Recent advances in antitubercular natural products

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 1-23

  García, Abraham ^a   Bocanegra García, Virgilio ^c   Palma Nicolás, Jose Prisco ^b   Rivera, Gildardo ^c  

^a UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^b INSTITUTO DE FISIOLOGÍA CELULAR   (Mexico)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Alkaloid; Antitubercular; Natural products; Peptide; Polyketide; Terpene

Indexed keywords

4 AMINOBENZOIC ACID; ACETYLENE DERIVATIVE; ALKALOID DERIVATIVE; ANTHRACENE DERIVATIVE; ANTHRAQUINONE DERIVATIVE; AROMATIC COMPOUND; BENZOFURAN DERIVATIVE; CHALCONE DERIVATIVE; CHROMENE DERIVATIVE; COUMARIN DERIVATIVE; DITERPENE; ESTER DERIVATIVE; FATTY ACID SYNTHASE INHIBITOR; FLAVONOID; HYDROQUINONE DERIVATIVE; LIGNAN DERIVATIVE; NAPHTHALENE DERIVATIVE; PEPTIDE DERIVATIVE; PHENOL DERIVATIVE; POLYKETIDE; QUINONE DERIVATIVE; RNA DIRECTED RNA POLYMERASE INHIBITOR; SESQUITERPENE DERIVATIVE; SESTERTERPENE; STEROID; TERPENE DERIVATIVE; TRITERPENE DERIVATIVE; TUBERCULOSTATIC AGENT; UNINDEXED DRUG; XANTHONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL GROWTH; BACTERIAL STRAIN; DRUG ISOLATION; DRUG STRUCTURE; FUNGUS; GROWTH INHIBITION; HUMAN; IC 50; IN VITRO STUDY; MARINE SPECIES; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLANT; REVIEW; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; BIOLOGICAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, BACTERIAL; HUMANS; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 84857231344     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.029     Document Type: Review

References (117)

1. World Health Organization WHO, http://whqlibdoc.who.int/publication/2010/ 9789241564069-eng.pdf.
2. T.R. Frieden, T.R. Sterling, S.S. Munsiff, C.J. Watt, and C. Dye Tuberculosis Lancet 362 2008 887 899
3. L.A. Kayukova, and K.D. Praliev Main directions in the search for new antituberculous drugs Pharm. Chem. J. 34 2000 11 18
4. G.A. Chung, Z. Aktar, S. Jackson, and K. Duncan High-throughput screen for detecting antimycobacterial agents Antimicrob. Agents Chemother. 39 1995 2235 2238
5. I. Orme Search for new drugs for treatment of tuberculosis Antimicrob. Agents Chemother. 45 2001 1943 1946 (Pubitemid 32591680)
6. R.P. Tripathi, N. Tewari, N. Dwivedi, and V.K. Tiwari Fighting tuberculosis: an old disease with new challenges Med. Res. Rev. 25 2005 93 131 (Pubitemid 39642233)
7. A. Nayyar, and R. Jain Recent advances in new structural classes of anti-tuberculosis agents Curr. Med. Chem. 12 2005 1873 1886 (Pubitemid 41015184)
8. B.R. Copp Antimycobacterial natural products Nat. Prod. Rep. 20 2003 535 557 (Pubitemid 38024760)
9. A.L. Okunade, M.P.F. Elvin-Lewis, and W.H. Lewis Natural antimycobacterial metabolites: current status Phytochemistry 65 2004 1017 1032 (Pubitemid 38542737)
10. B.R. Copp, and A.N. Pearce Natural product growth inhibitors of Mycobacterium tuberculosis Nat. Prod. Rep. 24 2007 278 297 (Pubitemid 46496562)
