Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in type 2 diabetic mice

Phytotherapy Research

Volumn 23, Issue 8, 2009, Pages 1140-1145

  Jatwa, Rameshwar ^a   Kar, Anand ^a  

^a DEVI AHILYA UNIVERSITY   (India)

Author keywords

Dexamethasone; Lipid peroxidation; Metformin; Mice; Thyroid hormones; Type 2 diabetes mellitus

Indexed keywords

BAUHINIA PURPUREA EXTRACT; CATALASE; DEXAMETHASONE; GLUCOSE; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIOTHYRONINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; SUPEROXIDE DISMUTASE; THYROXINE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG INDUCED HYPOTHYROIDISM; EUTHYROIDISM; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPOTHYROIDISM; INSULIN BLOOD LEVEL; LIOTHYRONINE BLOOD LEVEL; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BAUHINIA; DEXAMETHASONE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; FEMALE; HYPOTHYROIDISM; METFORMIN; MICE; PLANT BARK; PLANT EXTRACTS; PLANT ROOTS; THYROXINE; TRIIODOTHYRONINE; WITHANIA;

ANIMALIA; BAUHINIA PURPUREA; MUS; WITHANIA SOMNIFERA;

EID: 68049111227     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2765     Document Type: Article

References (30)

1. Babu PV, Sabitha KE, Srinivasan P, Sheyamaladevi CS. 2007. Green tea attenuates diabetes induced maillard-type fluorescence and collagen cross-linking in the heart of streptozotocin diabetic rats. Pharmacol Res 55: 433-440. (Pubitemid 46560396)
2. Bagchi D, Ray SD, Patel D, Bagchi M. 2001. Protection against drug and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. Drug Exp Clin Res 27: 3-15. (Pubitemid 32215891)
3. Bhattacharya A, Ramanathan M, Ghosal S, Bhattacharya SK. 2000. Effect of Withania somnifera glycowithanolides on iron-induced hepatotoxicity in rats. Phytother Res 14: 568-570. (Pubitemid 30824994)
4. Buckingham JC. 2006. Glucocorticoids: exemplars of multi-tasking. Br J Pharmacol 147: S258-S268.
5. Bulow PI, Laurberg P, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Rasmussen L-B. 2006. Lack of association between thyroid autoantibodies and parity in a population study argues against microchimerism as a trigger of thyroid autoimmunity. Eur J Endocrinol 154: 39-45. (Pubitemid 43250734)
6. Ganong WF. 2005. Review of Medical Physiology, 22nd edn. Appleton & Lange: Connecticut, USA.
7. Hamza A, Amin A, Daoud S. 2008. The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats. Cell Biol Toxicol 24: 63-73.
8. Holland EG, Degruy FV. 1998. Drug-induced disorders. Am Fam Phy 56: 1781-1788.
9. Isidro ML, Penin MA, Nemina R, Cordido F. 2007. Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy. Endocrine 32: 79-82. (Pubitemid 350242550)
10. Jatwa R, Kar A. 2006a. Antihyperglycemic and antiperoxidative roles of acarbose in Type 2 diabetes mellitus are possibly mediated through changes in thyroid function. Clin Exp Pharm Physiol 33: 1104-1106.
11. Jatwa R, Kar A. 2006b. Cardio-protective role of terazosin is possibly mediated through alteration in thyroid function. Eur J Pharmacol 551: 87-91. (Pubitemid 44648055)
12. Jatwa R, Parmar HS, Panda S, Kar A. 2007. Amelioration of corticosteroid-induced Type 2 diabetes mellitus by rosiglitazone is possibly mediated through stimulation of thyroid function and inhibition of tissue lipid peroxidation in mice. Basic Clin Pharmacol Toxicol 101: 177-180. (Pubitemid 47256389)
13. Jatwa R, Kar A. 2008. Protective effect of l-ornithine-l-aspartate and silymarin on chemically induced kidney toxicity and thyroid dysfunction in mice. Excli J 7: 139-150.
14. Kar A, Panda S. 2005. Plant extracts in the regulation of hypothyroidism. In Recent Progress in Medicinal Plants, Sharma SK, Govil JN, Singh VK (eds). Studium Press: Texas, USA; 419-426.
15. Lannello S, Milazzo P, Bordonaro F, Belfiore F. 2005. Effect of in vitro glucose and diabetic hyperglycemia on mouse kidney protein synthesis: Relevance to diabetic microangiopathy. Medsc Gen Med 7: 1-7.
16. Lazarou J, Pomeranz BH, Corey PN. 1998. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. J Am Med Assoc 279: 1200-1205. (Pubitemid 28193431)
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin-phenol reagent. J Biol Chem 193: 265-275.
18. Ma RC, Kong AP, Chan N, Tong PC, Chan JC. 2007. Drug-induced endocrine and metabolic disorders. Drug Saf 30: 215-245.
19. Maiti PK, Kar A. 1998. Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation? J Appl Toxicol 18: 125-128.
20. Meier CA, Burger AG. 2000. Effects of drugs and other substances on thyroid hormone synthesis and metabolism. In Werner & Ingbarg's The Thyroid: A fundamental and clinical text, Braverman LE, Utiger RD (eds). Williams and Wilkins: Lippincott; 265-277.
21. Mlinar B, Marc J, Janez A, Pfeifer M. 2007. Molecular mechanisms of insulin resistance and associated diseases. Clin Chim Acta 375: 20-35. (Pubitemid 44584240)
22. Ohkawa H, Ohishi N, Yagi K. 1979. Assays of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358. (Pubitemid 9194347)
23. Panda S, Kar A. 1999. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 67: 233-239. (Pubitemid 29421681)
24. Roith DL, Taylor SI, Olefsky JM. 2000. Diabetes Mellitus: A Fundamental and Clinical Text. Lippincott-Raven: Philadelphia.
25. Severino C, Brizzi P, Solinas A, Secchi G, Maioli M, Tonolo G. 2002. Low-dose dexamethasone in the rat: a model to study insulin resistance. Am J Physiol Endocrinol Metab 283: 367-373. (Pubitemid 34827454)
26. Sivalingam N, Basivireddy J, Balasubramanian KA, Jacob M. 2008. Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. Arch Toxicol 82: 471-481.
27. Szkudelski T. 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 50: 536-546. (Pubitemid 34087272)
28. Tiwari AK. 2004. Antioxidants: New-generation therapeutic base for treatment of polygenic disorders. Curr Sci 86: 1092-1102.
29. Vigerrsky RA, Filmore-Nassar A, Glass AR. 2006. Thyrotropin suppression by metformin. J Clin Endocrinol Meta 91: 225-227.
30. Yoon SH, Han EJ, Sung JH, Chung SH. 2007. Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice. Biol Pharm Bull 30: 2196-2200.