Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study

Diabetic Medicine

Volumn 25, Issue 4, 2008, Pages 400-406

  Ruchat, S M ^a   Loos, R J F ^b   Rankinen, T ^b   Vohl, M C ^c   Weisnagel, S J ^a,c   Despres J P ^a,d   Bouchard, C ^b   Perusse L ^a,c  

^a UNIVERSITÉ LAVAL   (Canada)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c LAVAL UNIVERSITY   (Canada)

^d LAVAL UNIVERSITY   (Canada)

Author keywords

Adiponectin; Adiponectin receptors; Glucose tolerance; Insulin secretion; Insulin sensitivity; Single nucleotide polymorphisms

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; C PEPTIDE; CYTOSINE; GLUCOSE; GUANINE; INSULIN; THYMINE;

ADIPOR1 GENE; ADIPOR2 GENE; ADULT; APM1 GENE; AREA UNDER THE CURVE; ARTICLE; CANADA; DIET RESTRICTION; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GLUCOSE TOLERANCE; HOMEOSTASIS; HOMOZYGOTE; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PATHOGENESIS; PHENOTYPE; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; ADIPOSE TISSUE; ADULT; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; EPIDEMIOLOGIC METHODS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; RECEPTORS, ADIPONECTIN; VARIATION (GENETICS);

EID: 41749089562     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2008.02396.x     Document Type: Article

References (37)

1. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993 329 : 1988 1992.
2. Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999 104 : 787 794.
3. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991 14 : 173 194.
4. Gil-Campos M, Canete RR, Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004 23 : 963 974.
5. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999 257 : 79 83.
6. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000 20 : 1595 1599.
7. Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003 361 : 226 228.
8. Vionnet N, Hani El H, Dupont S, Gallina S, Francke S, Dotte S et al. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 2000 67 : 1470 1480.
9. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 2000 97 : 14478 14483.
10. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005 26 : 439 451.
11. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002 8 : 1288 1295.
12. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001 7 : 941 946.
13. Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003 52 : 239 243.
14. Zhao YF, Chen C. Regulation of pancreatic beta-cell function by adipocytes. Sheng Li Xue Bao 2007 59 : 247 252.
15. Vasseur F, Meyre D, Froguel P. Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Rev Mol Med 2006 8 : 1 12.
16. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003 423 : 762 769.
17. Kharroubi I, Rasschaert J, Eizirik DL, Cnop M. Expression of adiponectin receptors in pancreatic beta cells. Biochem Biophys Res Commun 2003 312 : 1118 1122.
18. Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X et al. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance. Diabetes 2004 53 : 2132 2136.
19. Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S et al. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia 2004 47 : 816 820.
20. Crimmins NA, Martin LJ. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance. Obes Rev 2007 8 : 419 423.
21. Richardson DK, Schneider J, Fourcaudot MJ, Rodriguez LM, Arya R, Dyer TD et al. Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans. Diabetologia 2006 49 : 2317 2328.
22. Siitonen N, Pulkkinen L, Mager U, Lindstrom J, Eriksson JG, Valle TT et al. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Diabetologia 2006 49 : 1795 1805.
23. Collins SC, Luan J, Thompson AJ, Daly A, Semple RK, O'Rahilly S et al. Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations. Diabetologia 2007 50 : 555 562.
24. Weyer C, Tataranni PA, Bogardus C, Pratley RE. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 2001 24 : 89 94.
25. Bouchard C. Genetic epidemiology, association and sib-pair linkage: results from the Quebec Family Study. In : Bray G, Ryan D, eds. Molecular and Genetic Aspects of Obesity. Baton Rouge, LA : Louisiana State University Press, 1994, 470 481.
26. Rice T, Nadeau A, Perusse L, Bouchard C, Rao DC. Familial correlations in the Quebec family study: cross-trait familial resemblance for body fat with plasma glucose and insulin. Diabetologia 1996 39 : 1357 1364.
27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 : 412 419.
28. Cederholm J, Wibell L. Insulin release and peripheral sensitivity at the oral glucose tolerance test. Diabetes Res Clin Pract 1990 10 : 167 175.
29. Bergstrom RW, Wahl PW, Leonetti DL, Fujimoto WY. Association of fasting glucose levels with a delayed secretion of insulin after oral glucose in subjects with glucose intolerance. J Clin Endocrinol Metab 1990 71 : 1447 1453.
30. Bergman RN, Ader M, Huecking K, Van Citters G. Accurate assessment of beta-cell function: the hyperbolic correction. Diabetes 2002 51 (Suppl. 1 212 220.
31. Loos RJ, Ruchat S, Rankinen T, Tremblay A, Perusse L, Bouchard C. Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study. Am J Clin Nutr 2007 85 : 26 34.
32. Devlin B, Risch N. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 1995 29 : 311 322.
33. Zacharova J, Chiasson JL, Laakso M. The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2005 54 : 893 899.
34. Fumeron F, Aubert R, Siddiq A, Betoulle D, Pean F, Hadjadj S et al. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 2004 53 : 1150 1157.
35. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 51 : 536 540.
36. Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P et al. Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes 2006 55 : 523 529.
37. Comuzzie AG, Tejero ME, Funahashi T, Martin LJ, Kissebah A, Takahashi M et al. The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes. Hum Biol 2007 79 : 191 200.