11. J.J. Chen, C.S. Yang, C.F. Peng, I.S. Chen, and C.L. Miaw Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica J. Nat. Prod. 71 2008 1016 1021
12. J.J. Chen, T.H. Chou, C.F. Peng, I.S. Chen, and S.Z. Yang Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis J. Nat. Prod. 70 2007 202 205
13. T. Bunyapaiboonsri, S. Veeranondha, T. Boonruangprapa, and S. Somrithipol Ramiferin, a bisphenol-sesquiterpene from the fungus Kionochaeta ramifera BCC 7585 Phytochem. Lett. 1 2008 204 206
14. P.S. Yang, M.J. Cheng, C.F. Peng, J.J. Chen, and I.S. Chen Endiandric acid analogues from the roots of Beilschmiedia erythrophloia J. Nat. Prod. 72 2009 53 58
15. S. Kanokmedhakul, K. Kanokmedhakul, and R. Lekphrom Bioactive constituents of the roots of Polyalthia cerasoides J. Nat. Prod. 70 2007 1536 1538 (Pubitemid 47584608)
16. N. Vongvanich, P. Kittakoop, P. Charoenchai, S. Intamas, K. Sriklung, and Y. Thebtaranonth Antiplasmodial, antimycobacterial, and cytitoxic principles from Camchaya calcarea Planta Med. 72 2006 1427 1430 (Pubitemid 46102401)
17. C.A. Ospina, and A.D. Rodríguez Corallolides A and B: bioactive diterpenes featuring a novel carbon skeleton Org. Lett. 11 2009 3786 3789
18. C.A. Ospina, A.D. Rodríguez, H. Zhao, and R.G. Raptis Bipinnapterolide B, a bioactive oxapolycyclic diterpene from the Colombian gorgonian coral Pseudopterogorgia bipinnata Tetrahedron Lett. 48 2007 7520 7523 (Pubitemid 47432782)
19. G.M. Molina-Salinas, J. Bórquez, A. Ardiles, S. Said-Fernández, L.A. Loyola, A. Yam-Puc, P. Becerril-Montes, F. Escalante-Erosa, A. San-Martin, I. González-Collado, and L.M. Peña-Rodríguez Bioactive metabolites from the Andean flora. Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids Phytochem. Rev. 9 2010 271 278
20. G.M. Molina-Salinas, J. Bórquez, A. Ardiles, S. Said-Fernández, L.A. Loyola, A. San-Martin, I. González-Collado, and L.M. Peña-Rodríguez Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids Fitoterapia 81 2010 50 54
21. G.M. Molina-Salinas, J. Bórquez, S. Said-Fernández, L.A. Loyola, A. Yam-Puc, P. Becerril-Montes, F. Escalante-Erosa, and L.M. Peña-Rodríguez Antituberculosis activity of alkylated mulinane diterpenoids Fitoterapia 81 2010 219 222
22. R. Lekphrom, S. Kanokmedhakul, and K. Kanokmedhakul Bioactive diterpenes from the aerial parts of Anisochilus harmandii Planta Med. 76 2010 726 728
23. P. Rijo, M.F. Simoes, A.P. Francisco, R. Rojas, R.H. Gilman, A.J. Vaisberg, B. Rodríguez, and C. Moiteiro Antimycobacterial metabolites from Plectranthus: royleanone derivatives against Mycobacterium tuberculosis strains Chem. Biodiv. 7 2010 922 932
24. A.A. Hussein, J.J. Meyer, M.L. Jimeno, and B. Rodríguez Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea J. Nat. Prod. 70 2007 293 295 (Pubitemid 46447647)
25. J.J. Chen, H.M. Wu, C.F. Peng, I.S. Chen, and S.D. Chu seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima J. Nat. Prod. 72 2009 223 228
26. J.M. Scher, A. Schinkovitz, J. Zapp, Y. Wang, S.G. Franzblau, H. Becker, D.C. Lankin, and G.F. Pauli Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia J. Nat. Prod. 73 2010 656 663
