Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κb (NF-κB) signalling pathways, and improves diabetic nephropathy in mice

Diabetologia

Volumn 55, Issue 2, 2012, Pages 509-519

  Ka, S M ^a   Yeh, Y C ^a   Huang, X R ^c   Chao, T K ^a   Hung, Y J ^a   Yu, C P ^a   Lin, T J ^a   Wu, C C ^a   Lan, H Y ^c   Chen, A ^a,b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

db db mice; Diabetic nephropathy; Endothelial cell; Podocyte; SMAD7; Type 2 diabetes; Ultrasound mediated microbubble inducible gene transfer

Indexed keywords

ANTIDIABETIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL INFILTRATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; GENE; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE TRANSFER; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; KIDNEY FIBROSIS; MACROPHAGE; MALE; MOUSE; NEPHRITIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; SIGNAL TRANSDUCTION; SMAD7 GENE; TARGET ORGAN;

ANIMALS; APOPTOSIS; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; GENE TRANSFER TECHNIQUES; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NF-KAPPA B; PODOCYTES; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ULTRASONICS;

EID: 84856718373     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2364-5     Document Type: Article

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