Opposite effects of TGF-β1 and IFN-γ on transdifferentiation of myofibroblast in human gingival cell cultures

Journal of Clinical Periodontology

Volumn 34, Issue 5, 2007, Pages 397-406

  Sobral, Lays M ^a   Montan, Patrick F ^a   Martelli Jr , Hercilio ^b   Graner, Edgard ^a   Coletta, Ricardo D ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b University of Montes Claros   (Brazil)

Author keywords

Hereditary gingival fibromatosis; Interferon ; Myofibroblast; Transforming growth factor 1

Indexed keywords

ACTIN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; GAMMA INTERFERON; IMMEDIATE EARLY PROTEIN; SIGNAL PEPTIDE; SMAD7 PROTEIN; SMAD7 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; GINGIVA; GINGIVA FIBROMATOSIS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE; UPREGULATION;

ACTINS; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN TYPE I; DOWN-REGULATION; FIBROBLASTS; FIBROMATOSIS, GINGIVAL; GINGIVA; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON TYPE II; MUSCLE, SMOOTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 34247382146     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2007.01063.x     Document Type: Article

References (36)

1. Ahmed, A., Huang, L., Raftery, A. T., Ahmed, A. K., Fahmy, H., El Nahas, A. M. & Haylor, J. L. (2004) Cyclosporine A sensitizes the kidney to tubulointerstitial fibrosis induced by renal warm ischemia. Transplantation 77, 686-692.
2. Bisson, M. A., McGrouther, D. A., Mudera, V. & Grobbelaar, A. O. (2003) The different characteristics of Dupuytren's disease fibroblasts derived from either nodule or cord: expression of alpha-smooth muscle actin and the response to stimulation by TGF-betal. Journal of Hand Surgery [Br] 28, 351-356.
3. Bitu, C. C., Sobral, L. M., Kellermann, M. G., Martelli-Junior, H., Zecchin, K. G., Graner, E. & Coletta, R. D. (2006) Heterogeneous presence of myofibroblasts in hereditary gingival fibromatosis. Journal of Clinical Periodontology 33, 393-400.
4. Burns, W. C., Twigg, S. M., Forbes, J. M., Pete, J., Tikellis, C., Thallas-Bonke, V., Thomas, M. C., Cooper, M. E. & Kantharidis, P. (2006) Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. Journal of American Society of Nephrology 17, 2484-2494.
5. Coletta, R. D., Almeida, O. P., Ferreira, L. R., Reynolds, M. A. & Sauk, J. J. (1999) Increase in expression of Hsp47 and collagen in hereditary gingival fibromatosis is modulated by stress and terminal procollagen N-propeptides. Connective Tissue Research 40, 237-249.
6. Coletta, R. D. & Graner, E. (2006) Hereditary gingival fibromatosis: a systematic review. Journal of Periodontology 77, 753-764.
7. de Andrade, C. R., Cotrin, P., Graner, E., Almeida, O. P., Sauk, J. J. & Coletta, R. D. (2001) Transforming growth factor-beta1 autocrine stimulation regulates fibroblast proliferation in hereditary gingival fibromatosis. Journal of Periodontology 72, 1726-1733.
8. Desmouliere, A., Chaponnier, C. & Gabbiani, G. (2005) Tissue repair, contraction, and the myofibroblast. Wound Repair Regeneration 13, 7-12.
9. Desmouliere, A., Darby, I. A. & Gabbiani, G. (2003) Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Laboratory Investigation 83, 1689-1707.
10. Dooley, S., Said, H. M., Gressner, A. M., Floege, J., En-Nia, A. & Mertens, P. R. (2006) Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects. Journal of Biological Chemistry 281, 1784-1795.
11. Faler, B. J,. Macsata, R. A., Plummer, D., Mishra, L. & Sidawy, A. N. (2006) Transforming growth factor-beta and wound healing. Perspectives in Vascular Surgery and Endovascular Therapy 18, 55-62.
12. Foster, W., Li, Y., Usas, A., Somogyi, G. & Huard, J. (2003) Gamma interferon as an antifibrosis agent in skeletal muscle. Journal of Orthopaedic Research 21, 798-804.
13. Ghosh, A. K., Bhattacharyya, S., Mori, Y. & Varga, J. (2006) Inhibition of collagen gene expression by interferon-gamma: novel role of the CCAAT/enhancer binding protein beta (C/EBPbeta). Journal of Cell Physiology 207, 251-260.
14. Ghosh, A. K., Yuan, W., Mori, Y., Chen, S. & Varga, J. (2001) Antagonistic regulation of type 1 collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP tran-scriptional coactivators. Journal of Biological Chemistry 276, 11041-11048.
15. Gressner, A. M., Weiskirchen, R., Breitkopf, K. & Dooley, S. (2002) Roles of TGF-beta in hepatic fibrosis. Frontiers of Bioscience 7, d793-d807.
16. Grotendorst, G. R. & Duncan, M. R. (2005) Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation. FASEB Journal 19, 729-738.
