Quinoline alkaloids from Lunasia amara inhibit Mycobacterium tuberculosis H37Rv in vitro

International Journal of Antimicrobial Agents

Volumn 29, Issue 6, 2007, Pages 744-746

  Aguinaldo, Alicia M ^a   Dalangin Mallari, Victoria M ^a   Macabeo, Allan Patrick G ^a   Byrne, Lindsay T ^b   Abe, Fumiko ^c   Yamauchi, Tatsuo ^c   Franzblau, Scott G ^d  

^a UNIVERSITY OF SANTO TOMAS   (Philippines)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c FUKUOKA UNIVERSITY   (Japan)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHOXY 2 (3',4' METHYLENEDIOXY)PHENYLQUINOLINE; 4 METHOXY 2 PHENYLQUINOLINE; 7,8 METHYLENEDIOXYDICTAMINE; ACETIC ACID; ACETIC ACID ETHYL ESTER; ANTIMYCOBACTERIAL AGENT; BUTANOL; DICHLOROMETHANE; HEXANE; QUINOLINE DERIVATIVE; SILICA GEL; UNCLASSIFIED DRUG;

ACIDITY; BIOASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; INFRARED SPECTROSCOPY; LETTER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; SOLVENT EXTRACTION; ULTRAVIOLET SPECTROSCOPY;

ALKALOIDS; ANTITUBERCULAR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PLANT EXTRACTS; QUINOLINES; RUTACEAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34248164347     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.02.004     Document Type: Letter

References (10)

1. World Health Organization. Tuberculosis. Fact Sheet No. 104. Geneva, Switzerland: WHO; 2004.
2. Okunade A.L., Elvin-Lewis M.P.F., and Lewis W.H. Natural antimycobacterial metabolites: current status. Phytochemistry 65 (2004) 1017-1032
3. Copp B.R. Antimycobacterial natural products. Nat Prod Rep 20 (2003) 535-557
4. Aguinaldo A.M., and Chua N.M. Philippine medicinal plants active against Mycobacterium 607. Acta Manila Ser A 37 (1988) 81-84
5. Dalangin VM, Abe F, Yamauchi T, Byrne LT, Franzblau SG, Aguinaldo AM. Transactions of the National Academy of Science and Technology, Philippines. Bicutan, Taguig, Metro Manila: NAST, DOST; 1997.
6. Goodwin S., Smith A.F., Velasquez A.A., and Horning E.C. Alkaloids of Lunasia amara Blanco, Isolation studies. J Am Chem Soc 81 (1959) 6209-6213
7. Goodwin S., Smith A.F., and Horning E.C. Alkaloids of Lunasia amara, 4-methoxy-2-phenylquinoline. J Am Chem Soc 79 (1957) 2239-2241
8. Houghton P.J., Woldemariam T.Z., Watanabe Y., and Yates M. Activity against Mycobacterium tuberculosis of the alkaloid constituents of Angostura bark, Galipea officinalis. Planta Med 65 (1999) 250-254
9. Fischer N.H., Lu T., Cantrell C.L., Castañeda-Acosta J., Quijano L., and Franzblau S.G. Antimycobacterial evaluation of germacranolides. Phytochemistry 49 (1998) 559-564
10. Adams M., Wube A.A., Bucar F., Bauer R., Kunert O., and Haslinger E. Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds. Int J Antimicrob Agents 26 (2005) 262-264