27. E.D. Coy, L.E. Cuca, and M. Sefkow Macrophyllin-type bicyclo[3.2.1] octanoid neolignans from the leaves of Pleurothyrium cinereum J. Nat. Prod. 72 2009 1245 1248
28. Y.P. Shi, X. Wei, I.I. Rodríguez, A.D. Rodríguez, and A.M.S. Mayer New terpenoid constituents of the Southwestern Caribbean sea whip Pseudopterogorgia elisabethae (Bayer), including a unique pentanorditerpene Eur. J. Org. Chem. 2009 493 502
29. S. Sutthivaiyakit, W. Mongkolvisut, S. Prabpai, and P. Kongsaeree Diterpenes, sesquiterpenes, and a sesquiterpene-coumarin conjugate from Jatropha integerrima J. Nat. Prod. 72 2009 2024 2027
30. W. Mongkolvisut, and S. Sutthivaiyakit Antimalarial and antituberculous poly-O-acylated jatrophane diterpenoids from Pedilanthus tithymaloides J. Nat. Prod. 70 2007 1434 1438 (Pubitemid 47584583)
31. A. Vik, A. James, and L.L. Gundersen Screnning of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranylacetate as potent inhibitors of Mycobacterium tuberculosis in vitro Planta Med. 73 2007 1410 1412 (Pubitemid 350084462)
32. J.J. Chen, W.J. Lin, P.C. Shieh, I.S. Chen, C.F. Peng, and P.J. Sung A new long-chain alkene and antituberculosis constituents from the leaves of Pourthiaea lucida Chem. Biodiv. 7 2010 717 721
33. R. Encarnación-Dimayuga, E.J. Agúndez, A. García, G. Delgado, G.M. Molina-Salinas, and S. Said-Fernández Two new cassane-type diterpenes from Calliandra californica Benth. (Fabaceae) with antituberculosis and cytotoxic activities Planta Med. 72 2006 757 761 (Pubitemid 44073462)
34. S. Mo, A. Krunic, S.D. Pegan, S.G. Franzblau, and J. Orjala An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp J. Nat. Prod. 72 2009 2043 2045
35. M. Isaka, S. Palasarn, S. Supothina, S. Komwijit, and J.J. Luangsa-Ard Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627 J. Nat. Prod. 74 2011 782 789
36. N.B. Truong, C.V. Pham, H.T.M. Doan, H.V. Nguyen, C.M. Nguyen, H.T. Nguyen, H.J. Zhang, H.H.S. Fong, S.G. Franzblau, D.D. Soejarto, and M.V. Chau Antituberculosis cycloartane triterpenoids from Radermachera boniana J. Nat. Prod. 74 2011 1318 1322
37. W. Maneerat, S. Laphookhieo, S. Koysomboon, and K. Chantrapromma Antimalarial, antimycobacterial and cytotoxic limonoids from Chisocheton siamensis Phytomedicine 15 2008 1130 1134
38. B.U. Jaki, S.G. Franzblau, L.R. Chadwick, D.C. Lankin, F. Zhang, Y. Wang, and G.F. Pauli Purity-activity relationships of natural Products: the case of anti-TB active ursolic acid J. Nat. Prod. 71 2008 1742 1748
39. R. Stanikunaite, M.M. Radwan, J.M. Trappe, F. Fronczek, and S.A. Ross Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity J. Nat. Prod. 71 2008 2077 2079
40. R. Rojas, L. Caviedes, J.C. Aponte, A.J. Vaisberg, W.H. Lewis, G. Lamas, C. Sarasara, R.H. Gilman, and G.B. Hammond Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera J. Nat. Prod. 69 2006 845 846 (Pubitemid 44021421)
