A Kunitz-type glycosylated elastase inhibitor with one disulfide bridge

Planta Medica

Volumn 72, Issue 5, 2006, Pages 393-397

  Sumikawa, Joana Tomomi ^a   Nakahata, Adriana Miti ^a   Fritz, Hans ^b   Mentele, Reinhardt ^c   Sampaio, Misako Uemura ^a   Vilela Oliva, Maria Luiza ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Bauhinia rufa; Elastase antagonists and inhibitors; Glycoproteins; Kunitz inhibitor; Leguminosae; Plant; Serine endopeptidases

Indexed keywords

ACETONE; AMINO ACID; APROTININ; ASPARAGINE; BAUHINIA RUFA EXTRACT; CARBOHYDRATE; CONCANAVALIN A; DISULFIDE; ELASTASE INHIBITOR; GLYCOSYLATED PROTEIN; KALLIKREIN; KALLIKREIN INHIBITOR; PANCREATIC ELASTASE; PLANT MEDICINAL PRODUCT; REAGENT; SEPHAROSE; TRYPSIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; VALINE;

AFFINITY CHROMATOGRAPHY; ARTICLE; BAUHINIA; COLUMN CHROMATOGRAPHY; DRUG PURIFICATION; DRUG STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN DATABASE; PROTEIN FAMILY; REVERSED PHASE LIQUID CHROMATOGRAPHY; STAINING;

AMINO ACID SEQUENCE; ANIMALS; BAUHINIA; CATTLE; DISULFIDES; ENZYME INHIBITORS; GLYCOSYLATION; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; PANCREATIC ELASTASE; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; SWINE;

BAUHINIA; BOVINAE; FABACEAE; SUIDAE;

EID: 33645986185     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-916237     Document Type: Article

References (23)

1. De Leo F, Volpicella M, Licciulli F, Liuni S, Gallerani R, Ceci LR. PLANT-PIs: a database for plant protease inhibitors and their genes. Nucleic Acids Res 2002; 30: 347-8
2. Ryan CA. Protease inhibitors in plants: genes for improving defenses against insects and pathogens. Annu Rev Phytopathol 1990; 28: 425-9
3. Rawlings ND, Tolle DP, Barrett AJ. Evolutionary families of peptidase inhibitors. Biochem J 2004; 378: 705-16
4. Do Socorro M, Cavalcanti M, Oliva ML, Fritz H, Jochum M, Mentele R et al. Characterization of a Kunitz trypsin inhibitor with one disulfide bridge purified from Swartzia pickellii. Biochem Biophys Res Commun 2002; 291: 635-9
5. Oliveira C, Santana LA, Carmona AK, Cezari MH, Sampaio M, Sampaio CA et al. Structure of cruzipain and cruzain inhibitors isolated from Bauhinia bauhinioides seeds. Biol Chem 2001; 382: 847-52
6. Ueda H, Ogawa H. Glycobiology of the plant glycoprotein epitope: structure, immunogenicity and allergenicity of plant glycotopes. Trends Glycosci Glycotechnol 1999; 11: 413-28
7. Edwards JV, Bopp AF, Batiste SBS, Ullah AJ, Cohen K, Diegelmann RF et al. Inhibition of elastase by a synthetic cotton-bound serine protease inhibitor: in vivo kinetics and inhibitor release. Wound Repair Regen 1999; 7: 106-18
8. Fortunato R. Bauhinia amambayensis nomen novum para B. uniflora Hassl. non S. Watson (Cercideae-Caesalpinioideae-Fabaceae). Candollea 1985; 40: 637-9
9. Oliva MLV, Grisolia D, Sampaio MU, Sampaio CAM. Properties of highly purified human plasma kallikrein. Agents Actions 1982; 9: 52-7
10. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5
11. Oliva MLV, Andrade SA, Juliano MA, Sallai RC, Torquato RJ, Sampaio MU et al. Kinetic characterization of factor Xa binding using a quenched fluorescent substrate based on the reactive site of factor Xa inhibitor from Bauhinia ungulata. Seeds Curr Med Chem 2003; 10: 1085-93
12. Knight CG. The characterization of enzymes inhibition. In: Barrett AJ, Salvesen G, editors. Proteinase inhibitors Amsterdam: Elsevier, 1986: pp 23-51
13. Serrano SM, Mentele R, Sampaio CA, Fink E. Purification, characterization, and amino acid sequence of a serine proteinase, PA-BJ, with platelet-aggregating activity from the venom of Bothrops jararaca. Biochemistry 1995; 34: 7186-93
14. Mann M. Electrospray: its potential and limitations as an ionization method for biomolecules. Org Mass Spectrom 1990; 25: 575-87
15. Hunkapiller MWH, Hewick RM, Dreyer WJ, Hood LE. High-sensitive applications of a rediscovered food crop. Food Technol 1983; 39: 49-61
16. Srinivasan A, Giri AP, Harsulkar AM, Gatehouse JA, Gupta VS. Kunitz trypsin inhibitor from chickpea (Cicer arietinum L.) that exerts antimetabolic effect on podborer (Helicoverpa armigera) larvae. Plant Mol Biol 2005; 57: 359-74
17. Shimizu M, Fujiwara Y, Fukada H, Hara A. Purification and identification of a second form of vitellogenin from ascites of medaka (Oryzias latipes) treated with estrogen. J Exp Zool 2002; 293: 726-35
18. Oliva MLV, Souza-Pinto JC, Batista IF, Araujo MS, Silveira VF, Auerswald EA et al. Leucaena leucocephala serine proteinase Inhibitor: primary structure and action on blood coagulation, kinin release and rat paw edema. Biochim Biophys Acta 2000; 1477: 64-74
19. Macedo MLR, De Matos DG, Machado OL, Marangoni S, Novello JC. Trypsin inhibitor from Dimorphandra mollis seeds: purification and properties. Phytochemistry 2000; 54: 553-8
20. Oliva MLV, Andrade SA, Batista IFC, Sampaio MU, Juliano M, Fritz H et al. Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a FXa inhibitor isolated from Bauhinia ungulata seeds. J Immunopharmacol 1999; 45: 141-9
21. Heinz DW, Hyberts SG, Peng JW, Priestle JP, Wagner G, Grutter MG. Changing the inhibitory specificity and function of the proteinase inhibitor eglin c by site-directed mutagenesis: functional and structural investigation. Biochemistry 1992; 31: 8755-66
22. Schoofs L, Salzet M. Trypsin and chymotrypsin inhibitors in insects and gut leeches. Curr Pharm Des 2002; 8: 125-33
23. Kim SH, Hara S, Hase S, Ikenaka T, Toda H, Kitamura K et al. Comparative study on amino acid sequences of Kunitz-type soybean trypsin inhibitor, Tia, Tib, and Tic. J Biochem 1985; 98: 435-48