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Volumn 27, Issue 4, 2012, Pages 1219-1226

Valproic acid overcomes hypoxia-induced resistance to apoptosis

Author keywords

Apoptosis; Hypoxia; Neuroblastoma; Valproic acid

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; CISPLATIN; OXYGEN; PROTEIN BID; VALPROIC ACID;

EID: 84856573900     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1577     Document Type: Article
Times cited : (25)

References (44)
  • 1
    • 0037366067 scopus 로고    scopus 로고
    • Neuroblastoma: Biological insights into a clinical enigma
    • Brodeur GM: Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 3: 203-216, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 203-216
    • Brodeur, G.M.1
  • 2
    • 33947153003 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
    • DOI 10.1002/ijc.22401
    • Furchert SE, Lanvers-Kaminsky C, Juurgens H, Jung M, Loidl A and Frühwald MC: Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 120: 1787-1794, 2007. (Pubitemid 46399367)
    • (2007) International Journal of Cancer , vol.120 , Issue.8 , pp. 1787-1794
    • Furchert, S.E.1    Lanvers-Kaminsky, C.2    Jurgens, H.3    Jung, M.4    Loidl, A.5    Fruhwald, M.C.6
  • 3
    • 79961148308 scopus 로고    scopus 로고
    • Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation
    • Mossman D and Scott RJ: Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation. PloS One 6: e23127, 2011.
    • (2011) PloS One , vol.6
    • Mossman, D.1    Scott, R.J.2
  • 4
    • 34249033131 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular and biological activity as a premise to clinical application
    • Santini V, Gozzini A and Ferrari G: Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 8: 383-393, 2007.
    • (2007) Curr Drug Metab , vol.8 , pp. 383-393
    • Santini, V.1    Gozzini, A.2    Ferrari, G.3
  • 5
    • 40349100607 scopus 로고    scopus 로고
    • Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- And antiapoptotic proteins
    • Bokelmann I and Mahlknecht U: Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins. Mol Med 14: 20-27, 2007.
    • (2007) Mol Med , vol.14 , pp. 20-27
    • Bokelmann, I.1    Mahlknecht, U.2
  • 6
    • 77954659911 scopus 로고    scopus 로고
    • Cracking the death code: Apoptosis-related histone modifications
    • Fullgrabe J, Hajji N and Joseph B: Cracking the death code: apoptosis-related histone modifications. Cell Death Differ 1: 1238-1243, 2010.
    • (2010) Cell Death Differ , vol.1 , pp. 1238-1243
    • Fullgrabe, J.1    Hajji, N.2    Joseph, B.3
  • 7
    • 77956329493 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells
    • Hrebackova J, Poljakova J, Eckschlager T, et al: Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells. Interdiscip Toxicol 2: 205-210, 2009.
    • (2009) Interdiscip Toxicol , vol.2 , pp. 205-210
    • Hrebackova, J.1    Poljakova, J.2    Eckschlager, T.3
  • 9
    • 16644379041 scopus 로고    scopus 로고
    • Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo
    • Michaelis M, Suhan T, Cinatl J, Driever PH and Cinatl J: Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo. Int J Oncol 25: 1795-1799, 2004.
    • (2004) Int J Oncol , vol.25 , pp. 1795-1799
    • Michaelis, M.1    Suhan, T.2    Cinatl, J.3    Driever, P.H.4    Cinatl, J.5
  • 10
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL: Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 11
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F and Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465, 1989. (Pubitemid 20008770)
    • (1989) Cancer Research , vol.49 , Issue.23 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 12
    • 33749556704 scopus 로고    scopus 로고
    • Chronic hypoxia promotes hypoxia-inducible factor-1-alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells
    • DOI 10.1158/1535-7163.MCT-06-0145
    • Hussein D, Estlin EJ, Dive C and Makin GW: Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. Mol Cancer Ther 5: 2241-2250, 2006. (Pubitemid 44530461)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.9 , pp. 2241-2250
    • Hussein, D.1    Estlin, E.J.2    Dive, C.3    Makin, G.W.J.4
  • 13
    • 69049083600 scopus 로고    scopus 로고
    • Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression
    • Lara PC, Lloret M, Clavo B, et al: Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression. Radiat Oncol 4: 29, 2009.
    • (2009) Radiat Oncol , vol.4 , pp. 29