17. Gu, L., Zhu, Y. J., Quo, Z. J., Xu, X. X. & Xu, W. B. (2004) Effect of IFN-gamma and dexamethasone on TGF-beta1-induced human fetal lung fibroblast-myofibroblast differentiation. Acta Pharmacologica Sinica 25, 1479-1488.
18. Hasegawa, T., Nakao, A., Sumiyoshi, K., Tsuboi, R. & Ogawa, H. (2003) IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts. Journal of Dermatological Science 32, 19-24.
19. Ishida, Y., Kondo, T., Takayasu, T., Iwakura, Y. & Mukaida, N. (2004) The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. Journal of Immunology 172, 1848-1855.
20. Kobayashi, H., Hayoshi, N., Hayashi, K., Yamataka, A., Lane, G. J. & Miyano, T. (2005) Connective tissue growth factor and progressive fibrosis in biliary atresia. Pediatric Surgery International 21, 12-16.
21. Larrabee, W. F. Jr. (1997) Keloid excision and recurrence prophylaxis via interdermal interferon-gamma injections. Laryngoscope 107, 1284.
22. Martelli-Junior, H., Cotrim, P., Graner, E., Sauk, J. J. & Coletta, R. D. (2003) Effect of transforming growth factor-beta1, interleukin-6,and interteron-gamma on the expression of type I collagen, heat shock protein 47, matrix metal-loproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis. Journal of Periodontology 74, 296-306.
23. Martelli-Junior, H., Lemos, D, P.. Silva, C. O., Graner, E, & Coletta, R. D. (2005) Hereditary gingival fibromatosis: report of a five-generation family using cellular proliferation analysis. Journal of Periodonrology 76, 2299-2305.
24. Pittet, B., Rubbia-Brandt, L., Desmouliere, A., Sappino, A. P., Roggero, P., Guerret, S., Grimaud, J. A., Lacher, R., Montandon, D. & Gabbiani, G. (1994) Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease: an open pilot study. Plastic and Reconstructive Surgery 93, 1224-1235.
25. Qi, W., Chen, X., Polhill, T. S., Sumual, S., Twigg, S., Gilbert, R. E. & Pollock, C. A. (2006) TGF-betal induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway. American Journal of Physiology Renal Physiology 290, F703-F709.
26. Rehan, V. K., Wang, Y., Sugano, S., Romero, S., Chen, X., Santos, J., Khazanchi, A. & Torday, J. S. (2005) Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation. American Journal of Physiology Lung Cell Molecular Physiology 289, L667-L676.
27. Sanders, Y. Y., Kumbla, P. & Hagood, J. S. (2006) Enhanced myofibroblastic differentia-tion and survival in Thy-1(-) lung fibroblasts. American Journal Respiratory Cell and Molecular Biology 36, 226-235.
28. Slattery, C., Campbell, E., McMorrow, T. & Ryan, M. P. (2005) Cyclosporine a-induced renal fibrosis: a role for epithelial-mesenchymal transition. American Journal of Pathology 167, 395-407.
29. Smith, P. C., Cáceres, M. & Martinez, J. (2006) Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-β1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways. Journal of Periodontal Research 41, 418-425.
30. Tanaka, K., Sano, K., Yuba, K., Katsumura, K., Nakano, T., Kobayashi, M., Ikeda, T. & Abe, M. (2003) Inhibition of induction of myofibroblasts by interferon gamma in a human fibroblast cell line. International Immunopliarmacology 3, 1273-1280.
31. Ulloa, L., Doody, J. & Massague, J. (1999) Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397, 710-713.
32. Untergasser, G., Gander, R., Lilg, C., Lepperdinger, G., Plas, E. & Berger, P. (2005) Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation. Mechanisms of Ageing and Development 126, 59-69.
33. Yamanaka, O., Saika, S., Okada, Y., Ooshima, A. & Ohnishi, Y. (2003) Effects of interferon-gamma on human subconjunctival fibro-blasts in the presence of TGFbetal: reversal of TGFbeta-stimulated collagen production. Craefes Archives for Clinical Experimental Ophthalmology 241, 116-124.
34. Yokoi, H., Mukoyama, M., Sugawara, A., Mori, K., Nagae, T., Makino, H., Suganami, T., Yahata, K., Fujinaga, Y., Tanaka, I. & Nakao, K. (2002) Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. American Journal of Physiology Renal Physiology 282, F933-F942.
35. Yokoi, H., Sugawara, A., Mukoyama, M., Mori, K., Makino, H., Suganarai, T., Nagae, T., Yahata, K., Fujinaga, Y., Tanaka, I. & Nakao, K. (2001) Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis. American Journal of Kidney Disease 38, S134-S138.
36. Zhang, C., Meng, X., Zhu, Z., Liu, J. & Deng, A. (2004) Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro. Cell Biology International 28, 863-873.