Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model

American Journal of Pathology

Volumn 162, Issue 6, 2003, Pages 1975-1984

  Rowan, Andrew ^a   Hui, Wang ^a   Cawston, Tim E ^a   Richards, Carl D ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; INTERLEUKIN 1; MATRIX METALLOPROTEINASE; ONCOSTATIN M; PROTEOGLYCAN; TISSUE INHIBITOR OF METALLOPROTEINASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DESTRUCTION; CARTILAGE; CELL INFILTRATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE TRANSFER; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; JOINT DESTRUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SYNOVIUM;

EID: 0037906397     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64330-1     Document Type: Article

References (51)

1. Dayer JM, Bresnihan B: Targeting interleukin-1 in the treatment of rheumatoid arthritis. Arthritis Rheum 2002, 46:574-578
2. Manicourt DH, Poilvache P, van Egeren A, Devogelaer JP, Lenz ME, Thonar EJ: Synovial fluid levels of tumor necrosis factor-α and on-costatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. Arthritis Rheum 2000, 43:281-288
3. Chu CQ, Field M, Allard S, Abney E, Feldmann M, Maini RN: Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. Br J Rheumatol 1992, 31:653-661
4. Rooney M, Symons JA, Duff GW: Interleukin 1β in synovial fluid is related to local disease activity in rheumatoid arthritis. Rheumatol Int 1990, 10:217-219
5. Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, Duff GW: Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet 1988, 2:706-709
6. van de Loo FA, van den Berg WB: Gene therapy for rheumatoid arthritis: lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators. Rheum Dis Clin North Am 2002, 28:127-149
7. Cawston TE, Curry VA, Summers CA, Clark IM, Riley GP, Life PF, Spaull JR, Goldring MB, Koshy PJT, Rowan AD, Shingleton WD: The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint. Arthritis Rheum 1998, 41:1760-1771
8. Hui W, Bell M, Carroll G: Detection of oncostatin M in synovial fluid from patients with rheumatoid arthritis. Ann Rheum Dis 1997, 56:184-187
9. Bell MC, Carroll GJ, Chapman HM, Mills JN, Hui W: Oncostatin M induces leukocyte infiltration and cartilage proteoglycan degradation in vivo in goat joints. Arthritis Rheum 1999, 42:2543-2551
10. Langdon C, Kerr C, Hassen M, Hara T, Arsenault AL, Richards CD: Murine oncostatin M stimulates mouse synovial fibroblasts in vitro and induces inflammation and destruction in mouse joints in vivo. Am J Pathol 2000, 157:1187-1196
11. de Hooge AS, van de Loo FA, Bennink MB, de Jong DS, Arntz OJ, Lubberts E, Richards CD, van den Berg WB: Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-κ B ligand. Am J Pathol 2002, 160:1733-1743
12. Plater-Zyberk C, Buckton J, Thompson S, Spaull J, Zanders E, Papworth J, Life PF: Amelioration of arthritis in two murine models using antibodies to oncostatin M. Arthritis Rheum 2001, 44:2697-2702
13. Hui W, Rowan AD, Cawston TE: Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α. Ann Rheum Dis 2001, 60:254-261
14. Li WQ, Dehnade F, Zafarullah M: Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol 2001, 166:3491-3498
15. Hui W, Cawston TE, Rowan AD: Transforming growth factor β1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor-α from bovine cartilage. Ann Rheum Dis 2003, 62:172-174
16. Koshy PJT, Henderson N, Logan C, Life PF, Cawston TE, Rowan AD: Interleukin-17 induces cartilage collagen breakdown: novel synergistic effects in combination with pro-inflammatory cytokines. Ann Rheum Dis 2002, 61:704-713
17. Rowan AD, Koshy PJT, Shingleton WD, Degnan BA, Heath J, Vernallis AB, Spaull JR, Life PF, Hudson K, Cawston TE: Synergistic effects of gp130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown. Arthritis Rheum 2001, 44:1620-1632
18. Cawston TE: Metalloproteinase inhibitors and the prevention of connective tissue breakdown. Pharmacol Ther 1996, 70:163-182
19. Goto T, Maeda H, Tanaka T: A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes. J Bone Miner Metab 2002, 20:98-105
20. Ishiguro N, Ito T, Obata K, Fujimoto N, Iwata H: Determination of stromelysin-1, 72 and 92 kDa type IV collagenase, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis. J Rheumatol 1996, 23:1599-1604
21. Tetlow LC, Woolley DE: Comparative immunolocalization studies of collagenase 1 and collagenase 3 production in the rheumatoid lesion, and by human chondrocytes and synoviocytes in vitro. Br J Rheumatol 1998, 37:64-70
22. Yoshihara Y, Nakamura H, Obata K, Yamada H, Hayakawa T, Fujikawa K, Okada Y: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis 2000, 59:455-461
