Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis

Thorax

Volumn 52, Issue 10, 1997, Pages 900-903

  Robinson, Michael ^a   Hemming, Ariane L ^a   Regnis, Jeffrey A ^a   Wong, Andrea G ^a   Bailey, Dale L ^b   Bautovich, George J ^a   King, M ^c   Bye, Peter T P ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cystic fibrosis; Hypertonic saline; Mucociliary clearance

Indexed keywords

SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; COUGHING; CYSTIC FIBROSIS; DOSE RESPONSE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; MUCOCILIARY CLEARANCE; NEBULIZATION; PRIORITY JOURNAL;

EID: 0030784262     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.10.900     Document Type: Article

References (20)

1. Regnis JA, Robinson M, Bailey DL, Cook P, Hooper P, Chan HK, et al. Mucociliary clearance in patients with cystic fibrosis and in normal subjects. Am J Respir Crit Care Med 1994;150:66-71.
2. Robinson M, Regnis JA, Bailey DL, King M, Bautovich GJ, Bye PT. Effect of Hypertonic saline, amiloride and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 1996;153:1503-9.
3. Bailey DL, Fulton RR, Jackson CB, Hutton BF. Dynamic geometric mean studies using a single headed rotating gamma camera. J Nucl Med 1989;30:1865-9.
4. Bailey DL, Robinson M, Meikle SR, Bye PTP. Simultaneous emission and transmission measurements as an adjunct to dynamic planar gamma camera studies. Eur J Nucl Med 1996;23:326-31.
5. Phipps PR, Gonda I, Anderson SD. Apparatus for the control of breathing patterns during aerosol inhalation. J Aerosol Med 1992;5:155-69.
6. Daviskas E, Anderson SD, Gonda I, Eberl S, Meikle S, Seale JP, et al. Inhalation of Hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur Respir J 1996;9:725 32.
7. Altman D. Practical statistics for medical research. 1st ed. London: Chapman & Hall, 1991; 210-12, 325-51.
8. Bennett WD, Foster WM, Chapman WF. Cough-enhanced mucus clearance in the normal lung. J Appl Physiol 1990;69:1670-5.
9. Dasgupta B, Tomkiewicz RP, Brown NE, King M. Combined effects of hypertonic saline and rhDNase on cystic fibrosis sputum in vitro. Pediatr Pulmonol 1995;20(Suppl 12):A201-36.
10. Ziment I. Respiratory pharmacology and therapeuties. Philadelphia: WB Saunders, 1978: 60-104.
11. Assouline G, Leibson V, Danon A. Stimulation of prostaglandin output from rat stomach by hypertonic solutions. Eur J Pharmacol 1977;44:271-3.
12. Wills PJ, Hall RL, Chan W-M, Cole PJ. Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea. J Clin Invest 1996;99:9-13.
13. Potter JL, Matthews LW, Spector S, Lemm J. Studies on pulmonary secretions II. Osmolality and the ionic environment of pulmonary secretions from patients with cystic fibrosis, bronchiectasis and laryngectomy. Am Rev Respir Dis 1967;96:83-7.
14. Joris L, Dab I, Quinton PM. Elemental composition of human airway surface fluid in healthy and diseased airways. Am Rev Respir Dis 1993;148:1633-7.
15. Folkesson HG, Kheradmand F, Matthay MA. The effect of salt water on alveolar epithelial barrier function. Am J Respir Crit Care Med 1994;150:1555-63.
16. Mizgerd JP, Kobzik L, Warner AE, Brain JD. Effects of sodium concentration on human neutrophil bactericidal functions. Am J Physiol 1995;269(3 Pt 1):L388-93.
17. Smith JJ, Travis SM, Greenberg EP, Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996;85:229-36.
18. Goldman MJ, Anderson GM, Stolzenberg ED, Kan UP, Zasloff M, Wilson JM. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997;88:553-60.
19. Rodwell LT, Anderson SD. Airway responsiveness to hyperosmolar saline challenge in cystic fibrosis - a pilot study. Pediatr Pulmonol 1996;21:282-9.
20. Eng PA, Morton J, Douglass JA, Riedler J, Wilson J, Robertson CF. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr Pulmonol 1996;21:77-83.