메뉴 건너뛰기




Volumn 86, Issue 2, 2012, Pages 293-304

A potential human hepatocellular carcinoma inhibitor from Bauhinia purpurea L. seeds: From purification to mechanism exploration

Author keywords

Apoptosis; Bauhinia purpurea L.; Cytokine; Liver cancer; Trypsin inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; BAUHINIA PURPUREA EXTRACT; BAUHINIA PURPUREA TRYPSIN INHIBITOR; CHYMOTRYPSIN A; DITHIOTHREITOL; INTERLEUKIN 1BETA; PROTEINASE; SOYBEAN TRYPSIN INHIBITOR; TRYPSIN; TRYPSIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84856968876     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0751-9     Document Type: Article
Times cited : (23)

References (62)
  • 2
    • 55749110433 scopus 로고    scopus 로고
    • Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism
    • 18454852 10.1186/bcr2090
    • V Androutsopoulos RR Arroo JF Hall S Surichan GA Potter 2008 Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism Breast Cancer Res 10 3 R39 18454852 10.1186/bcr2090
    • (2008) Breast Cancer Res , vol.10 , Issue.3 , pp. 39
    • Androutsopoulos, V.1    Arroo, R.R.2    Hall, J.F.3    Surichan, S.4    Potter, G.A.5
  • 4
    • 65849301026 scopus 로고    scopus 로고
    • Purification and biochemical characterization of a serine proteinase inhibitor from Derris trifoliata Lour seeds: Insight into structural and antimalarial features
    • 19409579 10.1016/j.phytochem.2009.04.001 1:CAS:528:DC%2BD1MXms1yht7o%3D
    • A Bhattacharyya CR Babu 2009 Purification and biochemical characterization of a serine proteinase inhibitor from Derris trifoliata Lour seeds: insight into structural and antimalarial features Phytochemistry 70 6 703 712 19409579 10.1016/j.phytochem.2009.04.001 1:CAS:528:DC%2BD1MXms1yht7o%3D
    • (2009) Phytochemistry , vol.70 , Issue.6 , pp. 703-712
    • Bhattacharyya, A.1    Babu, C.R.2
  • 6
    • 34250746945 scopus 로고    scopus 로고
    • Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities
    • DOI 10.1021/np070010e
    • S Boonphong P Puangsombat A Baramee C Mahidol S Ruchirawat P Kittakoop 2007 Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotoxic activities J Nat Prod 70 5 795 801 17480099 10.1021/np070010e 1:CAS:528:DC%2BD2sXltVWqtrw%3D (Pubitemid 46953602)
    • (2007) Journal of Natural Products , vol.70 , Issue.5 , pp. 795-801
    • Boonphong, S.1    Puangsombat, P.2    Baramee, A.3    Mahidol, C.4    Ruchirawat, S.5    Kittakoop, P.6
  • 8
    • 67349223523 scopus 로고    scopus 로고
    • Musa acuminata (Del Monte banana) lectin is a fructose-binding lectin with cytokine-inducing activity
    • 19195858 10.1016/j.phymed.2008.12.016 1:CAS:528:DC%2BD1MXotVCgt7o%3D
    • AH Cheung JH Wong TB Ng 2009 Musa acuminata (Del Monte banana) lectin is a fructose-binding lectin with cytokine-inducing activity Phytomedicine 16 6-7 594 600 19195858 10.1016/j.phymed.2008.12.016 1:CAS:528:DC%2BD1MXotVCgt7o%3D
    • (2009) Phytomedicine , vol.16 , Issue.67 , pp. 594-600
    • Cheung, A.H.1    Wong, J.H.2    Ng, T.B.3
  • 9
    • 70149086514 scopus 로고    scopus 로고
    • Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma
    • 19667180 10.1073/pnas.0900198106 1:CAS:528:DC%2BD1MXhtFWkurzI
    • AK Cheung HL Lung JM Ko, et al. 2009 Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma Proc Natl Acad Sci USA 106 34 14478 14483 19667180 10.1073/pnas.0900198106 1:CAS:528:DC%2BD1MXhtFWkurzI
