Molecular dynamics simulations for glutamate-binding and cleft-closing processes of the ligand-binding domain of GluR2

Biophysical Chemistry

Volumn 162, Issue , 2012, Pages 35-44

  Okada, Okimasa ^a   Odai, Kei ^b   Sugimoto, Tohru ^c   Ito, Etsuro ^d  

^a ZOEGENE Corporation   (Japan)

^b Shohoku College   (Japan)

^c KANTO GAKUIN UNIVERSITY   (Japan)

^d TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Free energy profile; Glutamate binding pathway; Inter domain conformational change; Semi open state; Unbiased molecular dynamics simulation

Indexed keywords

CATION; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; LIGAND; TYROSINE;

ARTICLE; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, AMPA; THERMODYNAMICS;

EID: 84857372724     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2011.12.004     Document Type: Article

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