Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

Tetrahedron

Volumn 64, Issue 7, 2008, Pages 1242-1249

  Giddens, Anna C ^a   Nielsen, Lone ^a   Boshoff, Helena I ^b   Tasdemir, Deniz ^c   Perozzo, Remo ^d   Kaiser, Marcel ^e   Wang, Feng ^f   Sacchettini, James C ^f   Copp, Brent R ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^f TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Fatty acid biosynthesis; Leishmania; Marine natural product; Mycobacterium

Indexed keywords

3 HEXANOYL 4 HYDROXY 6 PENTYL 2 PYRONE; 3 HEXYL 4 METHOXY 6 PENTYL 2 PYRONE; 4 HYDROXY 6 PENTYL 2 PYRONE; 5 HEXANOYL 4 HYDROXY 6 PENTYL 2 PYRONE; 5 HEXYL 4 HYDROXY 6 PENTYL 2 PYRONE; 6 HEPTYL 3 HEXANOYL 4 HYDROXY 2 PYRONE; 6 HEPTYL 4 HYDROXY 2 PYRIDONE; 6 HEPTYL 4 HYDROXY 2 PYRONE; 6 HEPTYL 4 HYDROXY 3 OCTANOYL 2 PYRONE; ANTIINFECTIVE AGENT; BENZNIDAZOLE; CHLOROQUINE; FATTY ACID; ISONIAZID; MELARSOPROL; MILTEFOSINE; MITOMYCIN C; NATURAL PRODUCT; PODOPHYLLOTOXIN; PSEUDOPYRONINE A; PSEUDOPYRONINE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEISHMANIA DONOVANI; LEUKEMIA CELL LINE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RAT; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE;

LEISHMANIA DONOVANI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM;

EID: 37649012730     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.11.075     Document Type: Article

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