4-Hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

Journal of Medicinal Chemistry

Volumn 53, Issue 10, 2010, Pages 4110-4118

  Lolli, Marco L ^a   Giordano, Cecilia ^a   Pickering, Darryl S ^b   Rolando, Barbara ^a   Hansen, Kasper B ^b,c   Foti, Antonio ^a   Contreras Sanz, Alberto ^b   Amir, Ahmad ^b   Fruttero, Roberta ^a   Gasco, Alberto ^a   Nielsen, Birgitte ^b   Johansen, Tommy N ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO (4 HYDROXY 1,2,5 OXADIAZOL 3 YL)ACETIC ACID; 2 AMINO 3 (4 HYDROXYL 1,2,5 OXADIAZOL 3 YL)PROPIONIC ACID; 2 AMINO 4 (4 HYDROXY 1,2,5 OXADIAZOL 3 YL)BUTANOIC ACID; 2 AMINO 5 (4 HYDROXY 1,2,5 OXADIAZOL 3 YL)PENTANOIC ACID; AMPA RECEPTOR; CARBOXYLIC ACID DERIVATIVE; GLUTAMATE RECEPTOR; HETEROCYCLIC COMPOUND; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

AMINO ACIDS, ACIDIC; ANIMALS; BRAIN; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLUTAMIC ACID; MALE; OOCYTES; OXADIAZOLES; PATCH-CLAMP TECHNIQUES; POTENTIOMETRY; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 77952721574     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1001452     Document Type: Article

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