-
1
-
-
0037366067
-
Neuroblastoma: Biological insights into a clinical enigma
-
Brodeur GM: Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 3: 203-216, 2003.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 203-216
-
-
Brodeur, G.M.1
-
2
-
-
33947153003
-
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
-
DOI 10.1002/ijc.22401
-
Furchert SE, Lanvers-Kaminsky C, Juurgens H, Jung M, Loidl A and Frühwald MC: Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 120: 1787-1794, 2007. (Pubitemid 46399367)
-
(2007)
International Journal of Cancer
, vol.120
, Issue.8
, pp. 1787-1794
-
-
Furchert, S.E.1
Lanvers-Kaminsky, C.2
Jurgens, H.3
Jung, M.4
Loidl, A.5
Fruhwald, M.C.6
-
3
-
-
79961148308
-
Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation
-
Mossman D and Scott RJ: Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation. PloS One 6: e23127, 2011.
-
(2011)
PloS One
, vol.6
-
-
Mossman, D.1
Scott, R.J.2
-
4
-
-
34249033131
-
Histone deacetylase inhibitors: Molecular and biological activity as a premise to clinical application
-
Santini V, Gozzini A and Ferrari G: Histone deacetylase inhibitors: molecular and biological activity as a premise to clinical application. Curr Drug Metab 8: 383-393, 2007.
-
(2007)
Curr Drug Metab
, vol.8
, pp. 383-393
-
-
Santini, V.1
Gozzini, A.2
Ferrari, G.3
-
5
-
-
40349100607
-
Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- And antiapoptotic proteins
-
Bokelmann I and Mahlknecht U: Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins. Mol Med 14: 20-27, 2007.
-
(2007)
Mol Med
, vol.14
, pp. 20-27
-
-
Bokelmann, I.1
Mahlknecht, U.2
-
6
-
-
77954659911
-
Cracking the death code: Apoptosis-related histone modifications
-
Fullgrabe J, Hajji N and Joseph B: Cracking the death code: apoptosis-related histone modifications. Cell Death Differ 1: 1238-1243, 2010.
-
(2010)
Cell Death Differ
, vol.1
, pp. 1238-1243
-
-
Fullgrabe, J.1
Hajji, N.2
Joseph, B.3
-
7
-
-
77956329493
-
Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells
-
Hrebackova J, Poljakova J, Eckschlager T, et al: Histone deacetylase inhibitors valproate and trichostatin A are toxic to neuroblastoma cells and modulate cytochrome P450 1A1, 1B1 and 3A4 expression in these cells. Interdiscip Toxicol 2: 205-210, 2009.
-
(2009)
Interdiscip Toxicol
, vol.2
, pp. 205-210
-
-
Hrebackova, J.1
Poljakova, J.2
Eckschlager, T.3
-
8
-
-
0029909687
-
Antitumor activity of sodium valproate in cultures of human neuroblastoma cells
-
Cinatl J, Scholz M, Driever PH, et al: Antitumor activity of sodium valproate in cultures of human neuroblastoma cells. Anticancer Drugs 7: 766-773, 1996. (Pubitemid 26388767)
-
(1996)
Anti-Cancer Drugs
, vol.7
, Issue.7
, pp. 766-773
-
-
Cinatl Jr., J.1
Cinatl, J.2
Scholz, M.3
Driever, P.H.4
Henrich, D.5
Kabickova, H.6
Vogel, J.-U.7
Doerr, H.W.8
Kornhuber, B.9
-
9
-
-
16644379041
-
Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo
-
Michaelis M, Suhan T, Cinatl J, Driever PH and Cinatl J: Valproic acid and interferon-α synergistically inhibit neuroblastoma cell growth in vitro and in vivo. Int J Oncol 25: 1795-1799, 2004.
-
(2004)
Int J Oncol
, vol.25
, pp. 1795-1799
-
-
Michaelis, M.1
Suhan, T.2
Cinatl, J.3
Driever, P.H.4
Cinatl, J.5
-
10
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
Harris AL: Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
11
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
Vaupel P, Kallinowski F and Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465, 1989. (Pubitemid 20008770)
-
(1989)
Cancer Research
, vol.49
, Issue.23
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
12
-
-
33749556704
-
Chronic hypoxia promotes hypoxia-inducible factor-1-alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells
-
DOI 10.1158/1535-7163.MCT-06-0145
-
Hussein D, Estlin EJ, Dive C and Makin GW: Chronic hypoxia promotes hypoxia-inducible factor-1alpha-dependent resistance to etoposide and vincristine in neuroblastoma cells. Mol Cancer Ther 5: 2241-2250, 2006. (Pubitemid 44530461)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.9
, pp. 2241-2250
-
-
Hussein, D.1
Estlin, E.J.2
Dive, C.3
Makin, G.W.J.4
-
13
-
-
69049083600
-
Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression
-
Lara PC, Lloret M, Clavo B, et al: Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression. Radiat Oncol 4: 29, 2009.
