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Volumn 1, Issue NOV, 2010, Pages

Hypertonic saline therapy in cystic fibrosis: Do population shifts caused by the osmotic sensitivity of infecting bacteria explain the effectiveness of this treatment?

Author keywords

Alginate; Infective exacerbation; Metabolomics; mucA; Mucoid; Pseudomonas aeruginosa

Indexed keywords


EID: 84856902574     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2010.00120     Document Type: Article
Times cited : (17)

References (68)
  • 1
    • 33645236736 scopus 로고    scopus 로고
    • Microarray analysis of the osmotic stress response in Pseudomonas aeruginosa
    • Aspedon, A., Palmer, K., and Whiteley, M. (2006). Microarray analysis of the osmotic stress response in Pseudomonas aeruginosa. J. Bacteriol. 188, 2721-2725.
    • (2006) J. Bacteriol , vol.188 , pp. 2721-2725
    • Aspedon, A.1    Palmer, K.2    Whiteley, M.3
  • 3
    • 64749088448 scopus 로고    scopus 로고
    • Time-resolved metabolic footprinting for nonlinear modeling of bacterial substrate utilization
    • Behrends, V., Ebbels, T. M., Williams, H. D., and Bundy, J. G. (2009). Time-resolved metabolic footprinting for nonlinear modeling of bacterial substrate utilization. Appl. Environ. Microbiol. 75, 2453-2463.
    • (2009) Appl. Environ. Microbiol. , vol.75 , pp. 2453-2463
    • Behrends, V.1    Ebbels, T.M.2    Williams, H.D.3    Bundy, J.G.4
  • 4
    • 77249159843 scopus 로고    scopus 로고
    • Metabolic profiling of Pseudomonas aeruginosa demonstrates that the anti-sigma factor MucA modulates osmotic stress tolerance
    • Behrends, V., Ryall, B., Wang, X., Bundy, J. G., and Williams, H. D. (2010). Metabolic profiling of Pseudomonas aeruginosa demonstrates that the anti-sigma factor MucA modulates osmotic stress tolerance. Mol. Biosyst. 6, 562-569.
    • (2010) Mol. Biosyst. , vol.6 , pp. 562-569
    • Behrends, V.1    Ryall, B.2    Wang, X.3    Bundy, J.G.4    Williams, H.D.5
  • 5
    • 70350449606 scopus 로고    scopus 로고
    • The approach to Pseudomonas aeruginosa in cystic fibrosis
    • Bendiak, G. N., and Ratjen, F. (2009). The approach to Pseudomonas aeruginosa in cystic fibrosis. Semin. Respir. Crit. Care Med. 30, 587-595.
    • (2009) Semin. Respir. Crit. Care Med. , vol.30 , pp. 587-595
    • Bendiak, G.N.1    Ratjen, F.2
  • 7
    • 77953162318 scopus 로고    scopus 로고
    • Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control
    • doi:10.1017/S1462399410001420
    • Bjarnsholt, T., Tolker-Nielsen, T., Hoiby, N., and Givskov, M. (2010). Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control. Expert Rev. Mol. Med. 12, e11. doi:10.1017/S1462399410001420.
    • (2010) Expert Rev. Mol. Med. , vol.12
    • Bjarnsholt, T.1    Tolker-Nielsen, T.2    Hoiby, N.3    Givskov, M.4
  • 8
    • 0030931824 scopus 로고    scopus 로고
    • Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection
    • Boucher, J. C., Yu, H., Mudd, M. H., and Deretic, V. (1997). Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection. Infect. Immun. 65, 3838-3846.
    • (1997) Infect. Immun. , vol.65 , pp. 3838-3846
    • Boucher, J.C.1    Yu, H.2    Mudd, M.H.3    Deretic, V.4
  • 9
    • 34249662628 scopus 로고    scopus 로고
    • Cystic fibrosis: a disease of vulnerability to airway surface dehydration
    • Boucher, R. C. (2007). Cystic fibrosis: a disease of vulnerability to airway surface dehydration. Trends Mol. Med. 13, 231-240.
    • (2007) Trends Mol. Med. , vol.13 , pp. 231-240
    • Boucher, R.C.1
  • 10
    • 40649112565 scopus 로고    scopus 로고
    • Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis
    • Campodonico, V. L., Gadjeva, M., Paradis-Bleau, C., Uluer, A., and Pier, G. B. (2008). Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis. Trends Mol. Med. 14, 120-133.