41. P. Nareeboon, W. Kraus, U. Beifuss, J. Conrad, I. Klaiber, and S. Sutthivaiyakit Novel 24-nor-, 24-nor-2,3-seco-, and 3,24-dinor-2,4-seco-ursane triterpenes from Diospyros decandra: evidences for ring A biosynthetic transformations Tetrahedron 62 2006 5519 5526
42. D. Pattamadilok, and R. Suttisri seco-Terpenoids and other constituents from Elateriospermum tapos J. Nat. Prod. 71 2008 292 294 (Pubitemid 351362998)
43. J.C. Aponte, Y. Estevez, R.H. Gilman, W.H. Lewis, R. Rojas, M. Sauvain, A.J. Vaisberg, and G.B. Hammond Anti-infective and cytotoxic compounds present in Blepharodon nitidum Planta Med. 74 2008 407 410 (Pubitemid 351578798)
44. J.C. Noro, L.R. Barrows, O.G. Gideon, C.M. Ireland, M. Koch, T. Matainaho, P. Piskaut, C.D. Pond, and T.S. Bugni Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis J. Nat. Prod. 71 2008 1623 1624
45. J.J. Chen, E.T. Chou, C.F. Peng, I.S. Chen, S.Z. Yang, and H.Y. Huang Novel epoxyfuranoid lignans and antitubercular constituents from the leaves of Beilschmiedia tsangii Planta Med. 73 2007 567 571
46. R.J. Case, Y. Wang, S.G. Franzblau, D.D. Soejarto, L. Matainaho, P. Piskaut, and G.F. Pauli Advanced applications of counter-current chromatography in the isolation of anti-tuberculosis constituents from Dracaena angustifolia J. Chromatogr. A 1151 2007 169 174 (Pubitemid 46678999)
47. F. Cateni, B. Doljak, M. Zacchigna, M. Anderluh, A. Piltaver, G. Scialino, and E. Banfi New biologically active epidioxysterols from Stereum hirsutum Bioorg. Med. Chem. Lett. 17 2007 6330 6334 (Pubitemid 47552809)
48. X. Wei, A.D. Rodríguez, Y. Wang, and S.G. Franzblau Novel ring B abeo-sterols as growth inhibitors of Mycobacterium tuberculosis isolated from a Caribbean Sea sponge, Svenzea zeai Tetrahedron Lett. 48 2007 8851 8854 (Pubitemid 350103714)
49. S. Mo, A. Krunic, G. Chlipala, and J. Orjala Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua J. Nat. Prod. 72 2009 894 899
50. S. Mo, A. Krunic, B.D. Santarsiero, S.G. Franzblau, and J. Orjala Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua Phytochemistry 71 2010 2116 2123
51. E. Avilés, and A.D. Rodríguez Monamphilectine A, a potent antimalarial-lactam from marine sponge Hymeniacidon sp: isolation, structure, semisynthesis, and bioactivity Org. Lett. 12 2010 5290 5293
52. X. Wei, K. Nieves, and A.D. Rodríguez Neopetrosiamine A, biologically active bis-piperidine alkaloid from the Caribbean Sea sponge Neopetrosia proxima Bioorg. Med. Chem. Lett. 20 2010 5905 5908
53. M. Arai, M. Sobou, C. Vilcheze, A. Baughn, H. Hashizume, P. Pruksakorn, S. Ishida, M. Matsumoto, W.R. Jacobs, and M. Kobayashi Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent Bioorg. Med. Chem. 16 2008 6732 6736
54. D.R. Appleton, A.N. Pearce, and B.R. Copp Anti-tuberculosis natural products: synthesis and biological evaluation of pyridoacridone alkaloids related to ascididemin Tetrahedron 66 2010 4977 4986
55. J. Vicente, B. Vera, A.D. Rodríguez, I. Rodríguez-Escudero, and R.G. Raptis Euryjanicin A: a new cycloheptapeptide from the Caribbean marine sponge Prosuberites laughlini Tetrahedron Lett. 50 2009 4571 4574
