Inhibitory effects of hypertonic saline on P. aeruginosa motility

Journal of Cystic Fibrosis

Volumn 7, Issue 4, 2008, Pages 267-269

  Havasi, Viktória ^a   Hurst, Casey O ^a   Briles, Travis C ^a   Yang, Fan ^a   Bains, David G ^a   Hassett, Daniel J ^b   Sorscher, Eric ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cystic fibrosis; High salt; Mucociliary clearance

Indexed keywords

PLACEBO; SODIUM; SODIUM CHLORIDE;

AEROSOL; BACTERIAL CELL; BACTERIAL FLAGELLUM; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOFILM; CELL MOTILITY; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CYSTIC FIBROSIS; DISEASE PREDISPOSITION; EDITORIAL; FORCED EXPIRATORY VOLUME; HUMAN; INCUBATION TIME; INHIBITION KINETICS; LUNG FUNCTION; OSMOLARITY; PATHOGENESIS; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SODIUM TRANSPORT; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; ANTI-INFECTIVE AGENTS; BIOFILMS; CHEMOTAXIS; CYSTIC FIBROSIS; FLAGELLA; HUMANS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS; SALINE SOLUTION, HYPERTONIC;

EID: 46749093835     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2007.11.009     Document Type: Editorial

References (21)

1. Feldman M., Bryan R., Rajan S., et al. Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection. Infect Immun 66 (1998) 43-51
2. Tang H.B., DiMango E., Bryan R., et al. Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect Immun 64 (1996) 37-43
3. Drake D., and Montie T.C. Flagella, motility and invasive virulence of Pseudomonas aeruginosa. J Gen Microbiol 134 (1988) 43-52
4. Fleiszig S.M., Arora S.K., Van R., and Ramphal R. FlhA, a component of the flagellum assembly apparatus of Pseudomonas aeruginosa, plays a role in internalization by corneal epithelial cells. Infect Immun 69 (2001) 4931-4937
5. Montie T.C., Doyle-Huntzinger D., Craven R.C., and Holder I.A. Loss of virulence associated with absence of flagellum in an isogenic mutant of Pseudomonas aeruginosa in the burned-mouse model. Infect Immun 38 (1982) 1296-1298
6. Eng P.A., Morton J., Douglass J.A., Riedler J., Wilson J., and Robertson C.F. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr Pulmonol 21 (1996) 77-83
7. Robinson M., Hemming A.L., Regnis J.A., et al. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 52 (1997) 900-903
8. Ballmann M., and von der Hardt H. Hypertonic saline and recombinant human DNase: a randomised cross-over pilot study in patients with cystic fibrosis. J Cyst Fibros 1 (2002) 35-37
9. Elkins M.R., Robinson M., Rose B.R., et al. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354 (2006) 229-240
10. Donaldson S.H., Bennett W.D., Zeman K.L., Knowles M.R., Tarran R., and Boucher R.C. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 354 (2006) 241-250
11. Li C., and Adler J. Escherichia coli shows two types of behavioral responses to osmotic upshift. J Bacteriol 175 (1993) 2564-2567
12. Shi W., Li C., Louise C.J., and Adler J. Mechanism of adverse conditions causing lack of flagella in Escherichia coli. J Bacteriol 175 (1993) 2236-2240
13. Soutourina O.A., Semenova E.A., Parfenova V.V., Danchin A., and Bertin P. Control of bacterial motility by environmental factors in polarly flagellated and peritrichous bacteria isolated from Lake Baikal. Appl Environ Microbiol 67 (2001) 3852-3859
14. Schweizer H.P. Allelic exchange in Pseudomonas aeruginosa using novel ColE1-type vectors and a family of cassettes containing a portable oriT and the counter-selectable Bacillus subtilis sacB marker. Mol Microbiol 6 (1992) 1195-1204
15. Wozniak D.J., and Ohman D.E. Involvement of the alginate algT gene and integration host factor in the regulation of the Pseudomonas aeruginosa algB gene. J Bacteriol 175 (1993) 4145-4153
16. Aitken M.L., Greene K.E., Tonelli M.R., et al. Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosis. Chest 123 (2003) 792-799
17. Sood N., Bennett W.D., Zeman K., et al. Increasing concentration of inhaled saline with or without amiloride: effect on mucociliary clearance in normal subjects. Am J Respir Crit Care Med 167 (2003) 158-163
18. Rashid M.H., and Kornberg A. Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 97 (2000) 4885-4890
19. Rashid M.H., Rao N.N., and Kornberg A. Inorganic polyphosphate is required for motility of bacterial pathogens. J Bacteriol 182 (2000) 225-227
20. Rao N.N., Kornberg A. Inorganic polyphosphates: biochemistry, biology, biotechnology. Schroeder, HC, Muller, WEG, editors. In: Progress in Molecular and Subcellular Biology. Berlin: Springer Verlag; 1999.
21. O'Toole G.A., and Kolter R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 30 (1998) 295-304