    • (2008) Trends Mol. Med. , vol.14 , pp. 120-133
    • Campodonico, V.L.1    Gadjeva, M.2    Paradis-Bleau, C.3    Uluer, A.4    Pier, G.B.5
  • 13
    • 0026523829 scopus 로고
    • Cystic fibrosis: molecular biology and therapeutic implications
    • Collins, F. S. (1992). Cystic fibrosis: molecular biology and therapeutic implications. Science 256, 774-779.
    • (1992) Science , vol.256 , pp. 774-779
    • Collins, F.S.1
  • 14
    • 41549127468 scopus 로고    scopus 로고
    • Current and novel antimicrobial approaches
    • Davies, J. C. (2006). Current and novel antimicrobial approaches. Prog. Respir. Res. 34, 180-186.
    • (2006) Prog. Respir. Res. , vol.34 , pp. 180-186
    • Davies, J.C.1
  • 15
    • 66849126372 scopus 로고    scopus 로고
    • Bugs, biofilms, and resistance in cystic fibrosis
    • Davies, J. C., and Bilton, D. (2009). Bugs, biofilms, and resistance in cystic fibrosis. Respir. Care 54, 628-640.
    • (2009) Respir. Care , vol.54 , pp. 628-640
    • Davies, J.C.1    Bilton, D.2
  • 16
    • 77950787429 scopus 로고    scopus 로고
    • Inhaled mannitol improves the hydration and surface properties of sputum in patients with cystic fibrosis
    • Daviskas, E., Anderson, S. D., Jaques, A., and Charlton, B. (2010). Inhaled mannitol improves the hydration and surface properties of sputum in patients with cystic fibrosis. Chest 137, 861-868.
    • (2010) Chest , vol.137 , pp. 861-868
    • Daviskas, E.1    Anderson, S.D.2    Jaques, A.3    Charlton, B.4
  • 17
    • 33847711906 scopus 로고    scopus 로고
    • Cystic fibrosis mortality and survival in the UK: 1947-2003
    • Dodge, J. A., Lewis, P. A., Stanton, M., and Wilsher, J. (2007). Cystic fibrosis mortality and survival in the UK: 1947-2003. Eur. Respir. J. 29, 522-526.
    • (2007) Eur. Respir. J. , vol.29 , pp. 522-526
    • Dodge, J.A.1    Lewis, P.A.2    Stanton, M.3    Wilsher, J.4
  • 19
  • 21
    • 0036152202 scopus 로고    scopus 로고
    • Global genomic analysis of AlgU (sigma(E))-dependent promoters (sigmulon) in Pseudomonas aeruginosa and implications for inflammatory processes in cystic fibrosis
    • Firoved, A. M., Boucher, J. C., and Deretic, V. (2002). Global genomic analysis of AlgU (sigma(E))-dependent promoters (sigmulon) in Pseudomonas aeruginosa and implications for inflammatory processes in cystic fibrosis. J. Bacteriol. 184, 1057-1064.
    • (2002) J. Bacteriol. , vol.184 , pp. 1057-1064
    • Firoved, A.M.1    Boucher, J.C.2    Deretic, V.3
  • 22
    • 0037309251 scopus 로고    scopus 로고
    • Microarray analysis of global gene expression in mucoid Pseudomonas aeruginosa
    • Firoved, A. M., and Deretic, V. (2003). Microarray analysis of global gene expression in mucoid Pseudomonas aeruginosa. J. Bacteriol. 185, 1071-1081.
    • (2003) J. Bacteriol. , vol.185 , pp. 1071-1081
    • Firoved, A.M.1    Deretic, V.2
  • 23
    • 68649127406 scopus 로고    scopus 로고
    • Recent advances in the microbiology of respiratory tract infection in cystic fibrosis
    • Foweraker, J. (2009). Recent advances in the microbiology of respiratory tract infection in cystic fibrosis. Br. Med. Bull. 89, 93-110.
    • (2009) Br. Med. Bull. , vol.89 , pp. 93-110
    • Foweraker, J.1
  • 24
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • Gibson, R. L., Burns, J. L., and Ramsey, B. W. (2003). Pathophysiology and management of pulmonary infections in cystic fibrosis. Am. J. Respir. Crit. Care Med. 168, 918-951.
    • (2003) Am. J. Respir. Crit. Care Med. , vol.168 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Ramsey, B.W.3
  • 25
    • 34147215995 scopus 로고    scopus 로고
    • Exacerbations in cystic fibrosis. 1 epidemiology and pathogenesis
    • Goss, C. H., and Burns, J. L. (2007). Exacerbations in cystic fibrosis. 1: epidemiology and pathogenesis. Thorax 62, 360-367.
