Nitrooxyacyl Derivatives of Salicylic Acid: Aspirin-Like Molecules that Covalently Inactivate Cyclooxygenase-1

ChemMedChem

Volumn 6, Issue 3, 2011, Pages 523-530

  Cena, Clara ^a   Tosco, Paolo ^a   Marini, Elisabetta ^a   Lazzarato, Loretta ^a   Piccinini, Marco ^a   Ramondetti, Cristina ^a   Lupino, Elisa ^a   Fruttero, Roberta ^a   Gasco, Alberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Cyclooxygenases; Inhibitors; NO donors; Reaction mechanisms; Site directed mutagenesis

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTITHROMBOCYTIC AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; NITRIC OXIDE; SALICYLIC ACID DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MODEL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; VASODILATATION;

ANTI-INFLAMMATORY AGENTS; ASPIRIN; CATALYTIC DOMAIN; CELL LINE; COMPUTER SIMULATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; HUMANS; PLATELET AGGREGATION INHIBITORS; RECOMBINANT PROTEINS; SALICYLIC ACID;

EID: 79952077671     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000397     Document Type: Article

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