56. K.A. El Sayed, A.A. Khalil, M. Yousaf, G. Labadie, G.M. Kumar, S.G. Franzblau, A.M.S. Mayer, M.A. Avery, and M.T. Hamann Semisynthetic studies on the manzamine alkaloids J. Nat. Prod. 71 2008 300 308 (Pubitemid 351549346)
57. H.M. Hua, J. Peng, D.C. Dunbar, R.F. Schinazi, A.G. de Castro Andrews, C. Cuevas, L.F. Garcia-Fernandez, M. Kelly, and M.T. Hamann Batzelladine alkaloids from the caribbean sponge Monanchora unguifera and the significant activities against HIV-1 and AIDS opportunistic infectious pathogens Tetrahedron 63 2007 11179 11188 (Pubitemid 47464400)
58. A. Aguinaldo, V.M. Dalangin-Mallari, A.P. Macabeo, L. Byrne, F. Abe, T. Yamauchi, and S.G. Franzblau Quinoline alkaloids from Lunasia amara inhibit Mycobacterium tuberculosis H37Rv in vitro Int. J. Antimicrob. Agents 29 2007 744 746 (Pubitemid 46722679)
59. H.Y. Huang, T. Ishikawa, C.F. Peng, I.L. Tsai, and I.S. Chen Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity J. Nat. Prod. 71 2008 1146 1151
60. J.H.H.L. de Oliveira, M.H.R. Seleghim, C. Timm, A. Grube, M. Köck, G.G.F. Nascimento, A.C.T. Martins, E.G.O. Silva, A.O. de Souza, P.R.R. Minarini, F.C.S. Galetti, C.L. Silva, E. Hadju, and R.G.S. Berlinck Antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge Pachychalina sp. Marine Drugs 4 2006 1 8 (Pubitemid 43763917)
61. M. Isaka, W. Prathumpai, P. Wongsa, and M. Tanticharoen Hirsutellone F, a dimer of antitubercular alkaloids from the seed fungus Trichoderma sp. BCC 7579 Org. Lett. 8 2006 2815 2817 (Pubitemid 44085874)
62. T. Thongthoom, U. Songsiang, C. Phaosiri, and C. Yenjai Biological activity of chemical constituents from Clausena harmandiana Arch. Pharm. Res. 33 2010 675 680
63. G. O'Donnell, R. Poeschl, O. Zimhony, M. Gunaratnam, J.B.C. Moreira, S. Neidle, D. Evangelopoulos, S. Bhakta, J.P. Malkinson, A. Lenaerts, and S. Gibbons Bioactive pyridine-N-oxide disulfides from Allium stipitatum J. Nat. Prod. 72 2009 360 365
64. L. Wirasathien, C. Boonarkart, T. Pengsuparp, and R. Suttisri Biological activities of alkaloids from Pseuduvaria setosa Pharm. Biol. 44 2006 274 278 (Pubitemid 43898442)
65. R.S. Lekphrom, and K. Kanokmedhakul Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus J. Ethnopharmacol. 125 2009 47 50
66. P. Tuntiwachwuttikul, P. Phansa, Y. Pootaengon, and W. Charles Chemical constituents of the roots of Piper sarmentosum Chem. Pharm. Bull. 54 2006 149 151 (Pubitemid 43200589)
67. S. Sutthivaiyakit, O. Thongnak, T.O. Lhinhatrakool, R. Srimark, P. Dowtaisong, and M. Chuankamnerdkarn Cytotoxic and antimycobacterial prenylated flavonoids from the roots of Eriosema chinense J. Nat. Prod. 72 2009 1092 1096
68. S. Koysomboon, I. van Altena, S. Kato, and K. Chantrapromma Antimycobacterial flavonoids from Derris indica Phytochemistry 67 2006 1034 1040 (Pubitemid 43766855)
69. U. Songsiang, S. Wanich, S. Pitchuanchom, S. Netsopa, K. Uanporn, and C. Yenjai Bioactive constituents from the stems of Dalbergia parviflora Fitoterapia 80 2009 427 431
