Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women

European Journal of Endocrinology

Volumn 161, Issue 6, 2009, Pages 845-852

  Melistas, Labros ^a   Mantzoros, Christos S ^b   Kontogianni, Meropi ^a   Antonopoulou, Smaragdi ^a   Ordovas, Jose M ^c   Yiannakouris, Nikos ^a  

^a HAROKOPIO UNIVERSITY   (Greece)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GUANINE; THYMINE;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENOTYPE; GREECE; HETEROZYGOSITY; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GREECE; HUMANS; INSULIN RESISTANCE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 72949108241     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-09-0492     Document Type: Article

References (41)

1. Gable DR, Hurel SJ & Humphries SE. Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease. Atherosclerosis 2006 188 231-244.
2. Whitehead JP, Richards AA, Hickman IJ, Macdonald GA & Prins JB. Adiponectin - a key adipokine in the metabolic syndrome. Diabetes, Obesity and Metabolism 2006 8 264-280.
3. Sheng T & Yang K. Adiponectin and its association with insulin resistance and type 2 diabetes. Journal of Genetics and Genomics 2008 35 321-326.
4. Oh DK, Ciaraldi T & Henry RR. Adiponectin in health and disease. Diabetes, Obesity and Metabolism 2007 9 282-289.
5. Ahima RS. Adipose tissue as an endocrine organ. Obesity 2006 14 242S-249S.
6. Wannamethee SG, Lowe GD, Rumley A, Cherry L, Whincup PH & Sattar N. Adipokines and risk of type 2 diabetes in older men. Diabetes Care 2007 30 1200-1205.
7. Heidemann C, Sun Q, van Dam RM, Meigs JB, Zhang C, Tworoger SS, Mantzoros CS & Hu FB. Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Annals of Internal Medicine 2008 149 307-316.
8. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P & Kadowaki T. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 51 536-540.
9. von Eynatten M, Humpert PM, Bluemm A, Lepper PM, Hamann A, Allolio B, Nawroth PP, Bierhaus A & Dugi KA. High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men. Atherosclerosis 2008 199 123-128.
10. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V & Doria A. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002 51 2306-2312.
11. Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F & Haring H. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002 51 37-41.
12. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Leprêtre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T & Froguel P. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Human Molecular Genetics 2002 11 2607-2614.
13. Ukkola O, Ravussin E, Jacobson P, Sjostrom L & Bouchard C. Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort. Metabolism 2003 52 881-884.
14. Qi L, Doria A, Manson JE, Meigs JB, Hunter D, Mantzoros CS & Hu FB. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes 2006 55 1512-1516.
15. Tankó LB, Siddiq A, Lecoeur C, Larsen PJ, Christiansen C,Walley A & Froguel P. ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity. Obesity Research 2005 13 2113-2121.
16. Yang WS & Chuang LM. Human genetics of adiponectin in the metabolic syndrome. Journal of Molecular Medicine 2006 84 112-121.
17. Jang Y, Chae JS, Koh SJ, Hyun YJ, Kim JY, Jeong YJ, Park S, Ahn CM & Lee JH. The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women. Clinica Chimica Acta 2008 391 85-90.
18. Menzaghi C, Trischitta V & Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 2007 56 1198-1209.
19. Yang WS, Tsou PL, Lee WJ, Tseng DL, Chen CL, Peng CC, Lee KC, Chen MJ, Huang CJ, Tai TY & Chuang LM. Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity. Journal of Molecular Medicine 2003 81 428-434.
20. Xita N, Georgiou I, Chatzikyriakidou A, Vounatsou M, Papassotiriou GP, Papassotiriou I & Tsatsoulis A. Effect of adiponectin gene polymorphisms on circulating adiponectin and insulin resistance indexes in women with polycystic ovary syndrome. Clinical Chemistry 2005 51 416-423.
