Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 1, 2011, Pages 271-279

  Park, Jeong Woo ^a   Park, Cheon Hoon ^a   Kim, In Jin ^a   Bae, Eun Hui ^a   Ma, Seong Kwon ^a   Lee, Jong Un ^a   Kim, Soo Wan ^a  

^a Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; CASPASE 3; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; CYCLOSPORIN A; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FASUDIL; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PROTEIN BAD; PROTEIN BAX; PROTEIN P53; RHO KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; INFLAMMATORY INFILTRATE; INHIBITION KINETICS; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; UPREGULATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; CELLS, CULTURED; CYCLOSPORINE; KIDNEY CORTEX; KIDNEY DISEASES; MALE; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 79959526403     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.179457     Document Type: Article

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