The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase

Biochemistry

Volumn 35, Issue 4, 1996, Pages 1270-1273

  Davis, June P ^a   Cain, Gary A ^a   Pitts, William J ^a   Magolda, Ronald L ^a   Copeland, Robert A ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREQUINAR; DIHYDROOROTATE DEHYDROGENASE; DRUG METABOLITE; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; OROTIC ACID DERIVATIVE; OXIDOREDUCTASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT PROTEIN; TERIFLUNOMIDE; UBIQUINONE;

ARTICLE; COMPETITIVE INHIBITION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; PRIORITY JOURNAL;

EID: 0030032806     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952168g     Document Type: Article

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