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.34 , pp. 14478-14483
    • Cheung, A.K.1    Lung, H.L.2    Ko, J.M.3
  • 10
    • 10044282921 scopus 로고    scopus 로고
    • Apoptosis pathway-targeted drugs - From the bench to the clinic
    • DOI 10.1016/j.bbcan.2004.09.005, PII S0304419X04000617
    • J Cummings TH Ward M Ranson C Dive 2004 Apoptosis pathway-targeted drugs-from the bench to the clinic Biochim Biophys Acta 1705 1 53 66 15585173 1:CAS:528:DC%2BD2cXhtVGgurrI (Pubitemid 39610420)
    • (2004) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1705 , Issue.1 , pp. 53-66
    • Cummings, J.1    Ward, T.H.2    Ranson, M.3    Dive, C.4
  • 12
    • 28244462005 scopus 로고    scopus 로고
    • Cloning, expression and characterization of Bauhinia variegata trypsin inhibitor BvTI
    • DOI 10.1515/BC.2005.135
    • AF de Souza RJ Torquato AS Tanaka CA Sampaio 2005 Cloning, expression and characterization of Bauhinia variegata trypsin inhibitor BvTI Biol Chem 386 11 1185 1189 16307484 10.1515/BC.2005.135 (Pubitemid 41705373)
    • (2005) Biological Chemistry , vol.386 , Issue.11 , pp. 1185-1189
    • De Souza, A.F.1    Torquato, R.J.S.2    Tanaka, A.S.3    Sampaio, C.A.M.4
  • 14
    • 77953373245 scopus 로고    scopus 로고
    • The pan-deacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis
    • 20208142 1:CAS:528:DC%2BC3cXlsV2qsLw%3D
    • P Di Fazio R Schneider-Stock D Neureiter, et al. 2010 The pan-deacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis Cell Oncol 32 4 285 300 20208142 1:CAS:528:DC%2BC3cXlsV2qsLw%3D
    • (2010) Cell Oncol , vol.32 , Issue.4 , pp. 285-300
    • Di Fazio, P.1    Schneider-Stock, R.2    Neureiter, D.3
  • 15
    • 68249123166 scopus 로고    scopus 로고
    • Purification and characterization of a Kunitz-type trypsin inhibitor from Acacia victoriae Bentham seeds
    • 19588923 10.1021/jf900923t 1:CAS:528:DC%2BD1MXot12gu78%3D
    • KY Ee J Zhao AU Rehman SO Agboola 2009 Purification and characterization of a Kunitz-type trypsin inhibitor from Acacia victoriae Bentham seeds J Agric Food Chem 57 15 7022 7029 19588923 10.1021/jf900923t 1:CAS:528: DC%2BD1MXot12gu78%3D
    • (2009) J Agric Food Chem , vol.57 , Issue.15 , pp. 7022-7029
    • Ee, K.Y.1    Zhao, J.2    Rehman, A.U.3    Agboola, S.O.4
  • 16
    • 79959293885 scopus 로고    scopus 로고
    • Bitter gourd (Momordica charantia) is a cornucopia of health: A review of its credited antidiabetic, Anti-HIV, and antitumor properties
    • 21568930 10.2174/156652411795976583 1:CAS:528:DC%2BC3MXpsVKqsbc%3D
    • EF Fang TB Ng 2011 Bitter gourd (Momordica charantia) is a cornucopia of health: a review of its credited antidiabetic, Anti-HIV, and antitumor properties Curr Mol Med 11 417 435 21568930 10.2174/156652411795976583 1:CAS:528:DC%2BC3MXpsVKqsbc%3D
    • (2011) Curr Mol Med , vol.11 , pp. 417-435
    • Fang, E.F.1    Ng, T.B.2
  • 17
    • 78650539904 scopus 로고    scopus 로고
    • Ribonucleases of different origins with a wide spectrum of medicinal applications
    • 20843477 1:CAS:528:DC%2BC3MXhtF2lsw%3D%3D
    • EF Fang TB Ng 2011 Ribonucleases of different origins with a wide spectrum of medicinal applications Biochim Biophys Acta 1815 1 65 74 20843477 1:CAS:528:DC%2BC3MXhtF2lsw%3D%3D
    • (2011) Biochim Biophys Acta , vol.1815 , Issue.1 , pp. 65-74
    • Fang, E.F.1    Ng, T.B.2
  • 18
