Quinols as novel therapeutic agents. 7. Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions

Journal of Medicinal Chemistry

Volumn 50, Issue 7, 2007, Pages 1707-1710

  McCarroll, Andrew J ^a   Bradshaw, Tracey D ^a   Westwell, Andrew D ^a,b   Matthews, Charles S ^a   Stevens, Malcolm F G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 IODOANILINE; 4 (1 BENZENESULFONYL 6 FLUORO 1H INDOL 2 YL) 4 HYDROXYCYCLOHEXA 2,5 DIEN 1 ONE; 4 ETHYNYL 4 HYDROXYCYCLOHEXA 2,5 DIEN 1 ONE; 4 HYDROXYCYCLOHEXA 2,5 DIEN 1 ONE DERIVATIVE; ALKYNE DERIVATIVE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; IODINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HCT116; CELL STRAIN HT29; CELL STRAIN MCF 7; CULTURE MEDIUM; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MELANOMA CELL; MICROWAVE IRRADIATION; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SONOGASHIRA REACTION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLOHEXENES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; KIDNEY NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 34147180527     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061163m     Document Type: Article

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