-
(2009)
Radiat Oncol
, vol.4
, pp. 29
-
-
Lara, P.C.1
Lloret, M.2
Clavo, B.3
-
14
-
-
33748458071
-
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene
-
DOI 10.1007/s00280-006-0224-7
-
Song X, Liu X, Chi W, et al: Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene. Cancer Chemother Pharmacol 58: 776-784, 2006. (Pubitemid 44351258)
-
(2006)
Cancer Chemotherapy and Pharmacology
, vol.58
, Issue.6
, pp. 776-784
-
-
Song, X.1
Liu, X.2
Chi, W.3
Liu, Y.4
Wei, L.5
Wang, X.6
Yu, J.7
-
15
-
-
33745198035
-
Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populations [2]
-
DOI 10.1038/sj.leu.2404224, PII 2404224
-
Giuntoli S, Rovida E, Barbetti V, Cipolleschi MG, Olivotto M and Dello Sbarba P: Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populations. Leukemia 20: 1291-1293, 2006. (Pubitemid 43905834)
-
(2006)
Leukemia
, vol.20
, Issue.7
, pp. 1291-1293
-
-
Giuntoli, S.1
Rovida, E.2
Barbetti, V.3
Cipolleschi, M.G.4
Olivotto, M.5
Dello, S.P.6
-
16
-
-
33846697957
-
Hypoxia-induced genetic instability - A calculated mechanism underlying tumor progression
-
DOI 10.1007/s00109-006-0133-6
-
Huang LE, Bindra RS, Glazer PM and Harris AL: Hypoxia-induced genetic instability - a calculated mechanism underlying tumor progression. J Mol Med (Berl) 85: 139-148, 2007. (Pubitemid 46188219)
-
(2007)
Journal of Molecular Medicine
, vol.85
, Issue.2
, pp. 139-148
-
-
Huang, L.E.1
Bindra, R.S.2
Glazer, P.M.3
Harris, A.L.4
-
17
-
-
0030022252
-
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
-
Brizel DM, Scully SP, Harrelson JM, et al: Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943, 1996. (Pubitemid 26065381)
-
(1996)
Cancer Research
, vol.56
, Issue.5
, pp. 941-943
-
-
Brizel, D.M.1
Scully, S.P.2
Harrelson, J.M.3
Layfield, L.J.4
Bean, J.M.5
Prosnitz, L.R.6
Dewhirst, M.W.7
-
18
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M, Schlenger K, Aral B, et al: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515, 1996. (Pubitemid 26330463)
-
(1996)
Cancer Research
, vol.56
, Issue.19
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
Mitze, M.4
Schaffer, U.5
Vaupel, P.6
-
19
-
-
0037480606
-
Hypoxic cervical cancers with low apoptotic index are highly aggressive
-
Hockel M, Schlenger K, Hockel S and Vaupel P: Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res 59: 4525-4528, 1999. (Pubitemid 29428951)
-
(1999)
Cancer Research
, vol.59
, Issue.18
, pp. 4525-4528
-
-
Hockel, M.1
Schlenger, K.2
Hockel, S.3
Vaupel, P.4
-
20
-
-
0033942067
-
Detection of apoptosis by annexin V labeling
-
Bossy-Wetzel E and Green DR: Detection of apoptosis by annexin V labeling. Methods Enzymol 322: 15-18, 2000. (Pubitemid 30482040)
-
(2000)
Methods in Enzymology
, vol.322
, pp. 15-18
-
-
Bossy-Wetzel, E.1
Green, D.R.2
-
21
-
-
0036581160
-
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
-
Pfaffl MW, Horgan GW and Dempfle L: Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
-
(2002)
Nucleic Acids Res
, vol.30
-
-
Pfaffl, M.W.1
Horgan, G.W.2
Dempfle, L.3
-
22
-
-
33644657517
-
Bid, a BH3-only multi-functional molecule, is at the cross road of life and death
-
Yin X-M: Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene 369: 7-19, 2006.
