New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 102-109

  Lolli, Marco L ^a   Giorgis, Marta ^a   Tosco, Paolo ^a   Foti, Antonio ^a   Fruttero, Roberta ^a   Gasco, Alberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Brequinar; Dihydroorotate dehydrogenase inhibitors; Hydroxyfurazan; Leflunomide

Indexed keywords

4 BENZYLOXY 1,2,5 OXADIAZOLE 3 CARBONYL CHLORIDE; 4 BENZYLOXY N (BIPHENYL 4 YL) 1,2,5 OXADIAZOLE 3 CARBOXAMIDE; 4 BENZYLOXY N [(1 TRIFLUOROMETHYL)PHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXAMIDE; 4 BENZYLOXY N [(2,3,5,6 TETRAFLUORO 3' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 BENZYLOXY N [(2,3,5,6 TETRAFLUORO 4' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 BENZYLOXY N [(2,3,5,6 TETRAFLUORO)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 BENZYLOXY N [(3,5 DIFLUORO 3' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 BENZYLOXY N [(3,5 DIFLUORO 4' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 BENZYLOXY N [(3,5 DIFLUORO)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 BENZYLOXY N [3' (TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N (BIPHENYL 2 YL) 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N (BIPHENYL 4 YL) 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(1 TRIFLUOROMETHYL)PHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(2,3,5,6 (TETRAFLUORO)BIPHENYL 4 YL)] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(2,3,5,6 TETRAFLUORO 3' TRIFLUOROMETHOXY)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(2,3,5,6 TETRAFLUORO 3' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(2,3,5,6 TETRAFLUORO 4' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(3,5 DIFLUORO 3' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(3,5 DIFLUORO 4' TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [(3,5 DIFLUORO)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [3' (TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; 4 HYDROXY N [4' (TRIFLUOROMETHYL)BIPHENYL 4 YL] 1,2,5 OXADIAZOLE 3 CARBOXYAMIDE; BIPHENYL DERIVATIVE; DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; FLUORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL INTERACTION; CONFORMATION; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORINATION; HYDROPHOBICITY; IC 50; LIVER MICROSOME; LIVER MITOCHONDRION; MICROSOME MEMBRANE; MOLECULAR MODEL; NONHUMAN; RAT; RING OPENING; SUBSTITUTION REACTION;

ANIMALS; BIPHENYL COMPOUNDS; ENZYME INHIBITORS; HALOGENATION; ISOXAZOLES; MALE; MICROSOMES, LIVER; MITOCHONDRIA, LIVER; MODELS, MOLECULAR; OXADIAZOLES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RATS; RATS, WISTAR;

EID: 84857234672     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.038     Document Type: Article

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