Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells

Biomaterials

Volumn 31, Issue 4, 2010, Pages 730-740

  Yuan, Yuan ^a,c   Liu, Changsheng ^a,b,c   Qian, Jiangchao ^a   Wang, Jing ^b,c   Zhang, Yuan ^c  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b East China University of Science and Technology   (China)

^c East China University of Science and Technology   (China)

Author keywords

Apoptosis induction; Cytotoxicity; Human hepatoma HepG2 cells; Hydroxyapatite nanoparticles; Mitochondrial dependent pathway; Size mediated

Indexed keywords

CELL DEATH; CELLS; CYTOLOGY; CYTOTOXICITY; HYDROXYAPATITE; MITOCHONDRIA; NANOPARTICLES; PARTICLE SIZE; PROTEINS; SOL-GEL PROCESS; SOL-GELS; TUMORS;

APOPTOSIS INDUCTION; HEP-G2 CELLS; HYDROXYAPATITE NANOPARTICLES; MITOCHONDRIAL-DEPENDENT PATHWAYS; SIZE-MEDIATED;

CELL SIGNALING;

CASPASE 3; CASPASE 9; CYTOCHROME C; FLUORESCEIN ISOTHIOCYANATE; HYDROXYAPATITE; HYDROXYAPATITE NANOPARTICLE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; INITIATOR CASPASE; NANOPARTICLE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; GEL; HUMAN; HUMAN CELL; INTERNALIZATION; LIVER CELL CARCINOMA; MITOCHONDRION; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN SECRETION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASES, INITIATOR; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DURAPATITE; HUMANS; MITOCHONDRIA; NANOPARTICLES; PARTICLE SIZE; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 75549089439     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.09.088     Document Type: Article

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