Risk factors for gingival overgrowth in patients medicated with ciclosporin in the absence of calcium channel blockers

Journal of Clinical Periodontology

Volumn 32, Issue 3, 2005, Pages 273-279

  Thomason, J Mark ^a   Seymour, Robin A ^a   Ellis, Janice S ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Azathioprine; Ciclosporin; Gingival overgrowth; Inflammation; Prednisolone; Transplant

Indexed keywords

ANTIINFLAMMATORY AGENT; AZATHIOPRINE; CALCIUM CHANNEL BLOCKING AGENT; CREATININE; CYCLOSPORIN; CYCLOSPORIN A; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; PHENYTOIN; PREDNISOLONE;

ADULT; ARTICLE; BLOOD; BODY WEIGHT; CALCIUM CHANNEL; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; DRUG EFFECT; FEMALE; GINGIVA OVERGROWTH; HEART TRANSPLANTATION; HUMAN; IATROGENIC DISEASE; INFORMATION PROCESSING; KIDNEY TRANSPLANTATION; LUNG TRANSPLANTATION; MALE; MEDICAL RECORD; ORGAN TRANSPLANTATION; PERIODONTICS; RISK FACTOR; TIME; TOOTH PLAQUE;

ANTI-INFLAMMATORY AGENTS; AZATHIOPRINE; BODY WEIGHT; CREATININE; CYCLOSPORINE; DENTAL PLAQUE INDEX; FEMALE; GINGIVAL OVERGROWTH; GLUCOCORTICOIDS; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PERIODONTAL INDEX; PREDNISOLONE; RISK FACTORS; TIME FACTORS;

EID: 16244375828     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2005.00657.x     Document Type: Article

References (43)