    • 77249112249 scopus 로고    scopus 로고
    • A lectin with anti-HIV-1 reverse transcriptase, antitumor, and nitric oxide inducing activities from seeds of Phaseolus vulgaris cv extralong autumn purple bean
    • 20095617 10.1021/jf903964u 1:CAS:528:DC%2BC3cXptlyrug%3D%3D
    • EF Fang P Lin JH Wong SW Tsao TB Ng 2010 A lectin with anti-HIV-1 reverse transcriptase, antitumor, and nitric oxide inducing activities from seeds of Phaseolus vulgaris cv extralong autumn purple bean J Agric Food Chem 58 4 2221 2229 20095617 10.1021/jf903964u 1:CAS:528:DC%2BC3cXptlyrug%3D%3D
    • (2010) J Agric Food Chem , vol.58 , Issue.4 , pp. 2221-2229
    • Fang, E.F.1    Lin, P.2    Wong, J.H.3    Tsao, S.W.4    Ng, T.B.5
  • 19
    • 77953288202 scopus 로고    scopus 로고
    • Bauhinia variegata var variegata trypsin inhibitor: From isolation to potential medicinal applications
    • 20435016 10.1016/j.bbrc.2010.04.140 1:CAS:528:DC%2BC3cXnsVantL0%3D
    • EF Fang JH Wong CS Bah P Lin SW Tsao TB Ng 2010 Bauhinia variegata var variegata trypsin inhibitor: from isolation to potential medicinal applications Biochem Biophys Res Commun 396 4 806 811 20435016 10.1016/j.bbrc.2010.04.140 1:CAS:528:DC%2BC3cXnsVantL0%3D
    • (2010) Biochem Biophys Res Commun , vol.396 , Issue.4 , pp. 806-811
    • Fang, E.F.1    Wong, J.H.2    Bah, C.S.3    Lin, P.4    Tsao, S.W.5    Ng, T.B.6
  • 20
    • 77956892000 scopus 로고    scopus 로고
    • Biochemical characterization of the RNA-hydrolytic activity of a pumpkin 2S albumin
    • Fang EF, Wong JH, Lin P, Ng TB (2010c) Biochemical characterization of the RNA-hydrolytic activity of a pumpkin 2S albumin. FEBS Lett 584(18):4089-4096
    • (2010) FEBS Lett , vol.584 , Issue.18 , pp. 4089-4096
    • Fang, E.F.1    Wong, J.H.2    Lin, P.3    Ng, T.B.4
  • 21
    • 76049109020 scopus 로고    scopus 로고
    • Thermostable Kunitz trypsin inhibitor with cytokine inducing, antitumor and HIV-1 reverse transcriptase inhibitory activities from Korean large black soybeans
    • 20159565 10.1016/j.jbiosc.2009.08.483 1:CAS:528:DC%2BC3cXmtleisLo%3D
    • EF Fang JH Wong TB Ng 2010 Thermostable Kunitz trypsin inhibitor with cytokine inducing, antitumor and HIV-1 reverse transcriptase inhibitory activities from Korean large black soybeans J Biosci Bioeng 109 3 211 217 20159565 10.1016/j.jbiosc.2009.08.483 1:CAS:528:DC%2BC3cXmtleisLo%3D
    • (2010) J Biosci Bioeng , vol.109 , Issue.3 , pp. 211-217
    • Fang, E.F.1    Wong, J.H.2    Ng, T.B.3
  • 22
    • 78049309091 scopus 로고    scopus 로고
    • Purification and modes of antifungal action by Vicia faba cv. Egypt trypsin inhibitor
    • Fang EF, Hassanien AA, Wong JH, Bah CS, Soliman SS, Ng TB (2010e) Purification and modes of antifungal action by Vicia faba cv. Egypt trypsin inhibitor. J Agric Food Chem 58(19):10729-10735
    • (2010) J Agric Food Chem , vol.58 , Issue.19 , pp. 10729-10735
    • Fang, E.F.1    Hassanien, A.A.2    Wong, J.H.3    Bah, C.S.4    Soliman, S.S.5    Ng, T.B.6
  • 23
    • 82355187576 scopus 로고    scopus 로고
    • A new Phaseolus vulgaris lectin induces selective toxicity on human liver carcinoma Hep G2 cells
    • (in press)
    • Fang EF, Pan WL, Wong JH, Chan YS, Ye XJ, Ng TB (in press) A new Phaseolus vulgaris lectin induces selective toxicity on human liver carcinoma Hep G2 cells. Arch Toxicol. http://www.ncbi.nlm.nih.gov/pubmed/21445585
    • Arch Toxicol.