23. Cunnane G, Fitzgerald O, Beeton C, Cawston TE, Bresnihan B: Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis. Arthritis Rheum 2001, 44:2263-2274
24. Clegg PD, Carter SD: Matrix metalloproteinase-2 and -9 are activated in joint diseases. Equine Vet J 1999, 31:324-330
25. Amin AR: Type II interleukin-1β receptor: a candidate for gene therapy in human arthritis. Clin Orthop 2000, 379:S179-S188
26. Jiang Y, Genant HK, Watt I, Cobby M, Bresnihan B, Aitchison R, McCabe D: A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 2000, 43:1001-1009
27. Cawston TE: Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases. Mol Med Today 1998, 4:130-137
28. Su S, Grover J, Roughley PJ, DiBattista JA, Martel-Pelletier J, Pelletier JP, Zafarullah M: Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints. Rheumatol Int 1999, 18:183-191
29. Keyszer G, Lambiri I, Nagel R, Keysser C, Keysser M, Gromnica-Ihle E, Franz J, Burmester GR, Jung K: Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease: correlation with clinical activity of rheumatoid arthritis versus other surrogate markers. J Rheumatol 1999, 26:251-258
30. Schett G, Hayer S, Tohidast-Akrad M, Schmid BJ, Lang S, Turk B, Kainberger F, Haralambous S, Kollias G, Newby AC, Xu Q, Steiner G, Smolen J: Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor-α transgenic mice. Arthritis Rheum 2001, 44:2888-2898
31. Greenwald RA: Thirty-six years in the clinic without an MMP inhibitor: what hath collagenase wrought? Ann NY Acad Sci 1999, 878:413-419
32. Koshy PJ, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, Clark IM, Cawston TE: The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction. Arthritis Rheum 2002, 46:961-967
33. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J: Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 2001, 107:1529-1536
34. Kerr C, Langdon C, Graham F, Gauldie J, Hara T, Richards CD: Adenovirus vector expressing mouse oncostatin M induces acute-phase proteins and TIMP-1 expression in vivo in mice. J Interferon Cytokine Res 1999, 19:1195-1205
35. Bett AJ, Haddara W, Prevec L, Graham FL: An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci USA 1994, 91:8802-8806
36. Goossens PH, Huizinga TW: Adenoviral-mediated gene transfer to the synovial tissue. Clin Exp Rheumatol 2002, 20:415-419
37. Staite ND, Richard KA, Aspar DG, Franz KA, Galinet LA, Dunn CJ: Induction of an acute erosive monarticular arthritis in mice by interleukin-1 and methylated bovine serum albumin. Arthritis Rheum 1990, 33:253-260
38. Shingleton WD, Ellis AJ, Rowan AD, Cawston TE: Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown. J Cell Biochem 2000, 79: 519-531
39. Balbin M, Fueyo A, Knauper V, Lopez JM, Alvarez J, Sanchez LM, Quesada V, Bordallo J, Murphy G, Lopez-Otin C: Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem 2001, 276:10253-10262
40. Cleaver C, Rowan AD, Cawston TE: Interleukin-13 blocks the release of collagen fragments from bovine nasal cartilage treated with proinflammatory cytokines by preventing pro-collagenase activation. Ann Rheum Dis 2001, 60:150-157
41. Catrina A, Lampa J, Ernestam S, af Klint E, Bratt J, Klareskog L, Ulfgren AK: Anti-tumour necrosis factor (TNF)-α therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis. Rheumatology 2002, 41: 484-489
42. Brennan FM, Browne KA, Green PA, Jaspar JM, Maini RN, Feldmann M: Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-α, (cA2) therapy. Br J Rheumatol 1997, 36:643-650
43. Billington CJ, Clark IM, Cawston TE: An aggrecan-degrading activity associated with chondrocyte membranes. Biochem J 1998, 336:207-212
44. Jubb RW, Fell HB: The breakdown of collagen by chondrocytes. J Pathol 1980, 130:159-167
45. Milner JM, Elliott SF, Cawston TE: Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways. Arthritis Rheum 2001, 44: 2084-2096
46. Billinghurst RC, Dahlberg L, Ionescu Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, Van Wart H, Poole AR: Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997, 99:1534-1545
47. Suzuki K, Enghild JJ, Morodomi T, Salvesen G, Nagase H: Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry 1990, 29:10261-10270
48. Saito S, Katoh M, Masumoto M, Matsumoto S, Masuho Y: Involvement of MMP-1 and MMP-3 in collagen degradation induced by IL-1 in rabbit cartilage explant culture. Life Sci 1998, 62:359-365
49. Nagase H, Woessner JF Jr: Matrix metalloproteinases. J Biol Chem 1999, 274:21491-21494
50. Cawston TE, Ellis AJ, Bigg H, Curry V, Lean E, Ward D: Interleukin-4 blocks the release of collagen fragments from bovine nasal cartilage treated with cytokines. Biochim Biophys Acta 1996, 1314:226-232
51. Chang C, Werb Z: The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 2001, 11: S37-S43