70. C.C. Chiang, M.J. Cheng, C.F. Peng, H.Y. Huang, and I.S. Chen A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa Chem. Biodiv. 7 2010 1728 1736
71. N. Lall, A.A. Hussein, and J.J.M. Meyer Antiviral and antituberculous activity of Helichrysum melanacme constituents Fitoterapia 77 2006 230 232
72. P.C. Pan, M.J. Cheng, C.F. Peng, H.Y. Huang, J.J. Chen, and I.S. Chen Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity J. Nat. Prod. 73 2010 890 896
73. D. Lakshmanan, J. Werngren, J. Jose, K.P. Suja, M.S. Nair, R.L. Varma, S. Mundayoor, S. Hoffner, and R.A. Kumar Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro Fitoterapia 82 2011 757 761
74. D.K. Agrawal, D. Saikia, R. Tiwari, S. Ojha, K. Shanker, J.K. Kumar, A.K. Gupta, S. Tandon, A.S. Negi, S. Preet, and S. Khanuja Demethoxycurcumin and its semisynthetic analogues as antitubercular agents Planta Med. 74 2008 1828 1831
75. P. Arunrattiyakorn, S. Suksamrarn, N. Suwannasai, and H. Kanzaki Microbial metabolism of α-mangostin isolated from Garcinia mangostana L Phytochemistry 72 2011 730 734
76. Y. Chien, C. Peng, C. Lin, I. Chen, and I. Tsai Secondary metabolites from the root of Ehretia longiflora and their antitubercular activity Planta Med. 2010 76
77. P. Khumkomkhet, S. Kanokmedhakul, K. Kanokmedhakul, C. Hahnvajanawong, and K. Soytong Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense J. Nat. Prod. 72 2009 1487 1491
78. H.X. Liang, H.Q. Dai, H.A. Fu, X.P. Dong, H.A. Adebayo, L.X. Zhang, and Y.X. Cheng Bioactive compounds from Rumex plants Phytochem. Lett. 3 2010 181 184
79. P. Pittayakhajonwut, P. Sohsomboon, A. Dramae, R. Suvannakad, S. Lapanun, and M. Tantichareon Antimycobacterial substances from Phaeosphaeria sp BCC8292 Planta Med. 74 2008 281 286 (Pubitemid 351449952)
80. M. Sturdy, A. Krunic, S. Cho, S.G. Franzblau, and J. Orjala Eucapsitrione, an anti-Mycobacterium tuberculosis anthraquinone derivative from the cultured freshwater cyanobacterium Eucapsis sp J. Nat. Prod. 73 2010 1441 1443
81. C.C. Wu, C.F. Peng, I.L. Tsai, M.H.A. El-Razek, H.S. Huang, and I.S. Chen Secondary metabolites from the roots of Engelhardia roxburghiana and their antitubercular activities Phytochemistry 68 2007 1338 1343
82. N.B. Bapela, N. Lall, P.B. Fourie, S.G. Franzblau, and C.E.J. van Rensburg Activity of 7-methyljuglone in combination with antituberculous drugs against Mycobacterium tuberculosis Phytomedicine 13 2006 630 635 (Pubitemid 44666406)
83. N. Phonkerd, S. Kanokmedhakul, K. Kanokmedhakul, K. Soytong, S. Prabpai, and P. Kongsearee Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05 Tetrahedron 64 2008 9636 9645
84. S. Dettrakul, S. Surerum, S. Rajviroongit, and P. Kittakoop Biomimetic transformation and biological activities of globiferin, a terpenoid benzoquinone from Cordia globifera J. Nat. Prod. 72 2009 861 865
85. N. Joycharat, H. Greger, O. Hofer, and E. Saifah Flavaglines and triterpenoids from the leaves of Aglaia forbesii Phytochemistry 69 2008 206 211 (Pubitemid 350256782)
