Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor Bauhinia ungulata seeds

Current Medicinal Chemistry

Volumn 10, Issue 13, 2003, Pages 1085-1093

  Oliva, Mysa L V ^a   Andrade, S A ^a   Juliano, M A ^a   Sallai, R C ^a   Torquato, R J ^a   Sampaio, M U ^a   Pott, V J ^b   Sampaio, C A M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b EMBRAPA CERRADOS   (Brazil)

Author keywords

Blood clotting enzymes; Factor Xa; Fluorescent substrate; Peptide substrate; Plant Kunitz inhibitor; Plasma kellikrein inhibitor; Primary sequence; Serine proteinase inhibitor

Indexed keywords

BAUHINIA EXTRACT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 12A; CHYMOTRYPSIN; METHIONINE; PLASMA KALLIKREIN; PLASMIN; SERINE; THREONINE; TRYPSIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITE; BLOOD CLOTTING; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ISOLATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; FLUORESCENCE; HUMAN; NONHUMAN; OXIDATION; PARTIAL THROMBOPLASTIN TIME; PEPTIDE SYNTHESIS; PLANT SEED; PROTEIN BINDING; PROTEIN HYDROLYSIS; PROTHROMBIN TIME; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BAUHINIA; BINDING SITES; CATTLE; FACTOR XA; FLUORESCENT DYES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; SEEDS; SEQUENCE HOMOLOGY; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 0037699905     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033457548     Document Type: Review

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