Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage

Neuropharmacology

Volumn 62, Issue 5-6, 2012, Pages 1954-1963

  Marolda, R ^a   Ciotti, M T ^a   Matrone, C ^a   Possenti, R ^a,b   Calissano, P ^c   Cavallaro, S ^d   Severini, C ^e  

^a CNR   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^d INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

^e INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

Author keywords

Alzheimer's disease; Cerebellar granule cells; sAPP ; Substance P

Indexed keywords

ADAM PROTEIN; ADAM9 PROTEIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; MESSENGER RNA; NEUROKININ 1 RECEPTOR; POTASSIUM; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL FUNCTION; CEREBELLUM GRANULE CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GRANULE CELL; INCUBATION TIME; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PROCESSING; RAT; STEADY STATE; UPREGULATION;

ADAM PROTEINS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; NEURONS; RATS; SUBSTANCE P;

EID: 84857047324     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.12.025     Document Type: Article

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