86. S. Boonphong, P. Puangsombat, A. Baramee, C. Mahidol, S. Ruchirawat, and P. Kittakoop Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities J. Nat. Prod. 70 2007 795 801 (Pubitemid 46953602)
87. P. Tuntiwachwuttikul, P. Phansa, Y. Pootaengon, and W. Charles Chromones from the branches of Harrisonia perforata Chem. Pharm. Bull. 54 2006 44 47 (Pubitemid 43036747)
88. J.S. Freundlich, M. Lalgondar, J.R. Wei, S. Swanson, E.J. Sorensen, E.J. Rubin, and J.C. Sacchettini The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis Tuberculosis 90 2010 298 300
89. C. Jiménez-Romero, I. Ortiz, J. Vicente, B. Vera, A.D. Rodríguez, S. Nam, and R. Jove Bioactive Cycloperoxides isolated from the Puerto Rican sponge Plakortis halichondrioides J. Nat. Prod. 73 2010 1694 1700
90. M. Koch, T.S. Bugni, C.D. Pond, M. Sondossi, M. Dindi, P. Piskaut, C.M. Ireland, and L.R. Barrows Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid Planta Med. 75 2010 1326 1330
91. T. Inui, Y. Wang, D. Nikolic, D.C. Smith, S.G. Franzblau, and G.F. Pauli Sesquiterpenes from Oplopanax horridus J. Nat. Prod. 73 2010 563 567
92. S. Deng, Y. Wang, T. Inui, S.N. Chen, N.R. Farnsworth, S. Cho, S.G. Franzblau, and G.F. Pauli Anti-TB polyynes from the roots of Angelica sinensis Phytother. Res. 22 2008 878 882
93. V. Rukachaisirikul, U. Sommart, S. Phongpaichit, J. Sakayaroj, and K. Kirtikara Metabolites from the endophytic fungus Phomopsis sp. PSU-D15 Phytochemistry 69 2008 783 787
94. J.F. Wang, H.Q. Dai, Y.L. Wei, H.J. Zhu, Y.M. Yan, Y.H. Wang, C.L. Long, H.M. Zhong, L.X. Zhang, and Y.X. Cheng Antituberculosis agents and an inhibitor of the p-aminobenzoic acid biosynthetic pathway from Hydnocarpus anthelminthica seeds Chem. Biodiv. 7 2010 2046 2053
95. N. Panthama, S. Kanokmedhakul, and K. Kanokmedhakul Polyacetylenes from the roots of Polyalthia debilis J. Nat. Prod. 73 2010 1366 1369
96. S. Kanokmedhakul, K. Kanokmedhakul, I. Kantikeaw, and N. Phonkerd 2-Substituted Furans from the roots of Polyalthia evecta J. Nat. Prod. 69 2006 68 72 (Pubitemid 43241757)
97. F. Cateni, J. Zilic, and M. Zacchigna Isolation and structure elucidation of cerebrosides from Euphorbia platyphyllos L Sci. Pharm. 76 2008 451 469
98. I. León-Rivera, G. Mirón-López, G.M. Molina-Salinas, M. Herrera-Ruiz, S. Estrada-Soto, M.C. Gutiérrez, D. Alonso-Cortes, G. Navarrete-Vázquez, M.Y.R. íos, and S. Said-Fernández J. Nat. Prod. 71 2008 1686 1691
99. N.K. Honda, F.R. Pavan, R.G. Coelho, S.R. de Andrade Leite, A.C. Micheletti, T.I.B. Lopes, M.Y. Misutsu, A. Beatriz, R.L. Brum, and C.Q.F. Leite Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system Phytomedicine 17 2010 328 332
100. N.R. Rangkaew, M. Moriyasu, and K. Kawanishi Antimycobacterial activity of lichen substances Arch. Pharm. Res. 32 2009 685 692
101. P. Pruksakorn, M. Arai, N. Kotoku, C. Vilchze, A.D. Baughn, P. Moodley, W.R. Jacobs Jr. , and M. Kobayashi Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria Bioorg. Med. Chem. Lett. 20 2010 3658 3663
102. R. Montaser, K.A. Abboud, V.J. Paul, and H. Luesch Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam J. Nat. Prod. 74 2011 109 112