-
(2006)
Gene
, vol.369
, pp. 7-19
-
-
Yin, X.-M.1
-
23
-
-
0034699326
-
Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
-
Baek JH, Jang JE, Kang CM, Chung HY, Kim ND and Kim KW: Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene 19: 4621-4631, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 4621-4631
-
-
Baek, J.H.1
Jang, J.E.2
Kang, C.M.3
Chung, H.Y.4
Kim, N.D.5
Kim, K.W.6
-
24
-
-
33645005086
-
HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression
-
Liu X-H, Yu EZ, Li Y-Y and Kagan E: HIF-1alpha has an anti-apoptotic effect in human airway epithelium that is mediated via Mcl-1 gene expression. J Cell Biochem 97: 755-765, 2006.
-
(2006)
J Cell Biochem
, vol.97
, pp. 755-765
-
-
Liu, X.-H.1
Yu, E.Z.2
Li, Y.-Y.3
Kagan, E.4
-
25
-
-
1642387020
-
Hypoxia-inducible factor (HIF-1)alpha: Its protein stability and biological functions
-
Lee J-W, Bae S-H, Jeong J-W, Kim S-H and Kim K-W: Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med 36: 1-12, 2004. (Pubitemid 38379631)
-
(2004)
Experimental and Molecular Medicine
, vol.36
, Issue.1
, pp. 1-12
-
-
Lee, J.-W.1
Bae, S.-H.2
Jeong, J.-W.3
Kim, S.-H.4
Kim, K.-W.5
-
26
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza GL: HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
27
-
-
0042411985
-
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
-
DOI 10.1016/S0305-7372(03)00003-3
-
Shannon AM, Bouchier-Hayes DJ, Condron CM and Toomey D: Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 29: 297-307, 2003. (Pubitemid 37069660)
-
(2003)
Cancer Treatment Reviews
, vol.29
, Issue.4
, pp. 297-307
-
-
Shannon, A.M.1
Bouchier-Hayes, D.J.2
Condron, C.M.3
Toomey, D.4
-
28
-
-
3242776224
-
Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells
-
Um JH, Kang CHD, Bae JH, et al: Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells. Exp Mol Med 36: 233-242, 2004. (Pubitemid 38981420)
-
(2004)
Experimental and Molecular Medicine
, vol.36
, Issue.3
, pp. 233-242
-
-
Um, J.H.1
Kang, C.D.2
Bae, J.H.3
Shin, G.G.4
Kim, D.W.5
Kim, D.W.6
Chung, B.S.7
Kim, S.H.8
-
29
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
DOI 10.1038/379088a0
-
Graeber TG, Osmanian C, Jacks T, et al: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: 88-91, 1996. (Pubitemid 26008141)
-
(1996)
Nature
, vol.379
, Issue.6560
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
30
-
-
36949000697
-
Hypoxia-inducible factor-1alpha contributes to hypoxia-induced chemoresistance in gastric cancer
-
DOI 10.1111/j.1349-7006.2007.00643.x
-
Liu L, Ning X, Sun L, et al: Hypoxia-inducible factor-1 alpha contributes to hypoxia-induced chemoresistance in gastric cancer. Cancer Sci 99: 121-128, 2008. (Pubitemid 350239040)
-
(2008)
Cancer Science
, vol.99
, Issue.1
, pp. 121-128
-
-
Liu, L.1
Ning, X.2
Sun, L.3
Zhang, H.4
Shi, Y.5
Guo, C.6
Han, S.7
Liu, J.8
Sun, S.9
Han, Z.10
Wu, K.11
Fan, D.12
-
32
-
-
0035855668
-
Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia
-
DOI 10.1038/sj.onc.1204742
-
Suzuki H, Tomida a and Tsuruo T: Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 20: 5779-5788, 2001. (Pubitemid 32937947)
-
(2001)
Oncogene
, vol.20
, Issue.41
, pp. 5779-5788
-
-
Suzuki, H.1
Tomida, A.2
Tsuruo, T.3
-
33
-
-
34247850849
-
Regulation of the HIF-1á stability by histone deacetylases
-
Kim SH, Jeong JW, Park JA, et al: Regulation of the HIF-1á stability by histone deacetylases. Oncol Rep 17: 647-651, 2007.
-
(2007)
Oncol Rep
, vol.17
, pp. 647-651
-
-
Kim, S.H.1
Jeong, J.W.2
Park, J.A.3
-
34
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An WG, Kanekal M, Simon MC, Maltepe E, Blagosklonny MV and Neckers LM: Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392: 405-408, 1998.
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
35
-
-
77953184918
-
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
-
Sendoel A, Kohler I, Fellmann C, Lowe WS and Hengartner OM: HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature 465: 577-585, 2010.