    • Fang, E.F.1    Pan, W.L.2    Wong, J.H.3    Chan, Y.S.4    Ye, X.J.5    Ng, T.B.6
  • 24
    • 0003443846 scopus 로고
    • K. Gawehn M. Grassl (eds). Academic Press New York
    • Gawehn K, Grassl M (eds) (1974) Methods of enzymatic analysis. Academic Press, New York
    • (1974) Methods of Enzymatic Analysis
  • 25
    • 62949149568 scopus 로고    scopus 로고
    • Rho GTPases in hepatocellular carcinoma
    • 19162129 1:CAS:528:DC%2BD1MXjvVWjsrw%3D
    • F Grise A Bidaud V Moreau 2009 Rho GTPases in hepatocellular carcinoma Biochim Biophys Acta 1795 2 137 151 19162129 1:CAS:528:DC%2BD1MXjvVWjsrw%3D
    • (2009) Biochim Biophys Acta , vol.1795 , Issue.2 , pp. 137-151
    • Grise, F.1    Bidaud, A.2    Moreau, V.3
  • 26
    • 33845789994 scopus 로고    scopus 로고
    • Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway
    • DOI 10.1016/j.canlet.2006.03.030, PII S0304383506001960
    • JT Hwang J Ha IJ Park, et al. 2007 Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway Cancer Lett 247 1 115 121 16797120 10.1016/j.canlet.2006.03.030 1:CAS:528:DC%2BD2sXht1elsQ%3D%3D (Pubitemid 46001507)
    • (2007) Cancer Letters , vol.247 , Issue.1-2 , pp. 115-121
    • Hwang, J.-T.1    Ha, J.2    Park, I.-J.3    Lee, S.-K.4    Baik, H.W.5    Kim, Y.M.6    Park, O.J.7
  • 27
    • 68049111227 scopus 로고    scopus 로고
    • Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice
    • 19170137 10.1002/ptr.2765
    • R Jatwa A Kar 2009 Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice Phytother Res 23 8 1140 1145 19170137 10.1002/ptr.2765
    • (2009) Phytother Res , vol.23 , Issue.8 , pp. 1140-1145
    • Jatwa, R.1    Kar, A.2
  • 28
    • 0017324044 scopus 로고
    • Serine proteases: Structure and mechanism of catalysis
    • 332063 10.1146/annurev.bi.46.070177.001555 1:CAS:528:DyaE2sXlsVOmtb0%3D
    • J Kraut 1977 Serine proteases: structure and mechanism of catalysis Annu Rev Biochem 46 331 358 332063 10.1146/annurev.bi.46.070177.001555 1:CAS:528:DyaE2sXlsVOmtb0%3D
    • (1977) Annu Rev Biochem , vol.46 , pp. 331-358
    • Kraut, J.1
  • 29
    • 0025854184 scopus 로고
    • CDNA cloning and expression of Bauhinia purpurea lectin
    • 1657898 1:CAS:528:DyaK38XjsFemtw%3D%3D
    • K Kusui K Yamamoto Y Konami T Osawa 1991 cDNA cloning and expression of Bauhinia purpurea lectin J Biochem 109 6 899 903 1657898 1:CAS:528: DyaK38XjsFemtw%3D%3D
    • (1991) J Biochem , vol.109 , Issue.6 , pp. 899-903
    • Kusui, K.1    Yamamoto, K.2    Konami, Y.3    Osawa, T.4
  • 31
    • 14644391571 scopus 로고    scopus 로고
    • Hybrid origin of "Bauhinia blakeana" (Leguminosae: Caesalpinioideae), inferred using morphological, reproductive, and molecular data
    • CPY Lau L Ramsden RMK Saunders 2005 Hybrid origin of "Bauhinia blakeana" (Leguminosae: Caesalpinioideae), inferred using morphological, reproductive, and molecular data Am J Bot 92 3 525 533 21652431 10.3732/ajb.92.3.525 (Pubitemid 40307595)
    • (2005) American Journal of Botany , vol.92 , Issue.3 , pp. 525-533
    • Lau, C.P.Y.1    Ramsden, L.2    Saunders, R.M.K.3
  • 32
    • 34250890733 scopus 로고    scopus 로고
    • Induction of autophagy by concanavalin A and its application in anti-tumor therapy
    • 17471013 1:CAS:528:DC%2BD2sXhtVGrtb7I
    • HY Lei CP Chang 2007 Induction of autophagy by concanavalin A and its application in anti-tumor therapy Autophagy 3 4 402 404 17471013 1:CAS:528:DC%2BD2sXhtVGrtb7I
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 402-404
