Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populations [2]

Leukemia

Volumn 20, Issue 7, 2006, Pages 1291-1293

  Giuntoli, S ^a   Rovida, E ^a   Barbetti, V ^a   Cipolleschi, M G ^a   Olivotto, M ^a   Dello Sbarba, Persio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; IMATINIB;

CANCER CELL CULTURE; CELL HYPOXIA; CELL POPULATION; CELL VIABILITY; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; GENE EXPRESSION; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LETTER; MOLECULAR CLONING; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 33745198035     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404224     Document Type: Letter

References (8)

1. Cipolleschi MG, Dello Sbarba P, Olivotto M. The role of hypoxia in the maintenance of hematopoietic stem cells. Blood 1993; 82: 2031-2037.
2. Cipolleschi MG, Rovida E, Ivanović Z, Praloran V, Olivotto M, Dello Sbarba P. The expansion of murine bone marrow cells preincubated in hypoxia as an in vitro indicator of their marrow-repopulating ability. Leukemia 2000; 14: 735-739.
3. Ivanovic Z, Belloc F, Faucher JL, Cipolleschi MG, Pralotan V, Dello Sbarba P. Hypoxia maintains and interleukin-3 reduces the pre-colony-forming cell potential of dividing CD34(+) murine bone marrow cells. Exp Hematol 2002; 30: 67-73.
4. Elrick LJ, Jorgensen HG, Mountford JC, Holyoake TL. Punish the parent not the progeny. Blood 2005; 105: 1862-1866.
5. Jamieson CHM, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004; 351: 657-667.
6. Weisberg E, Griffin JD. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood 2000; 95: 3498-3505.
7. Desplat V, Belloc F, Lagarde V, Boyer C, Melo JV, Reiffers J et al. Overproduction of BCR-ABL induces apoptosis in imatinib mesylate-resistant cell lines. Cancer 2005; 103: 102-110.
8. Jiang X, Ng E, Yip C, Eisterer W, Chalandon Y, Stuible M et al. Primitive interleukin-3-null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo. Blood 2002; 100: 3731-3740.