-
(2010)
Nature
, vol.465
, pp. 577-585
-
-
Sendoel, A.1
Kohler, I.2
Fellmann, C.3
Lowe, W.S.4
Hengartner, O.M.5
-
36
-
-
79958289721
-
HIF-1á antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
-
Nardinocchi L, Puca R and Orazi GD: HIF-1á antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. Aging 3: 33-43, 2011.
-
(2011)
Aging
, vol.3
, pp. 33-43
-
-
Nardinocchi, L.1
Puca, R.2
Orazi, G.D.3
-
37
-
-
77954401666
-
Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia
-
Flamant L, Notte A, Ninane N, Raes M and Michiels C: Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia. Mol Cancer 9: 191, 2010.
-
(2010)
Mol Cancer
, vol.9
, pp. 191
-
-
Flamant, L.1
Notte, A.2
Ninane, N.3
Raes, M.4
Michiels, C.5
-
38
-
-
0035378480
-
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms
-
Dong Z, Venkatachalam Ma, Wang J, et al: Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J Biol Chem 276: 18702-18709, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 18702-18709
-
-
Dong, Z.1
Venkatachalam, Ma.2
Wang, J.3
-
39
-
-
33747376305
-
Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway
-
Piret J-P, Cosse J-P, Ninane N, Raes M and Michiels C: Hypoxia protects HepG2 cells against etoposide-induced apoptosis via a HIF-1-independent pathway. Exp Cell Res 312: 2908-2920, 2006.
-
(2006)
Exp Cell Res
, vol.312
, pp. 2908-2920
-
-
Piret, J.-P.1
Cosse, J.-P.2
Ninane, N.3
Raes, M.4
Michiels, C.5
-
40
-
-
0033593573
-
Valproate robustly enhances AP-1 mediated gene expression
-
DOI 10.1016/S0169-328X(98)00303-9, PII S0169328X98003039
-
Chen G, Yuan PX, Jiang YM, Huang LD and Manji HK: Valproate robustly enhances AP-1 mediated gene expression. Brain Res Mol Brain Res 64: 52-58, 1999. (Pubitemid 29049235)
-
(1999)
Molecular Brain Research
, vol.64
, Issue.1
, pp. 52-58
-
-
Chen, G.1
Yuan, P.-X.2
Jiang, Y.-M.3
Huang, L.-D.4
Manji, H.K.5
-
41
-
-
77950829408
-
Valproic acid in the complex therapy of malignant tumors
-
Hrebackova J, Hrabeta J and Eckschlager T: Valproic acid in the complex therapy of malignant tumors. Curr Drug Targets 11: 361-379, 2010.
-
(2010)
Curr Drug Targets
, vol.11
, pp. 361-379
-
-
Hrebackova, J.1
Hrabeta, J.2
Eckschlager, T.3
-
42
-
-
15944372866
-
Valproic acid induces apoptosis and cell cycle arrest in poorly differentiated thyroid cancer cells
-
DOI 10.1210/jc.2004-1355
-
Catalano MG, Fortunati N, Pugliese M, et al: Valproic acid induces apoptosis and cell cycle arrest in poorly differentiated thyroid cancer cells. J Clin Endocrinol Metab 90: 1383-1389, 2005. (Pubitemid 40463993)
-
(2005)
Journal of Clinical Endocrinology and Metabolism
, vol.90
, Issue.3
, pp. 1383-1389
-
-
Catalano, M.G.1
Fortunati, N.2
Pugliese, M.3
Costantino, L.4
Poli, R.5
Bosco, O.6
Boccuzzi, G.7
-
43
-
-
13444306459
-
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
-
DOI 10.1038/nm1161
-
Nebbioso A Clarke N, Voltz E, et al: Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 11: 77-84, 2005. (Pubitemid 40215841)
-
(2005)
Nature Medicine
, vol.11
, Issue.1
, pp. 77-84
-
-
Nebbioso, A.1
Clarke, N.2
Voltz, E.3
Germain, E.4
Ambrosino, C.5
Bontempo, P.6
Alvarez, R.7
Schiavone, E.M.8
Ferrara, F.9
Bresciani, F.10
Weisz, A.11
De Lera, A.R.12
Gronemeyer, H.13
Altucci, L.14
-
44
-
-
47349097996
-
Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells
-
Muhlethaler-Mottet A, Meier R, Flahaut M, et al: Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. Mol Cancer 7: 55, 2008.
-
(2008)
Mol Cancer
, vol.7
, pp. 55
-
-
Muhlethaler-Mottet, A.1
Meier, R.2
Flahaut, M.3
|