Genetic variation in adipokine genes and risk of colorectal cancer

European Journal of Endocrinology

Volumn 160, Issue 6, 2009, Pages 933-940

  Pechlivanis, Sonali ^a   Bermejo, Justo Lorenzo ^a,b   Pardini, Barbara ^c   Naccarati, Alessio ^c   Vodickova, Ludmila ^c,d   Novotny, Jan ^e   Hemminki, Kari ^a,f   Vodicka, Pavel ^c   Försti, Asta ^a,f  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^d NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^e CHARLES UNIVERSITY   (Czech Republic)

^f KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; LEPTIN; LEPTIN RECEPTOR; RESISTIN;

ACADEMIC ACHIEVEMENT; ADULT; AGED; ARTICLE; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; COLORECTAL TUMOR; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED;

ADIPOKINES; ADIPONECTIN; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; LEPTIN; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEPTIN; RESISTIN;

EID: 66149128387     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-09-0039     Document Type: Article

References (51)

1. Calle EE & Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Reviews. Cancer 2004 4 579-591.
2. Moghaddam AA, Woodward M & Huxley R. Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events. Cancer Epidemiology, Biomarkers and Prevention 2007 16 2533-2547.
3. Austin MA, Friedlander Y, Newman B, Edwards K, Mayer-Davis EJ & King MC. Genetic influences on changes in body mass index: a longitudinal analysis of women twins. Obesity Research 1997 5 326-331.
4. Rice T, Perusse L, Bouchard C & Rao DC. Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Quebec family study. Genetic Epidemiology 1999 16 316-334.
5. Rankinen T, Zuberi A, Chagnon YC,Weisnagel SJ, Argyropoulos G, Walts B, Perusse L & Bouchard C. The human obesity gene map: the 2005 update. Obesity 2006 14 529-644.
6. Trujillo ME & Scherer PE. Adipose tissue-derived factors: impact on health and disease. Endocrine Reviews 2006 27 762-778.
7. Korner A, Bluher S, Kapellen T, Garten A, Klammt J, Kratzsch J & Kiess W. Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges. Hormones 2005 4 189-199.
8. Garofalo C & Surmacz E. Leptin and cancer. Journal of Cellular Physiology 2006 207 12-22.
9. Fantuzzi G. Adipose tissue, adipokines, and inflammation. Journal of Allergy and Clinical Immunology 2005 115 911-919.
10. Hardwick JC, Van Den Brink GR, Offerhaus GJ, Van Deventer SJ & Peppelenbosch MP. Leptin is a growth factor for colonic epithelial cells. Gastroenterology 2001 121 79-90.
11. Rouet-Benzineb P, Aparicio T, Guilmeau S, Pouzet C, Descatoire V, Buyse M & Bado A. Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-κB signaling. Journal of Biological Chemistry 2004 279 16495-16502.
12. Stattin P, Lukanova A, Biessy C, Soderberg S, Palmqvist R, Kaaks R, Olsson T & Jellum E. Obesity and colon cancer: does leptin provide a link? International Journal of Cancer 2004 109 149-152.
13. Stattin P, Palmqvist R, Soderberg S, Biessy C, Ardnor B, Hallmans G, Kaaks R & Olsson T. Plasma leptin and colorectal cancer risk: a prospective study in Northern Sweden. Oncology Reports 2003 10 2015-2021.
14. Stocks T, Lukanova A, Johansson M, Rinaldi S, Palmqvist R, Hallmans G, Kaaks R & Stattin P. Components of the metabolic syndrome and colorectal cancer risk; a prospective study. International Journal of Obesity 2008 32304-314.
15. Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y & Tamakoshi A. Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Oncology 2005 68 454-461.
16. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR,Wright CM, Patel HR, Ahima RS & Lazar MA. The hormone resistin links obesity to diabetes. Nature 2001 409 307-312.
17. Wagsater D, Mumtaz M, Lofgren S, Hugander A & Dimberg J. Resistin in human colorectal cancer: increased expression independently of resistin promoter -420C>G genotype. Cancer Investigation 2008 26 1008-1014.
18. Ferroni P, Palmirotta R, Spila A, Martini F, Raparelli V, Fossile E, Mariotti S, Del Monte G, Buonomo O, Roselli M & Guadagni F. Prognostic significance of adiponectin levels in non-metastatic colorectal cancer. Anticancer Research 2007 27 483-489.
19. Wei EK, Giovannucci E, Fuchs CS, Willett WC & Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. Journal of the National Cancer Institute 2005 97 1688-1694.
20. Lukanova A, Soderberg S, Kaaks R, Jellum E & Stattin P. Serum adiponectin is not associated with risk of colorectal cancer. Cancer Epidemiology, Biomarkers and Prevention 2006 15 401-402.
21. Hoffstedt J, Eriksson P, Mottagui-Tabar S & Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Hormone and Metabolic Research 2002 34 355-359.
22. Le Stunff C, Le Bihan C, Schork NJ & Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 2000 49 2196-2200.
23. Li WD, Reed DR, Lee JH, Xu W, Kilker RL, Sodam BR & Price RA. Sequence variants in the 50 flanking region of the leptin gene are associated with obesity in women. Annals of Human Genetics 1999 63 227-234.