    • Lei, H.Y.1    Chang, C.P.2
  • 33
    • 57849146632 scopus 로고    scopus 로고
    • Preparation and biological properties of a melibiose binding lectin from Bauhinia variegata seeds
    • 18942841 10.1021/jf8016332 1:CAS:528:DC%2BD1cXht1OlsLnF
    • P Lin TB Ng 2008 Preparation and biological properties of a melibiose binding lectin from Bauhinia variegata seeds J Agric Food Chem 56 22 10481 10486 18942841 10.1021/jf8016332 1:CAS:528:DC%2BD1cXht1OlsLnF
    • (2008) J Agric Food Chem , vol.56 , Issue.22 , pp. 10481-10486
    • Lin, P.1    Ng, T.B.2
  • 34
    • 39349086395 scopus 로고    scopus 로고
    • The biochemical and functional food properties of the Bowman-Birk inhibitor
    • DOI 10.1080/10408390601177589, PII 790614950
    • JN Losso 2008 The biochemical and functional food properties of the bowman-birk inhibitor Crit Rev Food Sci Nutr 48 1 94 118 18274967 10.1080/10408390601177589 1:CAS:528:DC%2BD1cXhvFWhs7c%3D (Pubitemid 351261525)
    • (2008) Critical Reviews in Food Science and Nutrition , vol.48 , Issue.1 , pp. 94-118
    • Losso, J.N.1
  • 36
    • 0037230114 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line INS-1
    • DOI 10.1210/en.2001-211282
    • I Maestre J Jordan S Calvo, et al. 2003 Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1 Endocrinology 144 1 335 345 12488362 10.1210/en.2001-211282 1:CAS:528:DC%2BD3sXhtFSlug%3D%3D (Pubitemid 36076123)
    • (2003) Endocrinology , vol.144 , Issue.1 , pp. 335-345
    • Maestre, I.1    Jordan, J.2    Calvo, S.3    Reig, J.A.4    Cena, V.5    Soria, B.6    Prentki, M.7    Roche, E.8
  • 37
    • 38049112702 scopus 로고    scopus 로고
    • Molecular evidence for the hybrid origin of Bauhinia blakeana (Caesalpinioideae)
    • 18666958 10.1111/j.1744-7909.2007.00591.x 1:CAS:528:DC%2BD1cXhvVCns7c%3D
    • CY Mak KS Cheung PY Yip HS Kwan 2008 Molecular evidence for the hybrid origin of Bauhinia blakeana (Caesalpinioideae) J Integr Plant Biol 50 1 111 118 18666958 10.1111/j.1744-7909.2007.00591.x 1:CAS:528:DC%2BD1cXhvVCns7c%3D
    • (2008) J Integr Plant Biol , vol.50 , Issue.1 , pp. 111-118
    • Mak, C.Y.1    Cheung, K.S.2    Yip, P.Y.3    Kwan, H.S.4
  • 38
    • 51649168781 scopus 로고
    • An acid stable trypsin-chymotrypsin inhibitor from horse gram (Dolichos biflorus)
    • 10.1007/BF02702742 1:CAS:528:DyaL3sXjtVertQ%3D%3D
    • SL Mehta MM Simlot 1982 An acid stable trypsin-chymotrypsin inhibitor from horse gram (Dolichos biflorus) J Biosci 4 3 295 306 10.1007/BF02702742 1:CAS:528:DyaL3sXjtVertQ%3D%3D
    • (1982) J Biosci , vol.4 , Issue.3 , pp. 295-306
    • Mehta, S.L.1    Simlot, M.M.2
  • 39
    • 0032412053 scopus 로고    scopus 로고
    • Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells
    • DOI 10.1023/A:1006576313979
    • S Miyata Y Miyagi N Koshikawa, et al. 1998 Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells Clin Exp Metastasis 16 7 613 622 9932608 10.1023/A:1006576313979 1:CAS:528: DyaK1MXht1ygtL8%3D (Pubitemid 29044584)
    • (1998) Clinical and Experimental Metastasis , vol.16 , Issue.7 , pp. 613-622
    • Miyata, S.1    Miyagi, Y.2    Koshikawa, N.3    Nagashima, Y.4    Kato, Y.5    Yasumitsu, H.6    Hirahara, F.7    Misugi, K.8    Miyazaki, K.9
  • 40
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • 19692680 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK
    • TS Mok YL Wu S Thongprasert, et al. 2009 Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 10 947 957 19692680 10.1056/NEJMoa0810699 1:CAS:528:DC%2BD1MXhtVygsbfK
