y Acad Sci 1999 878 : 120 129.
12. Clark IM, Powell LK, Wright JK, Cawston TE, Hazleman BL. Monoclonal antibodies against human fibroblast collagenase and the design of an enzyme-linked immunosorbent assay to measure total collagenase. Matrix 1992 12 : 475 480.
13. Plumpton TA, Clark IM, Plumton C, Calvin J, Cawston TE. Development of an enzyme-linked immunosorbent assay to measure total TIMP-1 (free TIMP-1 and TIMP-1 in combination with matrix metalloproteinases) and measurement of TIMP-1 and CRP in serum. Clin Chim Acta 1995 240 : 137 154.
14. Seymour RA, Ellis JS, Thomason JM. Risk factors for drug-induced gingival overgrowth. J Clin Periodontol 2000 27 : 217 223.
15. Koshy PJ, Henderson N, Logan C, Life PF, Cawston TE, Rowan AD. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Ann Rheum Dis 2002 61 : 704 713.
16. Zebrowski EJ, Ramamurthy Singer DL, Brunka JR. Collagenase activity of cyclosporine, nifedipine and phenytoin treated cells. J Dent Res 1988 67 : 331.
17. Tipton DA, Fry HR, Dabbous MK. Altered collagen metabolism in nifedipine-induced gingival overgrowth. J Periodont Res 1994 29 : 401 409.
18. Messing RO, Carpenter CL, Greenberg DA. Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists. J Pharmacol Exp Ther 1985 235 : 407 411.
19. Gelfand EW, Cheung RK, Mills GB. The cyclosporins inhibit lymphocyte activation at more than one site. J Immunol 1987 138 : 1115 1120.
20. Hassell TM, Romberg E, Sobhani S, Lesko L, Douglas R. Lymphocyte-mediated effects of cyclosporine on human fibroblasts. Transplant Proc 1988 : 993 1002.
21. Brinckerhoff CE, Plucinska IM, Sheldon LA, O'Connor GT. Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone. Biochemistry 1986 25 : 6378 6384.
22. James JA, Irwin CR, Linden GJ. The effects of culture environment on the response of human gingival fibroblasts to cyclosporin A. J Periodontol 1995 66 : 339 344.
23. Chae HJ, Ha MS, Yun DH et al. Mechanism of cyclosporine-induced overgrowth of gingival. J Dent Res 2006 85 : 515 519.
24. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991 5 : 2145 2154.
25. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodont Res 1993 28 : 500 510.
26. Sugano N, Ito K, Murai S. Cyclosporin A inhibits collagenase gene expression via AP-1 and JNK suppression in human gingival fibroblasts. J Periodont Res 1998 33 : 448 452.
27. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995 270 : 16483 16486.
28. McDonnell SE, Kerr LD, Matrisian LM. Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol Cell Biol 1990 10 : 4284 4293.
29. Korzus E, Nagase H, Rydell R, Travis J. The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression. J Biol Chem 1997 272 : 1188 1196.
30. Walters JD. Transmembrane signaling in periodontal mesenchymal cells: the linkage between stimulus and response. Periodontol 2000 1993 3 : 76 98.
31. Vogt PK, Bos TJ. The oncogene jun and nuclear signalling. Trends Biochem Sci 1989 14 : 172 175.
32. Case JP, Lafyatis R, Kumkumian GK, Remmers EF, Wilder RL. IL-1 regulation of transin/stromelysin transcription in rheumatoid synovial fibroblasts appears to involve two antagonistic transduction pathways, an inhibitory, prostaglandin-dependent pathway mediated by cAMP, and a stimulatory, protein kinase C-dependent pathway. J Immunol 1990 145 : 3755 3761.