1. Altman, D. G. (1991) Relation between several variables. In: Practical Statistics for Medical Research, Ist edition, pp. 325-364. London: Chapman & Hall.
2. Daley, T. D., Wysocki, G. P. & Day, C. (1986) Clinical and pharmacologic correlations in cyclosporine-induced gingival hyperplasia. Oral Surgery Oral Medicine and Oral Pathology 62, 417-421.
3. Daley, T. D., Wysocki, G. P. & Mamandras, A. H. (1991) Orthodontic therapy in the patient treated with cyclosporine. American Journal of Orthodontics and Dentofacial Orthopedics 100, 537-541.
4. Daly, C. G. (1992) Resolution of cyclosporin A (CsA)-induced gingival enlargement following reduction in CsA dosage. Journal of Clinical Periodontology 19, 143-145.
5. Dobbelstein, H. (1976) Immune system in uraemia. Nephron 17, 409-414.
6. Dunn, C. J., Wagstaff, A. J., Perr, C. M., Plosker, G. L. & Goa, K. L. (2001) Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral 1) in organ transplantation. Drugs 61, 1957-2016.
7. Ellis, J. S., Seymour, R. A., Steele, J. G., Robertson, P., Butler, T. J. & Thomason, J. M. (1999) Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. Journal of Periodontology 70, 63-67.
8. Faulds, D., Goa, K. L. & Benfield, P. (1993) Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs 45, 953-1040.
9. Kantarci, A., Cebeci, I., Tuncer, O., Carin, M. & Firatli, E. (1999) Clinical effects of periodontal therapy on the severity of cyclosporin A-induced gingival hyperplasia. Journal of Periodontology 70, 587-593.
10. King, G. N., Fullinfaw, R., Higgins, T. S., Walker, R. J., Francis, D. M. A. & Wiesenfeld, D. (1993) Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists. Journal of Clinical Periodontology 20, 286-293.
11. McGaw, T., Lam, S. & Coates, J. (1987) Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva. Oral Surgery, Oral Medicine and Oral Pathology 64, 293-297.
12. Montebugnoli, L., Bernardi, F. & Magelli, C. (1996) Cyclosporin-A-induced gingival overgrowth in heart transplant patients. A cross-sectional study. Journal of Clinical Periodontology 23, 868-872.
13. O'Valle, F., Mesa, F. L., Gomez-Morales, M., Aguilar, D., Caracuel, M. D., Medina-Cano, M. T., Andujar, M., Lopez-Hidalgo, J. & del Moral, R. G. (1994) Immunochemical study of 30 cases of cyclosporin A-induced gingival overgrowth. Journal of Periodontology 65, 724-730.
14. Pan, W. L., Chan, C. P., Huang, C. C. & Lai, M. K. (1992) Cyclosporine-induced gingival overgrowth. Transplantation Proceedings 24, 1393-1394.
15. Pernu, H. E., Pernu, L. M., Huttunen, K. R., Nieminen, P. A. & Knuuttila, M. L. (1992a) Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. Journal of Periodontology 63, 548-553.
16. Pernu, H. E., Pernu, L. M. H., Huttunen, K. R. H., Nieminen, P. A. & Knuuttila, M. L. E. (1992b) Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. Journal of Periodontology 63, 548-553.
17. Pernu, H. E., Pernu, L. M., Knuuttila, M. L. & Huttunen, K. R. (1993) Gingival overgrowth among renal transplant recipients and uraemic patients. Nephrology, Dialysis, Transplantation 8, 1254-1258.
18. Rateitschak-Plüss, E. M., Hefti, A., Lörtscher, R. & Thiel, G. (1983) Initial observation that cyclosporin-A induces gingival enlargement in man. Journal of Clinical Periodontology 10, 237-246.
19. Rebuck, J. W., LeSher, D. A., Perkins, M. J. & Leal, F. (1971) Leucocyte response as a monitor of immunosuppression in man. In: Forscher, B. K. & Houck, J. C. (eds). Immunopathology of Inflammation, pp. 132-157. Amsterdam: Excerpta medica.
20. Saravia, M. E., Svirsky, J. A. & Friedman, R. (1990) Chlorhexidine as an oral hygiene adjunct for cyclosporine-induced gingival hyperplasia. Journal of Dentistry for Children 57, 366-370.
21. Saxer, U. P. & Muhlemann, H. R. (1975) Motivation und Aufklarung. Schweiz Mschr Zahnheilk 85, 905-919.
22. Seibel, W., Yahia, N. A., McCleary, L. B., Lesko, L. J. & Hassell, T. M. (1989) Cyclosporine-induced gingival overgrowth in Beagle dogs. Journal of Oral Pathology and Medicine 18, 240-245.
23. Seymour, R. A. & Jacobs, D. J. (1992) Cyclosporin and the gingival tissues [review]. Journal of Clinical Periodontology 19, 1-11.
24. Seymour, R. A. & Smith, D. G. (1991) The effect of a plaque control programme on the incidence and severity of cyclosporin-induced gingival changes. Journal of Clinical Periodontology 18, 107-110.
25. Seymour, R. A., Smith, D. G. & Rogers, S. R. (1987) The comparative effect of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. Journal of Clinical Periodontology 14, 610-613.
26. Seymour, R. A., Smith, D. G. & Turnbull, D. N. (1985) The effect of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. Journal of Clinical Periodontology 12, 413-419.
27. Seymour, R. A., Thomason, J. M. & Ellis, J. S. (1996) The pathogenesis of drug-induced gingival overgrowth [review]. Journal of Clinical Periodontology 23, 165-175.
28. Silness, J. & Loe, H. (1964) Periodontal disease in pregnancy. II Correlation between oral hygiene and periodontal condition. Acta Odontologica Scandinarrica 22, 121.
29. Slavin, J. & Taylor, J. (1987) Cyclosporin, nifedipine, and gingival hyperplasia [letter]. Lancet 2, 739.
30. Somacarrera, M. L., Hernandez, G., Acero, J. & Moskow, B. S. (1994a) Factors relating to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. Journal of Periodontology 65, 671-675.
31. Somacarrera, M. L., Hernandez, G., Acero, J. & Moskow, B. S. (1994b) Localization of gingival overgrowth in heart transplant patients undergoing cyclosporin therapy. Journal of Periodontology 65, 666-670.
32. Thomas, D. W., Baboolal, K., Subramanian, N. & Newcombe, R. G. (2001) Cyclosporin A-induced gingival overgrowth is unrelated to allograft function in renal transplant recipients. Journal of Clinical Periodontology 28, 706-709.
33. Thomason, J. M. (1995) Drug-induced gingival overgrowth in organ transplant patients. PhD, Newcastle upon Tyne.
34. Thomason, J. M., Ellis, J. S., Kelly, P. J. & Seymour, R. A. (1997) Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients. Clinical Oral Investigations 1, 35-39.
35. Thomason, J., Kelly, P. & Seymour, R. (1996) The distribution of gingival overgrowth in organ transplant patients. Journal of Clinical Periodontology 23, 367-371.
36. Thomason, J. M., Seymour, R. A. & Ellis, J. (1994) The periodontal problems and management of the renal transplant patient. Renal Failure 16, 731-745.
37. Thomason, J. M., Seymour, R. A., Ellis, J. S., Kelly, P. J., Parry, G., Dark, J. & Idle, J. R. (1995) Iatrogenic gingival overgrowth in cardiac transplantation. Journal of Periodontology 66, 742-746.
38. Thomason, J. M., Seymour, R. A., Ellis, J. S., Kelly, P. J., Parry, G., Dark, J., Wilkinson, R. & Idle, J. R. (1996) Determinants of gingival overgrowth severity in organ transplant patients. An examination of the role of HLA phenotype. Journal of Clinical Periodontology 23, 628-634.
39. Thomason, J. M., Seymour, R. A. & Rawlins, M. D. (1992) Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical-practice. Community Dentistry and Oral Epidemiology 20, 288-291.
40. Thomason, J. M., Seymour, R. A. & Rice, N. (1993) The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth. Journal of Clinical Periodontology 20, 37-40.
41. Vescovi, P., Savi, A., Macaluso, G. M. & Gennari, P. U. (1997) Gingival hypertrophy due to cyclosporine. A clinico-statistical study in 82 patients. Minerva Stomatologica 46, 155-164.
42. Wilson, R. F., Morel, A., Smith, D., Koffman, C. G., Ogg, C. S., Rigden, S. P. & Ashley, F. P. (1998) Contribution of individual drugs to gingival overgrowth in adult and juvenile renal transplant patients treated with multiple therapy. Journal of Clinical Periodontology 25, 457-464.
43. Wondimu, B., Dahllof, G., Berg, U. & Modeer, T. (1993) Cyclosporin-A-induced gingival overgrowth in renal transplant children. Scandinavian Journal of Dental Research 101, 282-286.