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 42
    • 0035203755 scopus 로고    scopus 로고
    • Annexin v staining during reperfusion detects cardiomyocytes with unique properties
    • 11668053 1:CAS:528:DC%2BD3MXosFylsL8%3D
    • P Narayan RM Mentzer Jr RD Lasley 2001 Annexin V staining during reperfusion detects cardiomyocytes with unique properties Am J Physiol Heart Circ Physiol 281 5 H1931 H1937 11668053 1:CAS:528:DC%2BD3MXosFylsL8%3D
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , Issue.5
    • Narayan, P.1    Mentzer Jr., R.M.2    Lasley, R.D.3
  • 45
    • 0033963167 scopus 로고    scopus 로고
    • Cytokine-inducing activity and antitumor effect of a liposome- incorporated interferon-γ-inducing molecule derived from OK-432, a streptococcal preparation
    • DOI 10.1097/00002371-200001000-00012
    • M Okamoto H Gohda G Ohe, et al. 2000 Cytokine-inducing activity and antitumor effect of a liposome-incorporated interferon-gamma-inducing molecule derived from OK-432, a streptococcal preparation J Immunother 23 1 94 103 10687142 10.1097/00002371-200001000-00012 1:CAS:528:DC%2BD3cXht1eisrk%3D (Pubitemid 30079830)
    • (2000) Journal of Immunotherapy , vol.23 , Issue.1 , pp. 94-103
    • Okamoto, M.1    Gohda, H.2    Ohe, G.3    Yoshida, H.4    Matsuno, T.5    Saito, M.6    Sato, M.7
  • 46
    • 0033833081 scopus 로고    scopus 로고
    • Purification and characterization of cytokine-inducing protein of seed extract from Aeginetia indica L., a parasitic plant
    • 10996035 10.1016/S0162-3109(00)00253-8 1:CAS:528:DC%2BD3cXmtlGltbc%3D
    • M Okamoto G Ohe T Oshikawa, et al. 2000 Purification and characterization of cytokine-inducing protein of seed extract from Aeginetia indica L., a parasitic plant Immunopharmacology 49 3 377 389 10996035 10.1016/S0162-3109(00) 00253-8 1:CAS:528:DC%2BD3cXmtlGltbc%3D
    • (2000) Immunopharmacology , vol.49 , Issue.3 , pp. 377-389
    • Okamoto, M.1    Ohe, G.2    Oshikawa, T.3
  • 47
    • 0032733732 scopus 로고    scopus 로고
    • Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a factor Xa inhibitor isolated from Bauhinia ungulata seeds
    • 10615004 10.1016/S0162-3109(99)00146-0 1:CAS:528:DyaK1MXnslynsrg%3D
    • ML Oliva SA Andrade IF Batista, et al. 1999 Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a factor Xa inhibitor isolated from Bauhinia ungulata seeds Immunopharmacology 45 1-3 145 149 10615004 10.1016/S0162-3109(99)00146-0 1:CAS:528:DyaK1MXnslynsrg%3D
    • (1999) Immunopharmacology , vol.45 , Issue.13 , pp. 145-149
    • Oliva, M.L.1    Andrade, S.A.2    Batista, I.F.3
  • 48
    • 0037699905 scopus 로고    scopus 로고
    • Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor Bauhinia ungulata seeds
    • DOI 10.2174/0929867033457548
    • ML Oliva SA Andrade MA Juliano, et al. 2003 Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor from Bauhinia ungulata seeds Curr Med Chem 10 13 1085 1093 12678803 10.2174/0929867033457548 1:CAS:528:DC%2BD3sXksFSitL0%3D (Pubitemid 36758223)
    • (2003) Current Medicinal Chemistry , vol.10 , Issue.13 , pp. 1085-1093
    • Oliva, M.L.V.1    Andrade, S.A.2    Juliano, M.A.3    Sallai, R.C.4    Torquato, R.J.5    Sampaio, M.U.6    Pott, V.J.7    Sampaio, C.A.M.8
  • 49
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • 19671918 10.1182/blood-2009-05-223677 1:CAS:528:DC%2BD1MXhtlensb7L