    • Lara, P.C.1    Lloret, M.2    Clavo, B.3
  • 14
    • 33748458071 scopus 로고    scopus 로고
    • Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene
    • DOI 10.1007/s00280-006-0224-7
    • Song X, Liu X, Chi W, et al: Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene. Cancer Chemother Pharmacol 58: 776-784, 2006. (Pubitemid 44351258)
    • (2006) Cancer Chemotherapy and Pharmacology , vol.58 , Issue.6 , pp. 776-784
    • Song, X.1    Liu, X.2    Chi, W.3    Liu, Y.4    Wei, L.5    Wang, X.6    Yu, J.7
  • 15
    • 33745198035 scopus 로고    scopus 로고
    • Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populations [2]
    • DOI 10.1038/sj.leu.2404224, PII 2404224
    • Giuntoli S, Rovida E, Barbetti V, Cipolleschi MG, Olivotto M and Dello Sbarba P: Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populations. Leukemia 20: 1291-1293, 2006. (Pubitemid 43905834)
    • (2006) Leukemia , vol.20 , Issue.7 , pp. 1291-1293
    • Giuntoli, S.1    Rovida, E.2    Barbetti, V.3    Cipolleschi, M.G.4    Olivotto, M.5    Dello, S.P.6
  • 16
    • 33846697957 scopus 로고    scopus 로고
    • Hypoxia-induced genetic instability - A calculated mechanism underlying tumor progression
    • DOI 10.1007/s00109-006-0133-6
    • Huang LE, Bindra RS, Glazer PM and Harris AL: Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression. J Mol Med (Berl) 85: 139-148, 2007. (Pubitemid 46188219)
    • (2007) Journal of Molecular Medicine , vol.85 , Issue.2 , pp. 139-148
    • Huang, L.E.1    Bindra, R.S.2    Glazer, P.M.3    Harris, A.L.4
  • 18
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, et al: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515, 1996. (Pubitemid 26330463)
    • (1996) Cancer Research , vol.56 , Issue.19 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 19
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxic cervical cancers with low apoptotic index are highly aggressive
    • Hockel M, Schlenger K, Hockel S and Vaupel P: Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res 59: 4525-4528, 1999. (Pubitemid 29428951)
    • (1999) Cancer Research , vol.59 , Issue.18 , pp. 4525-4528
    • Hockel, M.1    Schlenger, K.2    Hockel, S.3    Vaupel, P.4
  • 20
    • 0033942067 scopus 로고    scopus 로고
    • Detection of apoptosis by annexin V labeling
    • Bossy-Wetzel E and Green DR: Detection of apoptosis by annexin V labeling. Methods Enzymol 322: 15-18, 2000. (Pubitemid 30482040)
    • (2000) Methods in Enzymology , vol.322 , pp. 15-18
    • Bossy-Wetzel, E.1    Green, D.R.2
  • 21
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • Pfaffl MW, Horgan GW and Dempfle L: Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
    • (2002) Nucleic Acids Res , vol.30
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 22
    • 33644657517 scopus 로고    scopus 로고
    • Bid, a BH3-only multi-functional molecule, is at the cross road of life and death
    • Yin X-M: Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene 369: 7-19, 2006.
    • (2006) Gene , vol.369 , pp. 7-19
    • Yin, X.-M.1
  • 23
    • 0034699326 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
    • Baek JH, Jang JE, Kang CM, Chung HY, Kim ND and Kim KW: Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene 19: 4621-4631, 2000.
    • (2000) Oncogene , vol.19 , pp. 4621-4631
    • Baek, J.H.1    Jang, J.E.2    Kang, C.M.3    Chung, H.Y.4    Kim, N.D.5    Kim, K.W.6
  • 24
    • 33645005086 scopus 로고    scopus 로고
    • HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression
    • Liu X-H, Yu EZ, Li Y-Y and Kagan E: HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression. J Cell Biochem 97: 755-765, 2006.
    • (2006) J Cell Biochem , vol.97 , pp. 755-765
    • Liu, X.-H.1    Yu, E.Z.2    Li, Y.-Y.3    Kagan, E.4
  • 26
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 27
    • 0042411985 scopus 로고    scopus 로고
    • Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
    • DOI 10.1016/S0305-7372(03)00003-3
    • Shannon AM, Bouchier-Hayes DJ, Condron CM and Toomey D: Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 29: 297-307, 2003. (Pubitemid 37069660)
    • (2003) Cancer Treatment Reviews , vol.29 , Issue.4 , pp. 297-307
    • Shannon, A.M.1    Bouchier-Hayes, D.J.2    Condron, C.M.3    Toomey, D.4
  • 28
    • 3242776224 scopus 로고    scopus 로고
    • Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells
    • Um JH, Kang CHD, Bae JH, et al: Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells. Exp Mol Med 36: 233-242, 2004. (Pubitemid 38981420)
    • (2004) Experimental and Molecular Medicine , vol.36 , Issue.3 , pp. 233-242
    • Um, J.H.1    Kang, C.D.2    Bae, J.H.3    Shin, G.G.4    Kim, D.W.5    Kim, D.W.6    Chung, B.S.7    Kim, S.H.8
  • 29
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • DOI 10.1038/379088a0
    • Graeber TG, Osmanian C, Jacks T, et al: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: 88-91, 1996. (Pubitemid 26008141)
    • (1996) Nature , vol.379 , Issue.6560 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 32
    • 0035855668 scopus 로고    scopus 로고
    • Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia
    • DOI 10.1038/sj.onc.1204742
    • Suzuki H, Tomida a and Tsuruo T: Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 20: 5779-5788, 2001. (Pubitemid 32937947)
    • (2001) Oncogene , vol.20 , Issue.41 , pp. 5779-5788
    • Suzuki, H.1    Tomida, A.2    Tsuruo, T.3
  • 33
    • 34247850849 scopus 로고    scopus 로고
    • Regulation of the HIF-1á stability by histone deacetylases
    • Kim SH, Jeong JW, Park JA, et al: Regulation of the HIF-1á stability by histone deacetylases. Oncol Rep 17: 647-651, 2007.
    • (2007) Oncol Rep , vol.17 , pp. 647-651
    • Kim, S.H.1    Jeong, J.W.2    Park, J.A.3
  • 35
    • 77953184918 scopus 로고    scopus 로고
    • HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
    • Sendoel A, Kohler I, Fellmann C, Lowe WS and Hengartner OM: HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 465: 577-585, 2010.
    • (2010) Nature , vol.465 , pp. 577-585
    • Sendoel, A.1    Kohler, I.2    Fellmann, C.3    Lowe, W.S.4    Hengartner, O.M.5
  • 36
    • 79958289721 scopus 로고    scopus 로고
    • HIF-1á antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
    • Nardinocchi L, Puca R and Orazi GD: HIF-1á antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. Aging 3: 33-43, 2011.
    • (2011) Aging , vol.3 , pp. 33-43
    • Nardinocchi, L.1    Puca, R.2    Orazi, G.D.3
  • 37
    • 77954401666 scopus 로고    scopus 로고
    • Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia
    • Flamant L, Notte A, Ninane N, Raes M and Michiels C: Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia. Mol Cancer 9: 191, 2010.
    • (2010) Mol Cancer , vol.9 , pp. 191
    • Flamant, L.1    Notte, A.2    Ninane, N.3    Raes, M.4    Michiels, C.5
  • 38
    • 0035378480 scopus 로고    scopus 로고
    • Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms
    • Dong Z, Venkatachalam Ma, Wang J, et al: Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J Biol Chem 276: 18702-18709, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 18702-18709
    • Dong, Z.1    Venkatachalam, Ma.2    Wang, J.3
  • 39
    • 33747376305 scopus 로고    scopus 로고
    • Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway
    • Piret J-P, Cosse J-P, Ninane N, Raes M and Michiels C: Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway. Exp Cell Res 312: 2908-2920, 2006.
    • (2006) Exp Cell Res , vol.312 , pp. 2908-2920
    • Piret, J.-P.1    Cosse, J.-P.2    Ninane, N.3    Raes, M.4    Michiels, C.5
  • 40
    • 0033593573 scopus 로고    scopus 로고
    • Valproate robustly enhances AP-1 mediated gene expression
    • DOI 10.1016/S0169-328X(98)00303-9, PII S0169328X98003039
    • Chen G, Yuan PX, Jiang YM, Huang LD and Manji HK: Valproate robustly enhances AP-1 mediated gene expression. Brain Res Mol Brain Res 64: 52-58, 1999. (Pubitemid 29049235)
    • (1999) Molecular Brain Research , vol.64 , Issue.1 , pp. 52-58
    • Chen, G.1    Yuan, P.-X.2    Jiang, Y.-M.3    Huang, L.-D.4    Manji, H.K.5
  • 41
    • 77950829408 scopus 로고    scopus 로고
    • Valproic acid in the complex therapy of malignant tumors
    • Hrebackova J, Hrabeta J and Eckschlager T: Valproic acid in the complex therapy of malignant tumors. Curr Drug Targets 11: 361-379, 2010.
    • (2010) Curr Drug Targets , vol.11 , pp. 361-379
    • Hrebackova, J.1    Hrabeta, J.2    Eckschlager, T.3
  • 44
    • 47349097996 scopus 로고    scopus 로고
    • Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells
    • Muhlethaler-Mottet A, Meier R, Flahaut M, et al: Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. Mol Cancer 7: 55, 2008.
    • (2008) Mol Cancer , vol.7 , pp. 55
    • Muhlethaler-Mottet, A.1    Meier, R.2    Flahaut, M.3


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