Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: The IRAS Family Study

Diabetes

Volumn 55, Issue 6, 2006, Pages 1723-1730

  Guo, Xiuqing ^a,b   Saad, Mohammed F ^b   Langefeld, Carl D ^c   Williams, Adrienne H ^c   Cui, Jinrui ^a   Taylor, Kent D ^a,b   Norris, Jill M ^d   Jinagouda, Sujata ^b   Darwin, Christine H ^b   Mitchell, Braxton D ^e   Bergman, Richard N ^f   Sutton, Beth ^c   Chen, Y D Ida ^a,b   Wagenknecht, Lynne E ^c   Bowden, Donald W ^c   Rotter, Jerome I ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

IBD, identity by descent; IRASFS, Insulin Resistance Atherosclerosis Study Family Study; LD, linkage disequilibrium; LOD, logarithm of odds; QTL, quantitative trait locus; SNP, single nucleotide polymorphism; SOLAR, Sequential Oligogenic Analysis Routines

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; TRIACYLGLYCEROL;

AFRICAN AMERICAN; ARTICLE; BODY MASS; CHROMOSOME 3Q; CHROMOSOME ANALYSIS; CONTROLLED STUDY; GENE LOCUS; GENETIC LINKAGE; GENOTYPE; HEREDITY; HISPANIC; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN RESISTANCE; POPULATION GENETIC PARAMETERS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; ADULT; AFRICAN AMERICANS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; DIABETES MELLITUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOTYPE; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI;

EID: 33748295594     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-0428     Document Type: Article

References (29)

1. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599, 2000
2. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA: Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935, 2001
3. Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, Chen CL, Tai TY, Chuang LM: Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab 86:3815-3819, 2001
4. Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A: The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 86:4321-4325, 2001
5. Lindsay RS, Funahashi T, Krakoff J, Matsuzawa Y, Tanaka S, Kobes S, Bennett PH, Tataranni PA, Knowler WC, Hanson RL: Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 52:2419-2425, 2003
6. Chuang LM, Chiu YF, Sheu WH, Hung YJ, Ho LT, Grove J, Rodriguez B, Quertermous T, Chen YD, Hsiung CA, Tai TY: Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin. J Clin Endocrinol Metab 89:5772-5778, 2004
7. Pollin TI, Tanner K, O'Connell JR, Ott SH, Damcott CM, Shuldiner AR, McLenithan JC, Mitchell BD: Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes 54:268-274, 2005
8. Henkin L, Bergman RN, Bowden DW, Ellsworth DL, Haffner SM, Langefeld CD, Mitchell BD, Norris JM, Rewers M, Saad MF, Stamm E, Wagenknecht LE, Rich SS: Genetic epidemiology of insulin resistance and visceral adiposity: the IRAS Family Study design and methods. Ann Epidemiol 13:211-217, 2003
9. Wagenknecht L, Mayer E, Rewers M, Haffner S, Selby J, Borok G, Henkin L, Howard G, Savage PJ, Saad M, Bergman RN, Hamman R: The Insulin Resistance Atherosclerosis Study (IRAS): objectives, design, and recruitment results. Ann Epidemiol 5:464-472, 1995
10. O'Connell JR, Weeks DE: PedCheck: a program for identifying marker typing incompatibilities in linkage analysis (Abstract). Am J Hum Genet 61(Suppl. 4):A288, 1997
11. McPeek MS, Sun L: Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66:1076-1094, 2000
12. Heath SC: Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am J Hum Genet 61:748-760, 1997
13. Heath SC, Snow SL, Thompson EA, Tseng C, Wijsman EM: MCMC segregation and linkage analysis. Genet Epidemiol 14:1011-1015, 1997
14. Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, Shimomura I, Hotta K, Kuriyama H, Kihara S, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y: Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes Relat Metab Disord 24:861-868, 2000
15. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T: Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536-540, 2002
16. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P: Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11:2607-2614, 2002
17. Sutton BS, Weinert S, Langefeld CD, Williams AH, Campbell JK, Saad MF, Haffner SM, Norris JM, Bowden DW: Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study. Hum Genet 117:107-118, 2005
18. Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F, Haring H: Association of the TG polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51:37-41, 2002
19. Liang KY, Zegar SL: Longitudinal data analysis using generalized linear models. Biometrika 73:13-22, 1986
20. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211, 1998
21. Blangero J, Williams JT, Almasy L: Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol 19 (Suppl. 1):S8-S14, 2000
22. Blangero J, Williams JT, Almasy L: Variance component methods for detecting complex trait loci. Adv Genet 42:151-181, 2001
23. Dudbridge F: Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-121, 2003
24. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946, 2001
25. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG: Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 97:14478-14483, 2000
26. Vionnet N, Hani El-H, Dupont S, Gallina S, Francke S, Dotte S, De Matos F, Durand E, Lepretre F, Lecoeur C, Gallina P, Zekiri L, Dina C, Froguel P: Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67:1470-1480,2000
27. Fumeron F, Aubert R, Siddiq A, Betoulle D, Pean F, Hadjadj S, Tichet J, Wilpart E, Chesnier MC, Balkau B, Froguel P, Marre M, the Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group: Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the Epidemiologic Data on the Insulin Resistance Syndrome prospective study. Diabetes 53:1150-1157, 2004
28. Ohashi K, Ouchi N, Kihara S, Funahashi T, Nakamura T, Sumitsuji S, Kawamoto T, Matsumoto S, Nagaretani H, Kumada M, Okamoto Y, Nishizawa H, Kishida K, Maeda N, Hiraoka H, Iwashima Y, Ishikawa K, Ohishi M, Katsuya T, Rakugi H, Ogihara T, Matsuzawa Y: Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol 43:1195-1200, 2004
29. Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE: Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 279:12152-12162, 2004