24. Mammes O, Betoulle D, Aubert R, Giraud V, Tuzet S, Petiet A, Colas-Linhart N & Fumeron F. Novel polymorphisms in the 5′ region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity. Diabetes 1998 47 487-489.
25. Mammes O, Betoulle D, Aubert R, Herbeth B, Siest G & Fumeron F. Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Annals of Human Genetics 2000 64 391-394.
26. Portoles O, Sorli JV, Frances F, Coltell O, Gonzalez JI, Saiz C & Corella D. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. European Journal of Epidemiology 2006 21 605-612.
27. Quinton ND, Lee AJ, Ross RJ, Eastell R & Blakemore AI. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Human Genetics 2001 108 233-236.
28. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D & Mantzoros CS. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. Journal of Clinical Endocrinology and Metabolism 2001 86 4434-4439.
29. Chiu KC, Chu A, Chuang LM & Saad MF. Association of leptin receptor polymorphism with insulin resistance. European Journal of Endocrinology 2004 150 725-729.
30. Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sorensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Gropp E & Allison DB. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. International Journal of Obesity and Related Metabolic Disorders 2002 26 640-646.
31. Paracchini V, Pedotti P & Taioli E. Genetics of leptin and obesity: a HuGE review. American Journal of Epidemiology 2005 162 101-114.
32. Smith SR, Bai F, Charbonneau C, Janderova L & Argyropoulos G. A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Diabetes 2003 52 1611-1618.
33. Engert JC, Vohl MC,Williams SM, Lepage P, Loredo-Osti JC, Faith J, Dore C, Renaud Y, Burtt NP, Villeneuve A, Hirschhorn JN, Altshuler D, Groop LC, Despres JP, Gaudet D & Hudson TJ. 5′ Flanking variants of resistin are associated with obesity. Diabetes 2002 51 1629-1634.
34. Wang H, Chu WS, Hemphill C & Elbein SC. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. Journal of Clinical Endocrinology and Metabolism 2002 87 2520-2524.
35. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T & Froguel P. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Human Molecular Genetics 2002 11 2607-2614.
36. Bouatia-Naji N, Meyre D, Lobbens S, Seron K, Fumeron F, Balkau B, Heude B, Jouret B, Scherer PE, Dina C, Weill J & Froguel P. ACDC/ adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006 55 545-550.
37. Pollin TI, Tanner K, O'Connell JR, Ott SH, Damcott CM, Shuldiner AR, McLenithan JC & Mitchell BD. Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes 2005 54 268-274.
38. Vasseur F, Helbecque N, Lobbens S, Vasseur-Delannoy V, Dina C, Clement K, Boutin P, Kadowaki T, Scherer PE & Froguel P. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia 2005 48 892-899.
39. Pechlivanis S, Pardini B, Bermejo JL, Wagner K, Naccarati A, Vodickova L, Novotny J, Hemminki K, Vodicka P & Forsti A. Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. Endocrine-Related Cancer 2007 14 733-740.
40. Akaike H. Information theory and an extension of the maximum likelihood principle. Second International Symposium on Information Theory Budapest Akademiai Kiado 1973 pp 267-281.
41. Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF & Moore JH. Multifactor-dimensionality reduction reveals highorder interactions among estrogen-metabolism genes in sporadic breast cancer. American Journal of Human Genetics 2001 69 138-147.
42. Conneely KN, Silander K, Scott LJ, Mohlke KL, Lazaridis KN, Valle TT, Tuomilehto J, Bergman RN, Watanabe RM, Buchanan TA, Collins FS & Boehnke M. Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia 2004 47 1782-1788.
43. Marchini J, Donnelly P & Cardon LR. Genome-wide strategies for detecting multiple loci that influence complex diseases. Nature Genetics 2005 37 413-417.
44. Motsinger-Reif AA, Reif DM, Fanelli TJ & Ritchie MD. A comparison of analytical methods for genetic association studies. Genetic Epidemiology 2008 32 767-778.
45. Bermejo JL & Hemminki K. Gene-environment studies: any advantage over environmental studies? Carcinogenesis 2007 28 1526-1532.
46. Cordell HJ & Clayton DG. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. American Journal of Human Genetics 2002 70 124-141.
47. Lusis AJ, Attie AD & Reue K. Metabolic syndrome: from epidemiology to systems biology. Nature Reviews. Genetics 2008 9 819-830.
48. Ho GY, Melman A, Liu SM, Li M, Yu H, Negassa A, Burk RD, Hsing AW, Ghavamian R & Chua SC Jr. Polymorphism of the insulin gene is associated with increased prostate cancer risk. British Journal of Cancer 2003 88 263-269.
49. Bennett ST & Todd JA. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annual Review of Genetics 1996 30 343-370.
50. Coussens LM & Werb Z. Inflammation and cancer. Nature 2002 420 860-867.
51. Slattery ML, Wolff RK, Herrick J, Caan BJ & Potter JD. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. International Journal of Cancer 2008 122 1611-1617.