    • (2007) Thorax , vol.62 , pp. 360-367
    • Goss, C.H.1    Burns, J.L.2
  • 26
    • 34248658815 scopus 로고    scopus 로고
    • Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection
    • Govan, J. R., Brown, A. R., and Jones, A. M. (2007). Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol. 2, 153-164.
    • (2007) Future Microbiol , vol.2 , pp. 153-164
    • Govan, J.R.1    Brown, A.R.2    Jones, A.M.3
  • 27
    • 0029814366 scopus 로고    scopus 로고
    • Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
    • Govan, J. R., and Deretic, V. (1996). Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 60, 539-574.
    • (1996) Microbiol. Rev. , vol.60 , pp. 539-574
    • Govan, J.R.1    Deretic, V.2
  • 29
    • 61449207967 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways
    • Hassett, D. J., Sutton, M. D., Schurr, M. J., Herr, A. B., Caldwell, C. C., and Matu, J. O. (2009). Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways. Trends Microbiol. 17, 130-138.
    • (2009) Trends Microbiol , vol.17 , pp. 130-138
    • Hassett, D.J.1    Sutton, M.D.2    Schurr, M.J.3    Herr, A.B.4    Caldwell, C.C.5    Matu, J.O.6
  • 32
    • 0029094045 scopus 로고
    • The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E)
    • Hershberger, C. D., Ye, R. W., Parsek, M. R., Xie, Z. D., and Chakrabarty, A. M. (1995). The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E). Proc. Natl. Acad. Sci. U.S.A. 92, 7941-7945.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 7941-7945
    • Hershberger, C.D.1    Ye, R.W.2    Parsek, M.R.3    Xie, Z.D.4    Chakrabarty, A.M.5
  • 36
    • 0030845454 scopus 로고    scopus 로고
    • Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I
    • King, M., Dasgupta, B., Tomkiewicz, R. P., and Brown, N. E. (1997). Rheology of cystic fibrosis sputum after in vitro treatment with hypertonic saline alone and in combination with recombinant human deoxyribonuclease I. Am. J. Respir. Crit. Care Med. 156, 173-177.
    • (1997) Am. J. Respir. Crit. Care Med. , vol.156 , pp. 173-177
    • King, M.1    Dasgupta, B.2    Tomkiewicz, R.P.3    Brown, N.E.4
  • 37
    • 35448944740 scopus 로고    scopus 로고
    • Biofilm differentiation and dispersal in mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Kirov, S. M., Webb, J. S., O'May C. Y., Reid, D. W., Woo, J. K., Rice, S. A., and Kjelleberg, S. (2007). Biofilm differentiation and dispersal in mucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Microbiology 153(Pt 10), 3264-3274.
    • (2007) Microbiology , vol.153 , Issue.10 , pp. 3264-3274
    • Kirov, S.M.1    Webb, J.S.2    O'May, C.Y.3    Reid, D.W.4    Woo, J.K.5    Rice, S.A.6    Kjelleberg, S.7
  • 38
    • 33748744717 scopus 로고    scopus 로고
    • Hypertonic saline therapy in cystic fibrosis: evidence against the proposed mechanism involvfibroing aquaporins
    • Levin, M. H., Sullivan, S., Nielson, D., Yang, B., Finkbeiner, W. E., and Verkman, A. S. (2006). Hypertonic saline therapy in cystic fibrosis: evidence against the proposed mechanism involvfibroing aquaporins. J. Biol. Chem. 281, 25803-25812.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25803-25812
    • Levin, M.H.1    Sullivan, S.2    Nielson, D.3    Yang, B.4    Finkbeiner, W.E.5    Verkman, A.S.6
  • 39
    • 33847289649 scopus 로고    scopus 로고
    • Cystic fibrosis and other respiratory diseases of impaired mucus clearance
    • Livraghi, A., and Randell, S. H. (2007). Cystic fibrosis and other respiratory diseases of impaired mucus clearance. Toxicol. Pathol. 35, 116-129.
    • (2007) Toxicol. Pathol , vol.35 , pp. 116-129
    • Livraghi, A.1    Randell, S.H.2
  • 40
    • 0036225688 scopus 로고    scopus 로고
    • Lung infections associated with cystic fibrosis
    • Lyczak, J. B., Cannon, C. L., and Pier, G. B. (2002). Lung infections associated with cystic fibrosis. Clin. Microbiol. Rev. 15, 194-222.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 194-222
    • Lyczak, J.B.1    Cannon, C.L.2    Pier, G.B.3
  • 43
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T., Davis, C. W., and Boucher, R. C. (1998). Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95, 1005-1015.
