Corallolides A and B: Bioactive diterpenes featuring a novel carbon skeleton

Organic Letters

Volumn 11, Issue 16, 2009, Pages 3786-3789

  Ospina, Claudia A ^a   Rodríguez, Abimael D ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; DITERPENE; TUBERCULOSTATIC AGENT;

ANIMAL; ANTHOZOA; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; ISOLATION AND PURIFICATION; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM;

ANIMALS; ANTHOZOA; ANTIMALARIALS; ANTITUBERCULAR AGENTS; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PLASMODIUM FALCIPARUM;

EID: 68949093547     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol901577a     Document Type: Article

References (12)

1. (a) Fenical, W. J. Nat. Prod. 1987, 50, 1001-1008.
2. (b) Rodríguez, A. D. Tetrahedron 1995, 51, 4571-4618.
3. Blunt, J. W.; Copp, B. R.; Hu, W.-P.; Munro, M. H. G.; Northcote, P. T.; Prinsep, M. R. Nat. Prod. Rep. 2009, 26, 170-244, and previous articles in this series.
4. (a) Heckrodt, T. J.; Mulzer, J. Top. Curr. Chem. 2005, 244, 1-41.
5. (b) Roethle, P. A.; Trauner, D. Nat. Prod. Rep. 2008, 25, 298-317.
6. (c) Berrue, F.; Kerr, R. G. Nat. Prod. Rep. 2009, 26, 681-710.
7. (a) Marrero, J.; Ospina, C. A.; Rodríguez, A. D.; Baran, P.; Zhao, H.; Franzblau, S. G.; Ortega-Barria, E. Tetrahedron 2006, 62, 6998-7008.
8. (b) Ospina, C. A.; Rodríguez, A. D.; Zhao, H.; Raptis, R. G. Tetrahedron Lett. 2007, 48, 7520-7523.
9. 6Na, 383.1471).
10. In some alkenes, coupling can occur between the C-H σ bonds on either side of the double bond. This type of coupling is generally very small or even nonexistent in most molecules, but it sometimes appears in NMR spectra; see: Jackman, L. M.; Sternhell, S. Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, 2nd ed.; Pergamon Press: New York, 1969; pp 316-328.
11. 6Na, 383.1471).
12. Erythrolide K, a diterpene isolated from the gorgonian coral Erythropodium caribaeorum, is based on a bicyclo[9.2.1]tetradecane ring system. Notwithstanding, the alkylation/substitution pattern about the corallolane skeleton is unprecedented in nature; see: Banjoo, D.; Maxwell, A. R.; Mootoo, B. S.; Lough, A. J.; McLean, S.; Reynolds, W. F. Tetrahedron Lett. 1998, 39, 1469-1472.