    • F Parlati SJ Lee M Aujay, et al. 2009 Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome Blood 114 16 3439 3447 19671918 10.1182/blood-2009-05-223677 1:CAS:528:DC%2BD1MXhtlensb7L
    • (2009) Blood , vol.114 , Issue.16 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3
  • 50
    • 52649172632 scopus 로고    scopus 로고
    • Purification and molecular cloning of a new galactose-specific lectin from Bauhinia variegata seeds
    • 19005235 10.1007/s12038-008-0055-2 1:CAS:528:DC%2BD1cXht1Wmu7jP
    • LS Pinto CS Nagano TM Oliveira, et al. 2008 Purification and molecular cloning of a new galactose-specific lectin from Bauhinia variegata seeds J Biosci 33 3 355 363 19005235 10.1007/s12038-008-0055-2 1:CAS:528: DC%2BD1cXht1Wmu7jP
    • (2008) J Biosci , vol.33 , Issue.3 , pp. 355-363
    • Pinto, L.S.1    Nagano, C.S.2    Oliveira, T.M.3
  • 51
    • 58949093617 scopus 로고    scopus 로고
    • Purification and characterization of a trypsin inhibitor from Plathymenia foliolosa seeds
    • 18991455 10.1021/jf802778b
    • S Ramos Vda S Silva Gde MG Freire OL Machado JR Parra ML Macedo 2008 Purification and characterization of a trypsin inhibitor from Plathymenia foliolosa seeds J Agric Food Chem 56 23 11348 11355 18991455 10.1021/jf802778b
    • (2008) J Agric Food Chem , vol.56 , Issue.23 , pp. 11348-11355
    • Ramos Vda, S.1    Silva Gde, S.2    Freire, M.G.3    MacHado, O.L.4    Parra, J.R.5    MacEdo, M.L.6
  • 53
    • 0035005375 scopus 로고    scopus 로고
    • Purification and characterization of a proteinase inhibitor from white croaker skeletal muscle (Micropogon opercularis)
    • DOI 10.1016/S1357-2725(01)00054-1, PII S1357272501000541
    • MP Sangorrin EJ Folco CM Martone JJ Sanchez 2001 Purification and characterization of a proteinase inhibitor from white croaker skeletal muscle (Micropogon opercularis) Int J Biochem Cell Biol 33 7 691 699 11390277 10.1016/S1357-2725(01)00054-1 1:CAS:528:DC%2BD3MXktVKltrk%3D (Pubitemid 32520965)
    • (2001) International Journal of Biochemistry and Cell Biology , vol.33 , Issue.7 , pp. 691-699
    • Sangorrin, M.P.1    Folco, E.J.2    Martone, C.M.3    Sanchez, J.J.4
  • 54
    • 34250171729 scopus 로고    scopus 로고
    • Isolation and biochemical characterization of a galactoside binding lectin from Bauhinia variegata candida (BvcL) seeds
    • DOI 10.1007/s10930-006-9061-0
    • JA Silva DC Damico PA Baldasso, et al. 2007 Isolation and biochemical characterization of a galactoside binding lectin from Bauhinia variegata candida (BvcL) seeds Protein J 26 3 193 201 17203390 10.1007/s10930-006-9061-0 1:CAS:528:DC%2BD2sXmtlShsbY%3D (Pubitemid 46904483)
    • (2007) Protein Journal , vol.26 , Issue.3 , pp. 193-201
    • Silva, J.A.1    Damico, D.C.S.2    Baldasso, P.A.3    Mattioli, M.A.4    Winck, F.V.5    Fraceto, L.F.6    Novello, J.C.7    Marangoni, S.8
  • 55
    • 33645986185 scopus 로고    scopus 로고
    • A Kunitz-type glycosylated elastase inhibitor with one disulfide bridge
    • 16557451 10.1055/s-2005-916237 1:CAS:528:DC%2BD28Xlt1eksbk%3D
    • JT Sumikawa AM Nakahata H Fritz R Mentele MU Sampaio ML Oliva 2006 A Kunitz-type glycosylated elastase inhibitor with one disulfide bridge Planta Med 72 5 393 397 16557451 10.1055/s-2005-916237 1:CAS:528:DC%2BD28Xlt1eksbk%3D
    • (2006) Planta Med , vol.72 , Issue.5 , pp. 393-397
    • Sumikawa, J.T.1    Nakahata, A.M.2    Fritz, H.3    Mentele, R.4    Sampaio, M.U.5    Oliva, M.L.6
  • 56
    • 0028833543 scopus 로고
    • Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities
    • 7806384 1:CAS:528:DyaK2MXisl2ksLc%3D
    • H Takada Y Kawabata R Arakaki, et al. 1995 Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities Infect Immun 63 1 57 65 7806384 1:CAS:528:DyaK2MXisl2ksLc%3D
    • (1995) Infect Immun , vol.63 , Issue.1 , pp. 57-65
    • Takada, H.1    Kawabata, Y.2    Arakaki, R.3
  • 57
    • 34548631786 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments
    • DOI 10.1017/S1462399407000312, PII S1462399407000312
    • Q Tao AT Chan 2007 Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments Expert Rev Mol Med 9 12 1 24 17477889 10.1017/S1462399407000312 (Pubitemid 47398642)
    • (2007) Expert Reviews in Molecular Medicine , vol.9 , Issue.12 , pp. 1-24
    • Tao, Q.1    Chan, A.T.C.2
  • 58
    • 72449131405 scopus 로고    scopus 로고
    • Alpha-1-antitrypsin phenotypes in adult liver disease patients
    • 19961268 10.3109/03009730903243472
    • A Topic T Alempijevic AS Milutinovic N Kovacevic 2009 Alpha-1-antitrypsin phenotypes in adult liver disease patients Ups J Med Sci 114 4 228 234 19961268 10.3109/03009730903243472
    • (2009) Ups J Med Sci , vol.114 , Issue.4 , pp. 228-234
    • Topic, A.1    Alempijevic, T.2    Milutinovic, A.S.3    Kovacevic, N.4
  • 59
    • 0029877078 scopus 로고    scopus 로고
    • Interleukin 1 trials in cancer patients: A review of the toxicity, antitumor and hematopoietic effects
    • S Veltri JW Smith 2nd 1996 Interleukin 1 trials in cancer patients: a review of the toxicity, antitumor and hematopoietic effects Stem Cells 14 2 164 176 8991536 10.1002/stem.140164 1:STN:280:DyaK283lsFCntQ%3D%3D (Pubitemid 26109198)
    • (1996) Stem Cells , vol.14 , Issue.2 , pp. 164-176
    • Veltri, S.1    Smith II, J.W.2
  • 60
    • 19444362449 scopus 로고    scopus 로고
    • Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: Role of mitochondrial permeability transition
    • DOI 10.1016/j.freeradbiomed.2005.02.030, PII S0891584905000900
    • M Whiteman P Rose JL Siau, et al. 2005 Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition Free Radic Biol Med 38 12 1571 1584 15917186 10.1016/j.freeradbiomed.2005.02.030 1:CAS:528:DC%2BD2MXks1Whu7s%3D (Pubitemid 40726064)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.12 , pp. 1571-1584
    • Whiteman, M.1    Rose, P.2    Jia, L.S.3    Nam, S.C.4    Gek, S.T.5    Halliwell, B.6    Armstrong, J.S.7
  • 61
    • 1642564606 scopus 로고    scopus 로고
    • Recognition profile of Bauhinia purpurea agglutinin (BPA)
    • DOI 10.1016/j.lfs.2003.08.031
    • AM Wu JH Wu JH Liu T Singh 2004 Recognition profile of Bauhinia purpurea agglutinin (BPA) Life Sci 74 14 1763 1779 14741734 10.1016/j.lfs.2003.08.031 1:CAS:528:DC%2BD2cXnvVKrsg%3D%3D (Pubitemid 38117103)
    • (2004) Life Sciences , vol.74 , Issue.14 , pp. 1763-1779
    • Wu, A.M.1    Wu, J.H.2    Liu, J.-H.3    Singh, T.4
  • 62
    • 35148826400 scopus 로고    scopus 로고
    • Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals
    • DOI 10.1159/000107749
    • ZA Zakaria LY Wen NI Abdul Rahman AH Abdul Ayub MR Sulaiman HK Gopalan 2007 Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals Med Princ Pract 16 6 443 449 17917444 10.1159/000107749 (Pubitemid 47538125)
    • (2007) Medical Principles and Practice , vol.16 , Issue.6 , pp. 443-449
    • Zakaria, Z.A.1    Wen, L.Y.2    Abdul Rahman, N.I.3    Abdul Ayub, A.H.4    Sulaiman, Mohd.R.5    Gopalan, H.K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.