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3    Randell, S.H.4    Gatzy, J.T.5    Davis, C.W.6    Boucher, R.C.7
  • 44
    • 57349176546 scopus 로고    scopus 로고
    • Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis
    • Minasian, C., Wallis, C., Metcalfe, C., and Bush, A. (2008). Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis. Pediatr. Pulmonol. 43, 1078-1084.
    • (2008) Pediatr. Pulmonol. , vol.43 , pp. 1078-1084
    • Minasian, C.1    Wallis, C.2    Metcalfe, C.3    Bush, A.4
  • 45
    • 47049126626 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway
    • Moreau-Marquis, S., Stanton, B. A., and O'Toole, G. A. (2008). Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway. Pulm. Pharmacol. Ther. 21, 595-599.
    • (2008) Pulm. Pharmacol. Ther. , vol.21 , pp. 595-599
    • Moreau-Marquis, S.1    Stanton, B.A.2    O'Toole, G.A.3
  • 47
    • 33846284918 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
    • Murray, T. S., Egan, M., and Kazmierczak, B. I. (2007). Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Curr. Opin. Pediatr. 19, 83-88.
    • (2007) Curr. Opin. Pediatr. , vol.19 , pp. 83-88
    • Murray, T.S.1    Egan, M.2    Kazmierczak, B.I.3
  • 49
    • 17144382063 scopus 로고    scopus 로고
    • Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis
    • Ramsey, D. M., and Wozniak, D. J. (2005). Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis. Mol. Microbiol. 56, 309-322.
    • (2005) Mol. Microbiol. , vol.56 , pp. 309-322
    • Ramsey, D.M.1    Wozniak, D.J.2
  • 50
    • 70350244436 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells
    • doi:10.1371/journal.pone.0007259
    • Raoust, E., Balloy, V., Garcia-Verdugo, I., Touqui, L., Ramphal, R., and Chignard,M. (2009). Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLR-dependent signaling in murine alveolar macrophages and airway epithelial cells. PLoS ONE 4, e7259. doi:10.1371/journal.pone.0007259.
    • (2009) PLoS ONE , vol.4
    • Raoust, E.1    Balloy, V.2    Garcia-Verdugo, I.3    Touqui, L.4    Ramphal, R.5    Chignard, M.6
  • 51
    • 0035145159 scopus 로고    scopus 로고
    • Changes in strategies for optimal antibacterial therapy in cystic fibrosis
    • Ratjen, F. (2001). Changes in strategies for optimal antibacterial therapy in cystic fibrosis. Int. J. Antimicrob. Agents 17, 93-96.
    • (2001) Int. J. Antimicrob. Agents , vol.17 , pp. 93-96
    • Ratjen, F.1
  • 52
    • 33750302487 scopus 로고    scopus 로고
    • Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis
    • Ratjen, F. (2006). Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis. Curr. Opin. Pulm. Med. 12, 428-432.
    • (2006) Curr. Opin. Pulm. Med. , vol.12 , pp. 428-432
    • Ratjen, F.1
  • 53
    • 0037460729 scopus 로고    scopus 로고
    • Cystic fibrosis
    • Ratjen, F., and Doring, G. (2003). Cystic fibrosis. Lancet 361, 681-689.
    • (2003) Lancet , vol.361 , pp. 681-689
    • Ratjen, F.1    Doring, G.2
  • 55
    • 0032834277 scopus 로고    scopus 로고
    • The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study
    • Robinson, M., Daviskas, E., Eberl, S., Baker, J., Chan, H. K., Anderson, S. D., and Bye, P. T. (1999). The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. Eur. Respir. J. 14, 678-685.
    • (1999) Eur. Respir. J. , vol.14 , pp. 678-685
    • Robinson, M.1    Daviskas, E.2    Eberl, S.3    Baker, J.4    Chan, H.K.5    Anderson, S.D.6    Bye, P.T.7
  • 56
    • 0030784262 scopus 로고    scopus 로고
    • Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis
    • Robinson, M., Hemming, A. L., Regnis, J. A., Wong, A. G., Bailey, D. L., Bautovich, G. J., King, M., and Bye, P. T. (1997). Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 52, 900-903.