103. Y. Xie, R. Chen, S. Si, C. Sun, and H. Xu A new nucleosidyl-peptide antibiotic, sansanmycin J. Antibiot. 60 2007 158 161
104. Y. Xie, H. Xu, C. Sun, Y. Yu, and R. Chen Two novel nucleosidyl-peptide antibiotics: sansanmycin F and G produced by Streptomyces sp SS J. Antibiot. 63 2010 143 146
105. A. Mukai, T. Fukai, Y. Hoshino, K. Yazawa, K.I. Harada, and Y. Mikami Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757 J. Antibiot. 62 2009 613 619
106. N. Koyama, S. Kojima, T. Fukuda, T. Nagamitsu, T. Yasuhara, S. O'mura, and H. Tomoda Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent Org. Lett. 12 2010 432 435
107. R. Haritakun, M. Sappan, R. Suvannakad, K. Tasanathai, and M. Isaka An antimycobacterial cyclodepsipeptide from the entomopathogenic fungus Ophiocordyceps communis BCC 16475 J. Nat. Prod. 73 2010 75 78
108. M. Isaka, P. Berkaew, K. Intereya, S. Komwijit, and T. Sathitkunanon Antiplasmodial and antiviral cyclohexadepsipeptides from the endophytic fungus Pullularia sp. BCC 8613 Tetrahedron 63 2007 6855 6860 (Pubitemid 46876650)
109. X. Huang, E. Roemer, I. Sattler, U. Moellmann, A. Christner, and S. Grabley Lydiamycins A-D: cyclodepsipetides with antimycobacterial properties Angew. Chem. Int. Ed. 45 2006 3067 3072 (Pubitemid 44099018)
110. M.T. Gutierrez-Lugo, and C.A. Bewley Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors Bioorg. Med. Chem. Lett. 21 2011 2480 2483
111. C.A. Machutta, G.R. Bommineni, S.R. Luckner, K. Kapilashrami, B. Ruzsicska, C. Simmerling, C. Kisker, and J. Tonge Slow onset inhibition of bacterial β-ketoacyl-acyl carrier protein synthases by thiolactomycin J. Biol. Chem. 285 2010 6161 6169
112. P. Kim, Y.M. Zhang, G. Shenoy, Q.A. Nguyen, H.I. Boshoff, U.H. Manjunatha, M.B. Goodwin, J. Lonsdale, A.C. Price, D.J. Miller, K. Duncan, S.W. White, C.O. Rock, C.E. Barry III, and C.S. Dowd Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli J. Med. Chem. 49 2006 159 171 (Pubitemid 43077329)
113. A.C. Giddens, L. Nielsen, H.I. Boshoff, D. Tasdemir, R. Perozzo, M. Kaiser, F. Wang, J.C. Sacchettini, and B.R. Copp Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities Tetrahedron 64 2008 1242 1249
114. M. Koch, T.S. Bugni, M. Sondossi, C.M. Ireland, and L.R. Barrows Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis Planta Med. 76 2010 1678 1682
115. D. Haebich, and F. von Nussbaum Lost in transcription-inhibition of RNA polymerase Angew. Chem. Int. Ed. 48 2009 3397 3400
116. H. Steinmetz, H. Irschik, B. Kunze, H. Reichenbach, G. Höfle, and R. Jansen Thuggacins, macrolide antibiotics active against Mycobacterium tuberculosis: isolation from myxobacteria, structure elucidation, conformation analysis and biosynthesis Chem. A Eur. J. 13 2007 5822 5832 (Pubitemid 47117404)
117. D. Müller, A. Krick, S. Kehraus, C. Mehner, M. Hart, F.C. Küpper, K. Saxena, H. Prinz, H. Schwalbe, P. Janning, H. Waldmann, and G.M. König Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity J. Med. Chem. 49 2006 4871 4878 (Pubitemid 44201045)