21. Gonzalez-Sanchez JL, Zabena CA, Martinez-Larrad MT, Fernandez-Perez C, Perez-Barba M, Laakso M & Serrano-Rios M. An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obesity Research 2005 13 807-812.
22. Filippi E, Sentinelli F, Romeo S, Arca M, Berni A, Tiberti C, Verrienti A, Fanelli M, Fallarino M, Sorropago G & Baroni MG. The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age
23. Kyriakou T, Collins LJ, Spencer-Jones NJ, Malcolm C, Wang X, Snieder H, Swaminathan R, Burling KA, Hart DJ, Spector TD & O'Dell SD. Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. Journal of Human Genetics 2008 53 718-727.
24. Salmenniemi U, Zacharova J, Ruotsalainen E, Vauhkonen I, Pihlajamaki J, Kainulainen S, Punnonen K & Laakso M. Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients. Journal of Clinical Endocrinology and Metabolism 2005 90 4216-4223.
25. Filippi E, Sentinelli F, Trischitta V, Romeo S, Arca M, Leonetti F, Di Mario U & Baroni MG. Association of the human adiponectin gene and insulin resistance. European Journal of Human Genetics 2004 12 199-205.
26. Szopa M, Malczewska-Malec M, Wilk B, Skupien J, Wolkow P, Malecki MT & Sieradzki J. Variants of the adiponectin gene and type 2 diabetes in a Polish population. Acta Diabetologica, 2009. In Press. DOI: 10.1007/s00592-008-0091-2.
27. Jang Y, Lee JH, Chae JS, Kim OY, Koh SJ, Kim JY, Cho H, Lee JE & Ordovas JM. Association of the 276G/T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans. American Journal of Clinical Nutrition 2005 82 760-767.
28. Jang Y, Lee JH, Kim OY, Koh SJ, Chae JS, Woo JH, Cho H, Lee JE & Ordovas JM. The SNP276G>T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism 2006 55 59-66.
29. Ishibashi K, Takamura N, Aoyagi K, Yamasaki H, Abiru N, Nakazato M, Kamihira S & Maeda T. Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas. Clinical Chemistry and Laboratory Medicine 2007 45 1457-1463.
30. Gonzalez Estrada M, Rodriguez Ferrer CR, Astarloa IR & Lahera EM. Use of serum cholesterol/triglyceride ratio to discern for which individuals the Friedewald formula can be used confidently. Clinical Chemistry 1990 36 1673-1675.
31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF & Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985 28 412-419.
32. Excoffier L & Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Molecular Biology and Evolution 1995 12 921-927.
33. Vasseur F, Meyre D & Froguel P. Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies. Expert Reviews in Molecular Medicine 2006 8 1-12.
34. Hu FB, Doria A, Li T, Meigs JB, Liu S, Memisoglu A, Hunter D & Manson JE. Genetic variation at the adiponectin locus and risk of type 2 diabetes in women. Diabetes 2004 53 209-213.
35. Richardson DK, Schneider J, Fourcaudot MJ, Rodriguez LM, Arya R, Dyer TD, Almasy L, Blangero J, Stern MP, Defronzo RA, Duggirala R & Jenkinson CP. Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans. Diabetologia 2006 49 2317-2328.
36. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J & Comuzzie AG. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. PNAS 2000 97 14478-14483.
37. Vionnet N, Hani EH, Dupont S, Gallina S, Francke S, Dotte S, De Matos F, Durand E, Leprêtre F, Lecoeur C, Gallina P, Zekiri L, Dina C & Froguel P. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. American Journal of Human Genetics 2000 67 1470-1480.
38. Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL & Bell GI. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nature Genetics 2000 26 163-175.
39. Comuzzie AG, Funahashi T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D & Kissebah A. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 2001 86 4321-4325.
40. Lindsay RS, Funahashi T, Krakoff J, Matsuzawa Y, Tanaka S, Kobes S, Bennett PH, Tataranni PA, Knowler WC & Hanson RL. Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 2003 52 2419-2425.
41. Shin MJ, Jang Y, Koh SJ, Chae JS, Kim OY, Lee JE, Ordovas JM & Lee JH. The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. International Journal of Obesity 2006 30 1702-1708.