    • (1997) Thorax , vol.52 , pp. 900-903
    • Robinson, M.1    Hemming, A.L.2    Regnis, J.A.3    Wong, A.G.4    Bailey, D.L.5    Bautovich, G.J.6    King, M.7    Bye, P.T.8
  • 57
    • 0029916071 scopus 로고    scopus 로고
    • Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis
    • Robinson, M., Regnis, J. A., Bailey, D. L., King, M., Bautovich, G. J., and Bye, P. T. (1996). Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 153, 1503-1509.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.153 , pp. 1503-1509
    • Robinson, M.1    Regnis, J.A.2    Bailey, D.L.3    King, M.4    Bautovich, G.J.5    Bye, P.T.6
  • 58
    • 0034010419 scopus 로고    scopus 로고
    • Membrane-to-cytosol redistribution of ECF sigma factor AlgU and conversion to mucoidy in Pseudomonas aeruginosa isolates from cystic fibrosis patients
    • Rowen, D. W., and Deretic, V. (2000). Membrane-to-cytosol redistribution of ECF sigma factor AlgU and conversion to mucoidy in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Mol. Microbiol. 36, 314-327.
    • (2000) Mol. Microbiol. , vol.36 , pp. 314-327
    • Rowen, D.W.1    Deretic, V.2
  • 59
    • 0029747226 scopus 로고    scopus 로고
    • Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis
    • Schurr, M. J., Yu, H., Martinez-Salazar, J. M., Boucher, J. C., and Deretic, V. (1996). Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. J. Bacteriol. 178, 4997-5004.
    • (1996) J. Bacteriol. , vol.178 , pp. 4997-5004
    • Schurr, M.J.1    Yu, H.2    Martinez-Salazar, J.M.3    Boucher, J.C.4    Deretic, V.5
  • 60
    • 0001564471 scopus 로고
    • Antiphagocytic effect of slime from a mucoid strain of Pseudomonas aeruginosa
    • Schwarzmann, S., and Boring, J. R. (1971). Antiphagocytic effect of slime from a mucoid strain of Pseudomonas aeruginosa. Infect. Immun. 3, 762-767.
    • (1971) Infect. Immun. , vol.3 , pp. 762-767
    • Schwarzmann, S.1    Boring, J.R.2
  • 61
    • 54449089545 scopus 로고    scopus 로고
    • A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients
    • Sibley, C. D., Parkins, M. D., Rabin, H. R., Duan, K., Norgaard, J. C., and Surette, M. G. (2008). A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients. Proc. Natl. Acad. Sci. U.S.A. 105, 15070-15075.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 15070-15075
    • Sibley, C.D.1    Parkins, M.D.2    Rabin, H.R.3    Duan, K.4    Norgaard, J.C.5    Surette, M.G.6
  • 62
    • 0029870085 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
    • Smith, J. J., Travis, S. M., Greenberg, E. P., and Welsh, M. J. (1996). Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85, 229-236.
    • (1996) Cell , vol.85 , pp. 229-236
    • Smith, J.J.1    Travis, S.M.2    Greenberg, E.P.3    Welsh, M.J.4
  • 64
    • 18844373631 scopus 로고    scopus 로고
    • How much do Pseudomonas biofilms contribute to symptoms of pulmonary exacerbation in cystic fibrosis? Pediatr
    • VanDevanter, D. R., and Van Dalfsen, J. M. (2005). How much do Pseudomonas biofilms contribute to symptoms of pulmonary exacerbation in cystic fibrosis? Pediatr. Pulmonol. 39, 504-506.
    • (2005) Pulmonol , vol.39 , pp. 504-506
    • VanDevanter, D.R.1    Van Dalfsen, J.M.2
  • 65
  • 66
    • 0029838523 scopus 로고    scopus 로고
    • The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa
    • Whitchurch, C. B., Alm, R. A., and Mattick, J. S. (1996). The alginate regulator AlgR and an associated sensor FimS are required for twitching motility in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A. 93, 9839-9843.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 9839-9843
    • Whitchurch, C.B.1    Alm, R.A.2    Mattick, J.S.3
  • 67
    • 33749181103 scopus 로고    scopus 로고
    • Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: roles of sigma (AlgT) and the AlgW and Prc proteases
    • Wood, L. F., Leech, A. J., and Ohman, D. E. (2006). Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: roles of sigma (AlgT) and the AlgW and Prc proteases. Mol. Microbiol. 62, 412-426.
    • (2006) Mol. Microbiol. , vol.62 , pp. 412-426
    • Wood, L.F.1    Leech, A.J.2    Ohman, D.E.3
  • 68
    • 7744241363 scopus 로고    scopus 로고
    • MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa
    • Wu, W., Badrane, H., Arora, S., Baker, H. V., and Jin, S. (2004). MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J. Bacteriol. 186, 7575-7585.
    • (2004) J. Bacteriol. , vol.186 , pp. 7575-7585
    • Wu, W.1    Badrane, H.2    Arora, S.3    Baker, H.V.4    Jin, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.